YLR024C / UBR2

Cytoplasmic ubiquitin-protein ligase (E3); required for ubiquitylation of Rpn4p; mediates formation of a Mub1p-Ubr2p-Rad6p complex

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR024C / UBR2

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:3.89|P-value:1.98E-5 ID:SGTC_41|Compound:0478-0632|FD-Score:3.81|P-value:2.89E-5 ID:SGTC_55|Compound:0767-0285|FD-Score:-4.22|P-value:5.08E-6 ID:SGTC_56|Compound:0957-0365|FD-Score:5.34|P-value:9.09E-9 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.39|P-value:2.14E-6 ID:SGTC_59|Compound:0330-0160|FD-Score:-5.28|P-value:1.64E-8 ID:SGTC_91|Compound:0417-1751|FD-Score:2.94|P-value:9.20E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:2.95|P-value:8.95E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:-4.45|P-value:1.56E-6 ID:SGTC_304|Compound:1310-0298|FD-Score:-4.46|P-value:1.49E-6 ID:SGTC_364|Compound:0083-0097|FD-Score:3.09|P-value:5.43E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:3.19|P-value:3.73E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.07|P-value:5.78E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:2.98|P-value:8.04E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:3.22|P-value:3.30E-4 ID:SGTC_595|Compound:3909-8003|FD-Score:3.22|P-value:3.38E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:4.01|P-value:1.13E-5 ID:SGTC_825|Compound:1988-2224|FD-Score:-3.18|P-value:4.46E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:3.15|P-value:4.36E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:-3.13|P-value:5.35E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:3.35|P-value:1.96E-4 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:-3.21|P-value:3.98E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:-3.18|P-value:4.42E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:-3.66|P-value:6.41E-5 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.05|P-value:6.29E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.36|P-value:2.26E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.78|P-value:3.33E-5 ID:SGTC_1267|Compound:0828-0272|FD-Score:5.02|P-value:5.89E-8 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.26|P-value:3.22E-4 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:-2.99|P-value:8.88E-4 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:3.93|P-value:1.68E-5 ID:SGTC_1683|Compound:st010134|FD-Score:-6.13|P-value:6.70E-11 ID:SGTC_1764|Compound:st044502|FD-Score:4.65|P-value:4.61E-7 ID:SGTC_1842|Compound:st055362|FD-Score:-4.73|P-value:3.60E-7 ID:SGTC_2015|Compound:5119600|FD-Score:3.15|P-value:4.38E-4 ID:SGTC_2264|Compound:7948757|FD-Score:-3.47|P-value:1.41E-4 ID:SGTC_2309|Compound:7664088|FD-Score:4.70|P-value:3.58E-7 ID:SGTC_2331|Compound:7980721|FD-Score:3.95|P-value:1.54E-5 ID:SGTC_2334|Compound:9017922|FD-Score:-3.23|P-value:3.62E-4 ID:SGTC_2335|Compound:9018011|FD-Score:5.91|P-value:2.26E-10 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.26|P-value:3.33E-4 ID:SGTC_2414|Compound:st077232|FD-Score:-3.61|P-value:8.04E-5 ID:SGTC_2417|Compound:cerulenin|FD-Score:-3.00|P-value:8.57E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-3.46|P-value:1.48E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.52|P-value:9.99E-5 ID:SGTC_2623|Compound:humulene|FD-Score:-3.12|P-value:5.51E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.41|P-value:5.92E-9 ID:SGTC_2892|Compound:9047358|FD-Score:-3.21|P-value:4.02E-4 ID:SGTC_3130|Compound:9127414|FD-Score:-3.90|P-value:2.24E-5 ID:SGTC_3206|Compound:9114350|FD-Score:-3.21|P-value:4.02E-4 ID:SGTC_3309|Compound:9129340|FD-Score:-3.90|P-value:2.23E-5 ID:SGTC_3314|Compound:9135860|FD-Score:4.75|P-value:2.73E-7 ID:SGTC_3320|Compound:9137005|FD-Score:-3.27|P-value:3.17E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:3.89|P-value:1.98E-5 ID:SGTC_41|Compound:0478-0632|FD-Score:3.81|P-value:2.89E-5 ID:SGTC_55|Compound:0767-0285|FD-Score:-4.22|P-value:5.08E-6 ID:SGTC_56|Compound:0957-0365|FD-Score:5.34|P-value:9.09E-9 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.39|P-value:2.14E-6 ID:SGTC_59|Compound:0330-0160|FD-Score:-5.28|P-value:1.64E-8 ID:SGTC_91|Compound:0417-1751|FD-Score:2.94|P-value:9.20E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:2.95|P-value:8.95E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:-4.45|P-value:1.56E-6 ID:SGTC_304|Compound:1310-0298|FD-Score:-4.46|P-value:1.49E-6 ID:SGTC_364|Compound:0083-0097|FD-Score:3.09|P-value:5.43E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:3.19|P-value:3.73E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:3.07|P-value:5.78E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:2.98|P-value:8.04E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:3.22|P-value:3.30E-4 ID:SGTC_595|Compound:3909-8003|FD-Score:3.22|P-value:3.38E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:4.01|P-value:1.13E-5 ID:SGTC_825|Compound:1988-2224|FD-Score:-3.18|P-value:4.46E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:3.15|P-value:4.36E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:-3.13|P-value:5.35E-4 ID:SGTC_903|Compound:1134-0042|FD-Score:3.35|P-value:1.96E-4 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:-3.21|P-value:3.98E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:-3.18|P-value:4.42E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:-3.66|P-value:6.41E-5 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.05|P-value:6.29E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.36|P-value:2.26E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:3.78|P-value:3.33E-5 ID:SGTC_1267|Compound:0828-0272|FD-Score:5.02|P-value:5.89E-8 ID:SGTC_1459|Compound:k035-0031|FD-Score:-3.26|P-value:3.22E-4 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:-2.99|P-value:8.88E-4 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:3.93|P-value:1.68E-5 ID:SGTC_1683|Compound:st010134|FD-Score:-6.13|P-value:6.70E-11 ID:SGTC_1764|Compound:st044502|FD-Score:4.65|P-value:4.61E-7 ID:SGTC_1842|Compound:st055362|FD-Score:-4.73|P-value:3.60E-7 ID:SGTC_2015|Compound:5119600|FD-Score:3.15|P-value:4.38E-4 ID:SGTC_2264|Compound:7948757|FD-Score:-3.47|P-value:1.41E-4 ID:SGTC_2309|Compound:7664088|FD-Score:4.70|P-value:3.58E-7 ID:SGTC_2331|Compound:7980721|FD-Score:3.95|P-value:1.54E-5 ID:SGTC_2334|Compound:9017922|FD-Score:-3.23|P-value:3.62E-4 ID:SGTC_2335|Compound:9018011|FD-Score:5.91|P-value:2.26E-10 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.26|P-value:3.33E-4 ID:SGTC_2414|Compound:st077232|FD-Score:-3.61|P-value:8.04E-5 ID:SGTC_2417|Compound:cerulenin|FD-Score:-3.00|P-value:8.57E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-3.46|P-value:1.48E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.52|P-value:9.99E-5 ID:SGTC_2623|Compound:humulene|FD-Score:-3.12|P-value:5.51E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.41|P-value:5.92E-9 ID:SGTC_2892|Compound:9047358|FD-Score:-3.21|P-value:4.02E-4 ID:SGTC_3130|Compound:9127414|FD-Score:-3.90|P-value:2.24E-5 ID:SGTC_3206|Compound:9114350|FD-Score:-3.21|P-value:4.02E-4 ID:SGTC_3309|Compound:9129340|FD-Score:-3.90|P-value:2.23E-5 ID:SGTC_3314|Compound:9135860|FD-Score:4.75|P-value:2.73E-7 ID:SGTC_3320|Compound:9137005|FD-Score:-3.27|P-value:3.17E-4

Top fitness defect scores for YLR024C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2335 9018011 5.91 154.2 µM 2.26E-10 5 1.68E-9
2 SGTC_2688 kanamycin b 5.41 96.7 µM 5.92E-9 calcium & mitochondrial duress 204 3.22E-8
3 SGTC_56 0957-0365 5.34 83.2 µM 9.09E-9 Golgi 21 4.75E-8
4 SGTC_1267 0828-0272 5.02 9.5 µM 5.89E-8 8 2.57E-7
5 SGTC_3314 9135860 4.75 59.4 µM 2.73E-7 8 1.03E-6
6 SGTC_2309 7664088 4.70 163.9 µM 3.58E-7 13 1.32E-6
7 SGTC_1764 st044502 4.65 93.5 µM 4.61E-7 20 1.66E-6
8 SGTC_736 0958-0254 4.01 92.6 µM 1.13E-5 Golgi 29 3.01E-5
9 SGTC_2331 7980721 3.95 200.0 µM 1.54E-5 28 3.98E-5
10 SGTC_1560 lithocholic acid 3.93 53.1 µM 1.68E-5 4 4.29E-5
11 SGTC_40 0327-0103 3.89 19.8 µM 1.98E-5 35 4.99E-5
12 SGTC_41 0478-0632 3.81 82.6 µM 2.89E-5 34 7.02E-5
13 SGTC_1246 0422-0085 3.78 105.0 µM 3.33E-5 37 7.99E-5
14 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 3.52 70.0 µM 9.99E-5 redox potentiating 92 2.16E-4
15 SGTC_903 1134-0042 3.35 114.0 µM 1.96E-4 43 3.98E-4
16 SGTC_563 tetrahydrosecaminediol 3.22 614.0 µM 3.30E-4 amide catabolism 38 6.38E-4
17 SGTC_595 3909-8003 3.22 73.7 µM 3.38E-4 37 6.51E-4
18 SGTC_372 0155-0182 3.19 15.9 µM 3.73E-4 mitochondrial response to ROS 62 7.12E-4
19 SGTC_878 0828-0289 3.15 13.7 µM 4.36E-4 93 8.21E-4
20 SGTC_2015 5119600 3.15 184.0 µM 4.38E-4 63 8.25E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.138 1.12E-15 YDR156W RPA14 hom RNA polymerase I subunit A14
0.132 1.71E-14 YGR206W MVB12 hom ESCRT-I subunit required to stabilize oligomers of the ESCRT-I core complex (Stp22p, Vps28p, Srn2p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin
0.130 4.07E-14 YDR400W URH1 hom Uridine nucleosidase (uridine-cytidine N-ribohydrolase), cleaves N-glycosidic bonds in nucleosides; involved in the pyrimidine salvage and nicotinamide riboside salvage pathways
0.123 8.31E-13 YEL022W GEA2 hom Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs); involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; GEA2 has a paralog, GEA1, that arose from the whole genome duplication
0.121 1.99E-12 YMR100W MUB1 hom MYND domain-containing protein required for ubiquitination and turnover of Rpn4p; interacts with Ubr2p (E3) and indirectly with Rad6p (E2); short-lived protein degraded in a Ubr2p/Rad6p dependent manner; similar to the A. nidulans samB gene
0.107 4.54E-10 YNL067W RPL9B hom Ribosomal 60S subunit protein L9B; nearly identical to paralog Rpl9Ap; homologous to mammalian ribosomal protein L9 and bacterial L6
0.104 1.32E-9 YPL226W NEW1 hom ATP binding cassette protein that cosediments with polysomes and is required for biogenesis of the small ribosomal subunit; Asn/Gln-rich rich region supports [NU+] prion formation and susceptibility to [PSI+] prion induction
0.104 1.53E-9 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.104 1.81E-9 YML054C-A_p YML054C-A_p hom Putative protein of unknown function
0.102 2.93E-9 YDR443C SSN2 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation
0.102 3.23E-9 YKL082C RRP14 het Essential protein, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF-6 family
0.100 6.79E-9 YML019W OST6 hom Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p
0.098 1.09E-8 YDR534C FIT1 hom Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
0.098 1.50E-8 YNL219C ALG9 hom Mannosyltransferase, involved in N-linked glycosylation; catalyzes both the transfer of seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation
0.097 1.59E-8 YMR099C YMR099C hom Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS