YLR083C / EMP70

Protein with a role in cellular adhesion, filamentous growth, and endosome-to-vacuole sorting; similar to Tmn2p and Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR083C / EMP70

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:4.37|P-value:3.37E-5 ID:SGTC_204|Compound:1543-0184|FD-Score:4.40|P-value:3.02E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:6.72|P-value:3.69E-10 ID:SGTC_320|Compound:4092-0846|FD-Score:4.20|P-value:6.35E-5 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:4.57|P-value:1.50E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.73|P-value:2.45E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:4.54|P-value:1.67E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:3.43|P-value:9.01E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:3.40|P-value:9.79E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.68|P-value:4.03E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:3.47|P-value:7.99E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:5.24|P-value:8.33E-7 ID:SGTC_1034|Compound:k072-0165|FD-Score:-4.55|P-value:1.14E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:-3.75|P-value:2.30E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:3.78|P-value:2.84E-4 ID:SGTC_1751|Compound:st044839|FD-Score:-3.34|P-value:9.04E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-5.18|P-value:7.11E-7 ID:SGTC_1755|Compound:st041960|FD-Score:-5.57|P-value:1.11E-7 ID:SGTC_1759|Compound:st043059|FD-Score:-4.56|P-value:1.09E-5 ID:SGTC_1793|Compound:st048256|FD-Score:-3.51|P-value:5.09E-4 ID:SGTC_2107|Compound:5363541|FD-Score:-3.53|P-value:4.88E-4 ID:SGTC_2141|Compound:5621638|FD-Score:4.09|P-value:9.51E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:5.63|P-value:1.29E-7 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.89|P-value:4.00E-6 ID:SGTC_2341|Compound:7987486|FD-Score:-4.63|P-value:7.93E-6 ID:SGTC_2343|Compound:7990716|FD-Score:3.55|P-value:6.14E-4 ID:SGTC_2346|Compound:9031566|FD-Score:-3.48|P-value:5.77E-4 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:-3.42|P-value:6.88E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:4.92|P-value:3.42E-6 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.72|P-value:3.46E-4 ID:SGTC_2861|Compound:9024595|FD-Score:-3.50|P-value:5.43E-4 ID:SGTC_2863|Compound:9028737|FD-Score:-3.41|P-value:7.11E-4 ID:SGTC_2994|Compound:9053520|FD-Score:-3.69|P-value:2.84E-4 ID:SGTC_2997|Compound:9067075|FD-Score:-4.91|P-value:2.45E-6 ID:SGTC_3037|Compound:9091026|FD-Score:3.54|P-value:6.31E-4 ID:SGTC_3052|Compound:9092717|FD-Score:3.83|P-value:2.45E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:3.72|P-value:3.51E-4 ID:SGTC_3218|Compound:9131285|FD-Score:3.90|P-value:1.89E-4 ID:SGTC_3313|Compound:9133968|FD-Score:-4.44|P-value:1.75E-5 ID:SGTC_3314|Compound:9135860|FD-Score:-4.26|P-value:3.50E-5 ID:SGTC_9|Compound:0092-0002|FD-Score:4.37|P-value:3.37E-5 ID:SGTC_204|Compound:1543-0184|FD-Score:4.40|P-value:3.02E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:6.72|P-value:3.69E-10 ID:SGTC_320|Compound:4092-0846|FD-Score:4.20|P-value:6.35E-5 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:4.57|P-value:1.50E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:-3.73|P-value:2.45E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:4.54|P-value:1.67E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:3.43|P-value:9.01E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:3.40|P-value:9.79E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.68|P-value:4.03E-4 ID:SGTC_750|Compound:4073-0104|FD-Score:3.47|P-value:7.99E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:5.24|P-value:8.33E-7 ID:SGTC_1034|Compound:k072-0165|FD-Score:-4.55|P-value:1.14E-5 ID:SGTC_1251|Compound:0490-5699|FD-Score:-3.75|P-value:2.30E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:3.78|P-value:2.84E-4 ID:SGTC_1751|Compound:st044839|FD-Score:-3.34|P-value:9.04E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-5.18|P-value:7.11E-7 ID:SGTC_1755|Compound:st041960|FD-Score:-5.57|P-value:1.11E-7 ID:SGTC_1759|Compound:st043059|FD-Score:-4.56|P-value:1.09E-5 ID:SGTC_1793|Compound:st048256|FD-Score:-3.51|P-value:5.09E-4 ID:SGTC_2107|Compound:5363541|FD-Score:-3.53|P-value:4.88E-4 ID:SGTC_2141|Compound:5621638|FD-Score:4.09|P-value:9.51E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:5.63|P-value:1.29E-7 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.89|P-value:4.00E-6 ID:SGTC_2341|Compound:7987486|FD-Score:-4.63|P-value:7.93E-6 ID:SGTC_2343|Compound:7990716|FD-Score:3.55|P-value:6.14E-4 ID:SGTC_2346|Compound:9031566|FD-Score:-3.48|P-value:5.77E-4 ID:SGTC_2550|Compound:chrysin dimethyl ether|FD-Score:-3.42|P-value:6.88E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:4.92|P-value:3.42E-6 ID:SGTC_2778|Compound:tioconazole|FD-Score:3.72|P-value:3.46E-4 ID:SGTC_2861|Compound:9024595|FD-Score:-3.50|P-value:5.43E-4 ID:SGTC_2863|Compound:9028737|FD-Score:-3.41|P-value:7.11E-4 ID:SGTC_2994|Compound:9053520|FD-Score:-3.69|P-value:2.84E-4 ID:SGTC_2997|Compound:9067075|FD-Score:-4.91|P-value:2.45E-6 ID:SGTC_3037|Compound:9091026|FD-Score:3.54|P-value:6.31E-4 ID:SGTC_3052|Compound:9092717|FD-Score:3.83|P-value:2.45E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:3.72|P-value:3.51E-4 ID:SGTC_3218|Compound:9131285|FD-Score:3.90|P-value:1.89E-4 ID:SGTC_3313|Compound:9133968|FD-Score:-4.44|P-value:1.75E-5 ID:SGTC_3314|Compound:9135860|FD-Score:-4.26|P-value:3.50E-5

Top fitness defect scores for YLR083C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_312 4092-0653 6.72 6.8 µM 3.69E-10 ergosterol depletion effects on membrane 27 8.95E-12
2 SGTC_2249 haloperidol 5.63 116.4 µM 1.29E-7 ergosterol depletion effects on membrane 49 8.91E-9
3 SGTC_1019 4262-0212 5.24 3.4 µM 8.33E-7 ergosterol depletion effects on membrane 31 8.04E-8
4 SGTC_2603 homopterocarpin 4.92 100.0 µM 3.42E-6 15 4.25E-7
5 SGTC_2250 alverine citrate 4.89 130.0 µM 4.00E-6 98 5.11E-7
6 SGTC_471 1-acyl-paf 4.57 4.0 µM 1.50E-5 DNA intercalators 21 2.43E-6
7 SGTC_528 3492-0019 4.54 172.0 µM 1.67E-5 calcium & mitochondrial duress 178 2.76E-6
8 SGTC_204 1543-0184 4.40 62.4 µM 3.02E-5 TRP & mitochondrial translation 23 5.53E-6
9 SGTC_9 0092-0002 4.37 10.4 µM 3.37E-5 21 6.30E-6
10 SGTC_320 4092-0846 4.20 5.3 µM 6.35E-5 ergosterol depletion effects on membrane 43 1.33E-5
11 SGTC_2141 5621638 4.09 7.7 µM 9.51E-5 tubulin folding & SWR complex 31 2.14E-5
12 SGTC_3218 9131285 3.90 49.5 µM 1.89E-4 endomembrane recycling 44 4.81E-5
13 SGTC_3052 9092717 3.83 49.5 µM 2.45E-4 32 6.50E-5
14 SGTC_1290 0986-0249 3.78 10.2 µM 2.84E-4 DNA intercalators 26 7.75E-5
15 SGTC_2778 tioconazole 3.72 65.1 nM 3.46E-4 ergosterol depletion effects on membrane 73 9.79E-5
16 SGTC_3059 1327-0034 3.72 3.0 µM 3.51E-4 60 9.94E-5
17 SGTC_690 glyoxal 3.68 20.3 µM 4.03E-4 94 1.17E-4
18 SGTC_2343 7990716 3.55 14.8 µM 6.14E-4 28 1.92E-4
19 SGTC_3037 9091026 3.54 49.5 µM 6.31E-4 NEO1-PIK1 148 1.98E-4
20 SGTC_750 4073-0104 3.47 132.0 µM 7.99E-4 21 2.62E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.218 3.26E-37 YJL085W EXO70 het Subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; PtdIns[4,5]P2-binding protein that localizes to exocytic sites in an actin-independent manner, targeting and anchoring the exocyst with Sec3p; involved in exocyst assembly; direct downstream effector of Rho3p and Cdc42p; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.196 3.00E-30 YIL068C SEC6 het Essential 88kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; anchors the assembled complex to sites of secretion; interacts with SM-like protein and SNARE regulator Sec1p and may recruit it to sites of secretion; interacts with Sec9p and inhibits formation of the t-SNARE complex between Sec9p and Sso1p
0.188 5.84E-28 YMR218C TRS130 het One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in ER to Golgi membrane traffic; mutation activates transcription of OCH1; mutants are defective in cytoplasm-to-vacuole targeting (Cvt) pathway and starvation-induced autophagy
0.181 3.37E-26 YER094C PUP3 het Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10
0.178 2.63E-25 YDR166C SEC5 het Essential 107kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in assembly of the exocyst complex; required with Sec3p for ER inheritance where it promotes anchoring of the cortical ER at the bud tip
0.177 6.11E-25 YGL233W SEC15 het Essential 113 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; interacts with and functions as a downstream effector of active, GTP-bound Sec4p, a Rab family GTPase
0.174 3.19E-24 YDL001W RMD1 hom Cytoplasmic protein required for sporulation
0.167 2.50E-22 YOL081W IRA2 hom GTPase-activating protein; negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions; similar to human neurofibromin; IRA2 has a paralog, IRA1, that arose from the whole genome duplication
0.163 1.79E-21 YPR055W SEC8 het Essential 121 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in ER and Golgi inheritance in small buds; relocalizes away from bud neck upon DNA replication stress
0.162 3.92E-21 YPL259C APM1 hom Mu1-like medium subunit of the clathrin-associated protein complex (AP-1); binds clathrin; involved in clathrin-dependent Golgi protein sorting
0.158 2.88E-20 YDR144C MKC7 hom GPI-anchored aspartyl protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p
0.156 9.18E-20 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.154 2.36E-19 YOR294W RRS1 het Essential protein that binds ribosomal protein L11; required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; localizes to the nucleolus and in foci along nuclear periphery; cooperates with Ebp2p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering; mouse homolog shows altered expression in Huntington's disease model mice
0.153 6.13E-19 YJL001W PRE3 het Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides
0.151 1.08E-18 YGL116W CDC20 het Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress