HIPHOP chemogenomics database
YKR099W / BAS1 
Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YKR099W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.399 | 1.47E-124 | YPR180W | AOS1 | het | Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability |
| 0.299 | 4.64E-68 | YMR088C | VBA1 | hom | Permease of basic amino acids in the vacuolar membrane |
| 0.213 | 1.84E-34 | YNL295W_p | YNL295W_p | hom | Putative protein of unknown function |
| 0.159 | 9.75E-20 | YDR096W | GIS1 | hom | Histone demethylase and transcription factor; regulates genes during nutrient limitation; negatively regulates DPP1, PHR1; activity modulated by limited proteasome-mediated proteolysis; has JmjC and JmjN domain in N-terminal region that interact, promoting stability and proper transcriptional activity; contains two transactivating domains downstream of Jmj domains and a C-terminal DNA binding domain; GIS1 has a paralog, RPH1, that arose from the whole genome duplication |
| 0.146 | 6.08E-17 | YHR153C | SPO16 | hom | Meiosis-specific protein involved in synaptonemal complex assembly; implicated in regulation of crossover formation; required for sporulation |
| 0.127 | 3.39E-13 | YBL066C | SEF1 | hom | Putative transcription factor, has homolog in Kluyveromyces lactis |
| 0.122 | 2.80E-12 | YAR028W_p | YAR028W_p | hom | Putative integral membrane protein, member of DUP240 gene family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS |
| 0.121 | 4.93E-12 | YBR125C | PTC4 | hom | Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity |
| 0.116 | 3.46E-11 | YGR043C | NQM1 | hom | Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift |
| 0.103 | 3.41E-9 | YEL001C | IRC22 | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci |
| 0.103 | 3.55E-9 | YML116W | ATR1 | hom | Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress |
| 0.102 | 5.37E-9 | YDR307W_p | PMT7_p | hom | Putative protein mannosyltransferase similar to Pmt1p; has a potential role in protein O-glycosylation |
| 0.100 | 1.31E-8 | YOR142W | LSC1 | hom | Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated |
| 0.095 | 6.50E-8 | YGR120C | COG2 | het | Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments |
| 0.094 | 7.65E-8 | YMR133W | REC114 | hom | Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division |