YLL026W / HSP104

Disaggregase; heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation; protein becomes more abundant and forms cytoplasmic foci in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YLL026W / HSP104

Click on Significant Values for Screen Details ID:SGTC_82|Compound:0054-0107|FD-Score:-3.27|P-value:5.52E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:3.13|P-value:9.45E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:5.79|P-value:4.22E-9 ID:SGTC_981|Compound:1488-1094|FD-Score:-3.88|P-value:5.30E-5 ID:SGTC_997|Compound:3996-0078|FD-Score:3.28|P-value:5.50E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:4.67|P-value:1.74E-6 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.14|P-value:9.17E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.25|P-value:6.13E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:3.26|P-value:5.92E-4 ID:SGTC_1735|Compound:st034310|FD-Score:-3.27|P-value:5.45E-4 ID:SGTC_1744|Compound:st037937|FD-Score:-5.46|P-value:2.64E-8 ID:SGTC_1750|Compound:st081859|FD-Score:-3.58|P-value:1.76E-4 ID:SGTC_1919|Compound:st067113|FD-Score:3.26|P-value:5.97E-4 ID:SGTC_2084|Compound:5306078|FD-Score:3.91|P-value:5.14E-5 ID:SGTC_2332|Compound:7982454|FD-Score:-3.36|P-value:3.93E-4 ID:SGTC_2625|Compound:euphol|FD-Score:3.21|P-value:7.23E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:7.81|P-value:3.96E-15 ID:SGTC_2695|Compound:st077686|FD-Score:4.21|P-value:1.44E-5 ID:SGTC_2715|Compound:st079500|FD-Score:-3.33|P-value:4.39E-4 ID:SGTC_2742|Compound:clothiapine|FD-Score:3.12|P-value:9.69E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.17|P-value:8.21E-4 ID:SGTC_2798|Compound:7813637|FD-Score:3.13|P-value:9.27E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.43|P-value:3.30E-4 ID:SGTC_2924|Compound:9010168|FD-Score:5.54|P-value:1.75E-8 ID:SGTC_3059|Compound:1327-0034|FD-Score:3.41|P-value:3.57E-4 ID:SGTC_3127|Compound:9126946|FD-Score:4.20|P-value:1.46E-5 ID:SGTC_3133|Compound:9127736|FD-Score:4.55|P-value:2.97E-6 ID:SGTC_3159|Compound:9100096|FD-Score:-4.46|P-value:4.38E-6 ID:SGTC_3191|Compound:9110352|FD-Score:-3.22|P-value:6.45E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.78|P-value:8.60E-5 ID:SGTC_3310|Compound:9130229|FD-Score:4.38|P-value:6.69E-6 ID:SGTC_82|Compound:0054-0107|FD-Score:-3.27|P-value:5.52E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:3.13|P-value:9.45E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:5.79|P-value:4.22E-9 ID:SGTC_981|Compound:1488-1094|FD-Score:-3.88|P-value:5.30E-5 ID:SGTC_997|Compound:3996-0078|FD-Score:3.28|P-value:5.50E-4 ID:SGTC_1279|Compound:0874-0590|FD-Score:4.67|P-value:1.74E-6 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.14|P-value:9.17E-4 ID:SGTC_1370|Compound:2001-0092|FD-Score:3.25|P-value:6.13E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:3.26|P-value:5.92E-4 ID:SGTC_1735|Compound:st034310|FD-Score:-3.27|P-value:5.45E-4 ID:SGTC_1744|Compound:st037937|FD-Score:-5.46|P-value:2.64E-8 ID:SGTC_1750|Compound:st081859|FD-Score:-3.58|P-value:1.76E-4 ID:SGTC_1919|Compound:st067113|FD-Score:3.26|P-value:5.97E-4 ID:SGTC_2084|Compound:5306078|FD-Score:3.91|P-value:5.14E-5 ID:SGTC_2332|Compound:7982454|FD-Score:-3.36|P-value:3.93E-4 ID:SGTC_2625|Compound:euphol|FD-Score:3.21|P-value:7.23E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:7.81|P-value:3.96E-15 ID:SGTC_2695|Compound:st077686|FD-Score:4.21|P-value:1.44E-5 ID:SGTC_2715|Compound:st079500|FD-Score:-3.33|P-value:4.39E-4 ID:SGTC_2742|Compound:clothiapine|FD-Score:3.12|P-value:9.69E-4 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.17|P-value:8.21E-4 ID:SGTC_2798|Compound:7813637|FD-Score:3.13|P-value:9.27E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.43|P-value:3.30E-4 ID:SGTC_2924|Compound:9010168|FD-Score:5.54|P-value:1.75E-8 ID:SGTC_3059|Compound:1327-0034|FD-Score:3.41|P-value:3.57E-4 ID:SGTC_3127|Compound:9126946|FD-Score:4.20|P-value:1.46E-5 ID:SGTC_3133|Compound:9127736|FD-Score:4.55|P-value:2.97E-6 ID:SGTC_3159|Compound:9100096|FD-Score:-4.46|P-value:4.38E-6 ID:SGTC_3191|Compound:9110352|FD-Score:-3.22|P-value:6.45E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.78|P-value:8.60E-5 ID:SGTC_3310|Compound:9130229|FD-Score:4.38|P-value:6.69E-6

Top fitness defect scores for YLL026W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_2651 1327-0036 7.81 5.0 µM 3.96E-15 40 2.89E-15
2 SGTC_769 0302-0231 5.79 76.0 µM 4.22E-9 10 3.51E-9
3 SGTC_2924 9010168 5.54 62.8 µM 1.75E-8 cell wall signaling 11 1.48E-8
4 SGTC_1279 0874-0590 4.67 65.2 µM 1.74E-6 22 1.53E-6
5 SGTC_3133 9127736 4.55 49.5 µM 2.97E-6 12 2.62E-6
6 SGTC_3310 9130229 4.38 44.1 µM 6.69E-6 Golgi 16 5.96E-6
7 SGTC_2695 st077686 4.21 52.0 µM 1.44E-5 30 1.29E-5
8 SGTC_3127 9126946 4.20 49.5 µM 1.46E-5 ERG2 16 1.31E-5
9 SGTC_2084 5306078 3.91 60.6 µM 5.14E-5 23 4.66E-5
10 SGTC_3308 9128332 3.78 17.6 µM 8.60E-5 plasma membrane duress 84 7.84E-5
11 SGTC_2807 7945238 3.43 52.0 µM 3.30E-4 48 3.05E-4
12 SGTC_3059 1327-0034 3.41 3.0 µM 3.57E-4 73 3.30E-4
13 SGTC_997 3996-0078 3.28 137.0 µM 5.50E-4 59 5.10E-4
14 SGTC_1404 3909-7820 3.26 48.3 µM 5.92E-4 60S ribosome export 25 5.50E-4
15 SGTC_1919 st067113 3.26 52.3 µM 5.97E-4 TSC3-RPN4 57 5.55E-4
16 SGTC_1370 2001-0092 3.25 44.6 µM 6.13E-4 71 5.69E-4
17 SGTC_2625 euphol 3.21 100.0 µM 7.23E-4 65 6.73E-4
18 SGTC_2749 bexarotene 3.17 57.4 µM 8.21E-4 55 7.65E-4
19 SGTC_1283 0922-0125 3.14 16.4 µM 9.17E-4 52 8.56E-4
20 SGTC_2798 7813637 3.13 45.5 µM 9.27E-4 70 8.65E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.208 5.03E-34 YFL037W TUB2 het Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules; mutation in human ortholog is associated with congenital fibrosis of the extraocular muscles (CFEOM) with polymicrogyria
0.198 5.95E-31 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.170 2.98E-23 YIL019W FAF1 het Protein required for pre-rRNA processing and 40S ribosomal subunit assembly
0.153 4.98E-19 YOR297C TIM18 hom Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex
0.148 7.09E-18 YIL135C VHS2 hom Cytoplasmic protein of unknown function; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; similar to Mlf3p
0.138 9.36E-16 YJL005W CYR1 het Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation
0.137 2.00E-15 YER009W NTF2 het Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport
0.126 2.23E-13 YIL022W TIM44 het Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex)
0.125 3.23E-13 YMR115W MGR3 hom Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA
0.125 4.19E-13 YIR012W SQT1 het Protein involved in 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay; protein abundance increases in response to DNA replication stress
0.123 8.31E-13 YJL013C MAD3 hom Subunit of the spindle-assembly checkpoint complex, which delays anaphase onset in cells with defects in mitotic spindle assembly; pseudosubstrate inhibitor of APC(Cdc20), the anaphase promoting complex involved in securin (Pds1p) turnover
0.113 4.49E-11 YHR082C KSP1 hom Serine/threonine protein kinase; associates with TORC1 and likely involved in TOR signaling cascades; negative regulator of autophagy; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10; protein abundance increases in response to DNA replication stress
0.111 1.02E-10 YJL054W TIM54 het Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane
0.111 1.46E-10 YCR053W THR4 hom Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway
0.110 1.84E-10 YBR215W HPC2 hom Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; mutants display synthetic defects with subunits of FACT, a complex that allows passage of RNA Pol II through nucleosomes