YLR049C_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR049C / YLR049C

Click on Significant Values for Screen Details ID:SGTC_172|Compound:1112-0046|FD-Score:-3.23|P-value:9.54E-5 ID:SGTC_301|Compound:4119-0100|FD-Score:-2.83|P-value:5.64E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:2.72|P-value:4.12E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:2.72|P-value:4.28E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.51|P-value:9.20E-6 ID:SGTC_754|Compound:3474-0146|FD-Score:2.96|P-value:1.42E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:2.52|P-value:9.56E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:-2.94|P-value:3.55E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:3.47|P-value:1.17E-5 ID:SGTC_961|Compound:1252-1571|FD-Score:2.78|P-value:3.22E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:3.09|P-value:7.96E-5 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:-3.21|P-value:1.03E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.67|P-value:4.00E-6 ID:SGTC_1172|Compound:0370-0043|FD-Score:-2.88|P-value:4.50E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:-3.45|P-value:3.27E-5 ID:SGTC_1180|Compound:1193-0155|FD-Score:4.48|P-value:2.73E-8 ID:SGTC_1305|Compound:1181-0477|FD-Score:2.60|P-value:6.98E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:2.75|P-value:3.73E-4 ID:SGTC_1477|Compound:0139-0234|FD-Score:-3.19|P-value:1.12E-4 ID:SGTC_1779|Compound:st039427|FD-Score:3.42|P-value:1.47E-5 ID:SGTC_1803|Compound:st050068|FD-Score:3.28|P-value:3.07E-5 ID:SGTC_1907|Compound:st060210|FD-Score:2.95|P-value:1.54E-4 ID:SGTC_1927|Compound:st060202|FD-Score:2.80|P-value:2.92E-4 ID:SGTC_1936|Compound:st074407|FD-Score:-3.75|P-value:6.71E-6 ID:SGTC_1966|Compound:st070145|FD-Score:2.74|P-value:3.84E-4 ID:SGTC_1984|Compound:st072354|FD-Score:-2.84|P-value:5.28E-4 ID:SGTC_2041|Compound:5107442|FD-Score:2.66|P-value:5.41E-4 ID:SGTC_2113|Compound:5491891|FD-Score:3.05|P-value:9.38E-5 ID:SGTC_2344|Compound:7990960|FD-Score:-3.27|P-value:7.66E-5 ID:SGTC_2368|Compound:9071271|FD-Score:-2.71|P-value:9.00E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:2.56|P-value:8.26E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-2.79|P-value:6.60E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:2.52|P-value:9.50E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:2.64|P-value:6.00E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:2.78|P-value:3.25E-4 ID:SGTC_2859|Compound:9028643|FD-Score:3.13|P-value:6.62E-5 ID:SGTC_2948|Compound:9070189|FD-Score:2.96|P-value:1.46E-4 ID:SGTC_3149|Compound:9097855|FD-Score:3.30|P-value:2.77E-5 ID:SGTC_3165|Compound:9101544|FD-Score:-3.35|P-value:5.31E-5 ID:SGTC_3213|Compound:9129884|FD-Score:-2.85|P-value:5.05E-4 ID:SGTC_3245|Compound:9134821|FD-Score:4.45|P-value:3.37E-8 ID:SGTC_172|Compound:1112-0046|FD-Score:-3.23|P-value:9.54E-5 ID:SGTC_301|Compound:4119-0100|FD-Score:-2.83|P-value:5.64E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:2.72|P-value:4.12E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:2.72|P-value:4.28E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:3.51|P-value:9.20E-6 ID:SGTC_754|Compound:3474-0146|FD-Score:2.96|P-value:1.42E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:2.52|P-value:9.56E-4 ID:SGTC_823|Compound:0417-1665|FD-Score:-2.94|P-value:3.55E-4 ID:SGTC_936|Compound:3005-4620|FD-Score:3.47|P-value:1.17E-5 ID:SGTC_961|Compound:1252-1571|FD-Score:2.78|P-value:3.22E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:3.09|P-value:7.96E-5 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:-3.21|P-value:1.03E-4 ID:SGTC_1171|Compound:0368-0077|FD-Score:3.67|P-value:4.00E-6 ID:SGTC_1172|Compound:0370-0043|FD-Score:-2.88|P-value:4.50E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:-3.45|P-value:3.27E-5 ID:SGTC_1180|Compound:1193-0155|FD-Score:4.48|P-value:2.73E-8 ID:SGTC_1305|Compound:1181-0477|FD-Score:2.60|P-value:6.98E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:2.75|P-value:3.73E-4 ID:SGTC_1477|Compound:0139-0234|FD-Score:-3.19|P-value:1.12E-4 ID:SGTC_1779|Compound:st039427|FD-Score:3.42|P-value:1.47E-5 ID:SGTC_1803|Compound:st050068|FD-Score:3.28|P-value:3.07E-5 ID:SGTC_1907|Compound:st060210|FD-Score:2.95|P-value:1.54E-4 ID:SGTC_1927|Compound:st060202|FD-Score:2.80|P-value:2.92E-4 ID:SGTC_1936|Compound:st074407|FD-Score:-3.75|P-value:6.71E-6 ID:SGTC_1966|Compound:st070145|FD-Score:2.74|P-value:3.84E-4 ID:SGTC_1984|Compound:st072354|FD-Score:-2.84|P-value:5.28E-4 ID:SGTC_2041|Compound:5107442|FD-Score:2.66|P-value:5.41E-4 ID:SGTC_2113|Compound:5491891|FD-Score:3.05|P-value:9.38E-5 ID:SGTC_2344|Compound:7990960|FD-Score:-3.27|P-value:7.66E-5 ID:SGTC_2368|Compound:9071271|FD-Score:-2.71|P-value:9.00E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:2.56|P-value:8.26E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-2.79|P-value:6.60E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:2.52|P-value:9.50E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:2.64|P-value:6.00E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:2.78|P-value:3.25E-4 ID:SGTC_2859|Compound:9028643|FD-Score:3.13|P-value:6.62E-5 ID:SGTC_2948|Compound:9070189|FD-Score:2.96|P-value:1.46E-4 ID:SGTC_3149|Compound:9097855|FD-Score:3.30|P-value:2.77E-5 ID:SGTC_3165|Compound:9101544|FD-Score:-3.35|P-value:5.31E-5 ID:SGTC_3213|Compound:9129884|FD-Score:-2.85|P-value:5.05E-4 ID:SGTC_3245|Compound:9134821|FD-Score:4.45|P-value:3.37E-8

Top fitness defect scores for YLR049C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1180 1193-0155 4.48 285.0 µM 2.73E-8 8 3.68E-6
2 SGTC_3245 9134821 4.45 49.5 µM 3.37E-8 7 4.27E-6
3 SGTC_1171 0368-0077 3.67 21.4 µM 4.00E-6 28 1.23E-4
4 SGTC_705 1124-0212 3.51 310.0 µM 9.20E-6 27 2.21E-4
5 SGTC_936 3005-4620 3.47 401.0 µM 1.17E-5 42 2.61E-4
6 SGTC_1779 st039427 3.42 55.0 µM 1.47E-5 48 3.08E-4
7 SGTC_3149 9097855 3.30 49.5 µM 2.77E-5 Golgi 50 4.80E-4
8 SGTC_1803 st050068 3.28 52.4 µM 3.07E-5 NEO1-PIK1 236 5.16E-4
9 SGTC_2859 9028643 3.13 45.5 µM 6.62E-5 40 8.87E-4
10 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 3.09 15.5 µM 7.96E-5 61 0.00101
11 SGTC_2113 5491891 3.05 107.0 µM 9.38E-5 TSC3-RPN4 71 0.00113
12 SGTC_754 3474-0146 2.96 171.0 µM 1.42E-4 copper-dependent oxidative stress 73 0.00152
13 SGTC_2948 9070189 2.96 9.4 µM 1.46E-4 plasma membrane duress 77 0.00155
14 SGTC_1907 st060210 2.95 83.7 µM 1.54E-4 77 0.00161
15 SGTC_1927 st060202 2.80 13.8 µM 2.92E-4 74 0.00253
16 SGTC_961 1252-1571 2.78 372.0 µM 3.22E-4 86 0.00270
17 SGTC_2684 capsaicin 2.78 100.0 µM 3.25E-4 67 0.00272
18 SGTC_1464 k208-0027 2.75 110.0 µM 3.73E-4 80 0.00300
19 SGTC_1966 st070145 2.74 16.1 µM 3.84E-4 81 0.00307
20 SGTC_694 1315-0438 2.72 43.2 µM 4.12E-4 58 0.00322

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.118 7.74E-12 YER118C SHO1 hom Transmembrane osmosensor involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway; phosphorylated by Hog1p; interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p
0.114 3.39E-11 YMR206W_p YMR206W_p hom Putative protein of unknown function; not an essential gene; YMR206W has a paralog, YNR014W, that arose from the whole genome duplication
0.112 6.80E-11 YPR092W_d YPR092W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.103 2.49E-9 YLR118C YLR118C hom Acyl-protein thioesterase responsible for depalmitoylation of Gpa1p; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS
0.098 1.11E-8 YOR034C AKR2 hom Ankyrin repeat-containing protein; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; possibly involved in constitutive endocytosis of Ste3p; AKR2 has a paralog, AKR1, that arose from the whole genome duplication
0.096 2.52E-8 YOL147C PEX11 hom Peroxisomal membrane protein required for medium-chain fatty acid oxidation and peroxisome proliferation, possibly by inducing membrane curvature; localization regulated by phosphorylation; transcription regulated by Adr1p and Pip2p-Oaf1p
0.094 4.88E-8 YLR281C_p YLR281C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR281C is not an essential gene
0.090 1.59E-7 YBL050W SEC17 het Peripheral membrane protein required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, and autophagy; stimulates the ATPase activity of Sec18p; has similarity to mammalian alpha-SNAP
0.088 3.79E-7 YPL030W TRM44 hom tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene
0.085 8.39E-7 YNL151C RPC31 het RNA polymerase III subunit C31
0.081 2.88E-6 YPL004C LSP1 hom Primary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Pil1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; member of the BAR domain family
0.079 4.71E-6 YBL068W PRS4 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication
0.079 4.88E-6 YDR492W IZH1 hom Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc
0.079 5.01E-6 YMR079W SEC14 het Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs
0.078 5.83E-6 YLL049W LDB18 hom Component of the dynactin complex, which is required for dynein activity; null mutant exhibits defects in nuclear migration and spindle orientation and has reduced affinity for alcian blue dye; has homology to mammalian dynactin subunit p24