YLR011W / LOT6

FMN-dependent NAD(P)H:quinone reductase, may be involved in quinone detoxification; expression elevated at low temperature; sequesters the Cin5p transcription factor in the cytoplasm in complex with the proteasome under reducing conditions

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR011W / LOT6

Click on Significant Values for Screen Details ID:SGTC_430|Compound:0958-0115|FD-Score:-2.95|P-value:8.39E-4 ID:SGTC_564|Compound:3555-0129|FD-Score:4.29|P-value:1.39E-6 ID:SGTC_582|Compound:0987-0078|FD-Score:-3.03|P-value:6.20E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:2.98|P-value:5.40E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.31|P-value:2.04E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:-2.94|P-value:8.88E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:2.93|P-value:6.58E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.21|P-value:3.06E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:-2.98|P-value:7.49E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.01|P-value:4.83E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:2.96|P-value:5.75E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:2.84|P-value:9.10E-4 ID:SGTC_1431|Compound:4049-0260|FD-Score:-2.91|P-value:9.90E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:-3.22|P-value:2.93E-4 ID:SGTC_1606|Compound:st000094|FD-Score:3.08|P-value:3.67E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.24|P-value:1.92E-4 ID:SGTC_1684|Compound:st024538|FD-Score:-3.35|P-value:1.75E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:3.34|P-value:1.27E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.02|P-value:6.45E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:3.36|P-value:1.14E-4 ID:SGTC_2303|Compound:7774051|FD-Score:3.66|P-value:3.01E-5 ID:SGTC_2346|Compound:9031566|FD-Score:2.96|P-value:5.85E-4 ID:SGTC_2376|Compound:9072922|FD-Score:4.56|P-value:3.24E-7 ID:SGTC_2402|Compound:5553605|FD-Score:3.44|P-value:8.32E-5 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.81|P-value:1.53E-5 ID:SGTC_2415|Compound:st077333|FD-Score:4.69|P-value:1.51E-7 ID:SGTC_2417|Compound:cerulenin|FD-Score:-3.13|P-value:4.30E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-3.20|P-value:3.29E-4 ID:SGTC_2429|Compound:5902844|FD-Score:-3.26|P-value:2.55E-4 ID:SGTC_2444|Compound:5485484|FD-Score:3.12|P-value:3.11E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.67|P-value:4.47E-5 ID:SGTC_2834|Compound:9001755|FD-Score:2.95|P-value:6.01E-4 ID:SGTC_2838|Compound:9002687|FD-Score:-5.19|P-value:1.29E-8 ID:SGTC_2842|Compound:9000675|FD-Score:-3.35|P-value:1.73E-4 ID:SGTC_2847|Compound:9005661|FD-Score:4.29|P-value:1.35E-6 ID:SGTC_2972|Compound:9093619|FD-Score:-3.09|P-value:5.07E-4 ID:SGTC_2985|Compound:9022375|FD-Score:4.12|P-value:3.27E-6 ID:SGTC_3090|Compound:9117696|FD-Score:3.32|P-value:1.39E-4 ID:SGTC_3096|Compound:9117468|FD-Score:3.91|P-value:9.25E-6 ID:SGTC_3212|Compound:9128307|FD-Score:-2.98|P-value:7.54E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:-2.95|P-value:8.39E-4 ID:SGTC_564|Compound:3555-0129|FD-Score:4.29|P-value:1.39E-6 ID:SGTC_582|Compound:0987-0078|FD-Score:-3.03|P-value:6.20E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:2.98|P-value:5.40E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-3.31|P-value:2.04E-4 ID:SGTC_923|Compound:1900-2434|FD-Score:-2.94|P-value:8.88E-4 ID:SGTC_933|Compound:2914-0560|FD-Score:2.93|P-value:6.58E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.21|P-value:3.06E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:-2.98|P-value:7.49E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.01|P-value:4.83E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:2.96|P-value:5.75E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:2.84|P-value:9.10E-4 ID:SGTC_1431|Compound:4049-0260|FD-Score:-2.91|P-value:9.90E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:-3.22|P-value:2.93E-4 ID:SGTC_1606|Compound:st000094|FD-Score:3.08|P-value:3.67E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.24|P-value:1.92E-4 ID:SGTC_1684|Compound:st024538|FD-Score:-3.35|P-value:1.75E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:3.34|P-value:1.27E-4 ID:SGTC_1947|Compound:st076332|FD-Score:-3.02|P-value:6.45E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:3.36|P-value:1.14E-4 ID:SGTC_2303|Compound:7774051|FD-Score:3.66|P-value:3.01E-5 ID:SGTC_2346|Compound:9031566|FD-Score:2.96|P-value:5.85E-4 ID:SGTC_2376|Compound:9072922|FD-Score:4.56|P-value:3.24E-7 ID:SGTC_2402|Compound:5553605|FD-Score:3.44|P-value:8.32E-5 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.81|P-value:1.53E-5 ID:SGTC_2415|Compound:st077333|FD-Score:4.69|P-value:1.51E-7 ID:SGTC_2417|Compound:cerulenin|FD-Score:-3.13|P-value:4.30E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-3.20|P-value:3.29E-4 ID:SGTC_2429|Compound:5902844|FD-Score:-3.26|P-value:2.55E-4 ID:SGTC_2444|Compound:5485484|FD-Score:3.12|P-value:3.11E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.67|P-value:4.47E-5 ID:SGTC_2834|Compound:9001755|FD-Score:2.95|P-value:6.01E-4 ID:SGTC_2838|Compound:9002687|FD-Score:-5.19|P-value:1.29E-8 ID:SGTC_2842|Compound:9000675|FD-Score:-3.35|P-value:1.73E-4 ID:SGTC_2847|Compound:9005661|FD-Score:4.29|P-value:1.35E-6 ID:SGTC_2972|Compound:9093619|FD-Score:-3.09|P-value:5.07E-4 ID:SGTC_2985|Compound:9022375|FD-Score:4.12|P-value:3.27E-6 ID:SGTC_3090|Compound:9117696|FD-Score:3.32|P-value:1.39E-4 ID:SGTC_3096|Compound:9117468|FD-Score:3.91|P-value:9.25E-6 ID:SGTC_3212|Compound:9128307|FD-Score:-2.98|P-value:7.54E-4

Top fitness defect scores for YLR011W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2415 st077333 4.69 57.7 µM 1.51E-7 25 1.35E-6
2 SGTC_2376 9072922 4.56 81.3 µM 3.24E-7 13 2.60E-6
3 SGTC_2847 9005661 4.29 71.4 µM 1.35E-6 7 8.79E-6
4 SGTC_564 3555-0129 4.29 330.0 µM 1.39E-6 4 8.98E-6
5 SGTC_2985 9022375 4.12 71.4 µM 3.27E-6 RPP1 & pyrimidine depletion 24 1.86E-5
6 SGTC_3096 9117468 3.91 49.5 µM 9.25E-6 4 4.52E-5
7 SGTC_2407 paclitaxel 3.81 400.0 µM 1.53E-5 43 6.96E-5
8 SGTC_2303 7774051 3.66 200.0 µM 3.01E-5 29 1.24E-4
9 SGTC_2402 5553605 3.44 200.0 µM 8.32E-5 54 2.94E-4
10 SGTC_2115 tiliquinol 3.36 12.8 µM 1.14E-4 20 3.85E-4
11 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 3.34 62.6 µM 1.27E-4 TSC3-RPN4 28 4.22E-4
12 SGTC_3090 9117696 3.32 49.5 µM 1.39E-4 30 4.56E-4
13 SGTC_1679 4130-1276 3.24 6.7 µM 1.92E-4 Golgi 110 6.01E-4
14 SGTC_2444 5485484 3.12 36.4 µM 3.11E-4 75 9.07E-4
15 SGTC_1606 st000094 3.08 49.2 µM 3.67E-4 60S ribosome export 52 0.00104
16 SGTC_1129 3453-1384 3.01 223.0 µM 4.83E-4 88 0.00132
17 SGTC_705 1124-0212 2.98 310.0 µM 5.40E-4 55 0.00145
18 SGTC_1246 0422-0085 2.96 105.0 µM 5.75E-4 87 0.00153
19 SGTC_2346 9031566 2.96 143.8 µM 5.85E-4 Golgi 65 0.00156
20 SGTC_2834 9001755 2.95 58.4 µM 6.01E-4 89 0.00159

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.180 8.83E-26 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.145 3.14E-17 YEL058W PCM1 het Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors
0.140 3.35E-16 YLL038C ENT4 hom Protein of unknown function, contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome
0.134 6.70E-15 YKL171W NNK1 hom Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.133 1.05E-14 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.132 1.76E-14 YOR010C TIR2 hom Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis
0.131 3.00E-14 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.130 3.85E-14 YOR062C_p YOR062C_p hom Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
0.122 1.39E-12 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.122 1.43E-12 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.121 2.06E-12 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.120 3.20E-12 YCR072C RSA4 het WD-repeat protein involved in ribosome biogenesis; may interact with ribosomes; required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus
0.120 3.67E-12 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.118 5.90E-12 YER064C VHR2 hom Non-essential nuclear protein; null mutation has global effects on transcription; VHR2 has a paralog, VHR1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.117 9.55E-12 YEL004W YEA4 hom Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER