YKR058W / GLG1

Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG1 has a paralog, GLG2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR058W / GLG1

Click on Significant Values for Screen Details ID:SGTC_69|Compound:0096-0274|FD-Score:-3.60|P-value:5.40E-5 ID:SGTC_76|Compound:0433-0009|FD-Score:4.15|P-value:4.60E-6 ID:SGTC_582|Compound:0987-0078|FD-Score:-3.06|P-value:4.98E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:3.41|P-value:1.32E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:-3.06|P-value:5.06E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:2.99|P-value:6.99E-4 ID:SGTC_843|Compound:0310-0051|FD-Score:3.57|P-value:6.78E-5 ID:SGTC_853|Compound:0419-0306|FD-Score:-3.24|P-value:2.46E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:4.57|P-value:5.05E-7 ID:SGTC_893|Compound:0958-0369|FD-Score:3.87|P-value:1.75E-5 ID:SGTC_1040|Compound:k898-0338|FD-Score:3.26|P-value:2.45E-4 ID:SGTC_1090|Compound:efavirenz|FD-Score:-3.08|P-value:4.56E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.94|P-value:5.63E-8 ID:SGTC_1118|Compound:chelidonine|FD-Score:3.02|P-value:6.25E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.42|P-value:1.27E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:3.58|P-value:6.49E-5 ID:SGTC_1339|Compound:1486-1321|FD-Score:-2.97|P-value:6.92E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.46|P-value:1.02E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:3.69|P-value:4.00E-5 ID:SGTC_1845|Compound:st056753|FD-Score:-2.89|P-value:9.47E-4 ID:SGTC_1848|Compound:st056003|FD-Score:3.78|P-value:2.65E-5 ID:SGTC_2081|Compound:5214970|FD-Score:3.18|P-value:3.34E-4 ID:SGTC_2085|Compound:5307070|FD-Score:3.38|P-value:1.48E-4 ID:SGTC_2087|Compound:5276107|FD-Score:3.47|P-value:1.05E-4 ID:SGTC_2105|Compound:5350118|FD-Score:3.06|P-value:5.33E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-3.16|P-value:3.44E-4 ID:SGTC_2283|Compound:7944793|FD-Score:5.87|P-value:1.62E-10 ID:SGTC_2290|Compound:7904846|FD-Score:2.89|P-value:9.94E-4 ID:SGTC_2300|Compound:7976697|FD-Score:3.69|P-value:3.90E-5 ID:SGTC_2472|Compound:5377652|FD-Score:-3.15|P-value:3.50E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:7.52|P-value:3.91E-16 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:5.24|P-value:1.01E-8 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-4.20|P-value:3.18E-6 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:5.44|P-value:2.88E-9 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:4.19|P-value:3.64E-6 ID:SGTC_2834|Compound:9001755|FD-Score:-3.57|P-value:6.18E-5 ID:SGTC_2905|Compound:7799065|FD-Score:3.15|P-value:3.79E-4 ID:SGTC_3099|Compound:9120367|FD-Score:4.74|P-value:2.02E-7 ID:SGTC_3190|Compound:9110366|FD-Score:-2.95|P-value:7.50E-4 ID:SGTC_3298|Compound:9116858|FD-Score:3.76|P-value:2.85E-5 ID:SGTC_3325|Compound:9138760|FD-Score:2.99|P-value:7.02E-4 ID:SGTC_3339|Compound:9145883|FD-Score:4.50|P-value:7.47E-7 ID:SGTC_3346|Compound:9158254|FD-Score:-3.11|P-value:4.13E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:-3.60|P-value:5.40E-5 ID:SGTC_76|Compound:0433-0009|FD-Score:4.15|P-value:4.60E-6 ID:SGTC_582|Compound:0987-0078|FD-Score:-3.06|P-value:4.98E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:3.41|P-value:1.32E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:-3.06|P-value:5.06E-4 ID:SGTC_788|Compound:1182-0090|FD-Score:2.99|P-value:6.99E-4 ID:SGTC_843|Compound:0310-0051|FD-Score:3.57|P-value:6.78E-5 ID:SGTC_853|Compound:0419-0306|FD-Score:-3.24|P-value:2.46E-4 ID:SGTC_886|Compound:0866-0150|FD-Score:4.57|P-value:5.05E-7 ID:SGTC_893|Compound:0958-0369|FD-Score:3.87|P-value:1.75E-5 ID:SGTC_1040|Compound:k898-0338|FD-Score:3.26|P-value:2.45E-4 ID:SGTC_1090|Compound:efavirenz|FD-Score:-3.08|P-value:4.56E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.94|P-value:5.63E-8 ID:SGTC_1118|Compound:chelidonine|FD-Score:3.02|P-value:6.25E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.42|P-value:1.27E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:3.58|P-value:6.49E-5 ID:SGTC_1339|Compound:1486-1321|FD-Score:-2.97|P-value:6.92E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:-3.46|P-value:1.02E-4 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:3.69|P-value:4.00E-5 ID:SGTC_1845|Compound:st056753|FD-Score:-2.89|P-value:9.47E-4 ID:SGTC_1848|Compound:st056003|FD-Score:3.78|P-value:2.65E-5 ID:SGTC_2081|Compound:5214970|FD-Score:3.18|P-value:3.34E-4 ID:SGTC_2085|Compound:5307070|FD-Score:3.38|P-value:1.48E-4 ID:SGTC_2087|Compound:5276107|FD-Score:3.47|P-value:1.05E-4 ID:SGTC_2105|Compound:5350118|FD-Score:3.06|P-value:5.33E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:-3.16|P-value:3.44E-4 ID:SGTC_2283|Compound:7944793|FD-Score:5.87|P-value:1.62E-10 ID:SGTC_2290|Compound:7904846|FD-Score:2.89|P-value:9.94E-4 ID:SGTC_2300|Compound:7976697|FD-Score:3.69|P-value:3.90E-5 ID:SGTC_2472|Compound:5377652|FD-Score:-3.15|P-value:3.50E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:7.52|P-value:3.91E-16 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:5.24|P-value:1.01E-8 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-4.20|P-value:3.18E-6 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:5.44|P-value:2.88E-9 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:4.19|P-value:3.64E-6 ID:SGTC_2834|Compound:9001755|FD-Score:-3.57|P-value:6.18E-5 ID:SGTC_2905|Compound:7799065|FD-Score:3.15|P-value:3.79E-4 ID:SGTC_3099|Compound:9120367|FD-Score:4.74|P-value:2.02E-7 ID:SGTC_3190|Compound:9110366|FD-Score:-2.95|P-value:7.50E-4 ID:SGTC_3298|Compound:9116858|FD-Score:3.76|P-value:2.85E-5 ID:SGTC_3325|Compound:9138760|FD-Score:2.99|P-value:7.02E-4 ID:SGTC_3339|Compound:9145883|FD-Score:4.50|P-value:7.47E-7 ID:SGTC_3346|Compound:9158254|FD-Score:-3.11|P-value:4.13E-4

Top fitness defect scores for YKR058W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2528 xanthyletin 7.52 44.8 µM 3.91E-16 2 2.64E-14
2 SGTC_2283 7944793 5.87 200.0 µM 1.62E-10 8 2.13E-9
3 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 5.44 100.0 µM 2.88E-9 60S ribosome export 5 2.64E-8
4 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 5.24 92.6 µM 1.01E-8 9 7.95E-8
5 SGTC_3099 9120367 4.74 49.5 µM 2.02E-7 5 1.09E-6
6 SGTC_886 0866-0150 4.57 153.0 µM 5.05E-7 11 2.43E-6
7 SGTC_3339 9145883 4.50 14.9 µM 7.47E-7 7 3.43E-6
8 SGTC_2595 hexamethylquercetagetin 4.19 100.0 µM 3.64E-6 19 1.38E-5
9 SGTC_76 0433-0009 4.15 400.3 µM 4.60E-6 11 1.69E-5
10 SGTC_893 0958-0369 3.87 48.9 µM 1.75E-5 25 5.45E-5
11 SGTC_1848 st056003 3.78 16.4 µM 2.65E-5 21 7.85E-5
12 SGTC_3298 9116858 3.76 71.4 µM 2.85E-5 14 8.37E-5
13 SGTC_2300 7976697 3.69 71.6 µM 3.90E-5 ERG2 38 1.10E-4
14 SGTC_1577 3(2'-chlorophenyl)-7-ethoxycoumarin 3.69 66.5 µM 4.00E-5 21 1.13E-4
15 SGTC_1320 1313-0481 3.58 95.3 µM 6.49E-5 34 1.73E-4
16 SGTC_843 0310-0051 3.57 143.0 µM 6.78E-5 18 1.79E-4
17 SGTC_2087 5276107 3.47 200.0 µM 1.05E-4 28 2.64E-4
18 SGTC_1256 0570-0116 3.42 285.0 µM 1.27E-4 33 3.11E-4
19 SGTC_697 0508-1955 3.41 564.0 µM 1.32E-4 57 3.21E-4
20 SGTC_2085 5307070 3.38 144.1 µM 1.48E-4 superoxide 47 3.57E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.162 4.93E-21 YBL086C_p YBL086C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.149 3.65E-18 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.128 1.01E-13 YJR019C TES1 hom Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids
0.123 7.44E-13 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.119 4.22E-12 YDR094W_d YDR094W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2
0.115 2.61E-11 YJL122W ALB1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p
0.115 2.95E-11 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.112 9.09E-11 YCR105W ADH7 hom NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance
0.111 9.70E-11 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.111 1.16E-10 YER068C-A_d YER068C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.109 2.24E-10 YMR305C SCW10 hom Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p
0.108 3.28E-10 YGR149W_p YGR149W_p hom Putative protein of unknown function; predicted to be an integal membrane protein
0.108 3.42E-10 YKR039W GAP1 hom General amino acid permease; Gap1p senses the presence of amino acid substrates to regulate localization to the plasma membrane when needed; essential for invasive growth
0.108 4.00E-10 YFL041W FET5 hom Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport
0.107 6.44E-10 YER071C_p TDA2_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele