HIPHOP chemogenomics database

YLL002W / RTT109

Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase; acetylates H3-K56 and H3-K9; involved in non-homologous end joining and in regulation of Ty1 transposition; interacts physically with Vps75p

Zygosity: Homozygous strain

fixedexpanded
Profile for YLL002W / RTT109

Click on Significant Values for Screen Details

Top fitness defect scores for YLL002W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2350	9023895	7.48	38.9 µM	2.37E-13	ergosterol biosynthesis	5	3.72E-14
2	SGTC_2957	9076800	6.50	11.5 µM	1.67E-10		3	4.12E-11
3	SGTC_1942	st076330	5.52	65.2 µM	4.67E-8		7	1.69E-8
4	SGTC_200	k038-0079	5.13	37.5 µM	3.57E-7	ubiquinone biosynthesis & proteasome	37	1.49E-7
5	SGTC_1707	st032323	4.95	6.3 µM	8.60E-7	DNA damage response	36	3.79E-7
6	SGTC_1665	st014639	4.88	11.4 µM	1.15E-6	NEO1	13	5.19E-7
7	SGTC_2955	9076254	4.53	12.2 µM	5.76E-6		8	2.89E-6
8	SGTC_1374	2889-5571	4.53	141.0 µM	5.92E-6	RSC complex & mRNA processing	22	2.97E-6
9	SGTC_93	0109-0045	4.26	59.2 µM	1.92E-5	DNA damage response	30	1.04E-5
10	SGTC_2487	5918373	4.15	44.0 µM	2.97E-5		11	1.66E-5
11	SGTC_1038	k292-0204	4.15	154.0 µM	2.99E-5		14	1.67E-5
12	SGTC_1137	ixabepilone	4.12	100.0 µM	3.31E-5		19	1.86E-5
13	SGTC_756	0508-1999	4.09	28.3 µM	3.78E-5	RPP1 & pyrimidine depletion	20	2.15E-5
14	SGTC_1409	3909-8004	4.08	61.9 µM	3.89E-5		17	2.22E-5
15	SGTC_219	mitoxanthrone	3.88	164.4 µM	8.67E-5	DNA intercalators	54	5.20E-5
16	SGTC_1107	amlodipine	3.83	47.0 µM	1.05E-4		36	6.36E-5
17	SGTC_2471	5466956	3.76	24.8 µM	1.38E-4	mitochondrial processes	14	8.54E-5
18	SGTC_2671	danthron	3.73	100.0 µM	1.55E-4	DNA damage response	52	9.68E-5
19	SGTC_949	1165-0505	3.66	146.0 µM	2.00E-4		26	1.27E-4
20	SGTC_36	0335-0881	3.61	14.2 µM	2.39E-4	ubiquinone biosynthesis & proteasome	140	1.54E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.125	4.41E-13	YGR035C_p	YGR035C_p	hom	Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
0.111	1.40E-10	YLR201C	COQ9	hom	Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.110	1.97E-10	YDL059C	RAD59	hom	Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p
0.109	2.17E-10	YPR064W_d	YPR064W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.108	3.46E-10	YGR255C	COQ6	hom	Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.101	4.65E-9	YGL240W	DOC1	hom	Processivity factor required for the ubiquitination activity of the anaphase promoting complex (APC), mediates the activity of the APC by contributing to substrate recognition; involved in cyclin proteolysis; contains a conserved DOC1 homology domain
0.096	2.72E-8	YPR065W	ROX1	hom	Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance
0.091	1.23E-7	YJL072C	PSF2	het	Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
0.091	1.41E-7	YNL250W	RAD50	hom	Subunit of MRX complex with Mre11p and Xrs2p; complex is involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining; forms nuclear foci upon DNA replication stress
0.091	1.40E-7	YJR039W_p	YJR039W_p	hom	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.089	2.23E-7	YML110C	COQ5	hom	2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes
0.087	4.13E-7	YJL092W	SRS2	hom	DNA helicase and DNA-dependent ATPase involved in DNA repair and checkpoint recovery, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability
0.087	4.26E-7	YER041W	YEN1	hom	Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.087	5.00E-7	YPL139C	UME1	hom	Negative regulator of meiosis, required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif; homologous with Wtm1p, Wtm2p
0.086	5.65E-7	YNR042W_d	YNR042W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2