YLR009W / RLP24

Essential protein required for ribosomal large subunit biogenesis; associated with pre-60S ribosomal subunits; stimulates the ATPase activity of Afg2p, which is required for release of Rlp24p from the pre-60S particle; has similarity to Rpl24Ap and Rpl24Bp

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR009W / RLP24

Click on Significant Values for Screen Details ID:SGTC_118|Compound:0083-0097|FD-Score:4.78|P-value:1.02E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:4.35|P-value:3.60E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:4.11|P-value:7.00E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:4.56|P-value:1.99E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:7.08|P-value:1.88E-8 ID:SGTC_321|Compound:4534-3890|FD-Score:4.30|P-value:4.17E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:4.42|P-value:2.95E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:4.12|P-value:6.90E-4 ID:SGTC_575|Compound:k072-0246|FD-Score:4.29|P-value:4.28E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:4.01|P-value:9.04E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:4.25|P-value:4.81E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:5.84|P-value:2.80E-6 ID:SGTC_793|Compound:0488-0545|FD-Score:-4.57|P-value:1.89E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:-7.47|P-value:3.00E-9 ID:SGTC_832|Compound:4083-0019|FD-Score:6.97|P-value:3.03E-8 ID:SGTC_882|Compound:0843-0131|FD-Score:4.93|P-value:6.37E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:4.04|P-value:8.40E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:4.17|P-value:5.93E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:5.90|P-value:2.27E-6 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.41|P-value:3.08E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:-4.36|P-value:3.46E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:4.07|P-value:7.75E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:5.49|P-value:9.87E-6 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:-4.55|P-value:1.96E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-4.67|P-value:1.39E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:-5.31|P-value:1.81E-5 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:4.48|P-value:2.49E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-5.50|P-value:9.46E-6 ID:SGTC_1708|Compound:st033234|FD-Score:4.40|P-value:3.12E-4 ID:SGTC_1740|Compound:st038286|FD-Score:4.76|P-value:1.09E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-4.20|P-value:5.36E-4 ID:SGTC_1871|Compound:st057448|FD-Score:-4.16|P-value:6.03E-4 ID:SGTC_2036|Compound:5160441|FD-Score:-5.12|P-value:3.41E-5 ID:SGTC_2041|Compound:5107442|FD-Score:-4.98|P-value:5.28E-5 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:4.24|P-value:4.87E-4 ID:SGTC_2044|Compound:5102272|FD-Score:4.15|P-value:6.32E-4 ID:SGTC_2050|Compound:5263056|FD-Score:4.00|P-value:9.37E-4 ID:SGTC_2092|Compound:5303694|FD-Score:-4.07|P-value:7.76E-4 ID:SGTC_2168|Compound:5727979|FD-Score:-4.25|P-value:4.67E-4 ID:SGTC_2179|Compound:6298986|FD-Score:-4.19|P-value:5.54E-4 ID:SGTC_2257|Compound:7960413|FD-Score:-3.98|P-value:9.79E-4 ID:SGTC_2285|Compound:7945142|FD-Score:4.57|P-value:1.93E-4 ID:SGTC_2338|Compound:7999974|FD-Score:-4.22|P-value:5.06E-4 ID:SGTC_2467|Compound:5474540|FD-Score:4.04|P-value:8.52E-4 ID:SGTC_2471|Compound:5466956|FD-Score:-4.01|P-value:8.96E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-4.94|P-value:6.07E-5 ID:SGTC_2690|Compound:usnic acid|FD-Score:4.14|P-value:6.45E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-5.06|P-value:4.07E-5 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-3.98|P-value:9.72E-4 ID:SGTC_2792|Compound:7535235|FD-Score:6.13|P-value:9.47E-7 ID:SGTC_2799|Compound:7812892|FD-Score:-5.27|P-value:2.05E-5 ID:SGTC_2823|Compound:7987624|FD-Score:5.78|P-value:3.53E-6 ID:SGTC_2838|Compound:9002687|FD-Score:7.30|P-value:6.92E-9 ID:SGTC_2841|Compound:9004761|FD-Score:6.51|P-value:2.07E-7 ID:SGTC_2848|Compound:9016370|FD-Score:-5.77|P-value:3.53E-6 ID:SGTC_2858|Compound:9025781|FD-Score:-8.23|P-value:7.66E-11 ID:SGTC_2880|Compound:9042983|FD-Score:5.97|P-value:1.73E-6 ID:SGTC_2887|Compound:9044784|FD-Score:8.87|P-value:2.68E-12 ID:SGTC_2920|Compound:7982904|FD-Score:5.98|P-value:1.65E-6 ID:SGTC_2948|Compound:9070189|FD-Score:-5.58|P-value:7.16E-6 ID:SGTC_2949|Compound:9072542|FD-Score:-4.72|P-value:1.18E-4 ID:SGTC_2993|Compound:9054257|FD-Score:6.92|P-value:3.72E-8 ID:SGTC_3027|Compound:9089541|FD-Score:5.15|P-value:3.07E-5 ID:SGTC_3033|Compound:9090887|FD-Score:4.52|P-value:2.18E-4 ID:SGTC_3054|Compound:9094397|FD-Score:4.02|P-value:8.87E-4 ID:SGTC_3071|Compound:9117417|FD-Score:4.43|P-value:2.91E-4 ID:SGTC_3106|Compound:9121286|FD-Score:4.38|P-value:3.31E-4 ID:SGTC_3222|Compound:9128301|FD-Score:-4.08|P-value:7.45E-4 ID:SGTC_3277|Compound:9138724|FD-Score:-3.97|P-value:9.96E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.78|P-value:1.02E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:4.35|P-value:3.60E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:4.11|P-value:7.00E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:4.56|P-value:1.99E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:7.08|P-value:1.88E-8 ID:SGTC_321|Compound:4534-3890|FD-Score:4.30|P-value:4.17E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:4.42|P-value:2.95E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:4.12|P-value:6.90E-4 ID:SGTC_575|Compound:k072-0246|FD-Score:4.29|P-value:4.28E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:4.01|P-value:9.04E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:4.25|P-value:4.81E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:5.84|P-value:2.80E-6 ID:SGTC_793|Compound:0488-0545|FD-Score:-4.57|P-value:1.89E-4 ID:SGTC_799|Compound:1310-0557|FD-Score:-7.47|P-value:3.00E-9 ID:SGTC_832|Compound:4083-0019|FD-Score:6.97|P-value:3.03E-8 ID:SGTC_882|Compound:0843-0131|FD-Score:4.93|P-value:6.37E-5 ID:SGTC_1052|Compound:3253-3998|FD-Score:4.04|P-value:8.40E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:4.17|P-value:5.93E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:5.90|P-value:2.27E-6 ID:SGTC_1131|Compound:3454-3128|FD-Score:4.41|P-value:3.08E-4 ID:SGTC_1269|Compound:0831-0796|FD-Score:-4.36|P-value:3.46E-4 ID:SGTC_1497|Compound:4476-2978|FD-Score:4.07|P-value:7.75E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:5.49|P-value:9.87E-6 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:-4.55|P-value:1.96E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-4.67|P-value:1.39E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:-5.31|P-value:1.81E-5 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:4.48|P-value:2.49E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:-5.50|P-value:9.46E-6 ID:SGTC_1708|Compound:st033234|FD-Score:4.40|P-value:3.12E-4 ID:SGTC_1740|Compound:st038286|FD-Score:4.76|P-value:1.09E-4 ID:SGTC_1786|Compound:berberine|FD-Score:-4.20|P-value:5.36E-4 ID:SGTC_1871|Compound:st057448|FD-Score:-4.16|P-value:6.03E-4 ID:SGTC_2036|Compound:5160441|FD-Score:-5.12|P-value:3.41E-5 ID:SGTC_2041|Compound:5107442|FD-Score:-4.98|P-value:5.28E-5 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:4.24|P-value:4.87E-4 ID:SGTC_2044|Compound:5102272|FD-Score:4.15|P-value:6.32E-4 ID:SGTC_2050|Compound:5263056|FD-Score:4.00|P-value:9.37E-4 ID:SGTC_2092|Compound:5303694|FD-Score:-4.07|P-value:7.76E-4 ID:SGTC_2168|Compound:5727979|FD-Score:-4.25|P-value:4.67E-4 ID:SGTC_2179|Compound:6298986|FD-Score:-4.19|P-value:5.54E-4 ID:SGTC_2257|Compound:7960413|FD-Score:-3.98|P-value:9.79E-4 ID:SGTC_2285|Compound:7945142|FD-Score:4.57|P-value:1.93E-4 ID:SGTC_2338|Compound:7999974|FD-Score:-4.22|P-value:5.06E-4 ID:SGTC_2467|Compound:5474540|FD-Score:4.04|P-value:8.52E-4 ID:SGTC_2471|Compound:5466956|FD-Score:-4.01|P-value:8.96E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-4.94|P-value:6.07E-5 ID:SGTC_2690|Compound:usnic acid|FD-Score:4.14|P-value:6.45E-4 ID:SGTC_2739|Compound:tacrine|FD-Score:-5.06|P-value:4.07E-5 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-3.98|P-value:9.72E-4 ID:SGTC_2792|Compound:7535235|FD-Score:6.13|P-value:9.47E-7 ID:SGTC_2799|Compound:7812892|FD-Score:-5.27|P-value:2.05E-5 ID:SGTC_2823|Compound:7987624|FD-Score:5.78|P-value:3.53E-6 ID:SGTC_2838|Compound:9002687|FD-Score:7.30|P-value:6.92E-9 ID:SGTC_2841|Compound:9004761|FD-Score:6.51|P-value:2.07E-7 ID:SGTC_2848|Compound:9016370|FD-Score:-5.77|P-value:3.53E-6 ID:SGTC_2858|Compound:9025781|FD-Score:-8.23|P-value:7.66E-11 ID:SGTC_2880|Compound:9042983|FD-Score:5.97|P-value:1.73E-6 ID:SGTC_2887|Compound:9044784|FD-Score:8.87|P-value:2.68E-12 ID:SGTC_2920|Compound:7982904|FD-Score:5.98|P-value:1.65E-6 ID:SGTC_2948|Compound:9070189|FD-Score:-5.58|P-value:7.16E-6 ID:SGTC_2949|Compound:9072542|FD-Score:-4.72|P-value:1.18E-4 ID:SGTC_2993|Compound:9054257|FD-Score:6.92|P-value:3.72E-8 ID:SGTC_3027|Compound:9089541|FD-Score:5.15|P-value:3.07E-5 ID:SGTC_3033|Compound:9090887|FD-Score:4.52|P-value:2.18E-4 ID:SGTC_3054|Compound:9094397|FD-Score:4.02|P-value:8.87E-4 ID:SGTC_3071|Compound:9117417|FD-Score:4.43|P-value:2.91E-4 ID:SGTC_3106|Compound:9121286|FD-Score:4.38|P-value:3.31E-4 ID:SGTC_3222|Compound:9128301|FD-Score:-4.08|P-value:7.45E-4 ID:SGTC_3277|Compound:9138724|FD-Score:-3.97|P-value:9.96E-4

Top fitness defect scores for YLR009W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2887 9044784 8.87 58.4 µM 2.68E-12 fatty acid desaturase (OLE1) 2 3.71E-19 0.82
2 SGTC_2838 9002687 7.30 71.4 µM 6.92E-9 fatty acid desaturase (OLE1) 3 1.44E-13 1.05
3 SGTC_309 k408-0051 7.08 1.5 µM 1.88E-8 5 7.41E-13 0.23
4 SGTC_832 4083-0019 6.97 164.0 µM 3.03E-8 translation 6 1.61E-12 0.46
5 SGTC_2993 9054257 6.92 71.4 µM 3.72E-8 fatty acid desaturase (OLE1) 6 2.26E-12 0.21
6 SGTC_2841 9004761 6.51 39.0 µM 2.07E-7 amide catabolism 1 3.71E-11 0.66
7 SGTC_2792 7535235 6.13 81.8 µM 9.47E-7 fatty acid desaturase (OLE1) 2 4.44E-10 0.77
8 SGTC_2920 7982904 5.98 15.8 µM 1.65E-6 2 1.10E-9 0.57
9 SGTC_2880 9042983 5.97 58.4 µM 1.73E-6 fatty acid desaturase (OLE1) 4 1.19E-9 0.18
10 SGTC_1074 carmofur 5.90 3.8 µM 2.27E-6 exosome 16 1.84E-9 0.54
11 SGTC_675 1309-0189 5.84 238.0 µM 2.80E-6 1 2.59E-9 1.04
12 SGTC_2823 7987624 5.78 58.4 µM 3.53E-6 3 3.77E-9 0.29
13 SGTC_1505 k297-0037 5.49 20.6 µM 9.87E-6 1 2.01E-8 0.86
14 SGTC_3027 9089541 5.15 49.5 µM 3.07E-5 fatty acid desaturase (OLE1) 8 1.27E-7 0.22
15 SGTC_882 0843-0131 4.93 351.0 µM 6.37E-5 5 4.13E-7 0.21
16 SGTC_118 0083-0097 4.78 135.3 µM 1.02E-4 translation 9 8.85E-7 0.06
17 SGTC_1740 st038286 4.76 13.2 µM 1.09E-4 4 9.86E-7 0.38
18 SGTC_2285 7945142 4.57 200.0 µM 1.93E-4 7 2.47E-6 0.48
19 SGTC_261 5-fluorouridine 4.56 15.4 µM 1.99E-4 exosome 8 2.60E-6 0.04
20 SGTC_3033 9090887 4.52 49.5 µM 2.18E-4 fatty acid desaturase (OLE1) 10 3.02E-6 0.25

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.259 1.26E-52 YBR190W_d YBR190W_d het Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified ribosomal protein gene RPL21A/YBR191W
0.221 3.74E-38 YPL131W RPL5 het Ribosomal 60S subunit protein L5; homologous to mammalian ribosomal protein L5 and bacterial L18; binds 5S rRNA and is required for 60S subunit assembly
0.212 2.94E-35 YOL120C RPL18A het Ribosomal 60S subunit protein L18A; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation; homologous to mammalian ribosomal protein L18, no bacterial homolog; RPL18A has a paralog, RPL18B, that arose from the whole genome duplication
0.193 1.49E-29 YGL055W OLE1 het Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
0.193 1.79E-29 YNL061W NOP2 het Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles
0.191 8.98E-29 YOR206W NOC2 het Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors
0.184 6.26E-27 YPL093W NOG1 het Putative GTPase that associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins
0.181 3.68E-26 YGL030W RPL30 het Ribosomal 60S subunit protein L30; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript; homologous to mammalian ribosomal protein L30, no bacterial homolog
0.179 2.02E-25 YLR076C_d YLR076C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10
0.175 1.54E-24 YGR095C RRP46 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5)
0.169 8.11E-23 YPR136C_d YPR136C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF RRP9
0.167 3.18E-22 YPR137W RRP9 het Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein
0.163 3.30E-21 YDR280W RRP45 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9); protein abundance increases in response to DNA replication stress
0.159 2.28E-20 YJR007W SUI2 het Alpha subunit of the translation initiation factor eIF2; eIF2 is involved in identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP; protein abundance increases in response to DNA replication stress
0.157 6.97E-20 YOL021C DIS3 het Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3; protein abundance increases in response to DNA replication stress