YLR063W_p

Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR063W / YLR063W

Click on Significant Values for Screen Details ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.25|P-value:3.17E-4 ID:SGTC_295|Compound:k015-0027|FD-Score:3.02|P-value:7.49E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:-3.30|P-value:2.51E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.09|P-value:5.77E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:4.71|P-value:3.49E-7 ID:SGTC_650|Compound:1328-0195|FD-Score:3.35|P-value:2.10E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:10.60|P-value:3.97E-29 ID:SGTC_658|Compound:3253-0951|FD-Score:3.63|P-value:6.68E-5 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.26|P-value:2.93E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:-3.85|P-value:2.46E-5 ID:SGTC_1061|Compound:3448-9325|FD-Score:3.80|P-value:3.20E-5 ID:SGTC_1131|Compound:3454-3128|FD-Score:-3.83|P-value:2.67E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.59|P-value:7.85E-5 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.41|P-value:1.66E-4 ID:SGTC_1316|Compound:1272-0050|FD-Score:-3.15|P-value:4.46E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.25|P-value:3.10E-4 ID:SGTC_1674|Compound:st016616|FD-Score:3.25|P-value:3.06E-4 ID:SGTC_1695|Compound:st026914|FD-Score:4.02|P-value:1.15E-5 ID:SGTC_1696|Compound:st025591|FD-Score:-3.71|P-value:4.47E-5 ID:SGTC_1711|Compound:st032263|FD-Score:-2.96|P-value:8.89E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:3.11|P-value:5.21E-4 ID:SGTC_2071|Compound:5230951|FD-Score:-3.00|P-value:7.62E-4 ID:SGTC_2164|Compound:5685496|FD-Score:3.02|P-value:7.48E-4 ID:SGTC_2332|Compound:7982454|FD-Score:-4.48|P-value:1.16E-6 ID:SGTC_2370|Compound:9071495|FD-Score:3.32|P-value:2.34E-4 ID:SGTC_2383|Compound:9036125|FD-Score:-3.51|P-value:1.06E-4 ID:SGTC_2386|Compound:9075165|FD-Score:-3.32|P-value:2.25E-4 ID:SGTC_2389|Compound:9091542|FD-Score:3.53|P-value:1.01E-4 ID:SGTC_2975|Compound:9084847|FD-Score:-2.94|P-value:9.66E-4 ID:SGTC_3081|Compound:9117243|FD-Score:5.55|P-value:2.55E-9 ID:SGTC_3300|Compound:9124615|FD-Score:2.95|P-value:9.59E-4 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.25|P-value:3.17E-4 ID:SGTC_295|Compound:k015-0027|FD-Score:3.02|P-value:7.49E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:-3.30|P-value:2.51E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.09|P-value:5.77E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:4.71|P-value:3.49E-7 ID:SGTC_650|Compound:1328-0195|FD-Score:3.35|P-value:2.10E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:10.60|P-value:3.97E-29 ID:SGTC_658|Compound:3253-0951|FD-Score:3.63|P-value:6.68E-5 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.26|P-value:2.93E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:-3.85|P-value:2.46E-5 ID:SGTC_1061|Compound:3448-9325|FD-Score:3.80|P-value:3.20E-5 ID:SGTC_1131|Compound:3454-3128|FD-Score:-3.83|P-value:2.67E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.59|P-value:7.85E-5 ID:SGTC_1255|Compound:0566-0045|FD-Score:3.41|P-value:1.66E-4 ID:SGTC_1316|Compound:1272-0050|FD-Score:-3.15|P-value:4.46E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.25|P-value:3.10E-4 ID:SGTC_1674|Compound:st016616|FD-Score:3.25|P-value:3.06E-4 ID:SGTC_1695|Compound:st026914|FD-Score:4.02|P-value:1.15E-5 ID:SGTC_1696|Compound:st025591|FD-Score:-3.71|P-value:4.47E-5 ID:SGTC_1711|Compound:st032263|FD-Score:-2.96|P-value:8.89E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:3.11|P-value:5.21E-4 ID:SGTC_2071|Compound:5230951|FD-Score:-3.00|P-value:7.62E-4 ID:SGTC_2164|Compound:5685496|FD-Score:3.02|P-value:7.48E-4 ID:SGTC_2332|Compound:7982454|FD-Score:-4.48|P-value:1.16E-6 ID:SGTC_2370|Compound:9071495|FD-Score:3.32|P-value:2.34E-4 ID:SGTC_2383|Compound:9036125|FD-Score:-3.51|P-value:1.06E-4 ID:SGTC_2386|Compound:9075165|FD-Score:-3.32|P-value:2.25E-4 ID:SGTC_2389|Compound:9091542|FD-Score:3.53|P-value:1.01E-4 ID:SGTC_2975|Compound:9084847|FD-Score:-2.94|P-value:9.66E-4 ID:SGTC_3081|Compound:9117243|FD-Score:5.55|P-value:2.55E-9 ID:SGTC_3300|Compound:9124615|FD-Score:2.95|P-value:9.59E-4

Top fitness defect scores for YLR063W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_653 0203-0016 10.60 55.2 µM 3.97E-29 1 1.98E-26
2 SGTC_3081 9117243 5.55 49.5 µM 2.55E-9 fatty acid desaturase (OLE1) 7 1.44E-8
3 SGTC_372 0155-0182 4.71 15.9 µM 3.49E-7 mitochondrial response to ROS 19 1.23E-6
4 SGTC_1695 st026914 4.02 34.5 µM 1.15E-5 19 2.91E-5
5 SGTC_1061 3448-9325 3.80 110.0 µM 3.20E-5 27 7.35E-5
6 SGTC_658 3253-0951 3.63 102.0 µM 6.68E-5 calcium & mitochondrial duress 73 1.43E-4
7 SGTC_1251 0490-5699 3.59 265.0 µM 7.85E-5 45 1.65E-4
8 SGTC_2389 9091542 3.53 195.5 µM 1.01E-4 iron homeostasis 49 2.09E-4
9 SGTC_1255 0566-0045 3.41 221.0 µM 1.66E-4 excess fatty acid 46 3.26E-4
10 SGTC_650 1328-0195 3.35 38.0 µM 2.10E-4 37 4.03E-4
11 SGTC_2370 9071495 3.32 200.0 µM 2.34E-4 mitochondrial processes 44 4.45E-4
12 SGTC_1674 st016616 3.25 23.6 µM 3.06E-4 57 5.68E-4
13 SGTC_1351 1496-0003 3.25 46.5 µM 3.10E-4 41 5.74E-4
14 SGTC_242 5hr heat shock (37°C) + 5-fluorouracil 3.25 4.6 µM 3.17E-4 heat shock/prefoldin 66 5.87E-4
15 SGTC_1894 3',6'-dihydroxyflavone 3.11 78.7 µM 5.21E-4 40 9.20E-4
16 SGTC_358 0075-0058 3.09 9.4 µM 5.77E-4 121 0.00101
17 SGTC_2164 5685496 3.02 200.0 µM 7.48E-4 49 0.00128
18 SGTC_295 k015-0027 3.02 31.0 µM 7.49E-4 PDR1 39 0.00128
19 SGTC_3300 9124615 2.95 50.5 µM 9.59E-4 70 0.00160
20 SGTC_2252 omeprazole 2.91 400.0 µM 0.00108 35 0.00178

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.155 1.52E-19 YNL254C RTC4 hom Protein of unknown function; null mutation suppresses cdc13-1 temperature sensitivity; (GFP)-fusion protein localizes to both the cytoplasm and the nucleus
0.121 2.35E-12 YDL221W_d YDL221W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 3' end of essential gene CDC13
0.118 7.78E-12 YOR150W MRPL23 hom Mitochondrial ribosomal protein of the large subunit
0.115 2.49E-11 YHR110W ERP5 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.112 9.78E-11 YNL061W NOP2 het Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles
0.111 1.08E-10 YPR108W-A_p YPR108W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.111 1.30E-10 YOR098C NUP1 het FG-nucleoporin component of central core of the nuclear pore complex (NPC); contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier; possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; both NUP1 and NUP60 are homologous to human NUP153
0.104 1.66E-9 YDL215C GDH2 hom NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels
0.102 3.13E-9 YKL005C BYE1 hom Negative regulator of transcription elongation, contains a TFIIS-like domain and a PHD finger, multicopy suppressor of temperature-sensitive ess1 mutations, probably binds RNA polymerase II large subunit
0.099 1.07E-8 YDL219W DTD1 hom D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes
0.098 1.19E-8 YPR033C HTS1 het Cytoplasmic and mitochondrial histidine tRNA synthetase; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence; mutations in human ortholog HARS2 are associated with Perrault syndrome
0.097 1.56E-8 YDR479C PEX29 hom Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress
0.097 1.70E-8 YEL030W ECM10 hom Heat shock protein of the Hsp70 family; localized in mitochondrial nucleoids, plays a role in protein translocation, interacts with Mge1p in an ATP-dependent manner; overexpression induces extensive mitochondrial DNA aggregations; ECM10 has a paralog, SSC1, that arose from the whole genome duplication
0.097 1.94E-8 YER092W IES5 hom Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions
0.097 1.94E-8 YBR066C NRG2 hom Transcriptional repressor; mediates glucose repression and negatively regulates filamentous growth; NRG2 has a paralog, NRG1, that arose from the whole genome duplication