HIPHOP chemogenomics database

YLR067C / PET309

Specific translational activator for the COX1 mRNA, also influences stability of intron-containing COX1 primary transcripts; localizes to the mitochondrial inner membrane; contains seven pentatricopeptide repeats (PPRs)

Zygosity: Homozygous strain

fixedexpanded
Profile for YLR067C / PET309

Click on Significant Values for Screen Details

Top fitness defect scores for YLR067C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_310	1273-0058	9.78	1.1 µM	9.91E-22	mitochondrial stress	44	6.64E-23
2	SGTC_275	trichlorophene	8.89	5.7 µM	2.86E-18	mitochondrial stress	57	3.06E-19
3	SGTC_236	1509-0011	7.17	5.3 µM	1.58E-12		267	3.65E-13
4	SGTC_173	1273-0061	6.86	2.7 µM	1.32E-11	mitochondrial stress	90	3.44E-12
5	SGTC_1909	st060837	6.47	51.5 µM	1.62E-10		16	4.88E-11
6	SGTC_10	0279-0212	5.99	42.6 µM	2.98E-9	TRP & mitochondrial translation	30	1.06E-9
7	SGTC_28	pentachloropyridine N-oxide	5.78	1.6 µM	9.71E-9	TSC3-RPN4	18	3.71E-9
8	SGTC_2526	patulin	5.60	37.6 µM	2.65E-8		32	1.07E-8
9	SGTC_119	0121-0043	4.87	24.8 µM	1.14E-6	mitochondrial stress	64	5.69E-7
10	SGTC_1742	st038235	4.78	28.9 µM	1.70E-6	mitochondrial stress	86	8.73E-7
11	SGTC_2232	chlorophetanol	4.60	41.5 µM	3.87E-6	TRP & mitochondrial translation	98	2.08E-6
12	SGTC_2368	9071271	4.55	200.0 µM	4.88E-6		17	2.66E-6
13	SGTC_2942	9052777	4.48	62.2 µM	6.87E-6		20	3.81E-6
14	SGTC_2250	alverine citrate	4.28	130.0 µM	1.61E-5		136	9.36E-6
15	SGTC_1017	4239-0030	4.26	168.0 µM	1.75E-5		19	1.03E-5
16	SGTC_3325	9138760	4.15	55.2 µM	2.80E-5	Golgi	22	1.69E-5
17	SGTC_1247	0448-0043	4.10	5.8 µM	3.40E-5	ERG2	36	2.07E-5
18	SGTC_832	4083-0019	4.04	164.0 µM	4.36E-5	translation	90	2.68E-5
19	SGTC_1908	st060353	3.97	56.5 µM	5.67E-5	RPP1 & pyrimidine depletion	34	3.55E-5
20	SGTC_63	0099-0242	3.91	26.7 µM	7.29E-5	mitochondrial stress	88	4.62E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.429	1.68E-150	YER050C	RSM18	hom	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.423	5.23E-146	YLR091W	GEP5	hom	Protein of unknown function, required for mitochondrial genome maintenance; detected in highly purified mitochondria in high-throughput studies; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine
0.422	1.78E-144	YLR260W	LCB5	hom	Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules
0.418	3.86E-142	YMR228W	MTF1	hom	Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.418	4.50E-142	YDR462W	MRPL28	hom	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.412	9.62E-138	YGR102C	GTF1	hom	Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.404	3.11E-132	YPL040C	ISM1	hom	Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.404	5.79E-132	YDR194C	MSS116	hom	DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.401	4.55E-130	YIL093C	RSM25	hom	Mitochondrial ribosomal protein of the small subunit
0.397	7.03E-127	YGR165W	MRPS35	hom	Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets
0.396	1.00E-125	YMR287C	DSS1	hom	3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.394	7.84E-125	YGR215W	RSM27	hom	Mitochondrial ribosomal protein of the small subunit
0.393	2.99E-124	YIL070C	MAM33	hom	Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation; related to the human complement receptor gC1q-R
0.393	5.33E-124	YNL081C	SWS2	hom	Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency
0.391	8.66E-123	YMR097C	MTG1	hom	Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals