YLR067C / PET309

Specific translational activator for the COX1 mRNA, also influences stability of intron-containing COX1 primary transcripts; localizes to the mitochondrial inner membrane; contains seven pentatricopeptide repeats (PPRs)

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR067C / PET309

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:5.99|P-value:2.98E-9 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:5.78|P-value:9.71E-9 ID:SGTC_63|Compound:0099-0242|FD-Score:3.91|P-value:7.29E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:3.71|P-value:1.57E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:4.87|P-value:1.14E-6 ID:SGTC_168|Compound:3970-0862|FD-Score:3.55|P-value:2.82E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:6.86|P-value:1.32E-11 ID:SGTC_195|Compound:4234-0266|FD-Score:3.36|P-value:5.46E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:7.17|P-value:1.58E-12 ID:SGTC_275|Compound:trichlorophene|FD-Score:8.89|P-value:2.86E-18 ID:SGTC_293|Compound:4049-0273|FD-Score:-3.29|P-value:6.98E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:9.78|P-value:9.91E-22 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.02|P-value:4.61E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:3.31|P-value:6.40E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:3.72|P-value:1.52E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-5.97|P-value:3.28E-9 ID:SGTC_832|Compound:4083-0019|FD-Score:4.04|P-value:4.36E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:3.38|P-value:5.06E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:3.64|P-value:2.03E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:4.26|P-value:1.75E-5 ID:SGTC_1074|Compound:carmofur|FD-Score:3.39|P-value:5.03E-4 ID:SGTC_1156|Compound:4092-0367|FD-Score:-4.05|P-value:4.15E-5 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.21|P-value:9.05E-4 ID:SGTC_1219|Compound:1469-0211|FD-Score:-3.23|P-value:8.37E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:4.10|P-value:3.40E-5 ID:SGTC_1627|Compound:st003713|FD-Score:3.20|P-value:9.50E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.38|P-value:5.15E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-4.18|P-value:2.41E-5 ID:SGTC_1715|Compound:st032160|FD-Score:-3.51|P-value:3.22E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.39|P-value:5.03E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.98|P-value:6.38E-7 ID:SGTC_1742|Compound:st038235|FD-Score:4.78|P-value:1.70E-6 ID:SGTC_1754|Compound:st042065|FD-Score:-3.89|P-value:7.71E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-4.17|P-value:2.53E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-6.65|P-value:5.08E-11 ID:SGTC_1847|Compound:st056231|FD-Score:3.19|P-value:9.59E-4 ID:SGTC_1887|Compound:st057648|FD-Score:3.39|P-value:4.93E-4 ID:SGTC_1908|Compound:st060353|FD-Score:3.97|P-value:5.67E-5 ID:SGTC_1909|Compound:st060837|FD-Score:6.47|P-value:1.62E-10 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.49|P-value:3.48E-4 ID:SGTC_1944|Compound:st076371|FD-Score:3.51|P-value:3.29E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.60|P-value:3.87E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.28|P-value:1.61E-5 ID:SGTC_2324|Compound:6149169|FD-Score:3.55|P-value:2.84E-4 ID:SGTC_2368|Compound:9071271|FD-Score:4.55|P-value:4.88E-6 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.21|P-value:9.06E-4 ID:SGTC_2442|Compound:5158906|FD-Score:-3.31|P-value:6.53E-4 ID:SGTC_2452|Compound:5863136|FD-Score:-3.56|P-value:2.73E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:3.30|P-value:6.73E-4 ID:SGTC_2526|Compound:patulin|FD-Score:5.60|P-value:2.65E-8 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-3.24|P-value:8.26E-4 ID:SGTC_2783|Compound:7738165|FD-Score:3.88|P-value:8.16E-5 ID:SGTC_2942|Compound:9052777|FD-Score:4.48|P-value:6.87E-6 ID:SGTC_3132|Compound:9126706|FD-Score:-3.73|P-value:1.46E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-4.11|P-value:3.27E-5 ID:SGTC_3143|Compound:9086658|FD-Score:3.88|P-value:8.10E-5 ID:SGTC_3214|Compound:9129694|FD-Score:-3.95|P-value:6.20E-5 ID:SGTC_3266|Compound:9136860|FD-Score:-3.22|P-value:8.64E-4 ID:SGTC_3290|Compound:9121031|FD-Score:3.21|P-value:9.18E-4 ID:SGTC_3325|Compound:9138760|FD-Score:4.15|P-value:2.80E-5 ID:SGTC_10|Compound:0279-0212|FD-Score:5.99|P-value:2.98E-9 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:5.78|P-value:9.71E-9 ID:SGTC_63|Compound:0099-0242|FD-Score:3.91|P-value:7.29E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:3.71|P-value:1.57E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:4.87|P-value:1.14E-6 ID:SGTC_168|Compound:3970-0862|FD-Score:3.55|P-value:2.82E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:6.86|P-value:1.32E-11 ID:SGTC_195|Compound:4234-0266|FD-Score:3.36|P-value:5.46E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:7.17|P-value:1.58E-12 ID:SGTC_275|Compound:trichlorophene|FD-Score:8.89|P-value:2.86E-18 ID:SGTC_293|Compound:4049-0273|FD-Score:-3.29|P-value:6.98E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:9.78|P-value:9.91E-22 ID:SGTC_339|Compound:3091-4833|FD-Score:-4.02|P-value:4.61E-5 ID:SGTC_365|Compound:0121-0052|FD-Score:3.31|P-value:6.40E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:3.72|P-value:1.52E-4 ID:SGTC_758|Compound:0868-0029|FD-Score:-5.97|P-value:3.28E-9 ID:SGTC_832|Compound:4083-0019|FD-Score:4.04|P-value:4.36E-5 ID:SGTC_908|Compound:3448-7491|FD-Score:3.38|P-value:5.06E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:3.64|P-value:2.03E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:4.26|P-value:1.75E-5 ID:SGTC_1074|Compound:carmofur|FD-Score:3.39|P-value:5.03E-4 ID:SGTC_1156|Compound:4092-0367|FD-Score:-4.05|P-value:4.15E-5 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.21|P-value:9.05E-4 ID:SGTC_1219|Compound:1469-0211|FD-Score:-3.23|P-value:8.37E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:4.10|P-value:3.40E-5 ID:SGTC_1627|Compound:st003713|FD-Score:3.20|P-value:9.50E-4 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:3.38|P-value:5.15E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-4.18|P-value:2.41E-5 ID:SGTC_1715|Compound:st032160|FD-Score:-3.51|P-value:3.22E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.39|P-value:5.03E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.98|P-value:6.38E-7 ID:SGTC_1742|Compound:st038235|FD-Score:4.78|P-value:1.70E-6 ID:SGTC_1754|Compound:st042065|FD-Score:-3.89|P-value:7.71E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-4.17|P-value:2.53E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-6.65|P-value:5.08E-11 ID:SGTC_1847|Compound:st056231|FD-Score:3.19|P-value:9.59E-4 ID:SGTC_1887|Compound:st057648|FD-Score:3.39|P-value:4.93E-4 ID:SGTC_1908|Compound:st060353|FD-Score:3.97|P-value:5.67E-5 ID:SGTC_1909|Compound:st060837|FD-Score:6.47|P-value:1.62E-10 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.49|P-value:3.48E-4 ID:SGTC_1944|Compound:st076371|FD-Score:3.51|P-value:3.29E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.60|P-value:3.87E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.28|P-value:1.61E-5 ID:SGTC_2324|Compound:6149169|FD-Score:3.55|P-value:2.84E-4 ID:SGTC_2368|Compound:9071271|FD-Score:4.55|P-value:4.88E-6 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.21|P-value:9.06E-4 ID:SGTC_2442|Compound:5158906|FD-Score:-3.31|P-value:6.53E-4 ID:SGTC_2452|Compound:5863136|FD-Score:-3.56|P-value:2.73E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:3.30|P-value:6.73E-4 ID:SGTC_2526|Compound:patulin|FD-Score:5.60|P-value:2.65E-8 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-3.24|P-value:8.26E-4 ID:SGTC_2783|Compound:7738165|FD-Score:3.88|P-value:8.16E-5 ID:SGTC_2942|Compound:9052777|FD-Score:4.48|P-value:6.87E-6 ID:SGTC_3132|Compound:9126706|FD-Score:-3.73|P-value:1.46E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-4.11|P-value:3.27E-5 ID:SGTC_3143|Compound:9086658|FD-Score:3.88|P-value:8.10E-5 ID:SGTC_3214|Compound:9129694|FD-Score:-3.95|P-value:6.20E-5 ID:SGTC_3266|Compound:9136860|FD-Score:-3.22|P-value:8.64E-4 ID:SGTC_3290|Compound:9121031|FD-Score:3.21|P-value:9.18E-4 ID:SGTC_3325|Compound:9138760|FD-Score:4.15|P-value:2.80E-5

Top fitness defect scores for YLR067C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_310 1273-0058 9.78 1.1 µM 9.91E-22 mitochondrial stress 44 6.64E-23
2 SGTC_275 trichlorophene 8.89 5.7 µM 2.86E-18 mitochondrial stress 57 3.06E-19
3 SGTC_236 1509-0011 7.17 5.3 µM 1.58E-12 267 3.65E-13
4 SGTC_173 1273-0061 6.86 2.7 µM 1.32E-11 mitochondrial stress 90 3.44E-12
5 SGTC_1909 st060837 6.47 51.5 µM 1.62E-10 16 4.88E-11
6 SGTC_10 0279-0212 5.99 42.6 µM 2.98E-9 TRP & mitochondrial translation 30 1.06E-9
7 SGTC_28 pentachloropyridine N-oxide 5.78 1.6 µM 9.71E-9 TSC3-RPN4 18 3.71E-9
8 SGTC_2526 patulin 5.60 37.6 µM 2.65E-8 32 1.07E-8
9 SGTC_119 0121-0043 4.87 24.8 µM 1.14E-6 mitochondrial stress 64 5.69E-7
10 SGTC_1742 st038235 4.78 28.9 µM 1.70E-6 mitochondrial stress 86 8.73E-7
11 SGTC_2232 chlorophetanol 4.60 41.5 µM 3.87E-6 TRP & mitochondrial translation 98 2.08E-6
12 SGTC_2368 9071271 4.55 200.0 µM 4.88E-6 17 2.66E-6
13 SGTC_2942 9052777 4.48 62.2 µM 6.87E-6 20 3.81E-6
14 SGTC_2250 alverine citrate 4.28 130.0 µM 1.61E-5 136 9.36E-6
15 SGTC_1017 4239-0030 4.26 168.0 µM 1.75E-5 19 1.03E-5
16 SGTC_3325 9138760 4.15 55.2 µM 2.80E-5 Golgi 22 1.69E-5
17 SGTC_1247 0448-0043 4.10 5.8 µM 3.40E-5 ERG2 36 2.07E-5
18 SGTC_832 4083-0019 4.04 164.0 µM 4.36E-5 translation 90 2.68E-5
19 SGTC_1908 st060353 3.97 56.5 µM 5.67E-5 RPP1 & pyrimidine depletion 34 3.55E-5
20 SGTC_63 0099-0242 3.91 26.7 µM 7.29E-5 mitochondrial stress 88 4.62E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.429 1.68E-150 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.423 5.23E-146 YLR091W GEP5 hom Protein of unknown function, required for mitochondrial genome maintenance; detected in highly purified mitochondria in high-throughput studies; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine
0.422 1.78E-144 YLR260W LCB5 hom Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules
0.418 3.86E-142 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.418 4.50E-142 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.412 9.62E-138 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.404 3.11E-132 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.404 5.79E-132 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.401 4.55E-130 YIL093C RSM25 hom Mitochondrial ribosomal protein of the small subunit
0.397 7.03E-127 YGR165W MRPS35 hom Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets
0.396 1.00E-125 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.394 7.84E-125 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.393 2.99E-124 YIL070C MAM33 hom Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation; related to the human complement receptor gC1q-R
0.393 5.33E-124 YNL081C SWS2 hom Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency
0.391 8.66E-123 YMR097C MTG1 hom Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals