YLL047W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RNP1

Zygosity: Homozygous strain
fixedexpanded
Profile for YLL047W / YLL047W

Click on Significant Values for Screen Details ID:SGTC_167|Compound:3672-0051|FD-Score:4.82|P-value:1.82E-6 ID:SGTC_245|Compound:methotrexate|FD-Score:3.40|P-value:5.41E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:-3.52|P-value:3.18E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:4.39|P-value:1.23E-5 ID:SGTC_578|Compound:3460-0051|FD-Score:7.25|P-value:1.52E-12 ID:SGTC_579|Compound:4491-1009|FD-Score:4.45|P-value:9.25E-6 ID:SGTC_748|Compound:0136-0228|FD-Score:3.60|P-value:2.72E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:3.49|P-value:4.01E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.38|P-value:5.84E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.31|P-value:7.45E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:3.25|P-value:8.96E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.23|P-value:9.64E-4 ID:SGTC_1663|Compound:st014140|FD-Score:3.71|P-value:1.85E-4 ID:SGTC_1853|Compound:st056710|FD-Score:3.73|P-value:1.70E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-3.45|P-value:4.09E-4 ID:SGTC_2026|Compound:5148700|FD-Score:3.64|P-value:2.40E-4 ID:SGTC_2030|Compound:5175110|FD-Score:3.49|P-value:4.02E-4 ID:SGTC_2097|Compound:5376186|FD-Score:3.29|P-value:7.86E-4 ID:SGTC_2698|Compound:st077697|FD-Score:3.27|P-value:8.36E-4 ID:SGTC_2716|Compound:st080858|FD-Score:-3.90|P-value:7.89E-5 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.84|P-value:1.13E-4 ID:SGTC_2797|Compound:7859098|FD-Score:3.23|P-value:9.69E-4 ID:SGTC_2854|Compound:9024559|FD-Score:3.45|P-value:4.58E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.23|P-value:9.68E-4 ID:SGTC_2965|Compound:9082772|FD-Score:3.40|P-value:5.52E-4 ID:SGTC_3080|Compound:9117754|FD-Score:-3.62|P-value:2.26E-4 ID:SGTC_3093|Compound:9117344|FD-Score:-3.57|P-value:2.68E-4 ID:SGTC_3120|Compound:9124077|FD-Score:3.53|P-value:3.55E-4 ID:SGTC_3121|Compound:9125696|FD-Score:3.50|P-value:3.83E-4 ID:SGTC_3203|Compound:9113543|FD-Score:3.63|P-value:2.48E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:4.82|P-value:1.82E-6 ID:SGTC_245|Compound:methotrexate|FD-Score:3.40|P-value:5.41E-4 ID:SGTC_571|Compound:k831-0106|FD-Score:-3.52|P-value:3.18E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:4.39|P-value:1.23E-5 ID:SGTC_578|Compound:3460-0051|FD-Score:7.25|P-value:1.52E-12 ID:SGTC_579|Compound:4491-1009|FD-Score:4.45|P-value:9.25E-6 ID:SGTC_748|Compound:0136-0228|FD-Score:3.60|P-value:2.72E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:3.49|P-value:4.01E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.38|P-value:5.84E-4 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.31|P-value:7.45E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:3.25|P-value:8.96E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:3.23|P-value:9.64E-4 ID:SGTC_1663|Compound:st014140|FD-Score:3.71|P-value:1.85E-4 ID:SGTC_1853|Compound:st056710|FD-Score:3.73|P-value:1.70E-4 ID:SGTC_2016|Compound:5121758|FD-Score:-3.45|P-value:4.09E-4 ID:SGTC_2026|Compound:5148700|FD-Score:3.64|P-value:2.40E-4 ID:SGTC_2030|Compound:5175110|FD-Score:3.49|P-value:4.02E-4 ID:SGTC_2097|Compound:5376186|FD-Score:3.29|P-value:7.86E-4 ID:SGTC_2698|Compound:st077697|FD-Score:3.27|P-value:8.36E-4 ID:SGTC_2716|Compound:st080858|FD-Score:-3.90|P-value:7.89E-5 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.84|P-value:1.13E-4 ID:SGTC_2797|Compound:7859098|FD-Score:3.23|P-value:9.69E-4 ID:SGTC_2854|Compound:9024559|FD-Score:3.45|P-value:4.58E-4 ID:SGTC_2887|Compound:9044784|FD-Score:3.23|P-value:9.68E-4 ID:SGTC_2965|Compound:9082772|FD-Score:3.40|P-value:5.52E-4 ID:SGTC_3080|Compound:9117754|FD-Score:-3.62|P-value:2.26E-4 ID:SGTC_3093|Compound:9117344|FD-Score:-3.57|P-value:2.68E-4 ID:SGTC_3120|Compound:9124077|FD-Score:3.53|P-value:3.55E-4 ID:SGTC_3121|Compound:9125696|FD-Score:3.50|P-value:3.83E-4 ID:SGTC_3203|Compound:9113543|FD-Score:3.63|P-value:2.48E-4

Top fitness defect scores for YLL047W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_578 3460-0051 7.25 92.0 µM 1.52E-12 1 2.14E-13
2 SGTC_167 3672-0051 4.82 66.2 µM 1.82E-6 23 7.32E-7
3 SGTC_579 4491-1009 4.45 110.0 µM 9.25E-6 60S ribosome export 14 4.20E-6
4 SGTC_574 1315-0397 4.39 40.0 µM 1.23E-5 22 5.69E-6
5 SGTC_2779 methotrexate 3.84 400.0 µM 1.13E-4 31 6.18E-5
6 SGTC_1853 st056710 3.73 91.2 µM 1.70E-4 amide catabolism 33 9.60E-5
7 SGTC_1663 st014140 3.71 55.4 µM 1.85E-4 60S ribosome export 22 1.05E-4
8 SGTC_2026 5148700 3.64 152.0 µM 2.40E-4 25 1.39E-4
9 SGTC_3203 9113543 3.63 49.5 µM 2.48E-4 41 1.44E-4
10 SGTC_748 0136-0228 3.60 77.9 µM 2.72E-4 redox potentiating 92 1.59E-4
11 SGTC_3120 9124077 3.53 49.5 µM 3.55E-4 32 2.11E-4
12 SGTC_3121 9125696 3.50 49.5 µM 3.83E-4 8 2.29E-4
13 SGTC_796 1234-0020 3.49 70.7 µM 4.01E-4 SWF1 & branched chain AA biosynthesis 38 2.41E-4
14 SGTC_2030 5175110 3.49 200.0 µM 4.02E-4 Golgi 38 2.41E-4
15 SGTC_2854 9024559 3.45 71.4 µM 4.58E-4 41 2.78E-4
16 SGTC_245 methotrexate 3.40 289.6 µM 5.41E-4 59 3.32E-4
17 SGTC_2965 9082772 3.40 38.6 µM 5.52E-4 mitochondrial response to ROS 56 3.39E-4
18 SGTC_1094 duloxetine 3.38 25.4 µM 5.84E-4 RPP1 & pyrimidine depletion 41 3.61E-4
19 SGTC_1178 0988-0033 3.31 191.0 µM 7.45E-4 54 4.68E-4
20 SGTC_2097 5376186 3.29 200.0 µM 7.86E-4 48 4.96E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.182 1.76E-26 YLL048C YBT1 hom Transporter of the ATP-binding cassette (ABC) family; involved in bile acid transport; negative regulator of vacuole fusion; regulates the release of lumenal Ca2+ stores; similar to mammalian bile transporters
0.152 6.61E-19 YGR267C FOL2 het GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway
0.145 2.59E-17 YOR074C CDC21 het Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S
0.137 1.45E-15 YIR039C YPS6 hom Putative GPI-anchored aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance
0.101 5.10E-9 YEL041W YEF1 hom ATP-NADH kinase; phosphorylates both NAD and NADH; homooctameric structure consisting of 60-kDa subunits; similar to Pos5p; overexpression complements certain pos5 phenotypes; YEF1 has a paralog, UTR1, that arose from the whole genome duplication
0.099 8.86E-9 YBR288C APM3 hom Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway
0.097 2.04E-8 YGL155W CDC43 het Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis
0.096 2.93E-8 YOL059W GPD2 hom NAD-dependent glycerol 3-phosphate dehydrogenase, homolog of Gpd1p, expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria; constitutively active but is inactivated via phosphorylation by energy-stress responsive kinase SNF1
0.093 6.45E-8 YPL195W APL5 hom Delta adaptin-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function
0.092 8.59E-8 YHR024C MAS2 het Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins
0.088 3.40E-7 YER056C FCY2 hom Purine-cytosine permease; mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation; relative distribution to the vacuole increases upon DNA replication stress
0.087 4.99E-7 YKL013C ARC19 het Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches
0.081 2.74E-6 YGL088W_d YGL088W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps snR10, a snoRNA required for preRNA processing
0.080 3.36E-6 YLR415C_p YLR415C_p hom Putative protein of unknown function; YLR415C is not an essential gene
0.079 4.08E-6 YPL206C PGC1 hom Phosphatidyl Glycerol phospholipase C; regulates the phosphatidylglycerol (PG) content via a phospholipase C-type degradation mechanism; contains glycerophosphodiester phosphodiesterase motifs