YLR027C / AAT2

Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR027C / AAT2

Click on Significant Values for Screen Details ID:SGTC_52|Compound:0329-0193|FD-Score:4.43|P-value:1.37E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:8.10|P-value:1.29E-11 ID:SGTC_66|Compound:0109-0187|FD-Score:7.80|P-value:6.86E-11 ID:SGTC_98|Compound:0074-0023|FD-Score:4.62|P-value:7.29E-5 ID:SGTC_121|Compound:0557-0495|FD-Score:-3.95|P-value:5.22E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:13.20|P-value:7.02E-28 ID:SGTC_150|Compound:3970-0969|FD-Score:7.89|P-value:4.11E-11 ID:SGTC_157|Compound:1348-1695|FD-Score:3.91|P-value:6.53E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:13.10|P-value:2.01E-27 ID:SGTC_163|Compound:1327-0036|FD-Score:6.78|P-value:1.19E-8 ID:SGTC_168|Compound:3970-0862|FD-Score:8.19|P-value:7.83E-12 ID:SGTC_177|Compound:1327-0068|FD-Score:5.16|P-value:1.12E-5 ID:SGTC_195|Compound:4234-0266|FD-Score:5.24|P-value:8.32E-6 ID:SGTC_207|Compound:4185-0010|FD-Score:4.87|P-value:3.14E-5 ID:SGTC_214|Compound:4373-3496|FD-Score:7.53|P-value:2.81E-10 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:21.40|P-value:2.99E-70 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:16.60|P-value:5.32E-43 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:30.80|P-value:1.56E-142 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:33.40|P-value:4.21E-167 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:25.30|P-value:3.74E-97 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:28.60|P-value:5.60E-123 ID:SGTC_268|Compound:camptothecin|FD-Score:6.66|P-value:2.12E-8 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.41|P-value:1.29E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:5.80|P-value:9.17E-7 ID:SGTC_663|Compound:1486-0733|FD-Score:4.32|P-value:1.95E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:8.99|P-value:6.72E-14 ID:SGTC_690|Compound:glyoxal|FD-Score:16.30|P-value:2.10E-41 ID:SGTC_768|Compound:0384-0033|FD-Score:-4.33|P-value:1.65E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:-4.62|P-value:6.43E-5 ID:SGTC_824|Compound:1304-0008|FD-Score:4.06|P-value:4.21E-4 ID:SGTC_918|Compound:glabranin|FD-Score:5.16|P-value:1.09E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:9.16|P-value:2.28E-14 ID:SGTC_1026|Compound:k007-1105|FD-Score:-4.39|P-value:1.39E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:4.18|P-value:2.98E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:4.80|P-value:4.04E-5 ID:SGTC_1360|Compound:1598-0022|FD-Score:-3.88|P-value:6.58E-4 ID:SGTC_1484|Compound:3473-2379|FD-Score:4.46|P-value:1.24E-4 ID:SGTC_1491|Compound:4138-0063|FD-Score:4.50|P-value:1.08E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.99|P-value:5.18E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-4.16|P-value:2.83E-4 ID:SGTC_1602|Compound:st001878|FD-Score:5.42|P-value:4.16E-6 ID:SGTC_1616|Compound:st002734|FD-Score:3.87|P-value:7.42E-4 ID:SGTC_1775|Compound:st081588|FD-Score:5.38|P-value:4.90E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.34|P-value:1.63E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:20.80|P-value:2.24E-66 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:5.46|P-value:3.59E-6 ID:SGTC_1944|Compound:st076371|FD-Score:3.96|P-value:5.78E-4 ID:SGTC_1981|Compound:st071826|FD-Score:3.81|P-value:8.74E-4 ID:SGTC_1982|Compound:st072467|FD-Score:6.67|P-value:2.03E-8 ID:SGTC_1989|Compound:st071868|FD-Score:4.74|P-value:4.89E-5 ID:SGTC_2007|Compound:4011539|FD-Score:5.39|P-value:4.72E-6 ID:SGTC_2013|Compound:4024628|FD-Score:6.07|P-value:3.02E-7 ID:SGTC_2017|Compound:5132927|FD-Score:-3.95|P-value:5.30E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-5.30|P-value:5.75E-6 ID:SGTC_2022|Compound:5136654|FD-Score:6.48|P-value:4.93E-8 ID:SGTC_2111|Compound:5486399|FD-Score:4.59|P-value:7.95E-5 ID:SGTC_2115|Compound:tiliquinol|FD-Score:5.17|P-value:1.06E-5 ID:SGTC_2233|Compound:sulbentine|FD-Score:7.23|P-value:1.32E-9 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.70|P-value:5.03E-5 ID:SGTC_2318|Compound:6029776|FD-Score:4.74|P-value:4.94E-5 ID:SGTC_2384|Compound:9036245|FD-Score:-3.97|P-value:4.99E-4 ID:SGTC_2399|Compound:5884133|FD-Score:3.97|P-value:5.61E-4 ID:SGTC_2416|Compound:tofa|FD-Score:4.92|P-value:2.60E-5 ID:SGTC_2459|Compound:5811157|FD-Score:3.81|P-value:8.75E-4 ID:SGTC_2475|Compound:5812728|FD-Score:5.51|P-value:2.90E-6 ID:SGTC_2507|Compound:purpurin|FD-Score:3.89|P-value:7.07E-4 ID:SGTC_2526|Compound:patulin|FD-Score:4.39|P-value:1.53E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.91|P-value:6.51E-9 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.96|P-value:5.75E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:12.20|P-value:6.29E-24 ID:SGTC_2817|Compound:7995342|FD-Score:-4.48|P-value:1.02E-4 ID:SGTC_2975|Compound:9084847|FD-Score:4.11|P-value:3.70E-4 ID:SGTC_3078|Compound:9116413|FD-Score:4.78|P-value:4.32E-5 ID:SGTC_3244|Compound:9134489|FD-Score:4.11|P-value:3.63E-4 ID:SGTC_3351|Compound:9150312|FD-Score:4.26|P-value:2.34E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:4.43|P-value:1.37E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:8.10|P-value:1.29E-11 ID:SGTC_66|Compound:0109-0187|FD-Score:7.80|P-value:6.86E-11 ID:SGTC_98|Compound:0074-0023|FD-Score:4.62|P-value:7.29E-5 ID:SGTC_121|Compound:0557-0495|FD-Score:-3.95|P-value:5.22E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:13.20|P-value:7.02E-28 ID:SGTC_150|Compound:3970-0969|FD-Score:7.89|P-value:4.11E-11 ID:SGTC_157|Compound:1348-1695|FD-Score:3.91|P-value:6.53E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:13.10|P-value:2.01E-27 ID:SGTC_163|Compound:1327-0036|FD-Score:6.78|P-value:1.19E-8 ID:SGTC_168|Compound:3970-0862|FD-Score:8.19|P-value:7.83E-12 ID:SGTC_177|Compound:1327-0068|FD-Score:5.16|P-value:1.12E-5 ID:SGTC_195|Compound:4234-0266|FD-Score:5.24|P-value:8.32E-6 ID:SGTC_207|Compound:4185-0010|FD-Score:4.87|P-value:3.14E-5 ID:SGTC_214|Compound:4373-3496|FD-Score:7.53|P-value:2.81E-10 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:21.40|P-value:2.99E-70 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:16.60|P-value:5.32E-43 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:30.80|P-value:1.56E-142 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:33.40|P-value:4.21E-167 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:25.30|P-value:3.74E-97 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:28.60|P-value:5.60E-123 ID:SGTC_268|Compound:camptothecin|FD-Score:6.66|P-value:2.12E-8 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-4.41|P-value:1.29E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:5.80|P-value:9.17E-7 ID:SGTC_663|Compound:1486-0733|FD-Score:4.32|P-value:1.95E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:8.99|P-value:6.72E-14 ID:SGTC_690|Compound:glyoxal|FD-Score:16.30|P-value:2.10E-41 ID:SGTC_768|Compound:0384-0033|FD-Score:-4.33|P-value:1.65E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:-4.62|P-value:6.43E-5 ID:SGTC_824|Compound:1304-0008|FD-Score:4.06|P-value:4.21E-4 ID:SGTC_918|Compound:glabranin|FD-Score:5.16|P-value:1.09E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:9.16|P-value:2.28E-14 ID:SGTC_1026|Compound:k007-1105|FD-Score:-4.39|P-value:1.39E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:4.18|P-value:2.98E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:4.80|P-value:4.04E-5 ID:SGTC_1360|Compound:1598-0022|FD-Score:-3.88|P-value:6.58E-4 ID:SGTC_1484|Compound:3473-2379|FD-Score:4.46|P-value:1.24E-4 ID:SGTC_1491|Compound:4138-0063|FD-Score:4.50|P-value:1.08E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.99|P-value:5.18E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:-4.16|P-value:2.83E-4 ID:SGTC_1602|Compound:st001878|FD-Score:5.42|P-value:4.16E-6 ID:SGTC_1616|Compound:st002734|FD-Score:3.87|P-value:7.42E-4 ID:SGTC_1775|Compound:st081588|FD-Score:5.38|P-value:4.90E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.34|P-value:1.63E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:20.80|P-value:2.24E-66 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:5.46|P-value:3.59E-6 ID:SGTC_1944|Compound:st076371|FD-Score:3.96|P-value:5.78E-4 ID:SGTC_1981|Compound:st071826|FD-Score:3.81|P-value:8.74E-4 ID:SGTC_1982|Compound:st072467|FD-Score:6.67|P-value:2.03E-8 ID:SGTC_1989|Compound:st071868|FD-Score:4.74|P-value:4.89E-5 ID:SGTC_2007|Compound:4011539|FD-Score:5.39|P-value:4.72E-6 ID:SGTC_2013|Compound:4024628|FD-Score:6.07|P-value:3.02E-7 ID:SGTC_2017|Compound:5132927|FD-Score:-3.95|P-value:5.30E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-5.30|P-value:5.75E-6 ID:SGTC_2022|Compound:5136654|FD-Score:6.48|P-value:4.93E-8 ID:SGTC_2111|Compound:5486399|FD-Score:4.59|P-value:7.95E-5 ID:SGTC_2115|Compound:tiliquinol|FD-Score:5.17|P-value:1.06E-5 ID:SGTC_2233|Compound:sulbentine|FD-Score:7.23|P-value:1.32E-9 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.70|P-value:5.03E-5 ID:SGTC_2318|Compound:6029776|FD-Score:4.74|P-value:4.94E-5 ID:SGTC_2384|Compound:9036245|FD-Score:-3.97|P-value:4.99E-4 ID:SGTC_2399|Compound:5884133|FD-Score:3.97|P-value:5.61E-4 ID:SGTC_2416|Compound:tofa|FD-Score:4.92|P-value:2.60E-5 ID:SGTC_2459|Compound:5811157|FD-Score:3.81|P-value:8.75E-4 ID:SGTC_2475|Compound:5812728|FD-Score:5.51|P-value:2.90E-6 ID:SGTC_2507|Compound:purpurin|FD-Score:3.89|P-value:7.07E-4 ID:SGTC_2526|Compound:patulin|FD-Score:4.39|P-value:1.53E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.91|P-value:6.51E-9 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:3.96|P-value:5.75E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:12.20|P-value:6.29E-24 ID:SGTC_2817|Compound:7995342|FD-Score:-4.48|P-value:1.02E-4 ID:SGTC_2975|Compound:9084847|FD-Score:4.11|P-value:3.70E-4 ID:SGTC_3078|Compound:9116413|FD-Score:4.78|P-value:4.32E-5 ID:SGTC_3244|Compound:9134489|FD-Score:4.11|P-value:3.63E-4 ID:SGTC_3351|Compound:9150312|FD-Score:4.26|P-value:2.34E-4

Top fitness defect scores for YLR027C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_241 5hr heat shock (37°C) + cantharidin 33.40 155.4 µM 4.21E-167 cell wall signaling 3 1.38E-244
2 SGTC_240 5hr heat shock (37°C) + Streptovitacin 30.80 300.0 µM 1.56E-142 heat shock/prefoldin 1 1.70E-208
3 SGTC_243 5hr heat shock (37°C) + splitomicin 28.60 1.0 µM 5.60E-123 heat shock/prefoldin 1 9.04E-180
4 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 25.30 4.6 µM 3.74E-97 heat shock/prefoldin 1 7.74E-142
5 SGTC_238 5hr heat shock (37°C) + nsc-638432 21.40 8.9 µM 2.99E-70 heat shock/prefoldin 1 2.52E-102
6 SGTC_1844 rapamycin 20.80 4.0 nM 2.24E-66 4 1.23E-96
7 SGTC_239 5hr heat shock (37°C) + mitomycin C 16.60 819.4 µM 5.32E-43 heat shock/prefoldin 2 2.60E-62
8 SGTC_690 glyoxal 16.30 20.3 µM 2.10E-41 3 5.73E-60
9 SGTC_149 3970-0822 13.20 46.1 µM 7.02E-28 tubulin folding & SWR complex 7 4.02E-40
10 SGTC_159 3970-0959 13.10 50.0 µM 2.01E-27 3 1.88E-39
11 SGTC_2679 rapamycin 12.20 1.0 nM 6.29E-24 16 2.52E-34
12 SGTC_919 tnp00227 9.16 403.6 nM 2.28E-14 RNA pol III & RNase P/MRP 1 2.57E-20
13 SGTC_673 1082-0474 8.99 110.0 µM 6.72E-14 RSC complex & mRNA processing 11 1.25E-19
14 SGTC_168 3970-0862 8.19 530.5 µM 7.83E-12 20 1.32E-16
15 SGTC_58 0957-0393 8.10 9.0 µM 1.29E-11 cell wall 119 2.74E-16
16 SGTC_150 3970-0969 7.89 77.2 µM 4.11E-11 9 1.49E-15
17 SGTC_66 0109-0187 7.80 42.4 µM 6.86E-11 5 3.16E-15
18 SGTC_214 4373-3496 7.53 70.0 µM 2.81E-10 7 2.48E-14
19 SGTC_2233 sulbentine 7.23 40.4 µM 1.32E-9 18 2.37E-13
20 SGTC_2582 agaric acid 6.91 100.0 µM 6.51E-9 redox potentiating 132 2.44E-12

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.536 7.98E-249 YDR260C SWM1 hom Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation
0.502 1.86E-213 YDR069C DOA4 hom Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole
0.423 1.63E-145 YLR200W YKE2 hom Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin
0.401 4.91E-130 YCR063W BUD31 hom Component of the SF3b subcomplex of the U2 snRNP; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern; facilitates passage through G1/S Start, but is not required for G2/M transition or exit from mitosis
0.359 1.78E-102 YOR001W RRP6 hom Nuclear exosome exonuclease component; has 3'-5' exonuclease activity; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
0.357 2.08E-101 YDR457W TOM1 hom E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase
0.327 3.17E-84 YNL098C RAS2 hom GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes
0.309 2.08E-75 YML094C-A_d YML094C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene GIM5/YML094W; deletion confers sensitivity to GSAO
0.281 1.60E-61 YKL213C DOA1 hom WD repeat protein required for ubiquitin-mediated protein degradation; forms a complex with Cdc48p; plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress
0.247 5.54E-48 YHR209W CRG1 hom S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin
0.220 5.14E-38 YDR049W VMS1 hom Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans
0.218 2.36E-37 YHR041C SRB2 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance
0.217 3.42E-37 YNL140C_p YNL140C_p hom Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps THO2/YNL139C
0.213 8.24E-36 YPL017C IRC15 hom Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci
0.209 1.30E-34 YKL007W CAP1 hom Alpha subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress