HIPHOP chemogenomics database

YKR068C / BET3

Hydrophilic protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles; component of the TRAPP (transport protein particle) complex

Zygosity: Heterozygous strain

fixedexpanded
Profile for YKR068C / BET3

Click on Significant Values for Screen Details

Top fitness defect scores for YKR068C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_1245	0418-0076	7.62	17.2 µM	3.50E-15	ERG2	2	1.25E-14	2.22
2	SGTC_579	4491-1009	5.54	110.0 µM	7.80E-9	60S ribosome export	3	1.50E-8	0.63
3	SGTC_1326	1431-2094	5.10	10.8 µM	9.52E-8	tubulin folding & SWR complex	1	1.65E-7	0.54
4	SGTC_3188	9110789	4.63	49.5 µM	1.15E-6	iron homeostasis	8	1.81E-6	0.30
5	SGTC_530	4358-1714	4.47	28.0 µM	2.59E-6		2	3.93E-6	0.36
6	SGTC_1501	4491-0275	4.29	38.4 µM	5.95E-6		2	8.74E-6	0.51
7	SGTC_1860	st056228	4.29	74.6 µM	6.16E-6		3	9.05E-6	0.02
8	SGTC_1251	0490-5699	4.20	265.0 µM	9.05E-6		7	1.31E-5	0.27
9	SGTC_930	2810-3379	4.08	265.0 µM	1.57E-5		3	2.22E-5	0.18
10	SGTC_1402	3909-7673	3.95	35.9 µM	2.83E-5		2	3.91E-5	0.26
11	SGTC_2769	toremifene	3.94	3.7 µM	2.95E-5		6	4.06E-5	0.01
12	SGTC_2589	lobaric acid	3.85	100.0 µM	4.30E-5		3	5.84E-5	0.51
13	SGTC_1268	0828-0275	3.77	2.5 µM	6.09E-5		6	8.16E-5	0.11
14	SGTC_2482	5981709	3.66	142.7 µM	9.70E-5	PDR1	16	1.28E-4	0.06
15	SGTC_520	3584-0023	3.55	682.0 µM	1.46E-4		17	1.89E-4	0.04
16	SGTC_2321	7390090	3.51	138.8 µM	1.72E-4		9	2.21E-4	0.21
17	SGTC_2316	5844804	3.51	197.4 µM	1.77E-4		15	2.27E-4	0.00
18	SGTC_2604	4'-hydroxychalcone	3.50	11.3 µM	1.82E-4		19	2.34E-4	0.23
19	SGTC_2020	4017018	3.49	200.0 µM	1.88E-4		11	2.40E-4	0.08
20	SGTC_2068	5226020	3.49	147.0 µM	1.89E-4		11	2.42E-4	0.05

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.115	2.36E-11	YKL152C	GPM1	het	Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis
0.109	2.58E-10	YDL153C	SAS10	het	Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance
0.101	4.80E-9	YOR249C	APC5	het	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to nuclear foci decreases upon DNA replication stress
0.096	2.59E-8	YLR195C	NMT1	het	N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction
0.094	5.02E-8	YPR068C	HOS1	hom	Class I histone deacetylase (HDAC) family member that deacetylates Smc3p on lysine residues at anaphase onset; has sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; interacts with the Tup1p-Ssn6p corepressor complex
0.093	6.25E-8	YBR155W	CNS1	het	TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion
0.093	7.70E-8	YPR105C	COG4	het	Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.091	1.25E-7	YDR235W	PRP42	het	U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats
0.089	2.49E-7	YNL091W	NST1	hom	Protein of unknown function, mediates sensitivity to salt stress; interacts physically with the splicing factor Msl1p and also displays genetic interaction with MSL1
0.088	2.99E-7	YER043C	SAH1	het	S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
0.085	8.59E-7	YKL095W	YJU2	het	Essential protein required for pre-mRNA splicing; associates transiently with the spliceosomal NTC (nineteen complex) and acts after Prp2p to promote the first catalytic reaction of splicing
0.079	4.36E-6	YGR290W_d	YGR290W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; putative HLH protein; partially overlaps the verified ORF MAL11/YGR289C (a high-affinity maltose transporter)
0.079	4.76E-6	YDR510W	SMT3	het	Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; phosphorylated at Ser2
0.077	8.35E-6	YER093C-A	AIM11	hom	Protein of unknown function; null mutant is viable but shows increased loss of mitochondrial genome and synthetic interaction with prohibitin (phb1); contains an intron; YER093C-A has a paralog, YBL059W, that arose from the whole genome duplication
0.074	1.93E-5	YHR019C	DED81	het	Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA