YLR016C / PML1

Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR016C / PML1

Click on Significant Values for Screen Details ID:SGTC_244|Compound:nsc-207895|FD-Score:-2.69|P-value:7.39E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:3.62|P-value:7.75E-6 ID:SGTC_416|Compound:estradiol valerate|FD-Score:3.42|P-value:2.30E-5 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.80|P-value:2.89E-6 ID:SGTC_497|Compound:capsazepine|FD-Score:-3.37|P-value:3.39E-5 ID:SGTC_511|Compound:blebbistatin|FD-Score:2.76|P-value:4.88E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.07|P-value:1.47E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:-3.19|P-value:8.31E-5 ID:SGTC_654|Compound:1124-0271|FD-Score:3.01|P-value:1.64E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.05|P-value:8.16E-7 ID:SGTC_866|Compound:0495-0101|FD-Score:-3.10|P-value:1.25E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:2.72|P-value:5.71E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.25|P-value:2.56E-10 ID:SGTC_1217|Compound:1183-1422|FD-Score:2.67|P-value:7.03E-4 ID:SGTC_1219|Compound:1469-0211|FD-Score:2.80|P-value:4.18E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:2.85|P-value:3.34E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:2.73|P-value:5.48E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:4.60|P-value:2.07E-8 ID:SGTC_1284|Compound:0929-0043|FD-Score:2.87|P-value:3.08E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:-5.14|P-value:5.98E-10 ID:SGTC_1729|Compound:st035615|FD-Score:-3.29|P-value:4.95E-5 ID:SGTC_1739|Compound:st037196|FD-Score:2.73|P-value:5.57E-4 ID:SGTC_1740|Compound:st038286|FD-Score:3.35|P-value:3.15E-5 ID:SGTC_1747|Compound:st037496|FD-Score:-3.02|P-value:1.79E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:4.20|P-value:2.77E-7 ID:SGTC_2103|Compound:5378138|FD-Score:3.51|P-value:1.45E-5 ID:SGTC_2144|Compound:5628481|FD-Score:-2.72|P-value:6.50E-4 ID:SGTC_2336|Compound:9001819|FD-Score:2.88|P-value:2.89E-4 ID:SGTC_2374|Compound:9071832|FD-Score:2.95|P-value:2.16E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-4.27|P-value:2.26E-7 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.25|P-value:6.13E-5 ID:SGTC_2794|Compound:7785382|FD-Score:2.87|P-value:3.00E-4 ID:SGTC_2839|Compound:9003951|FD-Score:2.98|P-value:1.87E-4 ID:SGTC_2847|Compound:9005661|FD-Score:2.91|P-value:2.54E-4 ID:SGTC_2851|Compound:9015922|FD-Score:4.36|P-value:1.05E-7 ID:SGTC_2856|Compound:9022925|FD-Score:2.80|P-value:4.05E-4 ID:SGTC_2956|Compound:9076196|FD-Score:-4.11|P-value:5.71E-7 ID:SGTC_2960|Compound:9079389|FD-Score:3.44|P-value:2.09E-5 ID:SGTC_2966|Compound:9084041|FD-Score:-3.07|P-value:1.43E-4 ID:SGTC_3086|Compound:9117350|FD-Score:2.70|P-value:6.23E-4 ID:SGTC_3147|Compound:9097027|FD-Score:3.18|P-value:7.30E-5 ID:SGTC_3313|Compound:9133968|FD-Score:3.01|P-value:1.63E-4 ID:SGTC_3336|Compound:9143619|FD-Score:2.91|P-value:2.52E-4 ID:SGTC_244|Compound:nsc-207895|FD-Score:-2.69|P-value:7.39E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:3.62|P-value:7.75E-6 ID:SGTC_416|Compound:estradiol valerate|FD-Score:3.42|P-value:2.30E-5 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.80|P-value:2.89E-6 ID:SGTC_497|Compound:capsazepine|FD-Score:-3.37|P-value:3.39E-5 ID:SGTC_511|Compound:blebbistatin|FD-Score:2.76|P-value:4.88E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.07|P-value:1.47E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:-3.19|P-value:8.31E-5 ID:SGTC_654|Compound:1124-0271|FD-Score:3.01|P-value:1.64E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-4.05|P-value:8.16E-7 ID:SGTC_866|Compound:0495-0101|FD-Score:-3.10|P-value:1.25E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:2.72|P-value:5.71E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.25|P-value:2.56E-10 ID:SGTC_1217|Compound:1183-1422|FD-Score:2.67|P-value:7.03E-4 ID:SGTC_1219|Compound:1469-0211|FD-Score:2.80|P-value:4.18E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:2.85|P-value:3.34E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:2.73|P-value:5.48E-4 ID:SGTC_1270|Compound:0831-1170|FD-Score:4.60|P-value:2.07E-8 ID:SGTC_1284|Compound:0929-0043|FD-Score:2.87|P-value:3.08E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:-5.14|P-value:5.98E-10 ID:SGTC_1729|Compound:st035615|FD-Score:-3.29|P-value:4.95E-5 ID:SGTC_1739|Compound:st037196|FD-Score:2.73|P-value:5.57E-4 ID:SGTC_1740|Compound:st038286|FD-Score:3.35|P-value:3.15E-5 ID:SGTC_1747|Compound:st037496|FD-Score:-3.02|P-value:1.79E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:4.20|P-value:2.77E-7 ID:SGTC_2103|Compound:5378138|FD-Score:3.51|P-value:1.45E-5 ID:SGTC_2144|Compound:5628481|FD-Score:-2.72|P-value:6.50E-4 ID:SGTC_2336|Compound:9001819|FD-Score:2.88|P-value:2.89E-4 ID:SGTC_2374|Compound:9071832|FD-Score:2.95|P-value:2.16E-4 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-4.27|P-value:2.26E-7 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.25|P-value:6.13E-5 ID:SGTC_2794|Compound:7785382|FD-Score:2.87|P-value:3.00E-4 ID:SGTC_2839|Compound:9003951|FD-Score:2.98|P-value:1.87E-4 ID:SGTC_2847|Compound:9005661|FD-Score:2.91|P-value:2.54E-4 ID:SGTC_2851|Compound:9015922|FD-Score:4.36|P-value:1.05E-7 ID:SGTC_2856|Compound:9022925|FD-Score:2.80|P-value:4.05E-4 ID:SGTC_2956|Compound:9076196|FD-Score:-4.11|P-value:5.71E-7 ID:SGTC_2960|Compound:9079389|FD-Score:3.44|P-value:2.09E-5 ID:SGTC_2966|Compound:9084041|FD-Score:-3.07|P-value:1.43E-4 ID:SGTC_3086|Compound:9117350|FD-Score:2.70|P-value:6.23E-4 ID:SGTC_3147|Compound:9097027|FD-Score:3.18|P-value:7.30E-5 ID:SGTC_3313|Compound:9133968|FD-Score:3.01|P-value:1.63E-4 ID:SGTC_3336|Compound:9143619|FD-Score:2.91|P-value:2.52E-4

Top fitness defect scores for YLR016C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1270 0831-1170 4.60 17.3 µM 2.07E-8 4 2.08E-6
2 SGTC_2851 9015922 4.36 71.4 µM 1.05E-7 24 6.63E-6
3 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 4.20 70.1 µM 2.77E-7 18 1.33E-5
4 SGTC_495 decylubiquinone 3.80 155.0 µM 2.89E-6 copper-dependent oxidative stress 26 7.14E-5
5 SGTC_383 2324-0395 3.62 7.4 µM 7.75E-6 azole & statin 51 1.45E-4
6 SGTC_2103 5378138 3.51 10.0 µM 1.45E-5 30 2.28E-4
7 SGTC_2960 9079389 3.44 6.0 µM 2.09E-5 48 2.96E-4
8 SGTC_416 estradiol valerate 3.42 100.0 µM 2.30E-5 27 3.17E-4
9 SGTC_1740 st038286 3.35 13.2 µM 3.15E-5 55 3.98E-4
10 SGTC_3147 9097027 3.18 49.5 µM 7.30E-5 55 7.29E-4
11 SGTC_3313 9133968 3.01 57.0 µM 1.63E-4 34 0.00130
12 SGTC_654 1124-0271 3.01 80.9 µM 1.64E-4 75 0.00131
13 SGTC_2839 9003951 2.98 26.0 µM 1.87E-4 49 0.00144
14 SGTC_2374 9071832 2.95 200.0 µM 2.16E-4 endomembrane recycling 37 0.00159
15 SGTC_3336 9143619 2.91 71.4 µM 2.52E-4 60 0.00179
16 SGTC_2847 9005661 2.91 71.4 µM 2.54E-4 28 0.00180
17 SGTC_2336 9001819 2.88 198.7 µM 2.89E-4 heme biosynthesis & mitochondrial translocase 117 0.00197
18 SGTC_2794 7785382 2.87 27.3 µM 3.00E-4 105 0.00202
19 SGTC_1284 0929-0043 2.87 16.0 µM 3.08E-4 79 0.00206
20 SGTC_1239 0337-0584 2.85 35.4 µM 3.34E-4 unfolded protein response 125 0.00219

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.292 3.83E-67 YKL179C COY1 hom Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function
0.267 1.22E-55 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.263 5.16E-54 YDL110C TMA17 hom Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion
0.260 6.56E-53 YMR210W YMR210W hom Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
0.258 3.49E-52 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.237 4.05E-44 YFL063W_d YFL063W_d hom Dubious open reading frame, based on available experimental and comparative sequence data
0.232 2.13E-42 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.231 4.88E-42 YKL220C FRE2 hom Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
0.230 1.58E-41 YML083C YML083C hom Protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit growth defects in anerobic or anaerobic conditions
0.216 1.15E-36 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.216 1.15E-36 YBR262C AIM5 hom Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
0.215 1.77E-36 YLR353W BUD8 hom Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
0.214 3.64E-36 YLR223C IFH1 het Coactivator that regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing
0.212 1.57E-35 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.209 1.74E-34 YBR118W TEF2 hom Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication