YLR040C_p

Protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; mRNA identified as translated by ribosome profiling data; YLR040C is not essential

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR040C / YLR040C

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:-10.40|P-value:3.43E-24 ID:SGTC_50|Compound:0929-0078|FD-Score:-3.79|P-value:1.18E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:-4.31|P-value:1.43E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:-5.32|P-value:1.17E-7 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.43|P-value:4.34E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:-3.40|P-value:4.82E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:3.88|P-value:8.19E-5 ID:SGTC_378|Compound:3970-0959|FD-Score:5.10|P-value:3.56E-7 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.62|P-value:2.17E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:3.27|P-value:7.50E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:3.67|P-value:1.79E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:3.88|P-value:8.09E-5 ID:SGTC_564|Compound:3555-0129|FD-Score:4.99|P-value:6.15E-7 ID:SGTC_576|Compound:1073-0113|FD-Score:4.16|P-value:2.65E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.68|P-value:1.77E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-12.20|P-value:8.90E-33 ID:SGTC_903|Compound:1134-0042|FD-Score:-3.64|P-value:2.03E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:-3.54|P-value:2.97E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.63|P-value:2.11E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:5.60|P-value:2.61E-8 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.43|P-value:4.22E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.50|P-value:3.32E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.33|P-value:5.96E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:5.88|P-value:5.41E-9 ID:SGTC_1443|Compound:4112-3303|FD-Score:3.42|P-value:4.42E-4 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:3.29|P-value:6.94E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.45|P-value:4.01E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.24|P-value:8.29E-4 ID:SGTC_1797|Compound:st048695|FD-Score:4.23|P-value:1.96E-5 ID:SGTC_1827|Compound:berberine|FD-Score:3.34|P-value:5.89E-4 ID:SGTC_1843|Compound:st055809|FD-Score:-4.18|P-value:2.46E-5 ID:SGTC_1845|Compound:st056753|FD-Score:3.56|P-value:2.73E-4 ID:SGTC_1881|Compound:5652484|FD-Score:4.96|P-value:7.22E-7 ID:SGTC_1978|Compound:st071761|FD-Score:3.86|P-value:8.90E-5 ID:SGTC_2012|Compound:4023501|FD-Score:4.12|P-value:3.13E-5 ID:SGTC_2058|Compound:5236698|FD-Score:3.20|P-value:9.33E-4 ID:SGTC_2160|Compound:5660466|FD-Score:3.37|P-value:5.21E-4 ID:SGTC_2196|Compound:6573537|FD-Score:3.24|P-value:8.19E-4 ID:SGTC_2397|Compound:5161689|FD-Score:4.00|P-value:4.98E-5 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:5.24|P-value:1.72E-7 ID:SGTC_2703|Compound:st077852|FD-Score:3.33|P-value:6.08E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-4.88|P-value:1.06E-6 ID:SGTC_2850|Compound:9015429|FD-Score:3.75|P-value:1.36E-4 ID:SGTC_2916|Compound:7875993|FD-Score:5.40|P-value:7.74E-8 ID:SGTC_2973|Compound:9094665|FD-Score:3.40|P-value:4.72E-4 ID:SGTC_2994|Compound:9053520|FD-Score:-4.49|P-value:6.36E-6 ID:SGTC_3204|Compound:9114183|FD-Score:9.16|P-value:2.81E-19 ID:SGTC_3205|Compound:9113483|FD-Score:-3.21|P-value:9.04E-4 ID:SGTC_3206|Compound:9114350|FD-Score:3.78|P-value:1.19E-4 ID:SGTC_3331|Compound:9141060|FD-Score:3.48|P-value:3.53E-4 ID:SGTC_44|Compound:0929-0055|FD-Score:-10.40|P-value:3.43E-24 ID:SGTC_50|Compound:0929-0078|FD-Score:-3.79|P-value:1.18E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:-4.31|P-value:1.43E-5 ID:SGTC_115|Compound:0527-0192|FD-Score:-5.32|P-value:1.17E-7 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.43|P-value:4.34E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:-3.40|P-value:4.82E-4 ID:SGTC_182|Compound:3448-4371|FD-Score:3.88|P-value:8.19E-5 ID:SGTC_378|Compound:3970-0959|FD-Score:5.10|P-value:3.56E-7 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.62|P-value:2.17E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:3.27|P-value:7.50E-4 ID:SGTC_557|Compound:1315-0110|FD-Score:3.67|P-value:1.79E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:3.88|P-value:8.09E-5 ID:SGTC_564|Compound:3555-0129|FD-Score:4.99|P-value:6.15E-7 ID:SGTC_576|Compound:1073-0113|FD-Score:4.16|P-value:2.65E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.68|P-value:1.77E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-12.20|P-value:8.90E-33 ID:SGTC_903|Compound:1134-0042|FD-Score:-3.64|P-value:2.03E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:-3.54|P-value:2.97E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.63|P-value:2.11E-4 ID:SGTC_1048|Compound:3161-0300|FD-Score:5.60|P-value:2.61E-8 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.43|P-value:4.22E-4 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.50|P-value:3.32E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:3.33|P-value:5.96E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:5.88|P-value:5.41E-9 ID:SGTC_1443|Compound:4112-3303|FD-Score:3.42|P-value:4.42E-4 ID:SGTC_1692|Compound:fluoroquinolonic acid|FD-Score:3.29|P-value:6.94E-4 ID:SGTC_1714|Compound:st033236|FD-Score:3.45|P-value:4.01E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.24|P-value:8.29E-4 ID:SGTC_1797|Compound:st048695|FD-Score:4.23|P-value:1.96E-5 ID:SGTC_1827|Compound:berberine|FD-Score:3.34|P-value:5.89E-4 ID:SGTC_1843|Compound:st055809|FD-Score:-4.18|P-value:2.46E-5 ID:SGTC_1845|Compound:st056753|FD-Score:3.56|P-value:2.73E-4 ID:SGTC_1881|Compound:5652484|FD-Score:4.96|P-value:7.22E-7 ID:SGTC_1978|Compound:st071761|FD-Score:3.86|P-value:8.90E-5 ID:SGTC_2012|Compound:4023501|FD-Score:4.12|P-value:3.13E-5 ID:SGTC_2058|Compound:5236698|FD-Score:3.20|P-value:9.33E-4 ID:SGTC_2160|Compound:5660466|FD-Score:3.37|P-value:5.21E-4 ID:SGTC_2196|Compound:6573537|FD-Score:3.24|P-value:8.19E-4 ID:SGTC_2397|Compound:5161689|FD-Score:4.00|P-value:4.98E-5 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:5.24|P-value:1.72E-7 ID:SGTC_2703|Compound:st077852|FD-Score:3.33|P-value:6.08E-4 ID:SGTC_2829|Compound:7992743|FD-Score:-4.88|P-value:1.06E-6 ID:SGTC_2850|Compound:9015429|FD-Score:3.75|P-value:1.36E-4 ID:SGTC_2916|Compound:7875993|FD-Score:5.40|P-value:7.74E-8 ID:SGTC_2973|Compound:9094665|FD-Score:3.40|P-value:4.72E-4 ID:SGTC_2994|Compound:9053520|FD-Score:-4.49|P-value:6.36E-6 ID:SGTC_3204|Compound:9114183|FD-Score:9.16|P-value:2.81E-19 ID:SGTC_3205|Compound:9113483|FD-Score:-3.21|P-value:9.04E-4 ID:SGTC_3206|Compound:9114350|FD-Score:3.78|P-value:1.19E-4 ID:SGTC_3331|Compound:9141060|FD-Score:3.48|P-value:3.53E-4

Top fitness defect scores for YLR040C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3204 9114183 9.16 49.5 µM 2.81E-19 2 2.67E-20
2 SGTC_1378 2093-0007 5.88 380.0 nM 5.41E-9 1 2.02E-9
3 SGTC_1048 3161-0300 5.60 24.5 µM 2.61E-8 5 1.07E-8
4 SGTC_2916 7875993 5.40 68.8 µM 7.74E-8 5 3.37E-8
5 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 5.24 70.0 µM 1.72E-7 redox potentiating 36 7.84E-8
6 SGTC_378 3970-0959 5.10 8.3 µM 3.56E-7 6 1.69E-7
7 SGTC_564 3555-0129 4.99 330.0 µM 6.15E-7 2 3.01E-7
8 SGTC_1881 5652484 4.96 16.0 µM 7.22E-7 TRP & mitochondrial translation 15 3.57E-7
9 SGTC_1797 st048695 4.23 56.8 µM 1.96E-5 NEO1 66 1.17E-5
10 SGTC_576 1073-0113 4.16 22.7 µM 2.65E-5 redox potentiating 57 1.61E-5
11 SGTC_2012 4023501 4.12 200.0 µM 3.13E-5 24 1.91E-5
12 SGTC_2397 5161689 4.00 200.0 µM 4.98E-5 32 3.12E-5
13 SGTC_562 3772-2733 3.88 112.0 µM 8.09E-5 ERG2 83 5.21E-5
14 SGTC_182 3448-4371 3.88 550.5 µM 8.19E-5 23 5.28E-5
15 SGTC_1978 st071761 3.86 42.0 µM 8.90E-5 TSC3-RPN4 16 5.76E-5
16 SGTC_3206 9114350 3.78 49.5 µM 1.19E-4 22 7.81E-5
17 SGTC_2850 9015429 3.75 58.4 µM 1.36E-4 16 9.01E-5
18 SGTC_557 1315-0110 3.67 16.2 µM 1.79E-4 Golgi 27 1.21E-4
19 SGTC_1031 k035-0009 3.63 16.0 µM 2.11E-4 40 1.43E-4
20 SGTC_454 lyso-paf C-16 3.62 6.7 µM 2.17E-4 27 1.47E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.314 8.51E-78 YHL045W_d YHL045W_d hom Putative protein of unknown function; not an essential gene
0.307 3.83E-74 YGL090W LIF1 hom Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein
0.285 6.23E-64 YPL246C RBD2 hom Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p
0.258 2.50E-52 YNL123W NMA111 hom Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases
0.249 9.17E-49 YML029W USA1 hom Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p
0.244 1.78E-46 YLR317W_d YLR317W_d het Dubious open reading frame; may be part of a bicistronic transcript with NKP2/YLR315W; overlaps the verified ORF TAD3/YLR316C
0.241 1.49E-45 YDL155W CLB3 hom B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation; relative distribution to the nucleus increases upon DNA replication stress
0.238 2.68E-44 YIL009W FAA3 hom Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.236 1.58E-43 YDL022W GPD1 hom NAD-dependent glycerol-3-phosphate dehydrogenase; key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p; protein abundance increases in response to DNA replication stress; constitutively inactivated via phosphorylation by the protein kinases YPK1 and YPK2, dephosphorylation increases catalytic activity
0.230 1.18E-41 YML025C YML6 het Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins
0.219 8.23E-38 YNL103W MET4 het Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p
0.218 2.43E-37 YOR271C_p FSF1_p hom Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis
0.198 5.92E-31 YOR033C EXO1 hom 5'-3' exonuclease and flap-endonuclease; involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains; relative distribution to the nucleus increases upon DNA replication stress
0.194 6.53E-30 YLR034C SMF3 hom Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins; protein abundance increases in response to DNA replication stress
0.179 1.37E-25 YOR014W RTS1 hom B-type regulatory subunit of protein phosphatase 2A (PP2A); Rts1p and Cdc55p are alternative regulatory subunits for PP2A catalytic subunits, Pph21p and Pph22p; PP2A-Rts1p protects cohesin when recruited by Sgo1p to the pericentromere; highly enriched at centromeres in the absence of Cdc55p; required for maintenance of septin ring organization during cytokinesis, for ring disassembly in G1 and for dephosphorylation of septin, Shs1p; homolog of the mammalian B' subunit of PP2A