HIPHOP chemogenomics database

YLR053C_p

Putative protein of unknown function

Zygosity: Homozygous strain

fixedexpanded
Profile for YLR053C / YLR053C

Click on Significant Values for Screen Details

Top fitness defect scores for YLR053C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_773	4358-1457	8.11	44.6 µM	2.01E-19		5	2.64E-16
2	SGTC_2930	9013230	5.32	14.9 µM	2.16E-9	heme biosynthesis & mitochondrial translocase	14	5.15E-8
3	SGTC_220	paclitaxel	4.38	373.4 µM	6.79E-7		3	6.03E-6
4	SGTC_1347	1493-0251	4.14	600.0 nM	2.47E-6	mitochondrial response to ROS	15	1.76E-5
5	SGTC_2059	5238311	4.14	157.0 µM	2.47E-6		16	1.76E-5
6	SGTC_3211	9128781	4.13	49.5 µM	2.52E-6		50	1.79E-5
7	SGTC_3229	9132204	3.81	49.5 µM	1.28E-5		4	6.89E-5
8	SGTC_1178	0988-0033	3.81	191.0 µM	1.32E-5		30	7.06E-5
9	SGTC_2631	bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone	3.64	100.0 µM	2.93E-5		46	1.37E-4
10	SGTC_2483	5729050	3.43	27.2 µM	7.51E-5		42	3.00E-4
11	SGTC_2847	9005661	3.40	71.4 µM	8.61E-5		15	3.36E-4
12	SGTC_381	3461-2219	3.36	42.7 µM	1.02E-4	copper-dependent oxidative stress	37	3.88E-4
13	SGTC_1345	1488-0192	3.31	31.4 µM	1.26E-4		34	4.63E-4
14	SGTC_551	k048-0028	3.30	34.9 µM	1.32E-4		43	4.81E-4
15	SGTC_1113	artemisinin	3.27	1.2 µM	1.50E-4	heme biosynthesis & mitochondrial translocase	32	5.32E-4
16	SGTC_261	5-fluorouridine	3.24	15.4 µM	1.69E-4	exosome	40	5.88E-4
17	SGTC_2490	carminic acid	3.15	95.4 µM	2.48E-4		20	8.10E-4
18	SGTC_2492	derrusnin	3.12	100.0 µM	2.84E-4		20	9.06E-4
19	SGTC_1309	pyrazolanthrone	3.11	13.4 µM	2.95E-4		51	9.36E-4
20	SGTC_689	0833-0039	3.09	98.0 µM	3.21E-4	ergosterol depletion effects on membrane	59	0.00100

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.213	9.55E-36	YAL043C	PTA1	het	Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII
0.179	2.10E-25	YFL024C	EPL1	het	Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); required for autophagy; homologous to Drosophila Enhancer of Polycomb
0.164	1.70E-21	YCL026C-A	FRM2	hom	Type II nitroreductase, using NADH as reductant; mutants are defective in fatty acid mediated repression of genes involved in fatty acid biosynthesis indicative of a role in lipid signaling; involved in the oxidative stress response; transcription induction by cadmium and selenite indicates a possible role in the metal stress response; expression induced in cells treated with the mycotoxin patulin
0.145	3.31E-17	YLR271W_p	YLR271W_p	hom	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS
0.142	1.68E-16	YDR166C	SEC5	het	Essential 107kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in assembly of the exocyst complex; required with Sec3p for ER inheritance where it promotes anchoring of the cortical ER at the bud tip
0.140	5.10E-16	YLR212C	TUB4	het	Gamma-tubulin; involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body; protein abundance increases in response to DNA replication stress
0.137	1.78E-15	YDR055W	PST1	hom	Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1
0.136	2.39E-15	YER069W	ARG5,6	hom	Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine
0.131	3.11E-14	YDR371W_p	CTS2_p	hom	Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect
0.127	1.86E-13	YBR241C_p	YBR241C_p	hom	Putative transporter, member of the sugar porter family; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane; YBR241C is not an essential gene
0.121	2.88E-12	YGL220W	FRA2	hom	Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; null mutant fails to repress iron regulon and is sensitive to nickel
0.119	4.68E-12	YGR122C-A_d	YGR122C-A_d	hom	Dubious open reading frame unlikely to encode a functional protein, similar to YLR334C and YOL106W
0.117	1.24E-11	YIL107C	PFK26	hom	6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A
0.112	9.36E-11	YJR001W	AVT1	hom	Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.112	8.97E-11	YKR054C	DYN1	hom	Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p