YLL012W / YEH1

Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes

Zygosity: Homozygous strain
fixedexpanded
Profile for YLL012W / YEH1

Click on Significant Values for Screen Details ID:SGTC_250|Compound:brefeldin a|FD-Score:-3.02|P-value:5.55E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:-4.09|P-value:4.68E-6 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.36|P-value:1.40E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:-2.96|P-value:6.82E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:3.81|P-value:1.41E-5 ID:SGTC_824|Compound:1304-0008|FD-Score:3.13|P-value:2.78E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:3.23|P-value:1.88E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.48|P-value:6.40E-5 ID:SGTC_1059|Compound:3448-6867|FD-Score:2.86|P-value:7.96E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:2.82|P-value:9.15E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.85|P-value:5.10E-8 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.51|P-value:7.32E-5 ID:SGTC_1174|Compound:0739-0097|FD-Score:-3.42|P-value:1.07E-4 ID:SGTC_1312|Compound:1218-2183|FD-Score:2.88|P-value:7.57E-4 ID:SGTC_1725|Compound:st036284|FD-Score:2.83|P-value:9.09E-4 ID:SGTC_1986|Compound:st071812|FD-Score:-3.24|P-value:2.30E-4 ID:SGTC_1988|Compound:st071872|FD-Score:3.23|P-value:1.90E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.06|P-value:3.67E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.09|P-value:3.30E-4 ID:SGTC_2053|Compound:5265679|FD-Score:-2.87|P-value:9.70E-4 ID:SGTC_2258|Compound:7960471|FD-Score:-3.16|P-value:3.16E-4 ID:SGTC_2379|Compound:9035213|FD-Score:3.78|P-value:1.60E-5 ID:SGTC_2435|Compound:5706476|FD-Score:2.96|P-value:5.48E-4 ID:SGTC_2602|Compound:kawain|FD-Score:3.32|P-value:1.29E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-2.88|P-value:9.39E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:-3.76|P-value:2.34E-5 ID:SGTC_3315|Compound:9136395|FD-Score:3.07|P-value:3.64E-4 ID:SGTC_3348|Compound:9149464|FD-Score:-2.94|P-value:7.52E-4 ID:SGTC_3355|Compound:9151058|FD-Score:-2.94|P-value:7.45E-4 ID:SGTC_250|Compound:brefeldin a|FD-Score:-3.02|P-value:5.55E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:-4.09|P-value:4.68E-6 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.36|P-value:1.40E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:-2.96|P-value:6.82E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:3.81|P-value:1.41E-5 ID:SGTC_824|Compound:1304-0008|FD-Score:3.13|P-value:2.78E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:3.23|P-value:1.88E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.48|P-value:6.40E-5 ID:SGTC_1059|Compound:3448-6867|FD-Score:2.86|P-value:7.96E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:2.82|P-value:9.15E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:4.85|P-value:5.10E-8 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.51|P-value:7.32E-5 ID:SGTC_1174|Compound:0739-0097|FD-Score:-3.42|P-value:1.07E-4 ID:SGTC_1312|Compound:1218-2183|FD-Score:2.88|P-value:7.57E-4 ID:SGTC_1725|Compound:st036284|FD-Score:2.83|P-value:9.09E-4 ID:SGTC_1986|Compound:st071812|FD-Score:-3.24|P-value:2.30E-4 ID:SGTC_1988|Compound:st071872|FD-Score:3.23|P-value:1.90E-4 ID:SGTC_1996|Compound:st072960|FD-Score:3.06|P-value:3.67E-4 ID:SGTC_2002|Compound:4023503|FD-Score:3.09|P-value:3.30E-4 ID:SGTC_2053|Compound:5265679|FD-Score:-2.87|P-value:9.70E-4 ID:SGTC_2258|Compound:7960471|FD-Score:-3.16|P-value:3.16E-4 ID:SGTC_2379|Compound:9035213|FD-Score:3.78|P-value:1.60E-5 ID:SGTC_2435|Compound:5706476|FD-Score:2.96|P-value:5.48E-4 ID:SGTC_2602|Compound:kawain|FD-Score:3.32|P-value:1.29E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-2.88|P-value:9.39E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:-3.76|P-value:2.34E-5 ID:SGTC_3315|Compound:9136395|FD-Score:3.07|P-value:3.64E-4 ID:SGTC_3348|Compound:9149464|FD-Score:-2.94|P-value:7.52E-4 ID:SGTC_3355|Compound:9151058|FD-Score:-2.94|P-value:7.45E-4

Top fitness defect scores for YLL012W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1083 didemethylchlorpromazine sulfoxide 4.85 707.4 nM 5.10E-8 redox potentiating 48 6.29E-7
2 SGTC_822 1487-0950 3.81 154.0 µM 1.41E-5 18 7.05E-5
3 SGTC_2379 9035213 3.78 200.0 µM 1.60E-5 26 7.84E-5
4 SGTC_996 3970-0799 3.48 1.8 µM 6.40E-5 116 2.52E-4
5 SGTC_2602 kawain 3.32 100.0 µM 1.29E-4 51 4.55E-4
6 SGTC_986 1493-0483 3.23 84.0 µM 1.88E-4 36 6.24E-4
7 SGTC_1988 st071872 3.23 53.4 µM 1.90E-4 30 6.29E-4
8 SGTC_824 1304-0008 3.13 100.0 µM 2.78E-4 DNA damage response 75 8.68E-4
9 SGTC_2002 4023503 3.09 131.0 µM 3.30E-4 mitochondrial processes 77 0.00100
10 SGTC_3315 9136395 3.07 68.5 µM 3.64E-4 37 0.00109
11 SGTC_1996 st072960 3.06 66.8 µM 3.67E-4 50 0.00110
12 SGTC_2435 5706476 2.96 10.6 µM 5.48E-4 71 0.00154
13 SGTC_1312 1218-2183 2.88 165.0 µM 7.57E-4 42 0.00202
14 SGTC_1059 3448-6867 2.86 171.0 µM 7.96E-4 58 0.00210
15 SGTC_1725 st036284 2.83 20.6 µM 9.09E-4 91 0.00235
16 SGTC_1061 3448-9325 2.82 110.0 µM 9.15E-4 70 0.00237
17 SGTC_2375 9072683 2.80 200.0 µM 0.00100 mitochondrial processes 84 0.00255
18 SGTC_426 0988-0037 2.80 14.6 µM 0.00101 ERAD & cell cycle 102 0.00257
19 SGTC_1032 k061-1018 2.67 98.7 µM 0.00158 113 0.00375
20 SGTC_3313 9133968 2.64 57.0 µM 0.00180 62 0.00418

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.354 1.76E-99 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.302 1.01E-71 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.253 4.13E-50 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.248 2.21E-48 YGR193C PDX1 hom Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core
0.241 1.60E-45 YBR083W TEC1 hom Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member
0.234 8.45E-43 YDR431W_d YDR431W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.223 6.21E-39 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.222 9.42E-39 YFL063W_d YFL063W_d hom Dubious open reading frame, based on available experimental and comparative sequence data
0.220 4.10E-38 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.218 2.59E-37 YOL141W PPM2 hom AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p
0.213 7.54E-36 YBL066C SEF1 hom Putative transcription factor, has homolog in Kluyveromyces lactis
0.208 4.66E-34 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.208 4.21E-34 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.207 7.13E-34 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.204 5.31E-33 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)