YKR084C / HBS1

GTPase with similarity to translation release factors; together with binding partner Dom34p, facilitates ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled; genetically implicated in mRNA no-go decay

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR084C / HBS1

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:-3.17|P-value:8.12E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:4.20|P-value:1.73E-5 ID:SGTC_543|Compound:3844-1095|FD-Score:3.96|P-value:4.78E-5 ID:SGTC_558|Compound:k064-0027|FD-Score:-3.53|P-value:2.27E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:3.92|P-value:5.61E-5 ID:SGTC_764|Compound:1951-2361|FD-Score:3.38|P-value:4.44E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:4.26|P-value:1.35E-5 ID:SGTC_886|Compound:0866-0150|FD-Score:5.92|P-value:2.56E-9 ID:SGTC_979|Compound:1426-2828|FD-Score:4.28|P-value:1.23E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:-3.49|P-value:2.64E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.37|P-value:4.57E-4 ID:SGTC_1393|Compound:3470-5649|FD-Score:4.21|P-value:1.69E-5 ID:SGTC_1403|Compound:3909-7815|FD-Score:4.41|P-value:7.02E-6 ID:SGTC_1406|Compound:3909-7906|FD-Score:5.39|P-value:5.34E-8 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.86|P-value:7.19E-5 ID:SGTC_1428|Compound:4049-0204|FD-Score:4.37|P-value:8.36E-6 ID:SGTC_1429|Compound:4049-0205|FD-Score:4.14|P-value:2.25E-5 ID:SGTC_1442|Compound:4112-3290|FD-Score:3.98|P-value:4.42E-5 ID:SGTC_1464|Compound:k208-0027|FD-Score:-3.22|P-value:6.83E-4 ID:SGTC_1655|Compound:st012546|FD-Score:4.14|P-value:2.23E-5 ID:SGTC_1656|Compound:st012921|FD-Score:3.53|P-value:2.54E-4 ID:SGTC_1663|Compound:st014140|FD-Score:7.35|P-value:2.02E-13 ID:SGTC_1665|Compound:st014639|FD-Score:3.52|P-value:2.66E-4 ID:SGTC_1670|Compound:st016595|FD-Score:4.69|P-value:1.90E-6 ID:SGTC_1716|Compound:st033144|FD-Score:-4.09|P-value:2.49E-5 ID:SGTC_1733|Compound:st037357|FD-Score:3.32|P-value:5.40E-4 ID:SGTC_1775|Compound:st081588|FD-Score:3.73|P-value:1.21E-4 ID:SGTC_1805|Compound:st050013|FD-Score:4.25|P-value:1.43E-5 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.72|P-value:1.25E-4 ID:SGTC_1990|Compound:st072050|FD-Score:4.92|P-value:6.31E-7 ID:SGTC_2083|Compound:5306046|FD-Score:3.82|P-value:8.44E-5 ID:SGTC_2096|Compound:5468907|FD-Score:-3.58|P-value:1.91E-4 ID:SGTC_2097|Compound:5376186|FD-Score:5.88|P-value:3.38E-9 ID:SGTC_2313|Compound:7726885|FD-Score:5.94|P-value:2.27E-9 ID:SGTC_2328|Compound:6201408|FD-Score:3.42|P-value:3.83E-4 ID:SGTC_2356|Compound:9061756|FD-Score:-5.63|P-value:1.16E-8 ID:SGTC_2378|Compound:9074213|FD-Score:4.13|P-value:2.33E-5 ID:SGTC_2477|Compound:5967686|FD-Score:3.50|P-value:2.87E-4 ID:SGTC_2483|Compound:5729050|FD-Score:-3.29|P-value:5.44E-4 ID:SGTC_2487|Compound:5918373|FD-Score:3.90|P-value:6.18E-5 ID:SGTC_2524|Compound:avocatin b|FD-Score:4.66|P-value:2.18E-6 ID:SGTC_2560|Compound:caryophyllene|FD-Score:3.97|P-value:4.55E-5 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-3.93|P-value:4.83E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.62|P-value:1.82E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.33|P-value:5.29E-4 ID:SGTC_2702|Compound:st077768|FD-Score:-3.61|P-value:1.71E-4 ID:SGTC_2715|Compound:st079500|FD-Score:4.85|P-value:8.62E-7 ID:SGTC_2788|Compound:5282734|FD-Score:6.24|P-value:3.87E-10 ID:SGTC_2856|Compound:9022925|FD-Score:3.81|P-value:8.65E-5 ID:SGTC_2907|Compound:7721985|FD-Score:4.40|P-value:7.34E-6 ID:SGTC_2982|Compound:9019404|FD-Score:-3.12|P-value:9.66E-4 ID:SGTC_3044|Compound:9093193|FD-Score:3.24|P-value:7.11E-4 ID:SGTC_3087|Compound:9117406|FD-Score:3.79|P-value:9.47E-5 ID:SGTC_3101|Compound:9120531|FD-Score:3.25|P-value:6.93E-4 ID:SGTC_3202|Compound:9113761|FD-Score:3.86|P-value:7.26E-5 ID:SGTC_3284|Compound:9108171|FD-Score:3.47|P-value:3.21E-4 ID:SGTC_3299|Compound:9121982|FD-Score:-3.73|P-value:1.06E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:-3.17|P-value:8.12E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:4.20|P-value:1.73E-5 ID:SGTC_543|Compound:3844-1095|FD-Score:3.96|P-value:4.78E-5 ID:SGTC_558|Compound:k064-0027|FD-Score:-3.53|P-value:2.27E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:3.92|P-value:5.61E-5 ID:SGTC_764|Compound:1951-2361|FD-Score:3.38|P-value:4.44E-4 ID:SGTC_789|Compound:1309-1135|FD-Score:4.26|P-value:1.35E-5 ID:SGTC_886|Compound:0866-0150|FD-Score:5.92|P-value:2.56E-9 ID:SGTC_979|Compound:1426-2828|FD-Score:4.28|P-value:1.23E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:-3.49|P-value:2.64E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.37|P-value:4.57E-4 ID:SGTC_1393|Compound:3470-5649|FD-Score:4.21|P-value:1.69E-5 ID:SGTC_1403|Compound:3909-7815|FD-Score:4.41|P-value:7.02E-6 ID:SGTC_1406|Compound:3909-7906|FD-Score:5.39|P-value:5.34E-8 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.86|P-value:7.19E-5 ID:SGTC_1428|Compound:4049-0204|FD-Score:4.37|P-value:8.36E-6 ID:SGTC_1429|Compound:4049-0205|FD-Score:4.14|P-value:2.25E-5 ID:SGTC_1442|Compound:4112-3290|FD-Score:3.98|P-value:4.42E-5 ID:SGTC_1464|Compound:k208-0027|FD-Score:-3.22|P-value:6.83E-4 ID:SGTC_1655|Compound:st012546|FD-Score:4.14|P-value:2.23E-5 ID:SGTC_1656|Compound:st012921|FD-Score:3.53|P-value:2.54E-4 ID:SGTC_1663|Compound:st014140|FD-Score:7.35|P-value:2.02E-13 ID:SGTC_1665|Compound:st014639|FD-Score:3.52|P-value:2.66E-4 ID:SGTC_1670|Compound:st016595|FD-Score:4.69|P-value:1.90E-6 ID:SGTC_1716|Compound:st033144|FD-Score:-4.09|P-value:2.49E-5 ID:SGTC_1733|Compound:st037357|FD-Score:3.32|P-value:5.40E-4 ID:SGTC_1775|Compound:st081588|FD-Score:3.73|P-value:1.21E-4 ID:SGTC_1805|Compound:st050013|FD-Score:4.25|P-value:1.43E-5 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.72|P-value:1.25E-4 ID:SGTC_1990|Compound:st072050|FD-Score:4.92|P-value:6.31E-7 ID:SGTC_2083|Compound:5306046|FD-Score:3.82|P-value:8.44E-5 ID:SGTC_2096|Compound:5468907|FD-Score:-3.58|P-value:1.91E-4 ID:SGTC_2097|Compound:5376186|FD-Score:5.88|P-value:3.38E-9 ID:SGTC_2313|Compound:7726885|FD-Score:5.94|P-value:2.27E-9 ID:SGTC_2328|Compound:6201408|FD-Score:3.42|P-value:3.83E-4 ID:SGTC_2356|Compound:9061756|FD-Score:-5.63|P-value:1.16E-8 ID:SGTC_2378|Compound:9074213|FD-Score:4.13|P-value:2.33E-5 ID:SGTC_2477|Compound:5967686|FD-Score:3.50|P-value:2.87E-4 ID:SGTC_2483|Compound:5729050|FD-Score:-3.29|P-value:5.44E-4 ID:SGTC_2487|Compound:5918373|FD-Score:3.90|P-value:6.18E-5 ID:SGTC_2524|Compound:avocatin b|FD-Score:4.66|P-value:2.18E-6 ID:SGTC_2560|Compound:caryophyllene|FD-Score:3.97|P-value:4.55E-5 ID:SGTC_2592|Compound:piperlongumine|FD-Score:-3.93|P-value:4.83E-5 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.62|P-value:1.82E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.33|P-value:5.29E-4 ID:SGTC_2702|Compound:st077768|FD-Score:-3.61|P-value:1.71E-4 ID:SGTC_2715|Compound:st079500|FD-Score:4.85|P-value:8.62E-7 ID:SGTC_2788|Compound:5282734|FD-Score:6.24|P-value:3.87E-10 ID:SGTC_2856|Compound:9022925|FD-Score:3.81|P-value:8.65E-5 ID:SGTC_2907|Compound:7721985|FD-Score:4.40|P-value:7.34E-6 ID:SGTC_2982|Compound:9019404|FD-Score:-3.12|P-value:9.66E-4 ID:SGTC_3044|Compound:9093193|FD-Score:3.24|P-value:7.11E-4 ID:SGTC_3087|Compound:9117406|FD-Score:3.79|P-value:9.47E-5 ID:SGTC_3101|Compound:9120531|FD-Score:3.25|P-value:6.93E-4 ID:SGTC_3202|Compound:9113761|FD-Score:3.86|P-value:7.26E-5 ID:SGTC_3284|Compound:9108171|FD-Score:3.47|P-value:3.21E-4 ID:SGTC_3299|Compound:9121982|FD-Score:-3.73|P-value:1.06E-4

Top fitness defect scores for YKR084C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1663 st014140 7.35 55.4 µM 2.02E-13 60S ribosome export 2 9.78E-14
2 SGTC_2788 5282734 6.24 71.4 µM 3.87E-10 10 2.25E-10
3 SGTC_2313 7726885 5.94 200.0 µM 2.27E-9 RPP1 & pyrimidine depletion 6 1.38E-9
4 SGTC_886 0866-0150 5.92 153.0 µM 2.56E-9 1 1.56E-9
5 SGTC_2097 5376186 5.88 200.0 µM 3.38E-9 4 2.07E-9
6 SGTC_1406 3909-7906 5.39 11.9 µM 5.34E-8 60S ribosome export 2 3.51E-8
7 SGTC_1990 st072050 4.92 59.8 µM 6.31E-7 4 4.41E-7
8 SGTC_2715 st079500 4.85 56.4 µM 8.62E-7 1 6.08E-7
9 SGTC_1670 st016595 4.69 4.0 µM 1.90E-6 3 1.37E-6
10 SGTC_2524 avocatin b 4.66 10.6 µM 2.18E-6 17 1.58E-6
11 SGTC_1403 3909-7815 4.41 62.9 µM 7.02E-6 11 5.22E-6
12 SGTC_2907 7721985 4.40 69.9 µM 7.34E-6 13 5.46E-6
13 SGTC_1428 4049-0204 4.37 61.7 µM 8.36E-6 6 6.24E-6
14 SGTC_979 1426-2828 4.28 121.0 µM 1.23E-5 16 9.23E-6
15 SGTC_789 1309-1135 4.26 70.6 µM 1.35E-5 ERG2 22 1.02E-5
16 SGTC_1805 st050013 4.25 60.3 µM 1.43E-5 3 1.08E-5
17 SGTC_1393 3470-5649 4.21 58.2 µM 1.69E-5 60S ribosome export 12 1.28E-5
18 SGTC_91 0417-1751 4.20 58.4 µM 1.73E-5 Golgi 44 1.32E-5
19 SGTC_1655 st012546 4.14 55.1 µM 2.23E-5 26 1.71E-5
20 SGTC_1429 4049-0205 4.14 9.5 µM 2.25E-5 10 1.72E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.113 4.91E-11 YHR195W NVJ1 hom Nuclear envelope protein, anchored to the nuclear inner membrane, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN)
0.090 1.76E-7 YAR035W YAT1 hom Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated
0.087 4.45E-7 YGL141W HUL5 hom Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD
0.083 1.33E-6 YLR253W_p YLR253W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; transcription is periodic during the metabolic cycle; YLR253W is not an essential gene
0.081 2.30E-6 YML082W_p YML082W_p hom Putative protein predicted to have carbon-sulfur lyase activity; transcriptionally regulated by Upc2p via an upstream sterol response element; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; YML082W is not an essential gene
0.079 4.52E-6 YJL218W_p YJL218W_p hom Putative acetyltransferase; similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene
0.077 8.26E-6 YBR269C_p FMP21_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.077 8.70E-6 YPL177C CUP9 hom Homeodomain-containing transcriptional repressor; regulates expression of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription; CUP9 has a paralog, TOS8, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.073 2.60E-5 YBR024W SCO2 hom Protein anchored to mitochondrial inner membrane; may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p; SCO2 has a paralog, SCO1, that arose from the whole genome duplication
0.069 5.99E-5 YPR130C_d YPR130C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.067 1.06E-4 YOR385W_p YOR385W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YOR385W is not an essential gene
0.066 1.18E-4 YDL081C RPP1A hom Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component
0.065 1.64E-4 YLR175W CBF5 het Pseudouridine synthase catalytic subunit of box H/ACA small nucleolar ribonucleoprotein particles (snoRNPs), acts on both large and small rRNAs and on snRNA U2; mutations in human ortholog dyskerin cause the disorder dyskeratosis congenita
0.065 1.73E-4 YPR009W SUT2 hom Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p
0.065 1.76E-4 YOR291W YPK9 hom Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome