| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|
| 0.118 |
7.74E-12 |
YER118C |
SHO1 |
hom |
Transmembrane osmosensor involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway; phosphorylated by Hog1p; interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p |
| 0.114 |
3.39E-11 |
YMR206W_p |
YMR206W_p |
hom |
Putative protein of unknown function; not an essential gene; YMR206W has a paralog, YNR014W, that arose from the whole genome duplication |
| 0.112 |
6.80E-11 |
YPR092W_d |
YPR092W_d |
hom |
Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.103 |
2.49E-9 |
YLR118C |
YLR118C |
hom |
Acyl-protein thioesterase responsible for depalmitoylation of Gpa1p; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS |
| 0.098 |
1.11E-8 |
YOR034C |
AKR2 |
hom |
Ankyrin repeat-containing protein; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; possibly involved in constitutive endocytosis of Ste3p; AKR2 has a paralog, AKR1, that arose from the whole genome duplication |
| 0.096 |
2.52E-8 |
YOL147C |
PEX11 |
hom |
Peroxisomal membrane protein required for medium-chain fatty acid oxidation and peroxisome proliferation, possibly by inducing membrane curvature; localization regulated by phosphorylation; transcription regulated by Adr1p and Pip2p-Oaf1p |
| 0.094 |
4.88E-8 |
YLR281C_p |
YLR281C_p |
hom |
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR281C is not an essential gene |
| 0.090 |
1.59E-7 |
YBL050W |
SEC17 |
het |
Peripheral membrane protein required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, and autophagy; stimulates the ATPase activity of Sec18p; has similarity to mammalian alpha-SNAP |
| 0.088 |
3.79E-7 |
YPL030W |
TRM44 |
hom |
tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene |
| 0.085 |
8.39E-7 |
YNL151C |
RPC31 |
het |
RNA polymerase III subunit C31 |
| 0.081 |
2.88E-6 |
YPL004C |
LSP1 |
hom |
Primary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Pil1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; member of the BAR domain family |
| 0.079 |
4.71E-6 |
YBL068W |
PRS4 |
hom |
5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication |
| 0.079 |
4.88E-6 |
YDR492W |
IZH1 |
hom |
Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc |
| 0.079 |
5.01E-6 |
YMR079W |
SEC14 |
het |
Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs |
| 0.078 |
5.83E-6 |
YLL049W |
LDB18 |
hom |
Component of the dynactin complex, which is required for dynein activity; null mutant exhibits defects in nuclear migration and spindle orientation and has reduced affinity for alcian blue dye; has homology to mammalian dynactin subunit p24 |
