YLL051C / FRE6

Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels

Zygosity: Homozygous strain
fixedexpanded
Profile for YLL051C / FRE6

Click on Significant Values for Screen Details ID:SGTC_61|Compound:0978-8327|FD-Score:-2.85|P-value:6.94E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:-2.82|P-value:7.65E-4 ID:SGTC_291|Compound:4130-1278|FD-Score:-3.25|P-value:1.34E-4 ID:SGTC_292|Compound:k038-0015|FD-Score:-4.28|P-value:7.35E-7 ID:SGTC_301|Compound:4119-0100|FD-Score:-3.00|P-value:3.86E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:3.27|P-value:1.03E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:3.47|P-value:4.28E-5 ID:SGTC_393|Compound:acivicin|FD-Score:2.99|P-value:3.53E-4 ID:SGTC_400|Compound:oxethazaine|FD-Score:-3.48|P-value:4.63E-5 ID:SGTC_742|Compound:0kpi-0133|FD-Score:2.73|P-value:9.92E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.40|P-value:6.60E-5 ID:SGTC_766|Compound:1391-0721|FD-Score:3.41|P-value:5.58E-5 ID:SGTC_773|Compound:4358-1457|FD-Score:3.42|P-value:5.42E-5 ID:SGTC_784|Compound:4579-0127|FD-Score:2.86|P-value:5.96E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:-3.99|P-value:3.69E-6 ID:SGTC_851|Compound:0394-0702|FD-Score:-3.93|P-value:4.98E-6 ID:SGTC_866|Compound:0495-0101|FD-Score:-3.56|P-value:3.20E-5 ID:SGTC_871|Compound:0574-0004|FD-Score:4.89|P-value:1.58E-8 ID:SGTC_875|Compound:0709-0210|FD-Score:3.89|P-value:5.41E-6 ID:SGTC_876|Compound:0720-0963|FD-Score:3.15|P-value:1.82E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:7.11|P-value:4.47E-16 ID:SGTC_912|Compound:3474-0017|FD-Score:3.03|P-value:2.90E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:2.83|P-value:6.55E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:2.85|P-value:6.24E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:3.49|P-value:3.91E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.64|P-value:2.12E-5 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-7.70|P-value:2.18E-18 ID:SGTC_1109|Compound:tnp00067|FD-Score:-3.51|P-value:3.94E-5 ID:SGTC_1111|Compound:tnp00062|FD-Score:-5.90|P-value:1.54E-11 ID:SGTC_1178|Compound:0988-0033|FD-Score:2.93|P-value:4.50E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.75|P-value:1.06E-5 ID:SGTC_1264|Compound:0783-0040|FD-Score:-3.29|P-value:1.12E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:4.31|P-value:5.20E-7 ID:SGTC_1343|Compound:1487-0095|FD-Score:2.79|P-value:7.89E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:-2.98|P-value:4.10E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.71|P-value:1.29E-5 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:2.80|P-value:7.51E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-3.42|P-value:6.14E-5 ID:SGTC_1733|Compound:st037357|FD-Score:2.85|P-value:6.20E-4 ID:SGTC_2478|Compound:5763493|FD-Score:-2.92|P-value:5.29E-4 ID:SGTC_2483|Compound:5729050|FD-Score:4.81|P-value:2.61E-8 ID:SGTC_2488|Compound:5268135|FD-Score:2.99|P-value:3.43E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.69|P-value:1.71E-5 ID:SGTC_2618|Compound:avocadyne|FD-Score:-2.90|P-value:5.76E-4 ID:SGTC_2650|Compound:prasterone|FD-Score:2.77|P-value:8.45E-4 ID:SGTC_2681|Compound:menadione|FD-Score:-2.77|P-value:9.51E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-4.41|P-value:3.49E-7 ID:SGTC_2755|Compound:lomerizine|FD-Score:-3.00|P-value:3.72E-4 ID:SGTC_2786|Compound:7743617|FD-Score:-3.66|P-value:1.93E-5 ID:SGTC_2868|Compound:9035608|FD-Score:-3.51|P-value:3.94E-5 ID:SGTC_2879|Compound:9041815|FD-Score:2.90|P-value:5.06E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.29|P-value:9.67E-5 ID:SGTC_2957|Compound:9076800|FD-Score:-2.88|P-value:6.17E-4 ID:SGTC_2985|Compound:9022375|FD-Score:3.08|P-value:2.38E-4 ID:SGTC_2991|Compound:9074669|FD-Score:-3.28|P-value:1.17E-4 ID:SGTC_2993|Compound:9054257|FD-Score:3.33|P-value:8.02E-5 ID:SGTC_2997|Compound:9067075|FD-Score:-2.97|P-value:4.27E-4 ID:SGTC_3012|Compound:9080433|FD-Score:3.70|P-value:1.38E-5 ID:SGTC_3027|Compound:9089541|FD-Score:4.79|P-value:3.02E-8 ID:SGTC_3213|Compound:9129884|FD-Score:-3.07|P-value:2.78E-4 ID:SGTC_3291|Compound:9121177|FD-Score:3.20|P-value:1.43E-4 ID:SGTC_3306|Compound:9127676|FD-Score:-4.65|P-value:8.28E-8 ID:SGTC_61|Compound:0978-8327|FD-Score:-2.85|P-value:6.94E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:-2.82|P-value:7.65E-4 ID:SGTC_291|Compound:4130-1278|FD-Score:-3.25|P-value:1.34E-4 ID:SGTC_292|Compound:k038-0015|FD-Score:-4.28|P-value:7.35E-7 ID:SGTC_301|Compound:4119-0100|FD-Score:-3.00|P-value:3.86E-4 ID:SGTC_329|Compound:k048-0121|FD-Score:3.27|P-value:1.03E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:3.47|P-value:4.28E-5 ID:SGTC_393|Compound:acivicin|FD-Score:2.99|P-value:3.53E-4 ID:SGTC_400|Compound:oxethazaine|FD-Score:-3.48|P-value:4.63E-5 ID:SGTC_742|Compound:0kpi-0133|FD-Score:2.73|P-value:9.92E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.40|P-value:6.60E-5 ID:SGTC_766|Compound:1391-0721|FD-Score:3.41|P-value:5.58E-5 ID:SGTC_773|Compound:4358-1457|FD-Score:3.42|P-value:5.42E-5 ID:SGTC_784|Compound:4579-0127|FD-Score:2.86|P-value:5.96E-4 ID:SGTC_792|Compound:4534-1957|FD-Score:-3.99|P-value:3.69E-6 ID:SGTC_851|Compound:0394-0702|FD-Score:-3.93|P-value:4.98E-6 ID:SGTC_866|Compound:0495-0101|FD-Score:-3.56|P-value:3.20E-5 ID:SGTC_871|Compound:0574-0004|FD-Score:4.89|P-value:1.58E-8 ID:SGTC_875|Compound:0709-0210|FD-Score:3.89|P-value:5.41E-6 ID:SGTC_876|Compound:0720-0963|FD-Score:3.15|P-value:1.82E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:7.11|P-value:4.47E-16 ID:SGTC_912|Compound:3474-0017|FD-Score:3.03|P-value:2.90E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:2.83|P-value:6.55E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:2.85|P-value:6.24E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:3.49|P-value:3.91E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.64|P-value:2.12E-5 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-7.70|P-value:2.18E-18 ID:SGTC_1109|Compound:tnp00067|FD-Score:-3.51|P-value:3.94E-5 ID:SGTC_1111|Compound:tnp00062|FD-Score:-5.90|P-value:1.54E-11 ID:SGTC_1178|Compound:0988-0033|FD-Score:2.93|P-value:4.50E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.75|P-value:1.06E-5 ID:SGTC_1264|Compound:0783-0040|FD-Score:-3.29|P-value:1.12E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:4.31|P-value:5.20E-7 ID:SGTC_1343|Compound:1487-0095|FD-Score:2.79|P-value:7.89E-4 ID:SGTC_1439|Compound:4092-1168|FD-Score:-2.98|P-value:4.10E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:3.71|P-value:1.29E-5 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:2.80|P-value:7.51E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-3.42|P-value:6.14E-5 ID:SGTC_1733|Compound:st037357|FD-Score:2.85|P-value:6.20E-4 ID:SGTC_2478|Compound:5763493|FD-Score:-2.92|P-value:5.29E-4 ID:SGTC_2483|Compound:5729050|FD-Score:4.81|P-value:2.61E-8 ID:SGTC_2488|Compound:5268135|FD-Score:2.99|P-value:3.43E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:-3.69|P-value:1.71E-5 ID:SGTC_2618|Compound:avocadyne|FD-Score:-2.90|P-value:5.76E-4 ID:SGTC_2650|Compound:prasterone|FD-Score:2.77|P-value:8.45E-4 ID:SGTC_2681|Compound:menadione|FD-Score:-2.77|P-value:9.51E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-4.41|P-value:3.49E-7 ID:SGTC_2755|Compound:lomerizine|FD-Score:-3.00|P-value:3.72E-4 ID:SGTC_2786|Compound:7743617|FD-Score:-3.66|P-value:1.93E-5 ID:SGTC_2868|Compound:9035608|FD-Score:-3.51|P-value:3.94E-5 ID:SGTC_2879|Compound:9041815|FD-Score:2.90|P-value:5.06E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.29|P-value:9.67E-5 ID:SGTC_2957|Compound:9076800|FD-Score:-2.88|P-value:6.17E-4 ID:SGTC_2985|Compound:9022375|FD-Score:3.08|P-value:2.38E-4 ID:SGTC_2991|Compound:9074669|FD-Score:-3.28|P-value:1.17E-4 ID:SGTC_2993|Compound:9054257|FD-Score:3.33|P-value:8.02E-5 ID:SGTC_2997|Compound:9067075|FD-Score:-2.97|P-value:4.27E-4 ID:SGTC_3012|Compound:9080433|FD-Score:3.70|P-value:1.38E-5 ID:SGTC_3027|Compound:9089541|FD-Score:4.79|P-value:3.02E-8 ID:SGTC_3213|Compound:9129884|FD-Score:-3.07|P-value:2.78E-4 ID:SGTC_3291|Compound:9121177|FD-Score:3.20|P-value:1.43E-4 ID:SGTC_3306|Compound:9127676|FD-Score:-4.65|P-value:8.28E-8

Top fitness defect scores for YLL051C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_882 0843-0131 7.11 351.0 µM 4.47E-16 2 5.73E-13
2 SGTC_871 0574-0004 4.89 149.0 µM 1.58E-8 24 5.08E-7
3 SGTC_2483 5729050 4.81 27.2 µM 2.61E-8 13 7.55E-7
4 SGTC_3027 9089541 4.79 49.5 µM 3.02E-8 fatty acid desaturase (OLE1) 8 8.48E-7
5 SGTC_1269 0831-0796 4.31 3.0 µM 5.20E-7 60S ribosome export 11 8.02E-6
6 SGTC_875 0709-0210 3.89 25.7 µM 5.41E-6 fatty acid desaturase (OLE1) 33 5.12E-5
7 SGTC_1206 3978-0017 3.75 132.0 µM 1.06E-5 ERG2 43 8.74E-5
8 SGTC_1483 3453-0561 3.71 55.9 µM 1.29E-5 26 1.02E-4
9 SGTC_3012 9080433 3.70 71.4 µM 1.38E-5 16 1.08E-4
10 SGTC_979 1426-2828 3.49 121.0 µM 3.91E-5 31 2.45E-4
11 SGTC_367 0335-0881 3.47 7.1 µM 4.28E-5 ubiquinone biosynthesis & proteasome 102 2.63E-4
12 SGTC_773 4358-1457 3.42 44.6 µM 5.42E-5 59 3.18E-4
13 SGTC_766 1391-0721 3.41 126.0 µM 5.58E-5 35 3.25E-4
14 SGTC_2993 9054257 3.33 71.4 µM 8.02E-5 fatty acid desaturase (OLE1) 71 4.34E-4
15 SGTC_2933 9026794 3.29 32.5 µM 9.67E-5 55 5.03E-4
16 SGTC_329 k048-0121 3.27 21.3 µM 1.03E-4 RSC & ERG11 30 5.31E-4
17 SGTC_3291 9121177 3.20 71.4 µM 1.43E-4 32 6.87E-4
18 SGTC_876 0720-0963 3.15 56.8 µM 1.82E-4 45 8.30E-4
19 SGTC_2985 9022375 3.08 71.4 µM 2.38E-4 RPP1 & pyrimidine depletion 70 0.00103
20 SGTC_912 3474-0017 3.03 2.2 µM 2.90E-4 62 0.00120

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.234 6.88E-43 YNL305C BXI1 hom Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p
0.152 7.66E-19 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.133 8.56E-15 YDL133C-A RPL41B hom Ribosomal 60S subunit protein L41B; comprises only 25 amino acids; rpl41a rpl41b double null mutant is viable; homologous to mammalian ribosomal protein L41, no bacterial homolog; RPL41B has a paralog, RPL41A, that arose from the whole genome duplication
0.132 1.61E-14 YIR038C GTT1 hom ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p
0.131 2.42E-14 YGL086W MAD1 hom Coiled-coil protein involved in the spindle-assembly checkpoint; required for inhibition of karyopherin/importin Pse1p (aka Kap121p) upon spindle assembly checkpoint arrest; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of the activity of the anaphase promoting complex; forms a complex with Mad2p
0.130 3.48E-14 YMR139W RIM11 hom Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress
0.128 9.97E-14 YJL130C URA2 hom Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP
0.125 5.00E-13 YGL246C RAI1 hom Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z
0.123 9.42E-13 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.122 1.58E-12 YFR039C_p YFR039C_p hom Putative protein of unknown function; may be involved in response to high salt and changes in carbon source; deletion mutant has decreased spore survival in Drosophila feces
0.121 1.67E-12 YOR080W DIA2 hom Origin-binding F-box protein; forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication; plays a role in transcription; required for correct assembly of RSC complex, correct RSC-mediated transcription regulation, and correct nucleosome positioning; involved in invasive and pseudohyphal growth; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase
0.121 2.32E-12 YLR407W_p YLR407W_p hom Putative protein of unknown function; null mutant displays elongated buds and a large fraction of budded cells have only one nucleus
0.112 6.70E-11 YKL220C FRE2 hom Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
0.110 1.44E-10 YCR072C RSA4 het WD-repeat protein involved in ribosome biogenesis; may interact with ribosomes; required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus
0.109 2.74E-10 YJL122W ALB1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p