YLR025W / SNF7

One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR025W / SNF7

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:7.21|P-value:1.16E-7 ID:SGTC_16|Compound:erodoxin|FD-Score:5.37|P-value:6.04E-5 ID:SGTC_21|Compound:0849-0113|FD-Score:11.80|P-value:1.44E-17 ID:SGTC_23|Compound:0213-0011|FD-Score:-4.71|P-value:3.39E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-5.63|P-value:2.48E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:6.78|P-value:5.79E-7 ID:SGTC_86|Compound:0417-1630|FD-Score:6.71|P-value:7.61E-7 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:5.68|P-value:2.32E-5 ID:SGTC_117|Compound:lucigenin|FD-Score:11.20|P-value:6.08E-16 ID:SGTC_156|Compound:3474-0145|FD-Score:5.59|P-value:3.10E-5 ID:SGTC_159|Compound:3970-0959|FD-Score:4.56|P-value:5.51E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:8.64|P-value:2.83E-10 ID:SGTC_172|Compound:1112-0046|FD-Score:4.96|P-value:1.92E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:4.85|P-value:2.57E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:10.40|P-value:3.76E-14 ID:SGTC_221|Compound:trifluoperazine|FD-Score:25.00|P-value:3.32E-72 ID:SGTC_227|Compound:fluconazole|FD-Score:13.50|P-value:1.92E-22 ID:SGTC_232|Compound:clozapine|FD-Score:14.30|P-value:4.65E-25 ID:SGTC_255|Compound:tunicamycin|FD-Score:6.29|P-value:3.22E-6 ID:SGTC_301|Compound:4119-0100|FD-Score:19.20|P-value:9.92E-44 ID:SGTC_304|Compound:1310-0298|FD-Score:-7.86|P-value:7.71E-9 ID:SGTC_309|Compound:k408-0051|FD-Score:-7.45|P-value:3.97E-8 ID:SGTC_313|Compound:3474-0040|FD-Score:7.79|P-value:1.18E-8 ID:SGTC_314|Compound:1671-0008|FD-Score:-4.28|P-value:9.99E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:7.18|P-value:1.29E-7 ID:SGTC_439|Compound:amiodarone|FD-Score:6.65|P-value:9.24E-7 ID:SGTC_447|Compound:ml7|FD-Score:4.34|P-value:9.40E-4 ID:SGTC_459|Compound:nigericin|FD-Score:4.56|P-value:5.41E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:10.10|P-value:1.88E-13 ID:SGTC_514|Compound:4466-0038|FD-Score:6.54|P-value:1.37E-6 ID:SGTC_524|Compound:r073-0010|FD-Score:4.66|P-value:4.28E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:7.68|P-value:1.81E-8 ID:SGTC_528|Compound:3492-0019|FD-Score:8.75|P-value:1.75E-10 ID:SGTC_535|Compound:2293-4129|FD-Score:7.12|P-value:1.66E-7 ID:SGTC_568|Compound:1193-0097|FD-Score:4.59|P-value:5.08E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:7.34|P-value:7.11E-8 ID:SGTC_637|Compound:1181-0519|FD-Score:7.76|P-value:1.31E-8 ID:SGTC_670|Compound:4204-0025|FD-Score:4.50|P-value:6.40E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:10.50|P-value:1.90E-14 ID:SGTC_748|Compound:0136-0228|FD-Score:13.60|P-value:7.78E-23 ID:SGTC_768|Compound:0384-0033|FD-Score:4.93|P-value:2.06E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:4.45|P-value:7.13E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:7.27|P-value:9.30E-8 ID:SGTC_847|Compound:0342-0274|FD-Score:5.84|P-value:1.41E-5 ID:SGTC_888|Compound:0916-0002|FD-Score:8.68|P-value:2.36E-10 ID:SGTC_900|Compound:1112-0045|FD-Score:5.09|P-value:1.34E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:4.52|P-value:6.10E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:4.65|P-value:4.37E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:11.80|P-value:9.99E-18 ID:SGTC_1057|Compound:3448-5381|FD-Score:6.04|P-value:7.56E-6 ID:SGTC_1058|Compound:3448-5425|FD-Score:-5.18|P-value:9.53E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:6.36|P-value:2.55E-6 ID:SGTC_1130|Compound:3454-2858|FD-Score:29.60|P-value:2.23E-100 ID:SGTC_1225|Compound:1216-0074|FD-Score:4.73|P-value:3.49E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:4.69|P-value:3.94E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:5.76|P-value:1.86E-5 ID:SGTC_1317|Compound:1273-0028|FD-Score:5.95|P-value:9.96E-6 ID:SGTC_1394|Compound:3474-0001|FD-Score:4.76|P-value:3.27E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:8.64|P-value:2.81E-10 ID:SGTC_1573|Compound:oleylamine|FD-Score:6.50|P-value:1.56E-6 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:17.10|P-value:8.50E-35 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-5.88|P-value:1.15E-5 ID:SGTC_1672|Compound:st016598|FD-Score:4.84|P-value:2.61E-4 ID:SGTC_1687|Compound:st020778|FD-Score:22.50|P-value:7.49E-59 ID:SGTC_1724|Compound:st037281|FD-Score:4.42|P-value:7.80E-4 ID:SGTC_1745|Compound:st081495|FD-Score:-4.58|P-value:4.76E-4 ID:SGTC_1750|Compound:st081859|FD-Score:10.50|P-value:3.11E-14 ID:SGTC_1754|Compound:st042065|FD-Score:5.38|P-value:5.77E-5 ID:SGTC_1760|Compound:st045453|FD-Score:7.88|P-value:8.13E-9 ID:SGTC_1770|Compound:st043884|FD-Score:-4.33|P-value:8.97E-4 ID:SGTC_1781|Compound:st038725|FD-Score:12.90|P-value:1.08E-20 ID:SGTC_1788|Compound:fluconazole|FD-Score:11.90|P-value:7.55E-18 ID:SGTC_1789|Compound:tunicamycin|FD-Score:4.38|P-value:8.68E-4 ID:SGTC_1795|Compound:st049545|FD-Score:-5.73|P-value:1.81E-5 ID:SGTC_1797|Compound:st048695|FD-Score:14.00|P-value:5.04E-24 ID:SGTC_1798|Compound:st045719|FD-Score:4.67|P-value:4.09E-4 ID:SGTC_1800|Compound:st050079|FD-Score:4.79|P-value:2.98E-4 ID:SGTC_1801|Compound:st050089|FD-Score:5.49|P-value:4.24E-5 ID:SGTC_1803|Compound:st050068|FD-Score:8.92|P-value:7.81E-11 ID:SGTC_1827|Compound:berberine|FD-Score:5.04|P-value:1.54E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:8.26|P-value:1.55E-9 ID:SGTC_1873|Compound:rapamycin|FD-Score:10.50|P-value:2.21E-14 ID:SGTC_1877|Compound:wortmannin|FD-Score:5.51|P-value:3.92E-5 ID:SGTC_1884|Compound:5633444|FD-Score:22.50|P-value:4.79E-59 ID:SGTC_1962|Compound:st076595|FD-Score:5.72|P-value:2.06E-5 ID:SGTC_2002|Compound:4023503|FD-Score:-4.32|P-value:9.09E-4 ID:SGTC_2004|Compound:4023728|FD-Score:-4.78|P-value:2.80E-4 ID:SGTC_2006|Compound:4011487|FD-Score:12.30|P-value:5.17E-19 ID:SGTC_2010|Compound:4012422|FD-Score:-4.72|P-value:3.34E-4 ID:SGTC_2016|Compound:5121758|FD-Score:5.75|P-value:1.89E-5 ID:SGTC_2028|Compound:5153890|FD-Score:4.66|P-value:4.23E-4 ID:SGTC_2036|Compound:5160441|FD-Score:4.50|P-value:6.34E-4 ID:SGTC_2054|Compound:5233173|FD-Score:6.02|P-value:8.00E-6 ID:SGTC_2087|Compound:5276107|FD-Score:4.72|P-value:3.61E-4 ID:SGTC_2183|Compound:6420625|FD-Score:6.52|P-value:1.49E-6 ID:SGTC_2210|Compound:7115885|FD-Score:6.28|P-value:3.34E-6 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.88|P-value:2.36E-4 ID:SGTC_2289|Compound:7946404|FD-Score:8.06|P-value:3.76E-9 ID:SGTC_2308|Compound:7584454|FD-Score:-4.39|P-value:7.79E-4 ID:SGTC_2313|Compound:7726885|FD-Score:-4.34|P-value:8.79E-4 ID:SGTC_2322|Compound:7413319|FD-Score:6.55|P-value:1.32E-6 ID:SGTC_2401|Compound:5128683|FD-Score:6.48|P-value:1.70E-6 ID:SGTC_2405|Compound:ticlatone|FD-Score:6.55|P-value:1.35E-6 ID:SGTC_2406|Compound:ethylparaben|FD-Score:4.38|P-value:8.64E-4 ID:SGTC_2413|Compound:inermin|FD-Score:4.66|P-value:4.20E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:10.20|P-value:1.43E-13 ID:SGTC_2424|Compound:5537928|FD-Score:4.34|P-value:9.42E-4 ID:SGTC_2485|Compound:5633444|FD-Score:5.85|P-value:1.39E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:11.10|P-value:7.51E-16 ID:SGTC_2582|Compound:agaric acid|FD-Score:7.87|P-value:8.40E-9 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:10.70|P-value:8.02E-15 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:8.42|P-value:7.77E-10 ID:SGTC_2619|Compound:obliquin|FD-Score:8.30|P-value:1.32E-9 ID:SGTC_2647|Compound:atorvastatin|FD-Score:4.55|P-value:5.65E-4 ID:SGTC_2648|Compound:atorvastatin|FD-Score:7.65|P-value:2.07E-8 ID:SGTC_2679|Compound:rapamycin|FD-Score:7.33|P-value:7.29E-8 ID:SGTC_2688|Compound:kanamycin b|FD-Score:8.29|P-value:1.37E-9 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:11.60|P-value:3.83E-17 ID:SGTC_2737|Compound:bleomycin|FD-Score:6.29|P-value:3.29E-6 ID:SGTC_2765|Compound:myclobutanil|FD-Score:4.91|P-value:2.21E-4 ID:SGTC_2790|Compound:5423970|FD-Score:4.66|P-value:4.22E-4 ID:SGTC_2816|Compound:7982706|FD-Score:4.71|P-value:3.76E-4 ID:SGTC_2851|Compound:9015922|FD-Score:4.72|P-value:3.62E-4 ID:SGTC_2867|Compound:9039098|FD-Score:4.98|P-value:1.82E-4 ID:SGTC_2879|Compound:9041815|FD-Score:-4.94|P-value:1.84E-4 ID:SGTC_2925|Compound:9010536|FD-Score:6.05|P-value:7.29E-6 ID:SGTC_2928|Compound:9011484|FD-Score:5.47|P-value:4.51E-5 ID:SGTC_2938|Compound:9059746|FD-Score:4.38|P-value:8.58E-4 ID:SGTC_3037|Compound:9091026|FD-Score:15.30|P-value:2.58E-28 ID:SGTC_3065|Compound:9113888|FD-Score:-5.10|P-value:1.17E-4 ID:SGTC_3077|Compound:9117319|FD-Score:5.09|P-value:1.34E-4 ID:SGTC_3082|Compound:9117008|FD-Score:5.47|P-value:4.43E-5 ID:SGTC_3110|Compound:9122132|FD-Score:9.76|P-value:1.24E-12 ID:SGTC_3124|Compound:9127567|FD-Score:-5.07|P-value:1.30E-4 ID:SGTC_3143|Compound:9086658|FD-Score:-7.68|P-value:1.58E-8 ID:SGTC_3152|Compound:9099253|FD-Score:6.05|P-value:7.31E-6 ID:SGTC_3266|Compound:9136860|FD-Score:-7.29|P-value:7.56E-8 ID:SGTC_3308|Compound:9128332|FD-Score:5.81|P-value:1.58E-5 ID:SGTC_15|Compound:0266-0086|FD-Score:7.21|P-value:1.16E-7 ID:SGTC_16|Compound:erodoxin|FD-Score:5.37|P-value:6.04E-5 ID:SGTC_21|Compound:0849-0113|FD-Score:11.80|P-value:1.44E-17 ID:SGTC_23|Compound:0213-0011|FD-Score:-4.71|P-value:3.39E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-5.63|P-value:2.48E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:6.78|P-value:5.79E-7 ID:SGTC_86|Compound:0417-1630|FD-Score:6.71|P-value:7.61E-7 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:5.68|P-value:2.32E-5 ID:SGTC_117|Compound:lucigenin|FD-Score:11.20|P-value:6.08E-16 ID:SGTC_156|Compound:3474-0145|FD-Score:5.59|P-value:3.10E-5 ID:SGTC_159|Compound:3970-0959|FD-Score:4.56|P-value:5.51E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:8.64|P-value:2.83E-10 ID:SGTC_172|Compound:1112-0046|FD-Score:4.96|P-value:1.92E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:4.85|P-value:2.57E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:10.40|P-value:3.76E-14 ID:SGTC_221|Compound:trifluoperazine|FD-Score:25.00|P-value:3.32E-72 ID:SGTC_227|Compound:fluconazole|FD-Score:13.50|P-value:1.92E-22 ID:SGTC_232|Compound:clozapine|FD-Score:14.30|P-value:4.65E-25 ID:SGTC_255|Compound:tunicamycin|FD-Score:6.29|P-value:3.22E-6 ID:SGTC_301|Compound:4119-0100|FD-Score:19.20|P-value:9.92E-44 ID:SGTC_304|Compound:1310-0298|FD-Score:-7.86|P-value:7.71E-9 ID:SGTC_309|Compound:k408-0051|FD-Score:-7.45|P-value:3.97E-8 ID:SGTC_313|Compound:3474-0040|FD-Score:7.79|P-value:1.18E-8 ID:SGTC_314|Compound:1671-0008|FD-Score:-4.28|P-value:9.99E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:7.18|P-value:1.29E-7 ID:SGTC_439|Compound:amiodarone|FD-Score:6.65|P-value:9.24E-7 ID:SGTC_447|Compound:ml7|FD-Score:4.34|P-value:9.40E-4 ID:SGTC_459|Compound:nigericin|FD-Score:4.56|P-value:5.41E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:10.10|P-value:1.88E-13 ID:SGTC_514|Compound:4466-0038|FD-Score:6.54|P-value:1.37E-6 ID:SGTC_524|Compound:r073-0010|FD-Score:4.66|P-value:4.28E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:7.68|P-value:1.81E-8 ID:SGTC_528|Compound:3492-0019|FD-Score:8.75|P-value:1.75E-10 ID:SGTC_535|Compound:2293-4129|FD-Score:7.12|P-value:1.66E-7 ID:SGTC_568|Compound:1193-0097|FD-Score:4.59|P-value:5.08E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:7.34|P-value:7.11E-8 ID:SGTC_637|Compound:1181-0519|FD-Score:7.76|P-value:1.31E-8 ID:SGTC_670|Compound:4204-0025|FD-Score:4.50|P-value:6.40E-4 ID:SGTC_733|Compound:4069-0007|FD-Score:10.50|P-value:1.90E-14 ID:SGTC_748|Compound:0136-0228|FD-Score:13.60|P-value:7.78E-23 ID:SGTC_768|Compound:0384-0033|FD-Score:4.93|P-value:2.06E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:4.45|P-value:7.13E-4 ID:SGTC_805|Compound:3852-0218|FD-Score:7.27|P-value:9.30E-8 ID:SGTC_847|Compound:0342-0274|FD-Score:5.84|P-value:1.41E-5 ID:SGTC_888|Compound:0916-0002|FD-Score:8.68|P-value:2.36E-10 ID:SGTC_900|Compound:1112-0045|FD-Score:5.09|P-value:1.34E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:4.52|P-value:6.10E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:4.65|P-value:4.37E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:11.80|P-value:9.99E-18 ID:SGTC_1057|Compound:3448-5381|FD-Score:6.04|P-value:7.56E-6 ID:SGTC_1058|Compound:3448-5425|FD-Score:-5.18|P-value:9.53E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:6.36|P-value:2.55E-6 ID:SGTC_1130|Compound:3454-2858|FD-Score:29.60|P-value:2.23E-100 ID:SGTC_1225|Compound:1216-0074|FD-Score:4.73|P-value:3.49E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:4.69|P-value:3.94E-4 ID:SGTC_1287|Compound:0971-0001|FD-Score:5.76|P-value:1.86E-5 ID:SGTC_1317|Compound:1273-0028|FD-Score:5.95|P-value:9.96E-6 ID:SGTC_1394|Compound:3474-0001|FD-Score:4.76|P-value:3.27E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:8.64|P-value:2.81E-10 ID:SGTC_1573|Compound:oleylamine|FD-Score:6.50|P-value:1.56E-6 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:17.10|P-value:8.50E-35 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-5.88|P-value:1.15E-5 ID:SGTC_1672|Compound:st016598|FD-Score:4.84|P-value:2.61E-4 ID:SGTC_1687|Compound:st020778|FD-Score:22.50|P-value:7.49E-59 ID:SGTC_1724|Compound:st037281|FD-Score:4.42|P-value:7.80E-4 ID:SGTC_1745|Compound:st081495|FD-Score:-4.58|P-value:4.76E-4 ID:SGTC_1750|Compound:st081859|FD-Score:10.50|P-value:3.11E-14 ID:SGTC_1754|Compound:st042065|FD-Score:5.38|P-value:5.77E-5 ID:SGTC_1760|Compound:st045453|FD-Score:7.88|P-value:8.13E-9 ID:SGTC_1770|Compound:st043884|FD-Score:-4.33|P-value:8.97E-4 ID:SGTC_1781|Compound:st038725|FD-Score:12.90|P-value:1.08E-20 ID:SGTC_1788|Compound:fluconazole|FD-Score:11.90|P-value:7.55E-18 ID:SGTC_1789|Compound:tunicamycin|FD-Score:4.38|P-value:8.68E-4 ID:SGTC_1795|Compound:st049545|FD-Score:-5.73|P-value:1.81E-5 ID:SGTC_1797|Compound:st048695|FD-Score:14.00|P-value:5.04E-24 ID:SGTC_1798|Compound:st045719|FD-Score:4.67|P-value:4.09E-4 ID:SGTC_1800|Compound:st050079|FD-Score:4.79|P-value:2.98E-4 ID:SGTC_1801|Compound:st050089|FD-Score:5.49|P-value:4.24E-5 ID:SGTC_1803|Compound:st050068|FD-Score:8.92|P-value:7.81E-11 ID:SGTC_1827|Compound:berberine|FD-Score:5.04|P-value:1.54E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:8.26|P-value:1.55E-9 ID:SGTC_1873|Compound:rapamycin|FD-Score:10.50|P-value:2.21E-14 ID:SGTC_1877|Compound:wortmannin|FD-Score:5.51|P-value:3.92E-5 ID:SGTC_1884|Compound:5633444|FD-Score:22.50|P-value:4.79E-59 ID:SGTC_1962|Compound:st076595|FD-Score:5.72|P-value:2.06E-5 ID:SGTC_2002|Compound:4023503|FD-Score:-4.32|P-value:9.09E-4 ID:SGTC_2004|Compound:4023728|FD-Score:-4.78|P-value:2.80E-4 ID:SGTC_2006|Compound:4011487|FD-Score:12.30|P-value:5.17E-19 ID:SGTC_2010|Compound:4012422|FD-Score:-4.72|P-value:3.34E-4 ID:SGTC_2016|Compound:5121758|FD-Score:5.75|P-value:1.89E-5 ID:SGTC_2028|Compound:5153890|FD-Score:4.66|P-value:4.23E-4 ID:SGTC_2036|Compound:5160441|FD-Score:4.50|P-value:6.34E-4 ID:SGTC_2054|Compound:5233173|FD-Score:6.02|P-value:8.00E-6 ID:SGTC_2087|Compound:5276107|FD-Score:4.72|P-value:3.61E-4 ID:SGTC_2183|Compound:6420625|FD-Score:6.52|P-value:1.49E-6 ID:SGTC_2210|Compound:7115885|FD-Score:6.28|P-value:3.34E-6 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.88|P-value:2.36E-4 ID:SGTC_2289|Compound:7946404|FD-Score:8.06|P-value:3.76E-9 ID:SGTC_2308|Compound:7584454|FD-Score:-4.39|P-value:7.79E-4 ID:SGTC_2313|Compound:7726885|FD-Score:-4.34|P-value:8.79E-4 ID:SGTC_2322|Compound:7413319|FD-Score:6.55|P-value:1.32E-6 ID:SGTC_2401|Compound:5128683|FD-Score:6.48|P-value:1.70E-6 ID:SGTC_2405|Compound:ticlatone|FD-Score:6.55|P-value:1.35E-6 ID:SGTC_2406|Compound:ethylparaben|FD-Score:4.38|P-value:8.64E-4 ID:SGTC_2413|Compound:inermin|FD-Score:4.66|P-value:4.20E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:10.20|P-value:1.43E-13 ID:SGTC_2424|Compound:5537928|FD-Score:4.34|P-value:9.42E-4 ID:SGTC_2485|Compound:5633444|FD-Score:5.85|P-value:1.39E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:11.10|P-value:7.51E-16 ID:SGTC_2582|Compound:agaric acid|FD-Score:7.87|P-value:8.40E-9 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:10.70|P-value:8.02E-15 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:8.42|P-value:7.77E-10 ID:SGTC_2619|Compound:obliquin|FD-Score:8.30|P-value:1.32E-9 ID:SGTC_2647|Compound:atorvastatin|FD-Score:4.55|P-value:5.65E-4 ID:SGTC_2648|Compound:atorvastatin|FD-Score:7.65|P-value:2.07E-8 ID:SGTC_2679|Compound:rapamycin|FD-Score:7.33|P-value:7.29E-8 ID:SGTC_2688|Compound:kanamycin b|FD-Score:8.29|P-value:1.37E-9 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:11.60|P-value:3.83E-17 ID:SGTC_2737|Compound:bleomycin|FD-Score:6.29|P-value:3.29E-6 ID:SGTC_2765|Compound:myclobutanil|FD-Score:4.91|P-value:2.21E-4 ID:SGTC_2790|Compound:5423970|FD-Score:4.66|P-value:4.22E-4 ID:SGTC_2816|Compound:7982706|FD-Score:4.71|P-value:3.76E-4 ID:SGTC_2851|Compound:9015922|FD-Score:4.72|P-value:3.62E-4 ID:SGTC_2867|Compound:9039098|FD-Score:4.98|P-value:1.82E-4 ID:SGTC_2879|Compound:9041815|FD-Score:-4.94|P-value:1.84E-4 ID:SGTC_2925|Compound:9010536|FD-Score:6.05|P-value:7.29E-6 ID:SGTC_2928|Compound:9011484|FD-Score:5.47|P-value:4.51E-5 ID:SGTC_2938|Compound:9059746|FD-Score:4.38|P-value:8.58E-4 ID:SGTC_3037|Compound:9091026|FD-Score:15.30|P-value:2.58E-28 ID:SGTC_3065|Compound:9113888|FD-Score:-5.10|P-value:1.17E-4 ID:SGTC_3077|Compound:9117319|FD-Score:5.09|P-value:1.34E-4 ID:SGTC_3082|Compound:9117008|FD-Score:5.47|P-value:4.43E-5 ID:SGTC_3110|Compound:9122132|FD-Score:9.76|P-value:1.24E-12 ID:SGTC_3124|Compound:9127567|FD-Score:-5.07|P-value:1.30E-4 ID:SGTC_3143|Compound:9086658|FD-Score:-7.68|P-value:1.58E-8 ID:SGTC_3152|Compound:9099253|FD-Score:6.05|P-value:7.31E-6 ID:SGTC_3266|Compound:9136860|FD-Score:-7.29|P-value:7.56E-8 ID:SGTC_3308|Compound:9128332|FD-Score:5.81|P-value:1.58E-5

Top fitness defect scores for YLR025W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1130 3454-2858 29.60 15.9 µM 2.23E-100 NEO1 2 2.02E-192
2 SGTC_221 trifluoperazine 25.00 10.3 µM 3.32E-72 NEO1-PIK1 5 6.61E-138
3 SGTC_1884 5633444 22.50 25.0 µM 4.79E-59 redox potentiating 1 1.89E-112
4 SGTC_1687 st020778 22.50 55.4 µM 7.49E-59 4 4.49E-112
5 SGTC_301 4119-0100 19.20 24.5 µM 9.92E-44 NEO1 4 7.84E-83
6 SGTC_1593 justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one 17.10 54.9 µM 8.50E-35 redox potentiating 2 1.44E-65
7 SGTC_3037 9091026 15.30 49.5 µM 2.58E-28 NEO1-PIK1 1 4.77E-53
8 SGTC_232 clozapine 14.30 119.0 µM 4.65E-25 NEO1 9 9.22E-47
9 SGTC_1797 st048695 14.00 56.8 µM 5.04E-24 NEO1 9 9.16E-45
10 SGTC_748 0136-0228 13.60 77.9 µM 7.78E-23 redox potentiating 3 1.80E-42
11 SGTC_227 fluconazole 13.50 33.5 µM 1.92E-22 azole & statin 7 1.03E-41
12 SGTC_1781 st038725 12.90 66.3 µM 1.08E-20 NEO1 11 2.44E-38
13 SGTC_2006 4011487 12.30 200.0 µM 5.17E-19 endomembrane recycling 7 4.22E-35
14 SGTC_1788 fluconazole 11.90 20.0 µM 7.55E-18 azole & statin 8 7.42E-33
15 SGTC_1044 1222-0021 11.80 1.8 µM 9.99E-18 heme biosynthesis & mitochondrial translocase 4 1.27E-32
16 SGTC_21 0849-0113 11.80 23.0 µM 1.44E-17 2 2.58E-32
17 SGTC_2697 mebhydrolin 11.60 72.4 µM 3.83E-17 NEO1 12 1.70E-31
18 SGTC_117 lucigenin 11.20 22.1 µM 6.08E-16 redox potentiating 5 3.47E-29
19 SGTC_2567 aureobasidin a 11.10 60.0 nM 7.51E-16 10 5.23E-29
20 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 10.70 70.0 µM 8.02E-15 redox potentiating 8 4.99E-27

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.615 0 YJR102C VPS25 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome
0.605 0 YLR417W VPS36 hom Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome
0.599 0 YPL065W VPS28 hom Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p
0.583 3.35E-305 YPL002C SNF8 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression
0.551 4.51E-266 YCL008C STP22 hom Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype
0.520 2.69E-231 YMR077C VPS20 hom Myristoylated subunit of ESCRTIII, the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes
0.485 2.08E-197 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.435 4.24E-155 YDR455C_d YDR455C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W
0.427 1.22E-148 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.421 3.58E-144 YDR456W NHX1 hom Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion
0.417 1.05E-141 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.415 1.07E-139 YHR004C NEM1 hom Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard
0.398 7.24E-128 YOR039W CKB2 hom Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
0.396 5.79E-126 YGL019W CKB1 hom Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases
0.395 1.64E-125 YIL048W NEO1 het Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus