YLR120C / YPS1

Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR120C / YPS1

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.91|P-value:1.53E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.55|P-value:5.17E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:5.07|P-value:1.43E-6 ID:SGTC_121|Compound:0557-0495|FD-Score:17.90|P-value:6.80E-62 ID:SGTC_138|Compound:0850-0259|FD-Score:3.59|P-value:4.63E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:4.19|P-value:5.57E-5 ID:SGTC_330|Compound:1488-0319|FD-Score:-3.45|P-value:6.98E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:-3.79|P-value:2.20E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:-3.53|P-value:5.29E-4 ID:SGTC_1109|Compound:tnp00067|FD-Score:3.52|P-value:5.85E-4 ID:SGTC_1219|Compound:1469-0211|FD-Score:-4.01|P-value:9.93E-5 ID:SGTC_1223|Compound:0764-0573|FD-Score:-3.58|P-value:4.56E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:3.69|P-value:3.25E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:-3.93|P-value:1.33E-4 ID:SGTC_1411|Compound:3909-8223|FD-Score:3.88|P-value:1.69E-4 ID:SGTC_1637|Compound:st007924|FD-Score:3.57|P-value:4.87E-4 ID:SGTC_1648|Compound:st011736|FD-Score:3.76|P-value:2.61E-4 ID:SGTC_1744|Compound:st037937|FD-Score:3.71|P-value:3.06E-4 ID:SGTC_1746|Compound:st038117|FD-Score:-4.79|P-value:4.56E-6 ID:SGTC_1747|Compound:st037496|FD-Score:5.52|P-value:1.70E-7 ID:SGTC_1934|Compound:st074720|FD-Score:3.63|P-value:4.01E-4 ID:SGTC_1953|Compound:st076800|FD-Score:3.36|P-value:9.66E-4 ID:SGTC_2018|Compound:5133068|FD-Score:3.53|P-value:5.60E-4 ID:SGTC_2022|Compound:5136654|FD-Score:3.56|P-value:5.08E-4 ID:SGTC_2070|Compound:5230947|FD-Score:3.40|P-value:8.47E-4 ID:SGTC_2076|Compound:5212012|FD-Score:-3.41|P-value:7.93E-4 ID:SGTC_2271|Compound:7849410|FD-Score:4.16|P-value:6.25E-5 ID:SGTC_2349|Compound:9023730|FD-Score:3.49|P-value:6.37E-4 ID:SGTC_2421|Compound:5690543|FD-Score:3.65|P-value:3.75E-4 ID:SGTC_2463|Compound:5473429|FD-Score:-3.42|P-value:7.60E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.57|P-value:4.88E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.43|P-value:7.79E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-3.55|P-value:5.07E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.41|P-value:8.22E-4 ID:SGTC_2956|Compound:9076196|FD-Score:4.86|P-value:3.53E-6 ID:SGTC_3336|Compound:9143619|FD-Score:-4.04|P-value:9.11E-5 ID:SGTC_3349|Compound:9149703|FD-Score:5.56|P-value:1.39E-7 ID:SGTC_3353|Compound:9151644|FD-Score:3.90|P-value:1.56E-4 ID:SGTC_3356|Compound:9151811|FD-Score:4.22|P-value:4.97E-5 ID:SGTC_6|Compound:0844-0013|FD-Score:3.91|P-value:1.53E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.55|P-value:5.17E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:5.07|P-value:1.43E-6 ID:SGTC_121|Compound:0557-0495|FD-Score:17.90|P-value:6.80E-62 ID:SGTC_138|Compound:0850-0259|FD-Score:3.59|P-value:4.63E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:4.19|P-value:5.57E-5 ID:SGTC_330|Compound:1488-0319|FD-Score:-3.45|P-value:6.98E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:-3.79|P-value:2.20E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:-3.53|P-value:5.29E-4 ID:SGTC_1109|Compound:tnp00067|FD-Score:3.52|P-value:5.85E-4 ID:SGTC_1219|Compound:1469-0211|FD-Score:-4.01|P-value:9.93E-5 ID:SGTC_1223|Compound:0764-0573|FD-Score:-3.58|P-value:4.56E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:3.69|P-value:3.25E-4 ID:SGTC_1238|Compound:0333-0287|FD-Score:-3.93|P-value:1.33E-4 ID:SGTC_1411|Compound:3909-8223|FD-Score:3.88|P-value:1.69E-4 ID:SGTC_1637|Compound:st007924|FD-Score:3.57|P-value:4.87E-4 ID:SGTC_1648|Compound:st011736|FD-Score:3.76|P-value:2.61E-4 ID:SGTC_1744|Compound:st037937|FD-Score:3.71|P-value:3.06E-4 ID:SGTC_1746|Compound:st038117|FD-Score:-4.79|P-value:4.56E-6 ID:SGTC_1747|Compound:st037496|FD-Score:5.52|P-value:1.70E-7 ID:SGTC_1934|Compound:st074720|FD-Score:3.63|P-value:4.01E-4 ID:SGTC_1953|Compound:st076800|FD-Score:3.36|P-value:9.66E-4 ID:SGTC_2018|Compound:5133068|FD-Score:3.53|P-value:5.60E-4 ID:SGTC_2022|Compound:5136654|FD-Score:3.56|P-value:5.08E-4 ID:SGTC_2070|Compound:5230947|FD-Score:3.40|P-value:8.47E-4 ID:SGTC_2076|Compound:5212012|FD-Score:-3.41|P-value:7.93E-4 ID:SGTC_2271|Compound:7849410|FD-Score:4.16|P-value:6.25E-5 ID:SGTC_2349|Compound:9023730|FD-Score:3.49|P-value:6.37E-4 ID:SGTC_2421|Compound:5690543|FD-Score:3.65|P-value:3.75E-4 ID:SGTC_2463|Compound:5473429|FD-Score:-3.42|P-value:7.60E-4 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:3.57|P-value:4.88E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.43|P-value:7.79E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-3.55|P-value:5.07E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.41|P-value:8.22E-4 ID:SGTC_2956|Compound:9076196|FD-Score:4.86|P-value:3.53E-6 ID:SGTC_3336|Compound:9143619|FD-Score:-4.04|P-value:9.11E-5 ID:SGTC_3349|Compound:9149703|FD-Score:5.56|P-value:1.39E-7 ID:SGTC_3353|Compound:9151644|FD-Score:3.90|P-value:1.56E-4 ID:SGTC_3356|Compound:9151811|FD-Score:4.22|P-value:4.97E-5

Top fitness defect scores for YLR120C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_121 0557-0495 17.90 61.3 µM 6.80E-62 calcium & mitochondrial duress 2 4.93E-72
2 SGTC_3349 9149703 5.56 23.0 µM 1.39E-7 2 1.33E-8
3 SGTC_1747 st037496 5.52 66.6 µM 1.70E-7 4 1.68E-8
4 SGTC_64 000l-0018 5.07 272.1 µM 1.43E-6 ubiquinone biosynthesis & proteasome 107 2.01E-7
5 SGTC_2956 9076196 4.86 2.5 µM 3.53E-6 6 5.75E-7
6 SGTC_3356 9151811 4.22 4.5 µM 4.97E-5 cell wall 17 1.25E-5
7 SGTC_313 3474-0040 4.19 5.0 µM 5.57E-5 NEO1-PIK1 63 1.42E-5
8 SGTC_2271 7849410 4.16 118.6 µM 6.25E-5 11 1.63E-5
9 SGTC_6 0844-0013 3.91 19.8 µM 1.53E-4 93 4.61E-5
10 SGTC_3353 9151644 3.90 39.3 µM 1.56E-4 13 4.71E-5
11 SGTC_1411 3909-8223 3.88 150.0 µM 1.69E-4 13 5.16E-5
12 SGTC_1648 st011736 3.76 69.8 µM 2.61E-4 PDR1 18 8.55E-5
13 SGTC_1744 st037937 3.71 38.9 µM 3.06E-4 37 1.03E-4
14 SGTC_1237 0330-0133 3.69 46.1 µM 3.25E-4 ergosterol biosynthesis 31 1.10E-4
15 SGTC_2421 5690543 3.65 90.7 µM 3.75E-4 25 1.30E-4
16 SGTC_1934 st074720 3.63 32.6 µM 4.01E-4 69 1.41E-4
17 SGTC_138 0850-0259 3.59 40.9 µM 4.63E-4 cell wall 219 1.66E-4
18 SGTC_1637 st007924 3.57 17.4 µM 4.87E-4 36 1.76E-4
19 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.57 3.7 µM 4.88E-4 118 1.77E-4
20 SGTC_2022 5136654 3.56 200.0 µM 5.08E-4 29 1.85E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.228 1.17E-40 YBR229C ROT2 hom Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations
0.154 2.72E-19 YJL192C SOP4 hom ER-membrane protein; suppressor of pma1-7, deletion of SOP4 slows down the export of wild-type Pma1p and Pma1-7 from the ER
0.149 4.27E-18 YCL038C ATG22 hom Vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation
0.137 1.80E-15 YGR110W CLD1 hom Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58
0.135 5.52E-15 YLR322W_d VPS65_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 75% of ORF overlaps the verified gene SFH1; deletion causes a vacuolar protein sorting defect and blocks anaerobic growth
0.126 2.65E-13 YDL021W GPM2 hom Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event
0.123 7.46E-13 YJL080C SCP160 hom Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins
0.123 8.21E-13 YDR206W EBS1 hom Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors
0.122 1.57E-12 YMR294W JNM1 hom Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B
0.121 2.27E-12 YGL027C CWH41 hom Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress
0.117 1.22E-11 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.115 2.64E-11 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.110 1.65E-10 YPL269W KAR9 hom Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase
0.110 1.99E-10 YIL112W HOS4 hom Subunit of the Set3 complex, which is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate
0.109 2.50E-10 YCR008W SAT4 hom Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p