YKR061W / KTR2

Mannosyltransferase involved in N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR2 has a paralog, YUR1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR061W / KTR2

Click on Significant Values for Screen Details ID:SGTC_19|Compound:0279-0214|FD-Score:3.34|P-value:1.61E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:3.50|P-value:8.09E-5 ID:SGTC_268|Compound:camptothecin|FD-Score:3.53|P-value:7.26E-5 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.90|P-value:1.30E-5 ID:SGTC_556|Compound:4058-0063|FD-Score:2.98|P-value:6.55E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:2.92|P-value:8.35E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:2.91|P-value:8.72E-4 ID:SGTC_844|Compound:0330-0132|FD-Score:3.94|P-value:1.10E-5 ID:SGTC_911|Compound:3456-4043|FD-Score:2.88|P-value:9.45E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:3.45|P-value:1.03E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:2.89|P-value:9.25E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:3.21|P-value:2.75E-4 ID:SGTC_1216|Compound:1165-0504|FD-Score:2.88|P-value:9.58E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.10|P-value:4.13E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.63|P-value:4.53E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.22|P-value:2.56E-4 ID:SGTC_1523|Compound:st012844|FD-Score:3.30|P-value:1.90E-4 ID:SGTC_1526|Compound:st051518|FD-Score:-3.03|P-value:5.44E-4 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:-2.96|P-value:7.19E-4 ID:SGTC_1555|Compound:citronellol|FD-Score:2.95|P-value:7.28E-4 ID:SGTC_1628|Compound:st004252|FD-Score:4.10|P-value:4.97E-6 ID:SGTC_1642|Compound:st009582|FD-Score:3.85|P-value:1.67E-5 ID:SGTC_1984|Compound:st072354|FD-Score:-3.46|P-value:9.51E-5 ID:SGTC_1986|Compound:st071812|FD-Score:-3.58|P-value:5.66E-5 ID:SGTC_2000|Compound:st075254|FD-Score:-3.26|P-value:2.21E-4 ID:SGTC_2099|Compound:5377090|FD-Score:3.62|P-value:4.76E-5 ID:SGTC_2246|Compound:7293507|FD-Score:3.28|P-value:2.06E-4 ID:SGTC_2275|Compound:7947463|FD-Score:2.88|P-value:9.47E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:2.87|P-value:9.91E-4 ID:SGTC_2683|Compound:piperine|FD-Score:3.61|P-value:4.97E-5 ID:SGTC_2769|Compound:toremifene|FD-Score:3.62|P-value:4.71E-5 ID:SGTC_2772|Compound:vinpocetine|FD-Score:2.94|P-value:7.70E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-3.03|P-value:5.49E-4 ID:SGTC_2892|Compound:9047358|FD-Score:3.20|P-value:2.78E-4 ID:SGTC_3159|Compound:9100096|FD-Score:-3.52|P-value:7.38E-5 ID:SGTC_3199|Compound:9111318|FD-Score:-3.10|P-value:4.17E-4 ID:SGTC_3208|Compound:9114115|FD-Score:-3.57|P-value:5.87E-5 ID:SGTC_3253|Compound:9135987|FD-Score:-3.34|P-value:1.62E-4 ID:SGTC_3302|Compound:9125395|FD-Score:-3.16|P-value:3.29E-4 ID:SGTC_3311|Compound:9131146|FD-Score:2.99|P-value:6.36E-4 ID:SGTC_19|Compound:0279-0214|FD-Score:3.34|P-value:1.61E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:3.50|P-value:8.09E-5 ID:SGTC_268|Compound:camptothecin|FD-Score:3.53|P-value:7.26E-5 ID:SGTC_361|Compound:000s-0510|FD-Score:-3.90|P-value:1.30E-5 ID:SGTC_556|Compound:4058-0063|FD-Score:2.98|P-value:6.55E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:2.92|P-value:8.35E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:2.91|P-value:8.72E-4 ID:SGTC_844|Compound:0330-0132|FD-Score:3.94|P-value:1.10E-5 ID:SGTC_911|Compound:3456-4043|FD-Score:2.88|P-value:9.45E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:3.45|P-value:1.03E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:2.89|P-value:9.25E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:3.21|P-value:2.75E-4 ID:SGTC_1216|Compound:1165-0504|FD-Score:2.88|P-value:9.58E-4 ID:SGTC_1230|Compound:0170-0365|FD-Score:3.10|P-value:4.13E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.63|P-value:4.53E-5 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.22|P-value:2.56E-4 ID:SGTC_1523|Compound:st012844|FD-Score:3.30|P-value:1.90E-4 ID:SGTC_1526|Compound:st051518|FD-Score:-3.03|P-value:5.44E-4 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:-2.96|P-value:7.19E-4 ID:SGTC_1555|Compound:citronellol|FD-Score:2.95|P-value:7.28E-4 ID:SGTC_1628|Compound:st004252|FD-Score:4.10|P-value:4.97E-6 ID:SGTC_1642|Compound:st009582|FD-Score:3.85|P-value:1.67E-5 ID:SGTC_1984|Compound:st072354|FD-Score:-3.46|P-value:9.51E-5 ID:SGTC_1986|Compound:st071812|FD-Score:-3.58|P-value:5.66E-5 ID:SGTC_2000|Compound:st075254|FD-Score:-3.26|P-value:2.21E-4 ID:SGTC_2099|Compound:5377090|FD-Score:3.62|P-value:4.76E-5 ID:SGTC_2246|Compound:7293507|FD-Score:3.28|P-value:2.06E-4 ID:SGTC_2275|Compound:7947463|FD-Score:2.88|P-value:9.47E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:2.87|P-value:9.91E-4 ID:SGTC_2683|Compound:piperine|FD-Score:3.61|P-value:4.97E-5 ID:SGTC_2769|Compound:toremifene|FD-Score:3.62|P-value:4.71E-5 ID:SGTC_2772|Compound:vinpocetine|FD-Score:2.94|P-value:7.70E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-3.03|P-value:5.49E-4 ID:SGTC_2892|Compound:9047358|FD-Score:3.20|P-value:2.78E-4 ID:SGTC_3159|Compound:9100096|FD-Score:-3.52|P-value:7.38E-5 ID:SGTC_3199|Compound:9111318|FD-Score:-3.10|P-value:4.17E-4 ID:SGTC_3208|Compound:9114115|FD-Score:-3.57|P-value:5.87E-5 ID:SGTC_3253|Compound:9135987|FD-Score:-3.34|P-value:1.62E-4 ID:SGTC_3302|Compound:9125395|FD-Score:-3.16|P-value:3.29E-4 ID:SGTC_3311|Compound:9131146|FD-Score:2.99|P-value:6.36E-4

Top fitness defect scores for YKR061W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1628 st004252 4.10 77.7 µM 4.97E-6 17 2.06E-5
2 SGTC_844 0330-0132 3.94 15.3 µM 1.10E-5 15 4.10E-5
3 SGTC_1642 st009582 3.85 77.7 µM 1.67E-5 RPP1 & pyrimidine depletion 17 5.90E-5
4 SGTC_1450 4112-4260 3.63 37.6 µM 4.53E-5 calcium & mitochondrial duress 39 1.40E-4
5 SGTC_2769 toremifene 3.62 3.7 µM 4.71E-5 31 1.45E-4
6 SGTC_2099 5377090 3.62 177.4 µM 4.76E-5 34 1.46E-4
7 SGTC_2683 piperine 3.61 63.0 µM 4.97E-5 21 1.52E-4
8 SGTC_268 camptothecin 3.53 39.6 µM 7.26E-5 DNA damage response 94 2.11E-4
9 SGTC_52 0329-0193 3.50 875.0 nM 8.09E-5 TSC3-RPN4 52 2.32E-4
10 SGTC_994 3910-0338 3.45 138.0 µM 1.03E-4 calcium & mitochondrial duress 71 2.85E-4
11 SGTC_19 0279-0214 3.34 38.4 µM 1.61E-4 TRP & mitochondrial translation 72 4.22E-4
12 SGTC_1523 st012844 3.30 44.7 µM 1.90E-4 60S ribosome export 50 4.86E-4
13 SGTC_2246 7293507 3.28 91.6 µM 2.06E-4 54 5.23E-4
14 SGTC_1210 3013-0140 3.21 750.0 nM 2.75E-4 23 6.70E-4
15 SGTC_2892 9047358 3.20 58.4 µM 2.78E-4 24 6.78E-4
16 SGTC_1230 0170-0365 3.10 3.8 µM 4.13E-4 endomembrane recycling 127 9.57E-4
17 SGTC_3311 9131146 2.99 2.9 µM 6.36E-4 cell wall 174 0.00139
18 SGTC_556 4058-0063 2.98 51.5 µM 6.55E-4 65 0.00143
19 SGTC_1555 citronellol 2.95 128.0 µM 7.28E-4 24 0.00157
20 SGTC_2772 vinpocetine 2.94 57.1 µM 7.70E-4 67 0.00164

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.162 4.28E-21 YFR025C HIS2 hom Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control
0.137 1.30E-15 YOL134C_d YOL134C_d het Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps HRT1, a verified gene that encodes an SCF ubiquitin ligase subunit
0.131 2.44E-14 YFR005C SAD1 het Conserved zinc-finger domain protein involved in pre-mRNA splicing, required for assembly of U4 snRNA into the U4/U6 particle
0.127 1.36E-13 YNL157W IGO1 hom Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo2p
0.116 1.39E-11 YJR137C MET5 hom Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine
0.115 2.63E-11 YDL010W GRX6 hom Cis-golgi localized monothiol glutaredoxin, binds Fe-S cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; GRX6 has a paralog, GRX7, that arose from the whole genome duplication
0.114 3.31E-11 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.104 1.48E-9 YJL013C MAD3 hom Subunit of the spindle-assembly checkpoint complex, which delays anaphase onset in cells with defects in mitotic spindle assembly; pseudosubstrate inhibitor of APC(Cdc20), the anaphase promoting complex involved in securin (Pds1p) turnover
0.100 5.98E-9 YLR457C NBP1 het Spindle pole body (SPB) component; required for the insertion of the duplication plaque into the nuclear membrane during SPB duplication; essential for bipolar spindle formation; component of the Mps2p-Bbp1p complex; NBP1 has a paralog, YPR174C, that arose from the whole genome duplication
0.098 1.16E-8 YKL071W_p YKL071W_p hom Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.094 4.26E-8 YGR032W GSC2 hom Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p)
0.090 1.69E-7 YBL020W RFT1 het Essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase; mutation is suppressed by expression of human p53 protein
0.090 1.79E-7 YGR072W UPF3 hom Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance
0.090 1.83E-7 YLR028C ADE16 hom Enzyme of 'de novo' purine biosynthesis; contains both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities; ADE16 has a paralog, ADE17, that arose from the whole genome duplication; ade16 ade17 mutants require adenine and histidine
0.089 2.57E-7 YDL218W_p YDL218W_p hom Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions; expression also induced in cells treated with the mycotoxin patulin