HIPHOP chemogenomics database
YLR063W_p 
Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YLR063W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.155 | 1.52E-19 | YNL254C | RTC4 | hom | Protein of unknown function; null mutation suppresses cdc13-1 temperature sensitivity; (GFP)-fusion protein localizes to both the cytoplasm and the nucleus |
| 0.121 | 2.35E-12 | YDL221W_d | YDL221W_d | het | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 3' end of essential gene CDC13 |
| 0.118 | 7.78E-12 | YOR150W | MRPL23 | hom | Mitochondrial ribosomal protein of the large subunit |
| 0.115 | 2.49E-11 | YHR110W | ERP5 | hom | Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport |
| 0.112 | 9.78E-11 | YNL061W | NOP2 | het | Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles |
| 0.111 | 1.08E-10 | YPR108W-A_p | YPR108W-A_p | hom | Putative protein of unknown function; identified by fungal homology and RT-PCR |
| 0.111 | 1.30E-10 | YOR098C | NUP1 | het | FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; both NUP1 and NUP60 are homologous to human NUP153 |
| 0.104 | 1.66E-9 | YDL215C | GDH2 | hom | NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels |
| 0.102 | 3.13E-9 | YKL005C | BYE1 | hom | Negative regulator of transcription elongation, contains a TFIIS-like domain and a PHD finger, multicopy suppressor of temperature-sensitive ess1 mutations, probably binds RNA polymerase II large subunit |
| 0.099 | 1.07E-8 | YDL219W | DTD1 | hom | D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes |
| 0.098 | 1.19E-8 | YPR033C | HTS1 | het | Cytoplasmic and mitochondrial histidine tRNA synthetase; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence; mutations in human ortholog HARS2 are associated with Perrault syndrome |
| 0.097 | 1.56E-8 | YDR479C | PEX29 | hom | Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress |
| 0.097 | 1.70E-8 | YEL030W | ECM10 | hom | Heat shock protein of the Hsp70 family; localized in mitochondrial nucleoids, plays a role in protein translocation, interacts with Mge1p in an ATP-dependent manner; overexpression induces extensive mitochondrial DNA aggregations; ECM10 has a paralog, SSC1, that arose from the whole genome duplication |
| 0.097 | 1.94E-8 | YER092W | IES5 | hom | Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions |
| 0.097 | 1.94E-8 | YBR066C | NRG2 | hom | Transcriptional repressor; mediates glucose repression and negatively regulates filamentous growth; NRG2 has a paralog, NRG1, that arose from the whole genome duplication |