YLL054C_p

Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YLL054C / YLL054C

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.40|P-value:4.97E-4 ID:SGTC_303|Compound:1348-1668|FD-Score:4.05|P-value:4.39E-5 ID:SGTC_369|Compound:0957-0393|FD-Score:3.77|P-value:1.30E-4 ID:SGTC_406|Compound:estrone|FD-Score:4.27|P-value:1.80E-5 ID:SGTC_411|Compound:enrofloxacin|FD-Score:3.36|P-value:5.68E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:4.22|P-value:2.23E-5 ID:SGTC_444|Compound:curcumin|FD-Score:-3.35|P-value:6.36E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:3.67|P-value:1.91E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:-5.35|P-value:1.27E-7 ID:SGTC_868|Compound:0527-0199|FD-Score:4.25|P-value:1.94E-5 ID:SGTC_911|Compound:3456-4043|FD-Score:-3.43|P-value:4.86E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:-3.37|P-value:5.79E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:-3.58|P-value:2.87E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:-3.57|P-value:2.98E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-8.89|P-value:4.94E-18 ID:SGTC_1463|Compound:k081-0032|FD-Score:-8.33|P-value:4.84E-16 ID:SGTC_1721|Compound:st082152|FD-Score:-3.38|P-value:5.61E-4 ID:SGTC_1726|Compound:st035556|FD-Score:3.41|P-value:4.87E-4 ID:SGTC_1728|Compound:st035614|FD-Score:4.62|P-value:3.95E-6 ID:SGTC_1916|Compound:st067606|FD-Score:-4.05|P-value:4.78E-5 ID:SGTC_1955|Compound:wogonin|FD-Score:3.47|P-value:3.87E-4 ID:SGTC_1975|Compound:st070967|FD-Score:3.28|P-value:7.51E-4 ID:SGTC_2018|Compound:5133068|FD-Score:4.48|P-value:7.38E-6 ID:SGTC_2023|Compound:5144124|FD-Score:3.88|P-value:8.84E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.35|P-value:1.28E-5 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-4.21|P-value:2.50E-5 ID:SGTC_2711|Compound:st079103|FD-Score:-3.28|P-value:7.84E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:-4.21|P-value:2.48E-5 ID:SGTC_2961|Compound:9083290|FD-Score:4.09|P-value:3.84E-5 ID:SGTC_2962|Compound:9082311|FD-Score:3.49|P-value:3.69E-4 ID:SGTC_2969|Compound:9091408|FD-Score:4.20|P-value:2.38E-5 ID:SGTC_3008|Compound:9078912|FD-Score:4.11|P-value:3.50E-5 ID:SGTC_3202|Compound:9113761|FD-Score:-3.47|P-value:4.25E-4 ID:SGTC_3336|Compound:9143619|FD-Score:-3.47|P-value:4.17E-4 ID:SGTC_3338|Compound:9144300|FD-Score:-3.37|P-value:5.82E-4 ID:SGTC_3343|Compound:9148379|FD-Score:-3.85|P-value:1.04E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.40|P-value:4.97E-4 ID:SGTC_303|Compound:1348-1668|FD-Score:4.05|P-value:4.39E-5 ID:SGTC_369|Compound:0957-0393|FD-Score:3.77|P-value:1.30E-4 ID:SGTC_406|Compound:estrone|FD-Score:4.27|P-value:1.80E-5 ID:SGTC_411|Compound:enrofloxacin|FD-Score:3.36|P-value:5.68E-4 ID:SGTC_416|Compound:estradiol valerate|FD-Score:4.22|P-value:2.23E-5 ID:SGTC_444|Compound:curcumin|FD-Score:-3.35|P-value:6.36E-4 ID:SGTC_781|Compound:4335-2806|FD-Score:3.67|P-value:1.91E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:-5.35|P-value:1.27E-7 ID:SGTC_868|Compound:0527-0199|FD-Score:4.25|P-value:1.94E-5 ID:SGTC_911|Compound:3456-4043|FD-Score:-3.43|P-value:4.86E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:-3.37|P-value:5.79E-4 ID:SGTC_1372|Compound:2752-0194|FD-Score:-3.58|P-value:2.87E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:-3.57|P-value:2.98E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-8.89|P-value:4.94E-18 ID:SGTC_1463|Compound:k081-0032|FD-Score:-8.33|P-value:4.84E-16 ID:SGTC_1721|Compound:st082152|FD-Score:-3.38|P-value:5.61E-4 ID:SGTC_1726|Compound:st035556|FD-Score:3.41|P-value:4.87E-4 ID:SGTC_1728|Compound:st035614|FD-Score:4.62|P-value:3.95E-6 ID:SGTC_1916|Compound:st067606|FD-Score:-4.05|P-value:4.78E-5 ID:SGTC_1955|Compound:wogonin|FD-Score:3.47|P-value:3.87E-4 ID:SGTC_1975|Compound:st070967|FD-Score:3.28|P-value:7.51E-4 ID:SGTC_2018|Compound:5133068|FD-Score:4.48|P-value:7.38E-6 ID:SGTC_2023|Compound:5144124|FD-Score:3.88|P-value:8.84E-5 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.35|P-value:1.28E-5 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-4.21|P-value:2.50E-5 ID:SGTC_2711|Compound:st079103|FD-Score:-3.28|P-value:7.84E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:-4.21|P-value:2.48E-5 ID:SGTC_2961|Compound:9083290|FD-Score:4.09|P-value:3.84E-5 ID:SGTC_2962|Compound:9082311|FD-Score:3.49|P-value:3.69E-4 ID:SGTC_2969|Compound:9091408|FD-Score:4.20|P-value:2.38E-5 ID:SGTC_3008|Compound:9078912|FD-Score:4.11|P-value:3.50E-5 ID:SGTC_3202|Compound:9113761|FD-Score:-3.47|P-value:4.25E-4 ID:SGTC_3336|Compound:9143619|FD-Score:-3.47|P-value:4.17E-4 ID:SGTC_3338|Compound:9144300|FD-Score:-3.37|P-value:5.82E-4 ID:SGTC_3343|Compound:9148379|FD-Score:-3.85|P-value:1.04E-4

Top fitness defect scores for YLL054C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1728 st035614 4.62 33.8 µM 3.95E-6 27 1.92E-6
2 SGTC_2018 5133068 4.48 143.0 µM 7.38E-6 13 3.74E-6
3 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 4.35 3.7 µM 1.28E-5 59 6.75E-6
4 SGTC_406 estrone 4.27 100.0 µM 1.80E-5 7 9.70E-6
5 SGTC_868 0527-0199 4.25 213.0 µM 1.94E-5 fatty acid desaturase (OLE1) 21 1.05E-5
6 SGTC_416 estradiol valerate 4.22 100.0 µM 2.23E-5 4 1.22E-5
7 SGTC_2969 9091408 4.20 28.7 µM 2.38E-5 20 1.31E-5
8 SGTC_3008 9078912 4.11 71.4 µM 3.50E-5 11 1.97E-5
9 SGTC_2961 9083290 4.09 32.5 µM 3.84E-5 16 2.18E-5
10 SGTC_303 1348-1668 4.05 34.2 µM 4.39E-5 7 2.51E-5
11 SGTC_2023 5144124 3.88 124.0 µM 8.84E-5 23 5.30E-5
12 SGTC_369 0957-0393 3.77 4.5 µM 1.30E-4 cell wall signaling 28 8.00E-5
13 SGTC_781 4335-2806 3.67 94.4 µM 1.91E-4 27 1.21E-4
14 SGTC_2962 9082311 3.49 13.2 µM 3.69E-4 36 2.43E-4
15 SGTC_1955 wogonin 3.47 32.4 µM 3.87E-4 27 2.56E-4
16 SGTC_1726 st035556 3.41 14.6 µM 4.87E-4 60 3.27E-4
17 SGTC_6 0844-0013 3.40 19.8 µM 4.97E-4 152 3.34E-4
18 SGTC_411 enrofloxacin 3.36 100.0 µM 5.68E-4 DNA damage response 22 3.86E-4
19 SGTC_1975 st070967 3.28 30.8 µM 7.51E-4 62 5.19E-4
20 SGTC_1964 st076914 3.10 61.0 µM 0.00135 RPP1 & pyrimidine depletion 51 9.67E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.353 3.63E-99 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.352 9.06E-99 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.331 1.76E-86 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.330 1.59E-85 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.313 1.52E-76 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.289 1.66E-65 YDR530C APA2 hom Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II; AP4A phosphorylase involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; APA2 has a paralog, APA1, that arose from the whole genome duplication
0.287 9.46E-65 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.286 4.06E-64 YNL218W MGS1 hom Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress
0.281 6.24E-62 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.279 7.92E-61 YDR169C STB3 hom Ribosomal RNA processing element (RRPE)-binding protein; involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p; relative distribution to the nucleus increases upon DNA replication stress
0.275 4.39E-59 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.274 6.10E-59 YMR137C PSO2 hom Nuclease required for DNA single- and double-strand break repair; acts at a post-incision step in repair of breaks that result from interstrand cross-links produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation; forms nuclear foci upon DNA replication stress
0.269 8.67E-57 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.257 9.61E-52 YBR274W CHK1 hom Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase
0.252 6.90E-50 YOR301W RAX1 hom Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily