YLR023C / IZH3

Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR023C / IZH3

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:-3.37|P-value:8.15E-5 ID:SGTC_38|Compound:0929-0051|FD-Score:2.79|P-value:5.30E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:5.71|P-value:1.94E-11 ID:SGTC_41|Compound:0478-0632|FD-Score:5.59|P-value:4.58E-11 ID:SGTC_45|Compound:0kpi-0036|FD-Score:4.04|P-value:1.26E-6 ID:SGTC_73|Compound:0327-0325|FD-Score:2.72|P-value:7.07E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:-2.96|P-value:4.70E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:-3.22|P-value:1.56E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:2.86|P-value:3.96E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:2.97|P-value:2.55E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:3.68|P-value:8.90E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:3.58|P-value:1.48E-5 ID:SGTC_376|Compound:3970-0862|FD-Score:3.20|P-value:9.05E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.42|P-value:3.31E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:-2.85|P-value:7.50E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-5.15|P-value:3.17E-9 ID:SGTC_755|Compound:1995-0008|FD-Score:-4.24|P-value:9.25E-7 ID:SGTC_766|Compound:1391-0721|FD-Score:2.91|P-value:3.23E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:-3.35|P-value:8.98E-5 ID:SGTC_865|Compound:0488-0499|FD-Score:3.15|P-value:1.12E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:-2.84|P-value:7.55E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.00|P-value:3.95E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:-2.95|P-value:5.01E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.70|P-value:1.68E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.47|P-value:2.47E-7 ID:SGTC_1176|Compound:0848-0131|FD-Score:2.79|P-value:5.37E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:2.84|P-value:4.34E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-3.00|P-value:4.11E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.38|P-value:7.57E-5 ID:SGTC_1465|Compound:k213-0056|FD-Score:-3.04|P-value:3.42E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:-3.45|P-value:5.47E-5 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:2.85|P-value:4.17E-4 ID:SGTC_1783|Compound:st039459|FD-Score:2.77|P-value:5.79E-4 ID:SGTC_1986|Compound:st071812|FD-Score:-3.00|P-value:3.95E-4 ID:SGTC_1988|Compound:st071872|FD-Score:2.72|P-value:7.04E-4 ID:SGTC_2070|Compound:5230947|FD-Score:-2.98|P-value:4.42E-4 ID:SGTC_2264|Compound:7948757|FD-Score:-2.79|P-value:9.33E-4 ID:SGTC_2265|Compound:7929201|FD-Score:-2.88|P-value:6.64E-4 ID:SGTC_2282|Compound:7944268|FD-Score:3.32|P-value:5.16E-5 ID:SGTC_2309|Compound:7664088|FD-Score:2.85|P-value:4.19E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:4.53|P-value:6.94E-8 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.55|P-value:1.71E-5 ID:SGTC_2602|Compound:kawain|FD-Score:4.52|P-value:7.72E-8 ID:SGTC_2708|Compound:st078559|FD-Score:3.66|P-value:9.90E-6 ID:SGTC_2711|Compound:st079103|FD-Score:3.26|P-value:7.09E-5 ID:SGTC_2716|Compound:st080858|FD-Score:3.98|P-value:1.83E-6 ID:SGTC_2717|Compound:st081029|FD-Score:2.96|P-value:2.59E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:-2.77|P-value:9.94E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.09|P-value:2.74E-4 ID:SGTC_3297|Compound:9117502|FD-Score:2.80|P-value:5.20E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:-3.37|P-value:8.15E-5 ID:SGTC_38|Compound:0929-0051|FD-Score:2.79|P-value:5.30E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:5.71|P-value:1.94E-11 ID:SGTC_41|Compound:0478-0632|FD-Score:5.59|P-value:4.58E-11 ID:SGTC_45|Compound:0kpi-0036|FD-Score:4.04|P-value:1.26E-6 ID:SGTC_73|Compound:0327-0325|FD-Score:2.72|P-value:7.07E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:-2.96|P-value:4.70E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:-3.22|P-value:1.56E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:2.86|P-value:3.96E-4 ID:SGTC_156|Compound:3474-0145|FD-Score:2.97|P-value:2.55E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:3.68|P-value:8.90E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:3.58|P-value:1.48E-5 ID:SGTC_376|Compound:3970-0862|FD-Score:3.20|P-value:9.05E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.42|P-value:3.31E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:-2.85|P-value:7.50E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:-5.15|P-value:3.17E-9 ID:SGTC_755|Compound:1995-0008|FD-Score:-4.24|P-value:9.25E-7 ID:SGTC_766|Compound:1391-0721|FD-Score:2.91|P-value:3.23E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:-3.35|P-value:8.98E-5 ID:SGTC_865|Compound:0488-0499|FD-Score:3.15|P-value:1.12E-4 ID:SGTC_868|Compound:0527-0199|FD-Score:-2.84|P-value:7.55E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:-3.00|P-value:3.95E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:-2.95|P-value:5.01E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.70|P-value:1.68E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.47|P-value:2.47E-7 ID:SGTC_1176|Compound:0848-0131|FD-Score:2.79|P-value:5.37E-4 ID:SGTC_1263|Compound:0774-1208|FD-Score:2.84|P-value:4.34E-4 ID:SGTC_1349|Compound:flufenamic acid|FD-Score:-3.00|P-value:4.11E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.38|P-value:7.57E-5 ID:SGTC_1465|Compound:k213-0056|FD-Score:-3.04|P-value:3.42E-4 ID:SGTC_1527|Compound:coumarin|FD-Score:-3.45|P-value:5.47E-5 ID:SGTC_1561|Compound:5-methoxyflavone|FD-Score:2.85|P-value:4.17E-4 ID:SGTC_1783|Compound:st039459|FD-Score:2.77|P-value:5.79E-4 ID:SGTC_1986|Compound:st071812|FD-Score:-3.00|P-value:3.95E-4 ID:SGTC_1988|Compound:st071872|FD-Score:2.72|P-value:7.04E-4 ID:SGTC_2070|Compound:5230947|FD-Score:-2.98|P-value:4.42E-4 ID:SGTC_2264|Compound:7948757|FD-Score:-2.79|P-value:9.33E-4 ID:SGTC_2265|Compound:7929201|FD-Score:-2.88|P-value:6.64E-4 ID:SGTC_2282|Compound:7944268|FD-Score:3.32|P-value:5.16E-5 ID:SGTC_2309|Compound:7664088|FD-Score:2.85|P-value:4.19E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:4.53|P-value:6.94E-8 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:3.55|P-value:1.71E-5 ID:SGTC_2602|Compound:kawain|FD-Score:4.52|P-value:7.72E-8 ID:SGTC_2708|Compound:st078559|FD-Score:3.66|P-value:9.90E-6 ID:SGTC_2711|Compound:st079103|FD-Score:3.26|P-value:7.09E-5 ID:SGTC_2716|Compound:st080858|FD-Score:3.98|P-value:1.83E-6 ID:SGTC_2717|Compound:st081029|FD-Score:2.96|P-value:2.59E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:-2.77|P-value:9.94E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-3.09|P-value:2.74E-4 ID:SGTC_3297|Compound:9117502|FD-Score:2.80|P-value:5.20E-4

Top fitness defect scores for YLR023C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_39 0986-0283 5.71 58.4 µM 1.94E-11 calcium & mitochondrial duress 7 5.80E-9
2 SGTC_41 0478-0632 5.59 82.6 µM 4.58E-11 7 1.11E-8
3 SGTC_2584 androsterone 4.53 48.7 µM 6.94E-8 cell wall 94 2.91E-6
4 SGTC_2602 kawain 4.52 100.0 µM 7.72E-8 16 3.15E-6
5 SGTC_45 0kpi-0036 4.04 14.9 µM 1.26E-6 excess fatty acid 22 2.64E-5
6 SGTC_2716 st080858 3.98 38.6 µM 1.83E-6 60S ribosome export 20 3.50E-5
7 SGTC_299 1273-0059 3.68 1.4 µM 8.90E-6 29 1.17E-4
8 SGTC_2708 st078559 3.66 56.0 µM 9.90E-6 11 1.27E-4
9 SGTC_310 1273-0058 3.58 1.1 µM 1.48E-5 mitochondrial stress 279 1.72E-4
10 SGTC_2595 hexamethylquercetagetin 3.55 100.0 µM 1.71E-5 38 1.92E-4
11 SGTC_453 enantio-paf c16 3.42 10.0 µM 3.31E-5 191 3.17E-4
12 SGTC_2282 7944268 3.32 200.0 µM 5.16E-5 RPP1 & pyrimidine depletion 62 4.45E-4
13 SGTC_2711 st079103 3.26 59.1 µM 7.09E-5 18 5.67E-4
14 SGTC_376 3970-0862 3.20 59.1 µM 9.05E-5 47 6.83E-4
15 SGTC_865 0488-0499 3.15 301.0 µM 1.12E-4 40 8.05E-4
16 SGTC_156 3474-0145 2.97 5.6 µM 2.55E-4 endomembrane recycling 99 0.00150
17 SGTC_2717 st081029 2.96 62.3 µM 2.59E-4 39 0.00152
18 SGTC_766 1391-0721 2.91 126.0 µM 3.23E-4 66 0.00180
19 SGTC_152 4469-0003 2.86 551.2 µM 3.96E-4 64 0.00210
20 SGTC_1561 5-methoxyflavone 2.85 52.9 µM 4.17E-4 30 0.00219

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.369 6.48E-109 YMR210W YMR210W hom Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification
0.293 1.36E-67 YFL063W_d YFL063W_d hom Dubious open reading frame, based on available experimental and comparative sequence data
0.252 1.11E-49 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.250 8.47E-49 YKL140W TGL1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.238 2.91E-44 YML101C CUE4 hom Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; CUE4 has a paralog, CUE1, that arose from the whole genome duplication
0.221 1.79E-38 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.216 1.39E-36 YBL015W ACH1 hom Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth
0.213 1.30E-35 YOR010C TIR2 hom Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis
0.208 5.88E-34 YLL038C ENT4 hom Protein of unknown function, contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome
0.201 6.78E-32 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.190 9.59E-29 YMR008C PLB1 hom Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol
0.190 1.14E-28 YBR050C REG2 hom Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease
0.188 4.62E-28 YDL110C TMA17 hom Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion
0.186 2.10E-27 YBR262C AIM5 hom Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
0.182 1.67E-26 YHR003C YHR003C hom Protein of unknown function, localized to the mitochondrial outer membrane