YLR001C_p

Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; predicted to be palmitoylated

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR001C / YLR001C

Click on Significant Values for Screen Details ID:SGTC_192|Compound:3455-0609|FD-Score:3.41|P-value:2.01E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.21|P-value:5.90E-4 ID:SGTC_334|Compound:1502-1024|FD-Score:5.86|P-value:7.64E-10 ID:SGTC_620|Compound:0109-0052|FD-Score:3.89|P-value:2.89E-5 ID:SGTC_989|Compound:1501-0895|FD-Score:3.74|P-value:5.46E-5 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.09|P-value:6.76E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.51|P-value:1.39E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.40|P-value:2.11E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.26|P-value:3.57E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.52|P-value:1.35E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.60|P-value:9.80E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.15|P-value:9.01E-6 ID:SGTC_1661|Compound:st013063|FD-Score:3.01|P-value:8.96E-4 ID:SGTC_1738|Compound:st035555|FD-Score:5.02|P-value:1.10E-7 ID:SGTC_1744|Compound:st037937|FD-Score:-3.47|P-value:2.22E-4 ID:SGTC_1748|Compound:st037455|FD-Score:-3.44|P-value:2.56E-4 ID:SGTC_1749|Compound:st037932|FD-Score:3.10|P-value:6.48E-4 ID:SGTC_1767|Compound:st044992|FD-Score:3.42|P-value:1.94E-4 ID:SGTC_1927|Compound:st060202|FD-Score:-3.33|P-value:3.76E-4 ID:SGTC_1949|Compound:st076024|FD-Score:2.98|P-value:9.78E-4 ID:SGTC_1954|Compound:st077032|FD-Score:4.37|P-value:3.09E-6 ID:SGTC_2011|Compound:4012611|FD-Score:-3.17|P-value:6.93E-4 ID:SGTC_2014|Compound:4013930|FD-Score:4.21|P-value:6.68E-6 ID:SGTC_2019|Compound:4016004|FD-Score:-4.11|P-value:1.57E-5 ID:SGTC_2022|Compound:5136654|FD-Score:-3.44|P-value:2.51E-4 ID:SGTC_2088|Compound:5278280|FD-Score:-3.47|P-value:2.25E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:3.31|P-value:2.97E-4 ID:SGTC_2244|Compound:6635614|FD-Score:-3.13|P-value:7.90E-4 ID:SGTC_2413|Compound:inermin|FD-Score:3.31|P-value:2.95E-4 ID:SGTC_2442|Compound:5158906|FD-Score:3.13|P-value:5.79E-4 ID:SGTC_2462|Compound:5162487|FD-Score:-4.01|P-value:2.42E-5 ID:SGTC_2479|Compound:5617353|FD-Score:5.88|P-value:6.67E-10 ID:SGTC_2482|Compound:5981709|FD-Score:6.94|P-value:4.36E-13 ID:SGTC_2483|Compound:5729050|FD-Score:8.40|P-value:2.70E-18 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.74|P-value:5.32E-5 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.27|P-value:3.52E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:4.55|P-value:1.27E-6 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-10.10|P-value:2.66E-25 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:-3.70|P-value:9.05E-5 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.78|P-value:4.59E-5 ID:SGTC_2696|Compound:st077691|FD-Score:-5.38|P-value:2.27E-8 ID:SGTC_2706|Compound:st078239|FD-Score:3.00|P-value:9.33E-4 ID:SGTC_2802|Compound:7925815|FD-Score:3.30|P-value:3.08E-4 ID:SGTC_2820|Compound:7989630|FD-Score:4.10|P-value:1.11E-5 ID:SGTC_2821|Compound:7996764|FD-Score:3.82|P-value:3.85E-5 ID:SGTC_3029|Compound:9088683|FD-Score:4.38|P-value:3.03E-6 ID:SGTC_3030|Compound:9087619|FD-Score:3.59|P-value:1.01E-4 ID:SGTC_3041|Compound:9091929|FD-Score:4.52|P-value:1.51E-6 ID:SGTC_3056|Compound:9094900|FD-Score:-4.06|P-value:1.93E-5 ID:SGTC_3140|Compound:9094243|FD-Score:5.16|P-value:5.10E-8 ID:SGTC_3141|Compound:9094609|FD-Score:5.16|P-value:4.95E-8 ID:SGTC_3272|Compound:9137413|FD-Score:-3.84|P-value:5.15E-5 ID:SGTC_192|Compound:3455-0609|FD-Score:3.41|P-value:2.01E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.21|P-value:5.90E-4 ID:SGTC_334|Compound:1502-1024|FD-Score:5.86|P-value:7.64E-10 ID:SGTC_620|Compound:0109-0052|FD-Score:3.89|P-value:2.89E-5 ID:SGTC_989|Compound:1501-0895|FD-Score:3.74|P-value:5.46E-5 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:3.09|P-value:6.76E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.51|P-value:1.39E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.40|P-value:2.11E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.26|P-value:3.57E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.52|P-value:1.35E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.60|P-value:9.80E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.15|P-value:9.01E-6 ID:SGTC_1661|Compound:st013063|FD-Score:3.01|P-value:8.96E-4 ID:SGTC_1738|Compound:st035555|FD-Score:5.02|P-value:1.10E-7 ID:SGTC_1744|Compound:st037937|FD-Score:-3.47|P-value:2.22E-4 ID:SGTC_1748|Compound:st037455|FD-Score:-3.44|P-value:2.56E-4 ID:SGTC_1749|Compound:st037932|FD-Score:3.10|P-value:6.48E-4 ID:SGTC_1767|Compound:st044992|FD-Score:3.42|P-value:1.94E-4 ID:SGTC_1927|Compound:st060202|FD-Score:-3.33|P-value:3.76E-4 ID:SGTC_1949|Compound:st076024|FD-Score:2.98|P-value:9.78E-4 ID:SGTC_1954|Compound:st077032|FD-Score:4.37|P-value:3.09E-6 ID:SGTC_2011|Compound:4012611|FD-Score:-3.17|P-value:6.93E-4 ID:SGTC_2014|Compound:4013930|FD-Score:4.21|P-value:6.68E-6 ID:SGTC_2019|Compound:4016004|FD-Score:-4.11|P-value:1.57E-5 ID:SGTC_2022|Compound:5136654|FD-Score:-3.44|P-value:2.51E-4 ID:SGTC_2088|Compound:5278280|FD-Score:-3.47|P-value:2.25E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:3.31|P-value:2.97E-4 ID:SGTC_2244|Compound:6635614|FD-Score:-3.13|P-value:7.90E-4 ID:SGTC_2413|Compound:inermin|FD-Score:3.31|P-value:2.95E-4 ID:SGTC_2442|Compound:5158906|FD-Score:3.13|P-value:5.79E-4 ID:SGTC_2462|Compound:5162487|FD-Score:-4.01|P-value:2.42E-5 ID:SGTC_2479|Compound:5617353|FD-Score:5.88|P-value:6.67E-10 ID:SGTC_2482|Compound:5981709|FD-Score:6.94|P-value:4.36E-13 ID:SGTC_2483|Compound:5729050|FD-Score:8.40|P-value:2.70E-18 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.74|P-value:5.32E-5 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.27|P-value:3.52E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:4.55|P-value:1.27E-6 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-10.10|P-value:2.66E-25 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:-3.70|P-value:9.05E-5 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.78|P-value:4.59E-5 ID:SGTC_2696|Compound:st077691|FD-Score:-5.38|P-value:2.27E-8 ID:SGTC_2706|Compound:st078239|FD-Score:3.00|P-value:9.33E-4 ID:SGTC_2802|Compound:7925815|FD-Score:3.30|P-value:3.08E-4 ID:SGTC_2820|Compound:7989630|FD-Score:4.10|P-value:1.11E-5 ID:SGTC_2821|Compound:7996764|FD-Score:3.82|P-value:3.85E-5 ID:SGTC_3029|Compound:9088683|FD-Score:4.38|P-value:3.03E-6 ID:SGTC_3030|Compound:9087619|FD-Score:3.59|P-value:1.01E-4 ID:SGTC_3041|Compound:9091929|FD-Score:4.52|P-value:1.51E-6 ID:SGTC_3056|Compound:9094900|FD-Score:-4.06|P-value:1.93E-5 ID:SGTC_3140|Compound:9094243|FD-Score:5.16|P-value:5.10E-8 ID:SGTC_3141|Compound:9094609|FD-Score:5.16|P-value:4.95E-8 ID:SGTC_3272|Compound:9137413|FD-Score:-3.84|P-value:5.15E-5

Top fitness defect scores for YLR001C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2483 5729050 8.40 27.2 µM 2.70E-18 3 2.19E-17
2 SGTC_2482 5981709 6.94 142.7 µM 4.36E-13 PDR1 6 1.94E-12
3 SGTC_2479 5617353 5.88 43.9 µM 6.67E-10 8 2.05E-9
4 SGTC_334 1502-1024 5.86 68.5 µM 7.64E-10 1 2.33E-9
5 SGTC_3141 9094609 5.16 49.5 µM 4.95E-8 iron homeostasis 17 1.22E-7
6 SGTC_3140 9094243 5.16 49.5 µM 5.10E-8 11 1.25E-7
7 SGTC_1738 st035555 5.02 74.0 µM 1.10E-7 TSC3-RPN4 13 2.59E-7
8 SGTC_2536 dehydroabietamide 4.55 32.0 µM 1.27E-6 17 2.64E-6
9 SGTC_3041 9091929 4.52 49.5 µM 1.51E-6 redox potentiating 13 3.11E-6
10 SGTC_3029 9088683 4.38 49.5 µM 3.03E-6 19 6.00E-6
11 SGTC_1954 st077032 4.37 68.9 µM 3.09E-6 12 6.12E-6
12 SGTC_2014 4013930 4.21 200.0 µM 6.68E-6 23 1.27E-5
13 SGTC_1495 4469-0029 4.15 237.0 µM 9.01E-6 101 1.69E-5
14 SGTC_2820 7989630 4.10 71.4 µM 1.11E-5 ERG2 16 2.06E-5
15 SGTC_620 0109-0052 3.89 432.0 µM 2.89E-5 21 5.08E-5
16 SGTC_2821 7996764 3.82 71.4 µM 3.85E-5 47 6.68E-5
17 SGTC_2690 usnic acid 3.78 100.0 µM 4.59E-5 30 7.88E-5
18 SGTC_2500 5-alpha-androstan-3,17-dione 3.74 61.4 µM 5.32E-5 44 9.07E-5
19 SGTC_989 1501-0895 3.74 10.3 µM 5.46E-5 13 9.30E-5
20 SGTC_1455 4262-0120 3.60 131.0 µM 9.80E-5 plasma membrane duress 31 1.62E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.243 1.98E-46 YER066W_p RRT13_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription
0.227 2.83E-40 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.212 2.41E-35 YLR395C COX8 hom Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.179 1.23E-25 YGR015C_p YGR015C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
0.159 2.34E-20 YJL043W_p YJL043W_p hom Putative protein of unknown function; YJL043W is a non-essential gene
0.152 7.35E-19 YCR102W-A_d YCR102W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.148 7.04E-18 YNL220W ADE12 hom Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence
0.145 2.64E-17 YIL115C NUP159 het FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport; regulates ADP release from the ATP-dependent RNA helicase Dbp5p; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup116p)
0.144 5.06E-17 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.144 5.56E-17 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
0.138 1.12E-15 YGL144C ROG1 hom Protein with putative serine active lipase domain; ROG1 has a paralog, YDL109C, that arose from the whole genome duplication
0.126 2.71E-13 YHR194W MDM31 hom Mitochondrial protein that may have a role in phospholipid metabolism; inner membrane protein with similarity to Mdm32p; required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MMM2, MDM10, MDM12, and MDM34
0.122 1.15E-12 YDL217C TIM22 het Essential core component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; forms the channel through which proteins are imported
0.122 1.43E-12 YER071C_p TDA2_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele
0.120 2.66E-12 YPL100W ATG21 hom Phosphoinositide binding protein required for vesicle formation in the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein