YKR100C / SKG1

Transmembrane protein with a role in cell wall polymer composition; localizes on the inner surface of the plasma membrane at the bud and in the daughter cell

Zygosity: Homozygous strain
fixedexpanded
Profile for YKR100C / SKG1

Click on Significant Values for Screen Details ID:SGTC_39|Compound:0986-0283|FD-Score:-4.03|P-value:4.52E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:3.23|P-value:9.11E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:4.07|P-value:4.16E-5 ID:SGTC_639|Compound:0833-0042|FD-Score:3.54|P-value:3.12E-4 ID:SGTC_844|Compound:0330-0132|FD-Score:-3.40|P-value:4.76E-4 ID:SGTC_854|Compound:0422-0053|FD-Score:3.56|P-value:2.91E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:4.70|P-value:2.77E-6 ID:SGTC_935|Compound:2996-0153|FD-Score:4.61|P-value:4.13E-6 ID:SGTC_976|Compound:1348-1067|FD-Score:4.30|P-value:1.59E-5 ID:SGTC_1076|Compound:itraconazole|FD-Score:4.04|P-value:4.63E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:5.44|P-value:7.24E-8 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:4.81|P-value:1.65E-6 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.82|P-value:1.12E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:3.70|P-value:1.76E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.71|P-value:1.69E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.35|P-value:6.02E-4 ID:SGTC_1352|Compound:1496-0991|FD-Score:4.11|P-value:3.57E-5 ID:SGTC_1574|Compound:spiramycin|FD-Score:4.22|P-value:2.24E-5 ID:SGTC_1636|Compound:st007707|FD-Score:-3.25|P-value:7.99E-4 ID:SGTC_1654|Compound:st012436|FD-Score:4.71|P-value:2.58E-6 ID:SGTC_1660|Compound:st012960|FD-Score:6.15|P-value:1.38E-9 ID:SGTC_1738|Compound:st035555|FD-Score:5.65|P-value:2.35E-8 ID:SGTC_1808|Compound:st050063|FD-Score:-3.52|P-value:3.17E-4 ID:SGTC_1824|Compound:st053723|FD-Score:4.09|P-value:3.84E-5 ID:SGTC_1839|Compound:st053978|FD-Score:4.45|P-value:8.29E-6 ID:SGTC_2062|Compound:5245942|FD-Score:3.31|P-value:6.83E-4 ID:SGTC_2078|Compound:5212016|FD-Score:-3.36|P-value:5.62E-4 ID:SGTC_2082|Compound:5219693|FD-Score:4.40|P-value:1.04E-5 ID:SGTC_2099|Compound:5377090|FD-Score:-3.69|P-value:1.70E-4 ID:SGTC_2113|Compound:5491891|FD-Score:3.28|P-value:7.76E-4 ID:SGTC_2154|Compound:5570129|FD-Score:3.41|P-value:4.83E-4 ID:SGTC_2157|Compound:5649910|FD-Score:3.50|P-value:3.53E-4 ID:SGTC_2245|Compound:6637752|FD-Score:4.70|P-value:2.77E-6 ID:SGTC_2402|Compound:5553605|FD-Score:-3.96|P-value:6.18E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.27|P-value:7.92E-4 ID:SGTC_2453|Compound:5731132|FD-Score:3.44|P-value:4.50E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.25|P-value:8.05E-4 ID:SGTC_2661|Compound:dactinomycin|FD-Score:3.76|P-value:1.40E-4 ID:SGTC_2882|Compound:9058044|FD-Score:3.52|P-value:3.30E-4 ID:SGTC_2897|Compound:9048598|FD-Score:3.33|P-value:6.50E-4 ID:SGTC_2975|Compound:9084847|FD-Score:3.68|P-value:1.85E-4 ID:SGTC_2982|Compound:9019404|FD-Score:3.30|P-value:7.25E-4 ID:SGTC_3082|Compound:9117008|FD-Score:3.51|P-value:3.48E-4 ID:SGTC_3132|Compound:9126706|FD-Score:-3.89|P-value:7.94E-5 ID:SGTC_3203|Compound:9113543|FD-Score:3.40|P-value:5.06E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:-4.03|P-value:4.52E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:3.23|P-value:9.11E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:4.07|P-value:4.16E-5 ID:SGTC_639|Compound:0833-0042|FD-Score:3.54|P-value:3.12E-4 ID:SGTC_844|Compound:0330-0132|FD-Score:-3.40|P-value:4.76E-4 ID:SGTC_854|Compound:0422-0053|FD-Score:3.56|P-value:2.91E-4 ID:SGTC_929|Compound:2805-0021|FD-Score:4.70|P-value:2.77E-6 ID:SGTC_935|Compound:2996-0153|FD-Score:4.61|P-value:4.13E-6 ID:SGTC_976|Compound:1348-1067|FD-Score:4.30|P-value:1.59E-5 ID:SGTC_1076|Compound:itraconazole|FD-Score:4.04|P-value:4.63E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:5.44|P-value:7.24E-8 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:4.81|P-value:1.65E-6 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.82|P-value:1.12E-4 ID:SGTC_1185|Compound:1319-0113|FD-Score:3.70|P-value:1.76E-4 ID:SGTC_1198|Compound:1612-1005|FD-Score:3.71|P-value:1.69E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.35|P-value:6.02E-4 ID:SGTC_1352|Compound:1496-0991|FD-Score:4.11|P-value:3.57E-5 ID:SGTC_1574|Compound:spiramycin|FD-Score:4.22|P-value:2.24E-5 ID:SGTC_1636|Compound:st007707|FD-Score:-3.25|P-value:7.99E-4 ID:SGTC_1654|Compound:st012436|FD-Score:4.71|P-value:2.58E-6 ID:SGTC_1660|Compound:st012960|FD-Score:6.15|P-value:1.38E-9 ID:SGTC_1738|Compound:st035555|FD-Score:5.65|P-value:2.35E-8 ID:SGTC_1808|Compound:st050063|FD-Score:-3.52|P-value:3.17E-4 ID:SGTC_1824|Compound:st053723|FD-Score:4.09|P-value:3.84E-5 ID:SGTC_1839|Compound:st053978|FD-Score:4.45|P-value:8.29E-6 ID:SGTC_2062|Compound:5245942|FD-Score:3.31|P-value:6.83E-4 ID:SGTC_2078|Compound:5212016|FD-Score:-3.36|P-value:5.62E-4 ID:SGTC_2082|Compound:5219693|FD-Score:4.40|P-value:1.04E-5 ID:SGTC_2099|Compound:5377090|FD-Score:-3.69|P-value:1.70E-4 ID:SGTC_2113|Compound:5491891|FD-Score:3.28|P-value:7.76E-4 ID:SGTC_2154|Compound:5570129|FD-Score:3.41|P-value:4.83E-4 ID:SGTC_2157|Compound:5649910|FD-Score:3.50|P-value:3.53E-4 ID:SGTC_2245|Compound:6637752|FD-Score:4.70|P-value:2.77E-6 ID:SGTC_2402|Compound:5553605|FD-Score:-3.96|P-value:6.18E-5 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.27|P-value:7.92E-4 ID:SGTC_2453|Compound:5731132|FD-Score:3.44|P-value:4.50E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.25|P-value:8.05E-4 ID:SGTC_2661|Compound:dactinomycin|FD-Score:3.76|P-value:1.40E-4 ID:SGTC_2882|Compound:9058044|FD-Score:3.52|P-value:3.30E-4 ID:SGTC_2897|Compound:9048598|FD-Score:3.33|P-value:6.50E-4 ID:SGTC_2975|Compound:9084847|FD-Score:3.68|P-value:1.85E-4 ID:SGTC_2982|Compound:9019404|FD-Score:3.30|P-value:7.25E-4 ID:SGTC_3082|Compound:9117008|FD-Score:3.51|P-value:3.48E-4 ID:SGTC_3132|Compound:9126706|FD-Score:-3.89|P-value:7.94E-5 ID:SGTC_3203|Compound:9113543|FD-Score:3.40|P-value:5.06E-4

Top fitness defect scores for YKR100C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1660 st012960 6.15 28.1 µM 1.38E-9 iron homeostasis 5 3.96E-10
2 SGTC_1738 st035555 5.65 74.0 µM 2.35E-8 TSC3-RPN4 8 8.13E-9
3 SGTC_1082 camptothecin 5.44 424.9 nM 7.24E-8 DNA damage response 25 2.70E-8
4 SGTC_1106 tegaserod maleate 4.81 11.7 µM 1.65E-6 6 7.56E-7
5 SGTC_1654 st012436 4.71 41.8 µM 2.58E-6 9 1.22E-6
6 SGTC_929 2805-0021 4.70 398.0 µM 2.77E-6 5 1.31E-6
7 SGTC_2245 6637752 4.70 200.0 µM 2.77E-6 12 1.31E-6
8 SGTC_935 2996-0153 4.61 430.0 µM 4.13E-6 PDR1 11 2.00E-6
9 SGTC_1839 st053978 4.45 48.0 µM 8.29E-6 9 4.21E-6
10 SGTC_2082 5219693 4.40 150.0 µM 1.04E-5 RNA processing & uracil transport 20 5.36E-6
11 SGTC_976 1348-1067 4.30 47.6 µM 1.59E-5 60S ribosome export 22 8.44E-6
12 SGTC_1574 spiramycin 4.22 23.7 µM 2.24E-5 20 1.21E-5
13 SGTC_1352 1496-0991 4.11 99.0 µM 3.57E-5 tubulin folding & SWR complex 30 1.99E-5
14 SGTC_1824 st053723 4.09 68.6 µM 3.84E-5 29 2.16E-5
15 SGTC_93 0109-0045 4.07 59.2 µM 4.16E-5 DNA damage response 41 2.35E-5
16 SGTC_1076 itraconazole 4.04 331.0 nM 4.63E-5 30 2.63E-5
17 SGTC_1135 dihydrocapsaicin 3.82 536.7 nM 1.12E-4 40 6.72E-5
18 SGTC_2661 dactinomycin 3.76 13.0 µM 1.40E-4 redox potentiating 24 8.53E-5
19 SGTC_1198 1612-1005 3.71 86.7 µM 1.69E-4 18 1.04E-4
20 SGTC_1185 1319-0113 3.70 81.3 µM 1.76E-4 DNA damage response 13 1.09E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.100 6.60E-9 YPR144C NOC4 het Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits
0.090 1.61E-7 YBR099C_d YBR099C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4
0.090 1.66E-7 YDR076W RAD55 hom Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p
0.085 7.92E-7 YIL113W SDP1 hom Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock
0.084 1.17E-6 YDL059C RAD59 hom Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p
0.081 2.65E-6 YOL084W PHM7 hom Protein of unknown function; expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole; protein abundance increases in response to DNA replication stress
0.079 4.13E-6 YPR148C YPR148C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.079 4.67E-6 YLR299W ECM38 hom Gamma-glutamyltranspeptidase, major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation
0.078 5.43E-6 YDR386W MUS81 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
0.075 1.28E-5 YGR185C TYS1 het Cytoplasmic tyrosyl-tRNA synthetase; required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies; protein abundance increases in response to DNA replication stress
0.074 1.62E-5 YPL018W CTF19 hom Outer kinetochore protein, needed for accurate chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-P and fission yeast fta2
0.074 1.91E-5 YBL096C_d YBL096C_d hom Non-essential protein of unknown function
0.073 2.04E-5 YKL045W PRI2 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.071 3.48E-5 YKR018C YKR018C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; YKR018C has a paralog, IML2, that arose from the whole genome duplication
0.071 4.28E-5 YPL245W_p YPL245W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm