YLR035C / MLH2

Protein involved in the mismatch repair of certain frameshift intermediates and involved in meiotic recombination; forms a complex with Mlh1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR035C / MLH2

Click on Significant Values for Screen Details ID:SGTC_91|Compound:0417-1751|FD-Score:3.92|P-value:1.93E-5 ID:SGTC_175|Compound:3793-3120|FD-Score:-3.54|P-value:6.53E-5 ID:SGTC_179|Compound:1273-0063|FD-Score:3.11|P-value:5.69E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:3.37|P-value:2.07E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:-3.87|P-value:1.45E-5 ID:SGTC_362|Compound:0310-0100|FD-Score:-3.51|P-value:7.28E-5 ID:SGTC_379|Compound:3970-0972|FD-Score:4.53|P-value:9.66E-7 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:-3.21|P-value:2.54E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:3.67|P-value:5.82E-5 ID:SGTC_622|Compound:1348-1566|FD-Score:3.66|P-value:6.14E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:3.11|P-value:5.64E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:-2.95|P-value:6.85E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:3.46|P-value:1.43E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:3.95|P-value:1.69E-5 ID:SGTC_1056|Compound:3448-1962|FD-Score:3.37|P-value:2.05E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:3.19|P-value:4.23E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.16|P-value:4.68E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:2.96|P-value:9.82E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:3.40|P-value:1.85E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:-2.85|P-value:9.95E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.03|P-value:7.62E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:2.97|P-value:9.61E-4 ID:SGTC_1549|Compound:4'-methoxyflavonol|FD-Score:-2.86|P-value:9.71E-4 ID:SGTC_1554|Compound:st069299|FD-Score:-4.52|P-value:5.54E-7 ID:SGTC_1558|Compound:st069300|FD-Score:4.22|P-value:4.58E-6 ID:SGTC_1628|Compound:st004252|FD-Score:3.74|P-value:4.35E-5 ID:SGTC_1861|Compound:st057647|FD-Score:4.17|P-value:5.77E-6 ID:SGTC_1899|Compound:st063254|FD-Score:3.34|P-value:2.32E-4 ID:SGTC_2068|Compound:5226020|FD-Score:3.92|P-value:1.95E-5 ID:SGTC_2314|Compound:7727897|FD-Score:-3.05|P-value:4.68E-4 ID:SGTC_2318|Compound:6029776|FD-Score:3.83|P-value:2.89E-5 ID:SGTC_2331|Compound:7980721|FD-Score:3.72|P-value:4.77E-5 ID:SGTC_2421|Compound:5690543|FD-Score:3.42|P-value:1.73E-4 ID:SGTC_2437|Compound:5741531|FD-Score:4.50|P-value:1.10E-6 ID:SGTC_2460|Compound:5552655|FD-Score:-2.86|P-value:9.52E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:3.40|P-value:1.83E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.13|P-value:5.25E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:4.17|P-value:5.97E-6 ID:SGTC_2687|Compound:chenodiol|FD-Score:5.70|P-value:9.38E-10 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-2.94|P-value:7.11E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.72|P-value:4.67E-5 ID:SGTC_2695|Compound:st077686|FD-Score:-4.35|P-value:1.40E-6 ID:SGTC_2792|Compound:7535235|FD-Score:-4.52|P-value:5.55E-7 ID:SGTC_2890|Compound:9046729|FD-Score:-2.87|P-value:9.19E-4 ID:SGTC_2917|Compound:7979103|FD-Score:-3.22|P-value:2.43E-4 ID:SGTC_2949|Compound:9072542|FD-Score:3.21|P-value:3.88E-4 ID:SGTC_2950|Compound:9072895|FD-Score:3.17|P-value:4.60E-4 ID:SGTC_3027|Compound:9089541|FD-Score:3.04|P-value:7.43E-4 ID:SGTC_3221|Compound:9128209|FD-Score:-3.52|P-value:7.13E-5 ID:SGTC_3344|Compound:9148862|FD-Score:3.22|P-value:3.73E-4 ID:SGTC_91|Compound:0417-1751|FD-Score:3.92|P-value:1.93E-5 ID:SGTC_175|Compound:3793-3120|FD-Score:-3.54|P-value:6.53E-5 ID:SGTC_179|Compound:1273-0063|FD-Score:3.11|P-value:5.69E-4 ID:SGTC_208|Compound:k072-0098|FD-Score:3.37|P-value:2.07E-4 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:-3.87|P-value:1.45E-5 ID:SGTC_362|Compound:0310-0100|FD-Score:-3.51|P-value:7.28E-5 ID:SGTC_379|Compound:3970-0972|FD-Score:4.53|P-value:9.66E-7 ID:SGTC_388|Compound:3',4'-dichloroisocoumarin|FD-Score:-3.21|P-value:2.54E-4 ID:SGTC_606|Compound:k015-0008|FD-Score:3.67|P-value:5.82E-5 ID:SGTC_622|Compound:1348-1566|FD-Score:3.66|P-value:6.14E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:3.11|P-value:5.64E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:-2.95|P-value:6.85E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:3.46|P-value:1.43E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:3.95|P-value:1.69E-5 ID:SGTC_1056|Compound:3448-1962|FD-Score:3.37|P-value:2.05E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:3.19|P-value:4.23E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.16|P-value:4.68E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:2.96|P-value:9.82E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:3.40|P-value:1.85E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:-2.85|P-value:9.95E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.03|P-value:7.62E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:2.97|P-value:9.61E-4 ID:SGTC_1549|Compound:4'-methoxyflavonol|FD-Score:-2.86|P-value:9.71E-4 ID:SGTC_1554|Compound:st069299|FD-Score:-4.52|P-value:5.54E-7 ID:SGTC_1558|Compound:st069300|FD-Score:4.22|P-value:4.58E-6 ID:SGTC_1628|Compound:st004252|FD-Score:3.74|P-value:4.35E-5 ID:SGTC_1861|Compound:st057647|FD-Score:4.17|P-value:5.77E-6 ID:SGTC_1899|Compound:st063254|FD-Score:3.34|P-value:2.32E-4 ID:SGTC_2068|Compound:5226020|FD-Score:3.92|P-value:1.95E-5 ID:SGTC_2314|Compound:7727897|FD-Score:-3.05|P-value:4.68E-4 ID:SGTC_2318|Compound:6029776|FD-Score:3.83|P-value:2.89E-5 ID:SGTC_2331|Compound:7980721|FD-Score:3.72|P-value:4.77E-5 ID:SGTC_2421|Compound:5690543|FD-Score:3.42|P-value:1.73E-4 ID:SGTC_2437|Compound:5741531|FD-Score:4.50|P-value:1.10E-6 ID:SGTC_2460|Compound:5552655|FD-Score:-2.86|P-value:9.52E-4 ID:SGTC_2520|Compound:obtusaquinone|FD-Score:3.40|P-value:1.83E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.13|P-value:5.25E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:4.17|P-value:5.97E-6 ID:SGTC_2687|Compound:chenodiol|FD-Score:5.70|P-value:9.38E-10 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-2.94|P-value:7.11E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.72|P-value:4.67E-5 ID:SGTC_2695|Compound:st077686|FD-Score:-4.35|P-value:1.40E-6 ID:SGTC_2792|Compound:7535235|FD-Score:-4.52|P-value:5.55E-7 ID:SGTC_2890|Compound:9046729|FD-Score:-2.87|P-value:9.19E-4 ID:SGTC_2917|Compound:7979103|FD-Score:-3.22|P-value:2.43E-4 ID:SGTC_2949|Compound:9072542|FD-Score:3.21|P-value:3.88E-4 ID:SGTC_2950|Compound:9072895|FD-Score:3.17|P-value:4.60E-4 ID:SGTC_3027|Compound:9089541|FD-Score:3.04|P-value:7.43E-4 ID:SGTC_3221|Compound:9128209|FD-Score:-3.52|P-value:7.13E-5 ID:SGTC_3344|Compound:9148862|FD-Score:3.22|P-value:3.73E-4

Top fitness defect scores for YLR035C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2687 chenodiol 5.70 100.0 µM 9.38E-10 2 6.07E-9
2 SGTC_379 3970-0972 4.53 5.9 µM 9.66E-7 tubulin folding & SWR complex 22 3.01E-6
3 SGTC_2437 5741531 4.50 144.2 µM 1.10E-6 26 3.37E-6
4 SGTC_1558 st069300 4.22 45.6 µM 4.58E-6 7 1.22E-5
5 SGTC_1861 st057647 4.17 17.4 µM 5.77E-6 17 1.50E-5
6 SGTC_2620 irigenin 4.17 100.0 µM 5.97E-6 32 1.54E-5
7 SGTC_990 3985-0011 3.95 41.3 µM 1.69E-5 amide catabolism 20 3.93E-5
8 SGTC_91 0417-1751 3.92 58.4 µM 1.93E-5 Golgi 56 4.43E-5
9 SGTC_2068 5226020 3.92 147.0 µM 1.95E-5 30 4.46E-5
10 SGTC_2318 6029776 3.83 164.0 µM 2.89E-5 34 6.36E-5
11 SGTC_1628 st004252 3.74 77.7 µM 4.35E-5 25 9.19E-5
12 SGTC_2693 st077581 3.72 40.7 µM 4.67E-5 45 9.80E-5
13 SGTC_2331 7980721 3.72 200.0 µM 4.77E-5 31 9.98E-5
14 SGTC_606 k015-0008 3.67 38.6 µM 5.82E-5 23 1.20E-4
15 SGTC_622 1348-1566 3.66 26.3 µM 6.14E-5 26 1.25E-4
16 SGTC_978 1416-0512 3.46 87.4 µM 1.43E-4 redox potentiating 43 2.69E-4
17 SGTC_2421 5690543 3.42 90.7 µM 1.73E-4 34 3.19E-4
18 SGTC_2520 obtusaquinone 3.40 4.7 µM 1.83E-4 36 3.35E-4
19 SGTC_1314 1222-0010 3.40 41.1 µM 1.85E-4 23 3.39E-4
20 SGTC_1056 3448-1962 3.37 115.0 µM 2.05E-4 amide catabolism 36 3.72E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.120 3.24E-12 YMR013C SEC59 het Dolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation
0.092 9.62E-8 YML116W ATR1 hom Multidrug efflux pump of the major facilitator superfamily; required for resistance to aminotriazole and 4-nitroquinoline-N-oxide; ATR1 has a paralog, YMR279C, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.092 1.08E-7 YGL080W FMP37 hom Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; null mutant displays slow growth that is complemented by expression of human or mouse ortholog; mutation in human ortholog is associated with lactic acidosis and hyperpyruvatemia
0.085 7.22E-7 YOR020W-A_p YOR020W-A_p hom Putative protein of unknown function, conserved in A. gossypii; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.085 8.64E-7 YNL251C NRD1 het RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3′ end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; interacts with the C-terminal domain of the RNA polymerase II large subunit (Rpo21p), preferentially at phosphorylated Ser5, to direct transcription termination of non-polyadenylated transcripts; H3K4 trimethylation of transcribed regions by Set1p enhances recruitment of Nrd1p to those sites
0.084 1.25E-6 YLR365W_d YLR365W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious gene YLR364C-A; YLR365W is not an essential gene
0.083 1.50E-6 YNL266W_d YNL266W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF IST1/YNL265C
0.080 3.10E-6 YHR078W_p YHR078W_p hom High osmolarity-regulated gene of unknown function
0.077 7.61E-6 YNL227C JJJ1 hom Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis
0.075 1.41E-5 YJL212C OPT1 hom Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family
0.074 1.61E-5 YNL311C SKP2 hom F-box protein of unknown function predicted to be part of an SCF ubiquitin protease complex; involved in regulating protein levels of sulfur metabolism enzymes; may interact with ribosomes, based on co-purification experiments
0.072 2.75E-5 YNL076W MKS1 hom Pleiotropic negative transcriptional regulator involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation; involved in retrograde (RTG) mitochondria-to-nucleus signaling
0.071 3.66E-5 YJR092W BUD4 hom Anillin-like protein involved in bud-site selection; required for the axial budding pattern; localizes with septins to the bud neck in mitosis and may constitute an axial landmark for the next round of budding; required for the formation and disassembly of the double septin ring structure, and generally for septin organization; in vivo substrate of Cdc28p/Clb2p
0.071 3.88E-5 YBL034C STU1 het Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
0.071 3.94E-5 YGR002C SWC4 het Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex