HIPHOP chemogenomics database
YLL018C / DPS1 
Aspartyl-tRNA synthetase, primarily cytoplasmic; homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YLL018C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.123 | 8.67E-13 | YDR509W_d | YDR509W_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.114 | 4.18E-11 | YGL064C | MRH4 | hom | Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function |
| 0.112 | 8.46E-11 | YBL105C | PKC1 | het | Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC) |
| 0.110 | 2.01E-10 | YER077C_p | YER077C_p | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport |
| 0.106 | 8.54E-10 | YIL038C | NOT3 | hom | Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation |
| 0.105 | 9.31E-10 | YDR238C | SEC26 | het | Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP) |
| 0.104 | 1.50E-9 | YKL170W | MRPL38 | hom | Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress |
| 0.104 | 1.63E-9 | YBR192W | RIM2 | het | Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family |
| 0.101 | 4.54E-9 | YNL284C | MRPL10 | hom | Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels |
| 0.101 | 5.48E-9 | YBL090W | MRP21 | hom | Mitochondrial ribosomal protein of the small subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences |
| 0.099 | 8.99E-9 | YDL145C | COP1 | het | Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway |
| 0.098 | 1.20E-8 | YDL140C | RPO21 | het | RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime |
| 0.097 | 1.86E-8 | YNR037C | RSM19 | hom | Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal protein |
| 0.093 | 6.73E-8 | YHR091C | MSR1 | hom | Mitochondrial arginyl-tRNA synthetase; mutations in human ortholog are associated with pontocerebellar hypoplasia type 6 |
| 0.093 | 7.85E-8 | YLR439W | MRPL4 | hom | Mitochondrial ribosomal protein of the large subunit, homolog of prokaryotic L29 ribosomal protein; located at the ribosomal tunnel exit |