YLR080W / EMP46

Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR080W / EMP46

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:2.89|P-value:9.30E-4 ID:SGTC_57|Compound:miconazole|FD-Score:3.16|P-value:3.35E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.07|P-value:4.74E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:-3.15|P-value:4.84E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:3.57|P-value:6.21E-5 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.14|P-value:3.66E-4 ID:SGTC_1410|Compound:3909-8106|FD-Score:2.91|P-value:8.42E-4 ID:SGTC_1677|Compound:st019204|FD-Score:-3.39|P-value:1.88E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:-3.96|P-value:1.56E-5 ID:SGTC_2035|Compound:5154463|FD-Score:2.87|P-value:9.73E-4 ID:SGTC_2341|Compound:7987486|FD-Score:3.00|P-value:6.22E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:3.08|P-value:4.56E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.17|P-value:3.16E-4 ID:SGTC_2650|Compound:prasterone|FD-Score:3.96|P-value:1.08E-5 ID:SGTC_2667|Compound:digitoxin|FD-Score:3.17|P-value:3.18E-4 ID:SGTC_2678|Compound:equilin|FD-Score:3.06|P-value:4.81E-4 ID:SGTC_2680|Compound:butyl paraben|FD-Score:-3.07|P-value:6.57E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.02|P-value:5.66E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.47|P-value:9.63E-5 ID:SGTC_2829|Compound:7992743|FD-Score:3.96|P-value:1.06E-5 ID:SGTC_2834|Compound:9001755|FD-Score:3.46|P-value:9.73E-5 ID:SGTC_2859|Compound:9028643|FD-Score:3.11|P-value:3.98E-4 ID:SGTC_2970|Compound:9090938|FD-Score:4.28|P-value:2.19E-6 ID:SGTC_2992|Compound:9074591|FD-Score:-3.01|P-value:8.10E-4 ID:SGTC_2999|Compound:9069765|FD-Score:3.61|P-value:5.13E-5 ID:SGTC_3155|Compound:9099265|FD-Score:4.24|P-value:2.72E-6 ID:SGTC_3191|Compound:9110352|FD-Score:-3.05|P-value:6.98E-4 ID:SGTC_3196|Compound:9111891|FD-Score:-3.12|P-value:5.33E-4 ID:SGTC_3214|Compound:9129694|FD-Score:3.80|P-value:2.26E-5 ID:SGTC_3219|Compound:9131112|FD-Score:6.17|P-value:2.05E-11 ID:SGTC_38|Compound:0929-0051|FD-Score:2.89|P-value:9.30E-4 ID:SGTC_57|Compound:miconazole|FD-Score:3.16|P-value:3.35E-4 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.07|P-value:4.74E-4 ID:SGTC_752|Compound:1896-0090|FD-Score:-3.15|P-value:4.84E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:3.57|P-value:6.21E-5 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.14|P-value:3.66E-4 ID:SGTC_1410|Compound:3909-8106|FD-Score:2.91|P-value:8.42E-4 ID:SGTC_1677|Compound:st019204|FD-Score:-3.39|P-value:1.88E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:-3.96|P-value:1.56E-5 ID:SGTC_2035|Compound:5154463|FD-Score:2.87|P-value:9.73E-4 ID:SGTC_2341|Compound:7987486|FD-Score:3.00|P-value:6.22E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:3.08|P-value:4.56E-4 ID:SGTC_2639|Compound:lactacystin|FD-Score:3.17|P-value:3.16E-4 ID:SGTC_2650|Compound:prasterone|FD-Score:3.96|P-value:1.08E-5 ID:SGTC_2667|Compound:digitoxin|FD-Score:3.17|P-value:3.18E-4 ID:SGTC_2678|Compound:equilin|FD-Score:3.06|P-value:4.81E-4 ID:SGTC_2680|Compound:butyl paraben|FD-Score:-3.07|P-value:6.57E-4 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.02|P-value:5.66E-4 ID:SGTC_2807|Compound:7945238|FD-Score:3.47|P-value:9.63E-5 ID:SGTC_2829|Compound:7992743|FD-Score:3.96|P-value:1.06E-5 ID:SGTC_2834|Compound:9001755|FD-Score:3.46|P-value:9.73E-5 ID:SGTC_2859|Compound:9028643|FD-Score:3.11|P-value:3.98E-4 ID:SGTC_2970|Compound:9090938|FD-Score:4.28|P-value:2.19E-6 ID:SGTC_2992|Compound:9074591|FD-Score:-3.01|P-value:8.10E-4 ID:SGTC_2999|Compound:9069765|FD-Score:3.61|P-value:5.13E-5 ID:SGTC_3155|Compound:9099265|FD-Score:4.24|P-value:2.72E-6 ID:SGTC_3191|Compound:9110352|FD-Score:-3.05|P-value:6.98E-4 ID:SGTC_3196|Compound:9111891|FD-Score:-3.12|P-value:5.33E-4 ID:SGTC_3214|Compound:9129694|FD-Score:3.80|P-value:2.26E-5 ID:SGTC_3219|Compound:9131112|FD-Score:6.17|P-value:2.05E-11

Top fitness defect scores for YLR080W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3219 9131112 6.17 49.5 µM 2.05E-11 Golgi 14 3.44E-10
2 SGTC_2970 9090938 4.28 41.9 µM 2.19E-6 RNA processing & uracil transport 29 9.35E-6
3 SGTC_3155 9099265 4.24 49.5 µM 2.72E-6 19 1.13E-5
4 SGTC_2829 7992743 3.96 58.4 µM 1.06E-5 38 3.76E-5
5 SGTC_2650 prasterone 3.96 100.0 µM 1.08E-5 16 3.82E-5
6 SGTC_3214 9129694 3.80 49.5 µM 2.26E-5 32 7.33E-5
7 SGTC_2999 9069765 3.61 71.4 µM 5.13E-5 amide catabolism 40 1.51E-4
8 SGTC_779 1360-0071 3.57 233.0 µM 6.21E-5 fatty acid desaturase (OLE1) 48 1.79E-4
9 SGTC_2807 7945238 3.47 52.0 µM 9.63E-5 45 2.64E-4
10 SGTC_2834 9001755 3.46 58.4 µM 9.73E-5 49 2.66E-4
11 SGTC_2639 lactacystin 3.17 53.0 µM 3.16E-4 58 7.52E-4
12 SGTC_2667 digitoxin 3.17 100.0 µM 3.18E-4 14 7.57E-4
13 SGTC_57 miconazole 3.16 162.5 nM 3.35E-4 ergosterol depletion effects on membrane 52 7.92E-4
14 SGTC_1004 4084-0029 3.14 199.0 µM 3.66E-4 56 8.57E-4
15 SGTC_2859 9028643 3.11 45.5 µM 3.98E-4 41 9.21E-4
16 SGTC_2586 curcumin 3.08 80.0 µM 4.56E-4 iron homeostasis 106 0.00104
17 SGTC_217 ketoconazole 3.07 989.0 nM 4.74E-4 ergosterol depletion effects on membrane 65 0.00108
18 SGTC_2678 equilin 3.06 100.0 µM 4.81E-4 54 0.00109
19 SGTC_2765 myclobutanil 3.02 7.7 µM 5.66E-4 azole & statin 94 0.00126
20 SGTC_2341 7987486 3.00 176.7 µM 6.22E-4 59 0.00137

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.244 1.19E-46 YKR031C SPO14 hom Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participates in transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions
0.148 6.78E-18 YMR079W SEC14 het Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs
0.144 4.71E-17 YJL042W MHP1 hom Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins
0.142 1.64E-16 YDL172C_d YDL172C_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
0.128 1.01E-13 YJR004C SAG1 hom Alpha-agglutinin of alpha-cells, binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchor
0.124 5.70E-13 YDR436W PPZ2 hom Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
0.104 1.35E-9 YNR039C ZRG17 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Msc2p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; zinc-regulated directly through Zap1p; transcription induced under conditions of zinc deficiency
0.104 1.66E-9 YDR534C FIT1 hom Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
0.103 2.57E-9 YDL165W CDC36 het Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor
0.102 3.65E-9 YOR269W PAC1 hom Involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; serves at interface between dynein's ATPase site and its microtubule binding stalk, causing individual dynein motors to remain attached to microtubules for long periods; synthetic lethal with bni1; homolog of human LIS1, mutations in which cause the severe brain disorder lissencephaly
0.099 1.04E-8 YGR153W_p YGR153W_p hom Putative protein of unknown function
0.098 1.22E-8 YCR020C-A MAK31 hom Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus; member of the Sm protein family
0.094 5.34E-8 YPR041W TIF5 het Translation initiation factor eIF5; functions both as a GTPase-activating protein to mediate hydrolysis of ribosome-bound GTP and as a GDP dissociation inhibitor to prevent recycling of eIF2
0.092 8.06E-8 YDR290W_d YDR290W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RTT103
0.090 1.75E-7 YDR328C SKP1 het Evolutionarily conserved kinetochore protein; part of multiple protein complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA, and the RAVE complex that regulates assembly of the V-ATPase; protein abundance increases in response to DNA replication stress