YLL009C / COX17

Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs

Zygosity: Homozygous strain
fixedexpanded
Profile for YLL009C / COX17

Click on Significant Values for Screen Details ID:SGTC_70|Compound:0141-0289|FD-Score:3.38|P-value:1.82E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.31|P-value:2.42E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:19.30|P-value:7.25E-93 ID:SGTC_149|Compound:3970-0822|FD-Score:3.05|P-value:6.43E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.54|P-value:9.41E-5 ID:SGTC_195|Compound:4234-0266|FD-Score:3.41|P-value:1.63E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:18.40|P-value:6.19E-84 ID:SGTC_310|Compound:1273-0058|FD-Score:4.47|P-value:1.20E-6 ID:SGTC_347|Compound:4534-1311|FD-Score:3.20|P-value:3.68E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:21.10|P-value:1.08E-109 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.12|P-value:4.90E-4 ID:SGTC_470|Compound:aa-861|FD-Score:5.05|P-value:4.85E-8 ID:SGTC_849|Compound:0386-0493|FD-Score:-3.09|P-value:5.49E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.30|P-value:2.49E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:-3.65|P-value:5.84E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:3.56|P-value:8.66E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.88|P-value:2.68E-10 ID:SGTC_1195|Compound:1502-0147|FD-Score:-3.10|P-value:5.36E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:-3.27|P-value:2.79E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.00|P-value:7.82E-4 ID:SGTC_1325|Compound:1431-0015|FD-Score:3.20|P-value:3.61E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:4.02|P-value:1.13E-5 ID:SGTC_1391|Compound:3442-0225|FD-Score:-3.25|P-value:2.97E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:3.70|P-value:4.84E-5 ID:SGTC_1628|Compound:st004252|FD-Score:6.33|P-value:1.18E-11 ID:SGTC_1630|Compound:st005209|FD-Score:-3.14|P-value:4.57E-4 ID:SGTC_1635|Compound:st007035|FD-Score:41.20|P-value:0 ID:SGTC_1638|Compound:st008370|FD-Score:-5.40|P-value:5.92E-9 ID:SGTC_1774|Compound:st048371|FD-Score:-3.22|P-value:3.43E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.95|P-value:8.78E-8 ID:SGTC_1792|Compound:st045773|FD-Score:3.03|P-value:6.92E-4 ID:SGTC_2008|Compound:4012253|FD-Score:3.94|P-value:1.61E-5 ID:SGTC_2090|Compound:5301565|FD-Score:5.06|P-value:4.61E-8 ID:SGTC_2097|Compound:5376186|FD-Score:-3.01|P-value:7.56E-4 ID:SGTC_2099|Compound:5377090|FD-Score:3.34|P-value:2.10E-4 ID:SGTC_2117|Compound:5521686|FD-Score:4.24|P-value:3.79E-6 ID:SGTC_2260|Compound:7964312|FD-Score:-4.37|P-value:2.00E-6 ID:SGTC_2491|Compound:paeonol|FD-Score:3.53|P-value:9.97E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:-3.77|P-value:3.52E-5 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:-4.30|P-value:2.86E-6 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:-4.04|P-value:9.92E-6 ID:SGTC_2533|Compound:agelasine|FD-Score:3.11|P-value:5.17E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:4.35|P-value:2.19E-6 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:-3.65|P-value:5.79E-5 ID:SGTC_2624|Compound:nerol|FD-Score:-3.05|P-value:6.45E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.52|P-value:1.02E-4 ID:SGTC_2719|Compound:novobiocin|FD-Score:-4.31|P-value:2.70E-6 ID:SGTC_2728|Compound:chlorpromazine|FD-Score:-3.37|P-value:1.84E-4 ID:SGTC_2817|Compound:7995342|FD-Score:5.34|P-value:8.73E-9 ID:SGTC_2823|Compound:7987624|FD-Score:4.75|P-value:2.65E-7 ID:SGTC_2834|Compound:9001755|FD-Score:-2.96|P-value:9.05E-4 ID:SGTC_2842|Compound:9000675|FD-Score:3.02|P-value:7.32E-4 ID:SGTC_2884|Compound:9058502|FD-Score:3.03|P-value:7.06E-4 ID:SGTC_3103|Compound:9120822|FD-Score:2.98|P-value:8.39E-4 ID:SGTC_3164|Compound:9100705|FD-Score:-4.91|P-value:1.12E-7 ID:SGTC_3173|Compound:9105693|FD-Score:-3.14|P-value:4.53E-4 ID:SGTC_3179|Compound:9107801|FD-Score:4.08|P-value:8.24E-6 ID:SGTC_3181|Compound:9108277|FD-Score:-4.50|P-value:1.00E-6 ID:SGTC_3184|Compound:9108758|FD-Score:3.59|P-value:7.62E-5 ID:SGTC_3191|Compound:9110352|FD-Score:-6.39|P-value:7.59E-12 ID:SGTC_3194|Compound:9111903|FD-Score:3.30|P-value:2.52E-4 ID:SGTC_3197|Compound:9113331|FD-Score:-5.34|P-value:8.54E-9 ID:SGTC_3205|Compound:9113483|FD-Score:-4.50|P-value:1.03E-6 ID:SGTC_3209|Compound:9113616|FD-Score:-3.21|P-value:3.46E-4 ID:SGTC_3344|Compound:9148862|FD-Score:-2.99|P-value:8.07E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:3.38|P-value:1.82E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:3.31|P-value:2.42E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:19.30|P-value:7.25E-93 ID:SGTC_149|Compound:3970-0822|FD-Score:3.05|P-value:6.43E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.54|P-value:9.41E-5 ID:SGTC_195|Compound:4234-0266|FD-Score:3.41|P-value:1.63E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:18.40|P-value:6.19E-84 ID:SGTC_310|Compound:1273-0058|FD-Score:4.47|P-value:1.20E-6 ID:SGTC_347|Compound:4534-1311|FD-Score:3.20|P-value:3.68E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:21.10|P-value:1.08E-109 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.12|P-value:4.90E-4 ID:SGTC_470|Compound:aa-861|FD-Score:5.05|P-value:4.85E-8 ID:SGTC_849|Compound:0386-0493|FD-Score:-3.09|P-value:5.49E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.30|P-value:2.49E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:-3.65|P-value:5.84E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:3.56|P-value:8.66E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.88|P-value:2.68E-10 ID:SGTC_1195|Compound:1502-0147|FD-Score:-3.10|P-value:5.36E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:-3.27|P-value:2.79E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:3.00|P-value:7.82E-4 ID:SGTC_1325|Compound:1431-0015|FD-Score:3.20|P-value:3.61E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:4.02|P-value:1.13E-5 ID:SGTC_1391|Compound:3442-0225|FD-Score:-3.25|P-value:2.97E-4 ID:SGTC_1430|Compound:4049-0248|FD-Score:3.70|P-value:4.84E-5 ID:SGTC_1628|Compound:st004252|FD-Score:6.33|P-value:1.18E-11 ID:SGTC_1630|Compound:st005209|FD-Score:-3.14|P-value:4.57E-4 ID:SGTC_1635|Compound:st007035|FD-Score:41.20|P-value:0 ID:SGTC_1638|Compound:st008370|FD-Score:-5.40|P-value:5.92E-9 ID:SGTC_1774|Compound:st048371|FD-Score:-3.22|P-value:3.43E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.95|P-value:8.78E-8 ID:SGTC_1792|Compound:st045773|FD-Score:3.03|P-value:6.92E-4 ID:SGTC_2008|Compound:4012253|FD-Score:3.94|P-value:1.61E-5 ID:SGTC_2090|Compound:5301565|FD-Score:5.06|P-value:4.61E-8 ID:SGTC_2097|Compound:5376186|FD-Score:-3.01|P-value:7.56E-4 ID:SGTC_2099|Compound:5377090|FD-Score:3.34|P-value:2.10E-4 ID:SGTC_2117|Compound:5521686|FD-Score:4.24|P-value:3.79E-6 ID:SGTC_2260|Compound:7964312|FD-Score:-4.37|P-value:2.00E-6 ID:SGTC_2491|Compound:paeonol|FD-Score:3.53|P-value:9.97E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:-3.77|P-value:3.52E-5 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:-4.30|P-value:2.86E-6 ID:SGTC_2506|Compound:ethyl hematommate|FD-Score:-4.04|P-value:9.92E-6 ID:SGTC_2533|Compound:agelasine|FD-Score:3.11|P-value:5.17E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:4.35|P-value:2.19E-6 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:-3.65|P-value:5.79E-5 ID:SGTC_2624|Compound:nerol|FD-Score:-3.05|P-value:6.45E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.52|P-value:1.02E-4 ID:SGTC_2719|Compound:novobiocin|FD-Score:-4.31|P-value:2.70E-6 ID:SGTC_2728|Compound:chlorpromazine|FD-Score:-3.37|P-value:1.84E-4 ID:SGTC_2817|Compound:7995342|FD-Score:5.34|P-value:8.73E-9 ID:SGTC_2823|Compound:7987624|FD-Score:4.75|P-value:2.65E-7 ID:SGTC_2834|Compound:9001755|FD-Score:-2.96|P-value:9.05E-4 ID:SGTC_2842|Compound:9000675|FD-Score:3.02|P-value:7.32E-4 ID:SGTC_2884|Compound:9058502|FD-Score:3.03|P-value:7.06E-4 ID:SGTC_3103|Compound:9120822|FD-Score:2.98|P-value:8.39E-4 ID:SGTC_3164|Compound:9100705|FD-Score:-4.91|P-value:1.12E-7 ID:SGTC_3173|Compound:9105693|FD-Score:-3.14|P-value:4.53E-4 ID:SGTC_3179|Compound:9107801|FD-Score:4.08|P-value:8.24E-6 ID:SGTC_3181|Compound:9108277|FD-Score:-4.50|P-value:1.00E-6 ID:SGTC_3184|Compound:9108758|FD-Score:3.59|P-value:7.62E-5 ID:SGTC_3191|Compound:9110352|FD-Score:-6.39|P-value:7.59E-12 ID:SGTC_3194|Compound:9111903|FD-Score:3.30|P-value:2.52E-4 ID:SGTC_3197|Compound:9113331|FD-Score:-5.34|P-value:8.54E-9 ID:SGTC_3205|Compound:9113483|FD-Score:-4.50|P-value:1.03E-6 ID:SGTC_3209|Compound:9113616|FD-Score:-3.21|P-value:3.46E-4 ID:SGTC_3344|Compound:9148862|FD-Score:-2.99|P-value:8.07E-4

Top fitness defect scores for YLL009C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1635 st007035 41.20 42.4 µM 0 2 0
2 SGTC_386 1509-0011 21.10 3.1 µM 1.08E-109 6 9.60E-99
3 SGTC_134 0269-0018 19.30 6.9 µM 7.25E-93 8 1.25E-83
4 SGTC_236 1509-0011 18.40 5.3 µM 6.19E-84 64 1.32E-75
5 SGTC_1628 st004252 6.33 77.7 µM 1.18E-11 1 1.21E-10
6 SGTC_2817 7995342 5.34 71.4 µM 8.73E-9 7 4.62E-8
7 SGTC_2090 5301565 5.06 104.5 µM 4.61E-8 TSC3-RPN4 26 2.07E-7
8 SGTC_470 aa-861 5.05 153.0 µM 4.85E-8 sphingolipid biosynthesis & PDR1 36 2.16E-7
9 SGTC_2823 7987624 4.75 58.4 µM 2.65E-7 12 1.00E-6
10 SGTC_310 1273-0058 4.47 1.1 µM 1.20E-6 mitochondrial stress 212 3.91E-6
11 SGTC_2538 3',7'-epoxycaryophyllan-6-one 4.35 100.0 µM 2.19E-6 18 6.73E-6
12 SGTC_2117 5521686 4.24 200.0 µM 3.79E-6 9 1.10E-5
13 SGTC_3179 9107801 4.08 49.5 µM 8.24E-6 7 2.22E-5
14 SGTC_1371 2421-0008 4.02 32.7 µM 1.13E-5 mitochondrial processes 34 2.97E-5
15 SGTC_2008 4012253 3.94 172.0 µM 1.61E-5 26 4.08E-5
16 SGTC_1430 4049-0248 3.70 69.1 µM 4.84E-5 25 1.10E-4
17 SGTC_3184 9108758 3.59 49.5 µM 7.62E-5 11 1.66E-4
18 SGTC_908 3448-7491 3.56 47.7 µM 8.66E-5 mitochondrial stress 149 1.86E-4
19 SGTC_2491 paeonol 3.53 100.0 µM 9.97E-5 13 2.11E-4
20 SGTC_2633 5,7-dihydroxyisoflavone 3.52 100.0 µM 1.02E-4 42 2.15E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.791 0 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.739 0 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.723 0 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.723 0 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.711 0 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.692 0 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.687 0 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.675 0 YDL067C COX9 hom Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.668 0 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.662 0 YPL189C-A COA2 hom Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p
0.654 0 YKL155C RSM22 hom Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase
0.652 0 YIR021W MRS1 hom Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
0.641 0 YJL062W-A COA3 hom Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly
0.634 0 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase
0.634 0 YHR116W COX23 hom Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs