YLR072W_p

Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YLR072W is not an esssential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR072W / YLR072W

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:3.74|P-value:1.11E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:6.34|P-value:1.99E-10 ID:SGTC_294|Compound:k038-0071|FD-Score:4.20|P-value:1.68E-5 ID:SGTC_335|Compound:4077-0256|FD-Score:4.45|P-value:5.54E-6 ID:SGTC_340|Compound:k038-0059|FD-Score:3.29|P-value:5.91E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:-3.64|P-value:1.58E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:3.60|P-value:1.89E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:-4.02|P-value:3.51E-5 ID:SGTC_828|Compound:2074-0507|FD-Score:3.97|P-value:4.40E-5 ID:SGTC_861|Compound:0443-0273|FD-Score:3.17|P-value:8.84E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:3.98|P-value:4.24E-5 ID:SGTC_926|Compound:2268-1401|FD-Score:4.45|P-value:5.65E-6 ID:SGTC_927|Compound:2425-1185|FD-Score:-4.09|P-value:2.57E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.33|P-value:5.07E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.41|P-value:3.87E-4 ID:SGTC_1289|Compound:0976-0073|FD-Score:-3.40|P-value:3.91E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.21|P-value:7.82E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:5.30|P-value:8.55E-8 ID:SGTC_1391|Compound:3442-0225|FD-Score:-3.77|P-value:9.64E-5 ID:SGTC_1401|Compound:3807-4679|FD-Score:-4.81|P-value:9.77E-7 ID:SGTC_1403|Compound:3909-7815|FD-Score:4.43|P-value:6.28E-6 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.52|P-value:2.54E-4 ID:SGTC_1498|Compound:4478-3555|FD-Score:3.38|P-value:4.20E-4 ID:SGTC_1654|Compound:st012436|FD-Score:-3.40|P-value:3.80E-4 ID:SGTC_1683|Compound:st010134|FD-Score:3.96|P-value:4.67E-5 ID:SGTC_1867|Compound:st057372|FD-Score:-3.18|P-value:8.21E-4 ID:SGTC_1939|Compound:st074455|FD-Score:7.65|P-value:2.13E-14 ID:SGTC_2305|Compound:7443522|FD-Score:-4.46|P-value:5.15E-6 ID:SGTC_2347|Compound:9049783|FD-Score:-3.24|P-value:6.82E-4 ID:SGTC_2359|Compound:9039622|FD-Score:-4.36|P-value:8.25E-6 ID:SGTC_2483|Compound:5729050|FD-Score:3.28|P-value:6.11E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:6.22|P-value:4.04E-10 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:-3.66|P-value:1.45E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:3.24|P-value:7.08E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.39|P-value:4.05E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-4.11|P-value:2.43E-5 ID:SGTC_2913|Compound:7966556|FD-Score:3.70|P-value:1.30E-4 ID:SGTC_2924|Compound:9010168|FD-Score:3.25|P-value:6.78E-4 ID:SGTC_3044|Compound:9093193|FD-Score:3.85|P-value:7.28E-5 ID:SGTC_3153|Compound:9100258|FD-Score:3.27|P-value:6.21E-4 ID:SGTC_3171|Compound:9103192|FD-Score:3.54|P-value:2.43E-4 ID:SGTC_3287|Compound:9117173|FD-Score:4.18|P-value:1.88E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:3.74|P-value:1.11E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:6.34|P-value:1.99E-10 ID:SGTC_294|Compound:k038-0071|FD-Score:4.20|P-value:1.68E-5 ID:SGTC_335|Compound:4077-0256|FD-Score:4.45|P-value:5.54E-6 ID:SGTC_340|Compound:k038-0059|FD-Score:3.29|P-value:5.91E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:-3.64|P-value:1.58E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:3.60|P-value:1.89E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:-4.02|P-value:3.51E-5 ID:SGTC_828|Compound:2074-0507|FD-Score:3.97|P-value:4.40E-5 ID:SGTC_861|Compound:0443-0273|FD-Score:3.17|P-value:8.84E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:3.98|P-value:4.24E-5 ID:SGTC_926|Compound:2268-1401|FD-Score:4.45|P-value:5.65E-6 ID:SGTC_927|Compound:2425-1185|FD-Score:-4.09|P-value:2.57E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.33|P-value:5.07E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:3.41|P-value:3.87E-4 ID:SGTC_1289|Compound:0976-0073|FD-Score:-3.40|P-value:3.91E-4 ID:SGTC_1355|Compound:1499-0035|FD-Score:3.21|P-value:7.82E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:5.30|P-value:8.55E-8 ID:SGTC_1391|Compound:3442-0225|FD-Score:-3.77|P-value:9.64E-5 ID:SGTC_1401|Compound:3807-4679|FD-Score:-4.81|P-value:9.77E-7 ID:SGTC_1403|Compound:3909-7815|FD-Score:4.43|P-value:6.28E-6 ID:SGTC_1426|Compound:4048-4480|FD-Score:3.52|P-value:2.54E-4 ID:SGTC_1498|Compound:4478-3555|FD-Score:3.38|P-value:4.20E-4 ID:SGTC_1654|Compound:st012436|FD-Score:-3.40|P-value:3.80E-4 ID:SGTC_1683|Compound:st010134|FD-Score:3.96|P-value:4.67E-5 ID:SGTC_1867|Compound:st057372|FD-Score:-3.18|P-value:8.21E-4 ID:SGTC_1939|Compound:st074455|FD-Score:7.65|P-value:2.13E-14 ID:SGTC_2305|Compound:7443522|FD-Score:-4.46|P-value:5.15E-6 ID:SGTC_2347|Compound:9049783|FD-Score:-3.24|P-value:6.82E-4 ID:SGTC_2359|Compound:9039622|FD-Score:-4.36|P-value:8.25E-6 ID:SGTC_2483|Compound:5729050|FD-Score:3.28|P-value:6.11E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:6.22|P-value:4.04E-10 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:-3.66|P-value:1.45E-4 ID:SGTC_2560|Compound:caryophyllene|FD-Score:3.24|P-value:7.08E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.39|P-value:4.05E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-4.11|P-value:2.43E-5 ID:SGTC_2913|Compound:7966556|FD-Score:3.70|P-value:1.30E-4 ID:SGTC_2924|Compound:9010168|FD-Score:3.25|P-value:6.78E-4 ID:SGTC_3044|Compound:9093193|FD-Score:3.85|P-value:7.28E-5 ID:SGTC_3153|Compound:9100258|FD-Score:3.27|P-value:6.21E-4 ID:SGTC_3171|Compound:9103192|FD-Score:3.54|P-value:2.43E-4 ID:SGTC_3287|Compound:9117173|FD-Score:4.18|P-value:1.88E-5

Top fitness defect scores for YLR072W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1939 st074455 7.65 53.6 µM 2.13E-14 2 1.00E-14
2 SGTC_103 0844-0104 6.34 51.8 µM 1.99E-10 ERAD & cell cycle 72 1.18E-10
3 SGTC_2546 rhodinyl acetate 6.22 100.0 µM 4.04E-10 3 2.43E-10
4 SGTC_1390 3413-2614 5.30 145.0 µM 8.55E-8 fatty acid desaturase (OLE1) 7 5.88E-8
5 SGTC_335 4077-0256 4.45 27.6 µM 5.54E-6 12 4.22E-6
6 SGTC_926 2268-1401 4.45 59.4 µM 5.65E-6 TSC3-RPN4 23 4.31E-6
7 SGTC_1403 3909-7815 4.43 62.9 µM 6.28E-6 10 4.80E-6
8 SGTC_294 k038-0071 4.20 157.0 µM 1.68E-5 ubiquinone biosynthesis & proteasome 53 1.32E-5
9 SGTC_3287 9117173 4.18 37.1 µM 1.88E-5 60S ribosome export 3 1.48E-5
10 SGTC_907 3448-6986 3.98 75.5 µM 4.24E-5 26 3.40E-5
11 SGTC_828 2074-0507 3.97 139.0 µM 4.40E-5 RPP1 & pyrimidine depletion 23 3.53E-5
12 SGTC_1683 st010134 3.96 710.0 nM 4.67E-5 28 3.75E-5
13 SGTC_3044 9093193 3.85 49.5 µM 7.28E-5 26 5.91E-5
14 SGTC_64 000l-0018 3.74 272.1 µM 1.11E-4 ubiquinone biosynthesis & proteasome 164 9.08E-5
15 SGTC_2913 7966556 3.70 36.6 µM 1.30E-4 60S ribosome export 19 1.07E-4
16 SGTC_372 0155-0182 3.60 15.9 µM 1.89E-4 mitochondrial response to ROS 39 1.57E-4
17 SGTC_3171 9103192 3.54 49.5 µM 2.43E-4 9 2.04E-4
18 SGTC_1426 4048-4480 3.52 71.7 µM 2.54E-4 60S ribosome export 28 2.12E-4
19 SGTC_1281 0884-0031 3.41 11.8 µM 3.87E-4 fatty acid desaturase (OLE1) 42 3.27E-4
20 SGTC_2593 nobiletin 3.39 86.2 µM 4.05E-4 47 3.43E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.197 9.54E-31 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.169 8.17E-23 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.164 9.24E-22 YOL065C INP54 hom Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins
0.156 1.04E-19 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.147 1.12E-17 YFR007W YFH7 hom Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases
0.133 1.21E-14 YDR031W MIC14 hom Mitochondrial intermembrane space protein of unknown function; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress
0.129 6.45E-14 YMR008C PLB1 hom Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol
0.127 1.54E-13 YGR089W NNF2 hom Protein that exhibits physical and genetic interactions with Rpb8p, which is a subunit of RNA polymerases I, II, and III; computational analysis of large-scale protein-protein interaction data suggests a role in chromosome segregation
0.125 4.38E-13 YDL126C CDC48 het AAA ATPase involved in multiple processes; subunit of polyubiquitin-selective segregase complex involved in ERAD, cell wall integrity during heat stress, mitotic spindle disassembly; subunit of complex involved in mitochondria-associated degradation; role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing; roles in macroautophagy, PMN, RAD, ribophagy, and homotypic ER membrane fusion; functional ortholog of human p97/VCP
0.124 4.86E-13 YOR057W SGT1 het Cochaperone protein; regulates activity of adenylyl cyclase Cyr1p; involved in kinetochore complex assembly; associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex; acts as a linker between Skp1p and HSP90 complexes; protein abundance increases in response to DNA replication stress
0.121 1.86E-12 YOR246C ENV9 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.121 2.31E-12 YAL051W OAF1 hom Oleate-activated transcription factor; acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis; OAF1 has a paralog, PIP2, that arose from the whole genome duplication
0.119 3.83E-12 YMR067C UBX4 hom UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress
0.119 3.99E-12 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.118 5.80E-12 YMR029C FAR8 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p