YLR013W / GAT3

Protein containing GATA family zinc finger motifs

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR013W / GAT3

Click on Significant Values for Screen Details ID:SGTC_76|Compound:0433-0009|FD-Score:3.13|P-value:6.12E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:3.53|P-value:1.34E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:-3.60|P-value:9.66E-5 ID:SGTC_617|Compound:3770-0098|FD-Score:3.45|P-value:1.86E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:3.73|P-value:5.75E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:3.13|P-value:6.22E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:3.27|P-value:3.61E-4 ID:SGTC_837|Compound:0091-0265|FD-Score:-3.77|P-value:4.81E-5 ID:SGTC_841|Compound:0251-0215|FD-Score:-3.06|P-value:7.73E-4 ID:SGTC_985|Compound:1493-0307|FD-Score:3.20|P-value:4.71E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.28|P-value:3.53E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:4.39|P-value:2.88E-6 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.47|P-value:1.73E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:3.16|P-value:5.56E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:-3.16|P-value:5.28E-4 ID:SGTC_1209|Compound:2323-2347|FD-Score:3.21|P-value:4.60E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.46|P-value:1.80E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.79|P-value:4.54E-5 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.05|P-value:8.23E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.50|P-value:1.51E-4 ID:SGTC_1741|Compound:st038134|FD-Score:3.19|P-value:5.00E-4 ID:SGTC_1836|Compound:st055642|FD-Score:6.22|P-value:6.65E-11 ID:SGTC_1837|Compound:st055472|FD-Score:-3.70|P-value:6.35E-5 ID:SGTC_2056|Compound:5235370|FD-Score:3.02|P-value:9.04E-4 ID:SGTC_2109|Compound:5483026|FD-Score:-3.25|P-value:3.87E-4 ID:SGTC_2226|Compound:7298446|FD-Score:3.36|P-value:2.66E-4 ID:SGTC_2241|Compound:6772625|FD-Score:3.12|P-value:6.37E-4 ID:SGTC_2283|Compound:7944793|FD-Score:-2.99|P-value:9.81E-4 ID:SGTC_2288|Compound:7946289|FD-Score:5.07|P-value:8.11E-8 ID:SGTC_2291|Compound:7917025|FD-Score:-6.20|P-value:6.88E-11 ID:SGTC_2316|Compound:5844804|FD-Score:3.45|P-value:1.82E-4 ID:SGTC_2399|Compound:5884133|FD-Score:3.57|P-value:1.15E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.66|P-value:7.78E-5 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:4.55|P-value:1.28E-6 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:-3.14|P-value:5.65E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.21|P-value:4.38E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:4.16|P-value:8.53E-6 ID:SGTC_2703|Compound:st077852|FD-Score:4.02|P-value:1.63E-5 ID:SGTC_2826|Compound:7992541|FD-Score:4.31|P-value:4.29E-6 ID:SGTC_2858|Compound:9025781|FD-Score:5.73|P-value:1.62E-9 ID:SGTC_2891|Compound:9063876|FD-Score:-3.63|P-value:8.44E-5 ID:SGTC_2893|Compound:9048488|FD-Score:-3.35|P-value:2.62E-4 ID:SGTC_2928|Compound:9011484|FD-Score:-3.62|P-value:9.07E-5 ID:SGTC_2951|Compound:9072950|FD-Score:3.40|P-value:2.22E-4 ID:SGTC_2963|Compound:9082507|FD-Score:-3.80|P-value:4.15E-5 ID:SGTC_2964|Compound:9083345|FD-Score:-4.33|P-value:3.75E-6 ID:SGTC_3041|Compound:9091929|FD-Score:3.60|P-value:1.01E-4 ID:SGTC_3145|Compound:9085516|FD-Score:-3.16|P-value:5.28E-4 ID:SGTC_3204|Compound:9114183|FD-Score:3.45|P-value:1.85E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-3.48|P-value:1.58E-4 ID:SGTC_76|Compound:0433-0009|FD-Score:3.13|P-value:6.12E-4 ID:SGTC_135|Compound:0933-0004|FD-Score:3.53|P-value:1.34E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:-3.60|P-value:9.66E-5 ID:SGTC_617|Compound:3770-0098|FD-Score:3.45|P-value:1.86E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:3.73|P-value:5.75E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:3.13|P-value:6.22E-4 ID:SGTC_775|Compound:4577-0580|FD-Score:3.27|P-value:3.61E-4 ID:SGTC_837|Compound:0091-0265|FD-Score:-3.77|P-value:4.81E-5 ID:SGTC_841|Compound:0251-0215|FD-Score:-3.06|P-value:7.73E-4 ID:SGTC_985|Compound:1493-0307|FD-Score:3.20|P-value:4.71E-4 ID:SGTC_996|Compound:3970-0799|FD-Score:3.28|P-value:3.53E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:4.39|P-value:2.88E-6 ID:SGTC_1063|Compound:disulfiram|FD-Score:3.47|P-value:1.73E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:3.16|P-value:5.56E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:-3.16|P-value:5.28E-4 ID:SGTC_1209|Compound:2323-2347|FD-Score:3.21|P-value:4.60E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.46|P-value:1.80E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.79|P-value:4.54E-5 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.05|P-value:8.23E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.50|P-value:1.51E-4 ID:SGTC_1741|Compound:st038134|FD-Score:3.19|P-value:5.00E-4 ID:SGTC_1836|Compound:st055642|FD-Score:6.22|P-value:6.65E-11 ID:SGTC_1837|Compound:st055472|FD-Score:-3.70|P-value:6.35E-5 ID:SGTC_2056|Compound:5235370|FD-Score:3.02|P-value:9.04E-4 ID:SGTC_2109|Compound:5483026|FD-Score:-3.25|P-value:3.87E-4 ID:SGTC_2226|Compound:7298446|FD-Score:3.36|P-value:2.66E-4 ID:SGTC_2241|Compound:6772625|FD-Score:3.12|P-value:6.37E-4 ID:SGTC_2283|Compound:7944793|FD-Score:-2.99|P-value:9.81E-4 ID:SGTC_2288|Compound:7946289|FD-Score:5.07|P-value:8.11E-8 ID:SGTC_2291|Compound:7917025|FD-Score:-6.20|P-value:6.88E-11 ID:SGTC_2316|Compound:5844804|FD-Score:3.45|P-value:1.82E-4 ID:SGTC_2399|Compound:5884133|FD-Score:3.57|P-value:1.15E-4 ID:SGTC_2415|Compound:st077333|FD-Score:3.66|P-value:7.78E-5 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:4.55|P-value:1.28E-6 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:-3.14|P-value:5.65E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:-3.21|P-value:4.38E-4 ID:SGTC_2635|Compound:hydroquinidine|FD-Score:4.16|P-value:8.53E-6 ID:SGTC_2703|Compound:st077852|FD-Score:4.02|P-value:1.63E-5 ID:SGTC_2826|Compound:7992541|FD-Score:4.31|P-value:4.29E-6 ID:SGTC_2858|Compound:9025781|FD-Score:5.73|P-value:1.62E-9 ID:SGTC_2891|Compound:9063876|FD-Score:-3.63|P-value:8.44E-5 ID:SGTC_2893|Compound:9048488|FD-Score:-3.35|P-value:2.62E-4 ID:SGTC_2928|Compound:9011484|FD-Score:-3.62|P-value:9.07E-5 ID:SGTC_2951|Compound:9072950|FD-Score:3.40|P-value:2.22E-4 ID:SGTC_2963|Compound:9082507|FD-Score:-3.80|P-value:4.15E-5 ID:SGTC_2964|Compound:9083345|FD-Score:-4.33|P-value:3.75E-6 ID:SGTC_3041|Compound:9091929|FD-Score:3.60|P-value:1.01E-4 ID:SGTC_3145|Compound:9085516|FD-Score:-3.16|P-value:5.28E-4 ID:SGTC_3204|Compound:9114183|FD-Score:3.45|P-value:1.85E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-3.48|P-value:1.58E-4

Top fitness defect scores for YLR013W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1836 st055642 6.22 81.0 µM 6.65E-11 2 2.52E-10
2 SGTC_2858 9025781 5.73 9.0 µM 1.62E-9 sphingolipid biosynthesis & PDR1 50 5.03E-9
3 SGTC_2288 7946289 5.07 167.3 µM 8.11E-8 10 1.97E-7
4 SGTC_2420 aureobasidin a 4.55 50.0 nM 1.28E-6 27 2.62E-6
5 SGTC_1020 4335-0961 4.39 93.3 µM 2.88E-6 7 5.63E-6
6 SGTC_2826 7992541 4.31 19.5 µM 4.29E-6 14 8.20E-6
7 SGTC_2635 hydroquinidine 4.16 100.0 µM 8.53E-6 20 1.56E-5
8 SGTC_2703 st077852 4.02 53.4 µM 1.63E-5 20 2.86E-5
9 SGTC_1251 0490-5699 3.79 265.0 µM 4.54E-5 39 7.52E-5
10 SGTC_762 1165-0429 3.73 115.0 µM 5.75E-5 TSC3-RPN4 25 9.39E-5
11 SGTC_2415 st077333 3.66 57.7 µM 7.78E-5 63 1.25E-4
12 SGTC_3041 9091929 3.60 49.5 µM 1.01E-4 redox potentiating 32 1.59E-4
13 SGTC_2399 5884133 3.57 200.0 µM 1.15E-4 cell wall signaling 89 1.80E-4
14 SGTC_135 0933-0004 3.53 26.4 µM 1.34E-4 60S ribosome export 36 2.08E-4
15 SGTC_1595 6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin 3.50 67.5 µM 1.51E-4 63 2.32E-4
16 SGTC_1063 disulfiram 3.47 1.8 µM 1.73E-4 41 2.64E-4
17 SGTC_1244 0416-0015 3.46 52.5 µM 1.80E-4 ERG2 59 2.74E-4
18 SGTC_2316 5844804 3.45 197.4 µM 1.82E-4 57 2.78E-4
19 SGTC_3204 9114183 3.45 49.5 µM 1.85E-4 53 2.82E-4
20 SGTC_617 3770-0098 3.45 35.0 µM 1.86E-4 exosome 25 2.84E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.139 6.17E-16 YCR015C_p YCR015C_p hom Putative protein of unknown function; YCR015C is not an essential gene
0.127 1.90E-13 YDR505C PSP1 hom Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition; PSP1 has a paralog, YLR177W, that arose from the whole genome duplication
0.125 3.49E-13 YDR210W_p YDR210W_p hom Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.121 1.67E-12 YMR105C PGM2 hom Phosphoglucomutase; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase; protein abundance increases in response to DNA replication stress
0.111 1.08E-10 YML118W NGL3 hom 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication
0.102 3.75E-9 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.101 5.31E-9 YBR207W FTH1 hom Putative high affinity iron transporter; involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis; protein abundance increases in response to DNA replication stress
0.099 9.69E-9 YJR094W-A RPL43B hom Ribosomal 60S subunit protein L43B; homologous to mammalian ribosomal protein L37A, no bacterial homolog; RPL43B has a paralog, RPL43A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.097 1.86E-8 YDR073W SNF11 hom Subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p; relocates to the cytosol under hypoxic conditions
0.096 2.20E-8 YGR158C MTR3 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)
0.095 3.96E-8 YBR084W MIS1 hom Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase
0.094 5.19E-8 YJL126W NIT2 hom Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member
0.093 6.75E-8 YJR116W_p TDA4_p hom Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele
0.092 8.67E-8 YBR299W MAL32 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
0.090 1.71E-7 YKL105C SEG2 hom Eisosome component and paralog of Seg1p; likely plays only minor role in eisosome assembly; shown to interact with Seg1p; similar to A. gossypii SEG gene which is important for stabilizing eisosomes