YLL023C / POM33

Transmembrane nucleoporin; involved in nuclear pore complex (NPC) distribution, assembly or stabilization; highly conserved across species, orthologous to human TMEM33 and paralogous to Per33p; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YLL023C / POM33

Click on Significant Values for Screen Details ID:SGTC_23|Compound:0213-0011|FD-Score:3.02|P-value:8.56E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.03|P-value:8.44E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:3.63|P-value:8.26E-5 ID:SGTC_383|Compound:2324-0395|FD-Score:3.54|P-value:1.20E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:3.12|P-value:6.12E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:3.38|P-value:2.32E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:3.08|P-value:6.92E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:3.11|P-value:6.23E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.11|P-value:6.23E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.02|P-value:9.22E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.03|P-value:8.34E-4 ID:SGTC_1502|Compound:4534-4282|FD-Score:-3.17|P-value:5.32E-4 ID:SGTC_1523|Compound:st012844|FD-Score:3.37|P-value:2.40E-4 ID:SGTC_1629|Compound:st005085|FD-Score:-3.14|P-value:6.04E-4 ID:SGTC_1630|Compound:st005209|FD-Score:3.72|P-value:5.83E-5 ID:SGTC_1788|Compound:fluconazole|FD-Score:-3.13|P-value:6.18E-4 ID:SGTC_1863|Compound:st057641|FD-Score:-3.18|P-value:5.19E-4 ID:SGTC_1948|Compound:st076329|FD-Score:3.04|P-value:8.04E-4 ID:SGTC_2056|Compound:5235370|FD-Score:3.16|P-value:5.31E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.20|P-value:4.54E-4 ID:SGTC_2132|Compound:5317594|FD-Score:-3.47|P-value:1.76E-4 ID:SGTC_2254|Compound:7938975|FD-Score:3.19|P-value:4.77E-4 ID:SGTC_2308|Compound:7584454|FD-Score:3.32|P-value:2.88E-4 ID:SGTC_2347|Compound:9049783|FD-Score:3.00|P-value:9.40E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-4.21|P-value:7.06E-6 ID:SGTC_2468|Compound:5987765|FD-Score:-3.15|P-value:5.90E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.11|P-value:6.82E-4 ID:SGTC_2602|Compound:kawain|FD-Score:2.99|P-value:9.78E-4 ID:SGTC_2855|Compound:9016525|FD-Score:-3.64|P-value:8.81E-5 ID:SGTC_2859|Compound:9028643|FD-Score:3.35|P-value:2.59E-4 ID:SGTC_3142|Compound:9086498|FD-Score:3.20|P-value:4.53E-4 ID:SGTC_3270|Compound:9137563|FD-Score:3.17|P-value:5.03E-4 ID:SGTC_3289|Compound:9119912|FD-Score:4.20|P-value:6.75E-6 ID:SGTC_23|Compound:0213-0011|FD-Score:3.02|P-value:8.56E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.03|P-value:8.44E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:3.63|P-value:8.26E-5 ID:SGTC_383|Compound:2324-0395|FD-Score:3.54|P-value:1.20E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:3.12|P-value:6.12E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:3.38|P-value:2.32E-4 ID:SGTC_590|Compound:k048-0076|FD-Score:3.08|P-value:6.92E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:3.11|P-value:6.23E-4 ID:SGTC_1009|Compound:4106-0057|FD-Score:3.11|P-value:6.23E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-3.02|P-value:9.22E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.03|P-value:8.34E-4 ID:SGTC_1502|Compound:4534-4282|FD-Score:-3.17|P-value:5.32E-4 ID:SGTC_1523|Compound:st012844|FD-Score:3.37|P-value:2.40E-4 ID:SGTC_1629|Compound:st005085|FD-Score:-3.14|P-value:6.04E-4 ID:SGTC_1630|Compound:st005209|FD-Score:3.72|P-value:5.83E-5 ID:SGTC_1788|Compound:fluconazole|FD-Score:-3.13|P-value:6.18E-4 ID:SGTC_1863|Compound:st057641|FD-Score:-3.18|P-value:5.19E-4 ID:SGTC_1948|Compound:st076329|FD-Score:3.04|P-value:8.04E-4 ID:SGTC_2056|Compound:5235370|FD-Score:3.16|P-value:5.31E-4 ID:SGTC_2126|Compound:5251174|FD-Score:3.20|P-value:4.54E-4 ID:SGTC_2132|Compound:5317594|FD-Score:-3.47|P-value:1.76E-4 ID:SGTC_2254|Compound:7938975|FD-Score:3.19|P-value:4.77E-4 ID:SGTC_2308|Compound:7584454|FD-Score:3.32|P-value:2.88E-4 ID:SGTC_2347|Compound:9049783|FD-Score:3.00|P-value:9.40E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:-4.21|P-value:7.06E-6 ID:SGTC_2468|Compound:5987765|FD-Score:-3.15|P-value:5.90E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:-3.11|P-value:6.82E-4 ID:SGTC_2602|Compound:kawain|FD-Score:2.99|P-value:9.78E-4 ID:SGTC_2855|Compound:9016525|FD-Score:-3.64|P-value:8.81E-5 ID:SGTC_2859|Compound:9028643|FD-Score:3.35|P-value:2.59E-4 ID:SGTC_3142|Compound:9086498|FD-Score:3.20|P-value:4.53E-4 ID:SGTC_3270|Compound:9137563|FD-Score:3.17|P-value:5.03E-4 ID:SGTC_3289|Compound:9119912|FD-Score:4.20|P-value:6.75E-6

Top fitness defect scores for YLL023C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3289 9119912 4.20 71.4 µM 6.75E-6 12 1.34E-5
2 SGTC_1630 st005209 3.72 31.3 µM 5.83E-5 27 1.01E-4
3 SGTC_360 0957-0399 3.63 1.0 µM 8.26E-5 cell wall 54 1.40E-4
4 SGTC_383 2324-0395 3.54 7.4 µM 1.20E-4 azole & statin 58 1.99E-4
5 SGTC_571 k831-0106 3.38 44.2 µM 2.32E-4 27 3.68E-4
6 SGTC_1523 st012844 3.37 44.7 µM 2.40E-4 60S ribosome export 46 3.80E-4
7 SGTC_2859 9028643 3.35 45.5 µM 2.59E-4 35 4.08E-4
8 SGTC_2308 7584454 3.32 197.6 µM 2.88E-4 49 4.50E-4
9 SGTC_3142 9086498 3.20 49.5 µM 4.53E-4 iron homeostasis 65 6.87E-4
10 SGTC_2126 5251174 3.20 33.9 µM 4.54E-4 74 6.90E-4
11 SGTC_2254 7938975 3.19 95.2 µM 4.77E-4 84 7.22E-4
12 SGTC_3270 9137563 3.17 49.5 µM 5.03E-4 RPP1 & pyrimidine depletion 23 7.59E-4
13 SGTC_2056 5235370 3.16 200.0 µM 5.31E-4 78 7.98E-4
14 SGTC_386 1509-0011 3.12 3.1 µM 6.12E-4 189 9.12E-4
15 SGTC_997 3996-0078 3.11 137.0 µM 6.23E-4 69 9.27E-4
16 SGTC_1009 4106-0057 3.11 9.9 µM 6.23E-4 35 9.28E-4
17 SGTC_590 k048-0076 3.08 22.4 µM 6.92E-4 RSC & ERG11 35 0.00102
18 SGTC_1948 st076329 3.04 66.6 µM 8.04E-4 71 0.00118
19 SGTC_1351 1496-0003 3.03 46.5 µM 8.34E-4 51 0.00122
20 SGTC_265 mycophenolic acid 3.03 32.9 µM 8.44E-4 RPP1 & pyrimidine depletion 65 0.00123

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.118 7.90E-12 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.107 4.84E-10 YKL189W HYM1 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response
0.107 6.21E-10 YGL085W_p LCL3_p hom Putative protein of unknown function; mutant has long chronological lifespan; has homology to Staphylococcus aureus nuclease; GFP-fusion protein localizes to mitochondria; is induced in response to the DNA-damaging agent MMS
0.106 8.69E-10 YML088W UFO1 hom F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation
0.100 6.12E-9 YNL128W TEP1 hom PTEN homolog with no demonstrated inositol lipid phosphatase activity; plays a role in normal sporulation; homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 and fission yeast ptn1
0.099 8.34E-9 YOR019W YOR019W hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments
0.095 3.19E-8 YHR116W COX23 hom Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs
0.094 4.99E-8 YGR076C MRPL25 hom Mitochondrial ribosomal protein of the large subunit; mutation confers increased replicative lifespan
0.091 1.20E-7 YKL194C MST1 hom Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro
0.090 1.80E-7 YLR390W-A CCW14 hom Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall
0.089 2.10E-7 YML119W_p YML119W_p hom Putative protein of unknown function; YML119W is not an essential gene; potential Cdc28p substrate
0.088 2.91E-7 YPL189W GUP2 hom Probable membrane protein with a possible role in proton symport of glycerol; member of the MBOAT family of putative membrane-bound O-acyltransferases; Gup1p homolog
0.088 3.60E-7 YBR239C_p ERT1_p hom Transcriptional regulator of nonfermentable carbon utilization; GFP-fusion protein localizes to cytoplasm, nucleus; null mutation affects periodicity of transcriptional and metabolic oscillation; plays role in restricting Ty1 transposition
0.087 4.92E-7 YBR234C ARC40 het Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
0.087 5.19E-7 YGR112W SHY1 hom Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome