YLL046C / RNP1

Ribonucleoprotein that contains two RNA recognition motifs (RRM)

Zygosity: Homozygous strain
fixedexpanded
Profile for YLL046C / RNP1

Click on Significant Values for Screen Details ID:SGTC_73|Compound:0327-0325|FD-Score:3.26|P-value:2.37E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:4.86|P-value:1.07E-7 ID:SGTC_381|Compound:3461-2219|FD-Score:3.11|P-value:4.29E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:-3.23|P-value:3.46E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-4.31|P-value:2.88E-6 ID:SGTC_644|Compound:1498-1197|FD-Score:3.94|P-value:1.26E-5 ID:SGTC_654|Compound:1124-0271|FD-Score:3.56|P-value:6.80E-5 ID:SGTC_656|Compound:4090-1979|FD-Score:3.09|P-value:4.67E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.76|P-value:3.91E-5 ID:SGTC_661|Compound:1304-0007|FD-Score:-3.34|P-value:2.26E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:3.28|P-value:2.21E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:2.99|P-value:6.66E-4 ID:SGTC_688|Compound:0527-0193|FD-Score:-2.96|P-value:9.46E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:5.08|P-value:2.97E-8 ID:SGTC_741|Compound:4582-0002|FD-Score:-3.83|P-value:2.87E-5 ID:SGTC_744|Compound:1594-0068|FD-Score:-5.41|P-value:5.93E-9 ID:SGTC_746|Compound:1095-0025|FD-Score:6.89|P-value:1.03E-13 ID:SGTC_748|Compound:0136-0228|FD-Score:-4.58|P-value:7.11E-7 ID:SGTC_749|Compound:1000-0129|FD-Score:3.15|P-value:3.67E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-8.85|P-value:4.41E-21 ID:SGTC_1016|Compound:4226-1401|FD-Score:-3.54|P-value:9.92E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.99|P-value:7.18E-8 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.55|P-value:7.13E-5 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.16|P-value:3.58E-4 ID:SGTC_1821|Compound:st053465|FD-Score:-3.80|P-value:3.28E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.65|P-value:6.39E-5 ID:SGTC_1943|Compound:st076331|FD-Score:-4.49|P-value:1.12E-6 ID:SGTC_1946|Compound:st076057|FD-Score:3.01|P-value:6.33E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.29|P-value:2.74E-4 ID:SGTC_1957|Compound:st077035|FD-Score:-3.05|P-value:7.01E-4 ID:SGTC_2020|Compound:4017018|FD-Score:-3.09|P-value:5.89E-4 ID:SGTC_2054|Compound:5233173|FD-Score:3.28|P-value:2.23E-4 ID:SGTC_2087|Compound:5276107|FD-Score:3.12|P-value:4.05E-4 ID:SGTC_2208|Compound:7283366|FD-Score:3.22|P-value:2.78E-4 ID:SGTC_2241|Compound:6772625|FD-Score:3.14|P-value:3.79E-4 ID:SGTC_2340|Compound:7987427|FD-Score:3.13|P-value:3.90E-4 ID:SGTC_2371|Compound:9071574|FD-Score:3.21|P-value:2.93E-4 ID:SGTC_2441|Compound:5730946|FD-Score:2.95|P-value:7.82E-4 ID:SGTC_2449|Compound:5812982|FD-Score:-3.13|P-value:5.12E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:2.95|P-value:7.69E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-4.38|P-value:1.99E-6 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.32|P-value:1.91E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:-3.28|P-value:2.93E-4 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:-3.49|P-value:1.26E-4 ID:SGTC_2851|Compound:9015922|FD-Score:3.49|P-value:9.37E-5 ID:SGTC_2861|Compound:9024595|FD-Score:3.74|P-value:3.20E-5 ID:SGTC_2871|Compound:9038510|FD-Score:3.88|P-value:1.67E-5 ID:SGTC_2876|Compound:9059903|FD-Score:4.24|P-value:2.85E-6 ID:SGTC_3159|Compound:9100096|FD-Score:-3.34|P-value:2.28E-4 ID:SGTC_3204|Compound:9114183|FD-Score:-3.91|P-value:1.95E-5 ID:SGTC_3206|Compound:9114350|FD-Score:-3.85|P-value:2.56E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:3.26|P-value:2.37E-4 ID:SGTC_361|Compound:000s-0510|FD-Score:4.86|P-value:1.07E-7 ID:SGTC_381|Compound:3461-2219|FD-Score:3.11|P-value:4.29E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:-3.23|P-value:3.46E-4 ID:SGTC_613|Compound:3914-0030|FD-Score:-4.31|P-value:2.88E-6 ID:SGTC_644|Compound:1498-1197|FD-Score:3.94|P-value:1.26E-5 ID:SGTC_654|Compound:1124-0271|FD-Score:3.56|P-value:6.80E-5 ID:SGTC_656|Compound:4090-1979|FD-Score:3.09|P-value:4.67E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.76|P-value:3.91E-5 ID:SGTC_661|Compound:1304-0007|FD-Score:-3.34|P-value:2.26E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:3.28|P-value:2.21E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:2.99|P-value:6.66E-4 ID:SGTC_688|Compound:0527-0193|FD-Score:-2.96|P-value:9.46E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:5.08|P-value:2.97E-8 ID:SGTC_741|Compound:4582-0002|FD-Score:-3.83|P-value:2.87E-5 ID:SGTC_744|Compound:1594-0068|FD-Score:-5.41|P-value:5.93E-9 ID:SGTC_746|Compound:1095-0025|FD-Score:6.89|P-value:1.03E-13 ID:SGTC_748|Compound:0136-0228|FD-Score:-4.58|P-value:7.11E-7 ID:SGTC_749|Compound:1000-0129|FD-Score:3.15|P-value:3.67E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-8.85|P-value:4.41E-21 ID:SGTC_1016|Compound:4226-1401|FD-Score:-3.54|P-value:9.92E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.99|P-value:7.18E-8 ID:SGTC_1263|Compound:0774-1208|FD-Score:3.55|P-value:7.13E-5 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.16|P-value:3.58E-4 ID:SGTC_1821|Compound:st053465|FD-Score:-3.80|P-value:3.28E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.65|P-value:6.39E-5 ID:SGTC_1943|Compound:st076331|FD-Score:-4.49|P-value:1.12E-6 ID:SGTC_1946|Compound:st076057|FD-Score:3.01|P-value:6.33E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.29|P-value:2.74E-4 ID:SGTC_1957|Compound:st077035|FD-Score:-3.05|P-value:7.01E-4 ID:SGTC_2020|Compound:4017018|FD-Score:-3.09|P-value:5.89E-4 ID:SGTC_2054|Compound:5233173|FD-Score:3.28|P-value:2.23E-4 ID:SGTC_2087|Compound:5276107|FD-Score:3.12|P-value:4.05E-4 ID:SGTC_2208|Compound:7283366|FD-Score:3.22|P-value:2.78E-4 ID:SGTC_2241|Compound:6772625|FD-Score:3.14|P-value:3.79E-4 ID:SGTC_2340|Compound:7987427|FD-Score:3.13|P-value:3.90E-4 ID:SGTC_2371|Compound:9071574|FD-Score:3.21|P-value:2.93E-4 ID:SGTC_2441|Compound:5730946|FD-Score:2.95|P-value:7.82E-4 ID:SGTC_2449|Compound:5812982|FD-Score:-3.13|P-value:5.12E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:2.95|P-value:7.69E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-4.38|P-value:1.99E-6 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.32|P-value:1.91E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:-3.28|P-value:2.93E-4 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:-3.49|P-value:1.26E-4 ID:SGTC_2851|Compound:9015922|FD-Score:3.49|P-value:9.37E-5 ID:SGTC_2861|Compound:9024595|FD-Score:3.74|P-value:3.20E-5 ID:SGTC_2871|Compound:9038510|FD-Score:3.88|P-value:1.67E-5 ID:SGTC_2876|Compound:9059903|FD-Score:4.24|P-value:2.85E-6 ID:SGTC_3159|Compound:9100096|FD-Score:-3.34|P-value:2.28E-4 ID:SGTC_3204|Compound:9114183|FD-Score:-3.91|P-value:1.95E-5 ID:SGTC_3206|Compound:9114350|FD-Score:-3.85|P-value:2.56E-5

Top fitness defect scores for YLL046C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_746 1095-0025 6.89 46.6 µM 1.03E-13 RSC & ERG11 4 2.76E-12
2 SGTC_735 3076-0345 5.08 636.0 µM 2.97E-8 10 1.92E-7
3 SGTC_361 000s-0510 4.86 1.4 µM 1.07E-7 18 6.00E-7
4 SGTC_2876 9059903 4.24 26.0 µM 2.85E-6 5 1.10E-5
5 SGTC_644 1498-1197 3.94 63.3 µM 1.26E-5 20 4.10E-5
6 SGTC_2871 9038510 3.88 13.0 µM 1.67E-5 18 5.26E-5
7 SGTC_2861 9024595 3.74 19.5 µM 3.20E-5 3 9.38E-5
8 SGTC_654 1124-0271 3.56 80.9 µM 6.80E-5 39 1.83E-4
9 SGTC_1263 0774-1208 3.55 64.8 µM 7.13E-5 63 1.91E-4
10 SGTC_2851 9015922 3.49 71.4 µM 9.37E-5 61 2.43E-4
11 SGTC_2572 astragaloside iv 3.32 100.0 µM 1.91E-4 53 4.58E-4
12 SGTC_676 falcarinol 3.28 140.0 µM 2.21E-4 84 5.21E-4
13 SGTC_2054 5233173 3.28 129.0 µM 2.23E-4 mitochondrial response to ROS 89 5.25E-4
14 SGTC_73 0327-0325 3.26 16.2 µM 2.37E-4 DNA damage response 84 5.55E-4
15 SGTC_2208 7283366 3.22 200.0 µM 2.78E-4 24 6.38E-4
16 SGTC_2371 9071574 3.21 200.0 µM 2.93E-4 32 6.70E-4
17 SGTC_1435 4092-0789 3.16 56.7 µM 3.58E-4 plasma membrane duress 39 8.00E-4
18 SGTC_749 1000-0129 3.15 128.0 µM 3.67E-4 amide catabolism 52 8.17E-4
19 SGTC_2241 6772625 3.14 37.8 µM 3.79E-4 56 8.41E-4
20 SGTC_2340 7987427 3.13 183.4 µM 3.90E-4 71 8.64E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.283 1.15E-62 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.277 3.66E-60 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.237 3.52E-44 YML083C YML083C hom Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
0.234 7.79E-43 YOL141W PPM2 hom AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p
0.203 1.55E-32 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.203 2.36E-32 YER053C PIC2 hom Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature
0.202 3.52E-32 YOR010C TIR2 hom Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis
0.199 2.47E-31 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.194 1.18E-29 YOR345C_d YOR345C_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2
0.190 1.40E-28 YBR118W TEF2 hom Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication
0.187 9.54E-28 YMR111C YMR111C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress
0.187 1.20E-27 YBL015W ACH1 hom Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
0.184 4.94E-27 YJR056C YJR056C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus; relative distribution to the nucleus increases upon DNA replication stress
0.184 5.92E-27 YER060W-A FCY22 hom Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function
0.183 1.63E-26 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function