YLR129W / DIP2

Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR129W / DIP2

Click on Significant Values for Screen Details ID:SGTC_116|Compound:0155-0182|FD-Score:-3.12|P-value:2.94E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:4.11|P-value:2.68E-6 ID:SGTC_171|Compound:k064-0041|FD-Score:-2.93|P-value:6.37E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:-6.03|P-value:1.48E-11 ID:SGTC_181|Compound:1447-1644|FD-Score:-4.25|P-value:1.42E-6 ID:SGTC_282|Compound:k297-0036|FD-Score:4.68|P-value:1.07E-7 ID:SGTC_306|Compound:1672-3436|FD-Score:3.10|P-value:2.92E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:-3.09|P-value:3.35E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-5.36|P-value:1.80E-9 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:-3.41|P-value:8.94E-5 ID:SGTC_617|Compound:3770-0098|FD-Score:6.62|P-value:1.20E-13 ID:SGTC_618|Compound:k072-0232|FD-Score:-3.90|P-value:8.80E-6 ID:SGTC_766|Compound:1391-0721|FD-Score:3.63|P-value:2.94E-5 ID:SGTC_770|Compound:0389-1121|FD-Score:2.81|P-value:9.25E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-5.09|P-value:1.04E-8 ID:SGTC_800|Compound:3448-7362|FD-Score:2.96|P-value:5.07E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:2.91|P-value:6.35E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-5.80|P-value:8.52E-11 ID:SGTC_1206|Compound:3978-0017|FD-Score:-3.59|P-value:3.89E-5 ID:SGTC_1209|Compound:2323-2347|FD-Score:-3.20|P-value:2.16E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.52|P-value:4.70E-5 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.38|P-value:9.09E-5 ID:SGTC_1375|Compound:2910-0797|FD-Score:4.59|P-value:1.90E-7 ID:SGTC_1380|Compound:2291-0730|FD-Score:4.96|P-value:2.01E-8 ID:SGTC_1503|Compound:4585-0012|FD-Score:5.05|P-value:1.12E-8 ID:SGTC_1518|Compound:st038567|FD-Score:-2.95|P-value:5.93E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:-2.94|P-value:6.19E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:2.94|P-value:5.53E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:2.93|P-value:5.76E-4 ID:SGTC_1591|Compound:genipin|FD-Score:2.79|P-value:9.94E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-3.93|P-value:7.66E-6 ID:SGTC_1829|Compound:berberine|FD-Score:-2.83|P-value:9.41E-4 ID:SGTC_1940|Compound:st075990|FD-Score:3.55|P-value:4.22E-5 ID:SGTC_1946|Compound:st076057|FD-Score:3.94|P-value:6.25E-6 ID:SGTC_1948|Compound:st076329|FD-Score:3.63|P-value:2.85E-5 ID:SGTC_2054|Compound:5233173|FD-Score:-4.01|P-value:5.19E-6 ID:SGTC_2374|Compound:9071832|FD-Score:4.88|P-value:3.20E-8 ID:SGTC_2412|Compound:st077135|FD-Score:3.01|P-value:4.23E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:3.10|P-value:2.94E-4 ID:SGTC_2511|Compound:berberine|FD-Score:-3.90|P-value:8.63E-6 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.66|P-value:2.77E-5 ID:SGTC_2792|Compound:7535235|FD-Score:-3.00|P-value:4.81E-4 ID:SGTC_2799|Compound:7812892|FD-Score:-3.52|P-value:5.29E-5 ID:SGTC_2906|Compound:7926292|FD-Score:3.21|P-value:1.88E-4 ID:SGTC_2920|Compound:7982904|FD-Score:3.09|P-value:3.05E-4 ID:SGTC_3049|Compound:9092223|FD-Score:3.07|P-value:3.36E-4 ID:SGTC_3083|Compound:9117465|FD-Score:2.84|P-value:8.26E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-3.96|P-value:6.52E-6 ID:SGTC_3245|Compound:9134821|FD-Score:-2.93|P-value:6.41E-4 ID:SGTC_3296|Compound:9122258|FD-Score:-3.73|P-value:2.01E-5 ID:SGTC_3346|Compound:9158254|FD-Score:3.59|P-value:3.39E-5 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.12|P-value:2.94E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:4.11|P-value:2.68E-6 ID:SGTC_171|Compound:k064-0041|FD-Score:-2.93|P-value:6.37E-4 ID:SGTC_177|Compound:1327-0068|FD-Score:-6.03|P-value:1.48E-11 ID:SGTC_181|Compound:1447-1644|FD-Score:-4.25|P-value:1.42E-6 ID:SGTC_282|Compound:k297-0036|FD-Score:4.68|P-value:1.07E-7 ID:SGTC_306|Compound:1672-3436|FD-Score:3.10|P-value:2.92E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:-3.09|P-value:3.35E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-5.36|P-value:1.80E-9 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:-3.41|P-value:8.94E-5 ID:SGTC_617|Compound:3770-0098|FD-Score:6.62|P-value:1.20E-13 ID:SGTC_618|Compound:k072-0232|FD-Score:-3.90|P-value:8.80E-6 ID:SGTC_766|Compound:1391-0721|FD-Score:3.63|P-value:2.94E-5 ID:SGTC_770|Compound:0389-1121|FD-Score:2.81|P-value:9.25E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-5.09|P-value:1.04E-8 ID:SGTC_800|Compound:3448-7362|FD-Score:2.96|P-value:5.07E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:2.91|P-value:6.35E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:-5.80|P-value:8.52E-11 ID:SGTC_1206|Compound:3978-0017|FD-Score:-3.59|P-value:3.89E-5 ID:SGTC_1209|Compound:2323-2347|FD-Score:-3.20|P-value:2.16E-4 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.52|P-value:4.70E-5 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.38|P-value:9.09E-5 ID:SGTC_1375|Compound:2910-0797|FD-Score:4.59|P-value:1.90E-7 ID:SGTC_1380|Compound:2291-0730|FD-Score:4.96|P-value:2.01E-8 ID:SGTC_1503|Compound:4585-0012|FD-Score:5.05|P-value:1.12E-8 ID:SGTC_1518|Compound:st038567|FD-Score:-2.95|P-value:5.93E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:-2.94|P-value:6.19E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:2.94|P-value:5.53E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:2.93|P-value:5.76E-4 ID:SGTC_1591|Compound:genipin|FD-Score:2.79|P-value:9.94E-4 ID:SGTC_1827|Compound:berberine|FD-Score:-3.93|P-value:7.66E-6 ID:SGTC_1829|Compound:berberine|FD-Score:-2.83|P-value:9.41E-4 ID:SGTC_1940|Compound:st075990|FD-Score:3.55|P-value:4.22E-5 ID:SGTC_1946|Compound:st076057|FD-Score:3.94|P-value:6.25E-6 ID:SGTC_1948|Compound:st076329|FD-Score:3.63|P-value:2.85E-5 ID:SGTC_2054|Compound:5233173|FD-Score:-4.01|P-value:5.19E-6 ID:SGTC_2374|Compound:9071832|FD-Score:4.88|P-value:3.20E-8 ID:SGTC_2412|Compound:st077135|FD-Score:3.01|P-value:4.23E-4 ID:SGTC_2495|Compound:cafestol|FD-Score:3.10|P-value:2.94E-4 ID:SGTC_2511|Compound:berberine|FD-Score:-3.90|P-value:8.63E-6 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-3.66|P-value:2.77E-5 ID:SGTC_2792|Compound:7535235|FD-Score:-3.00|P-value:4.81E-4 ID:SGTC_2799|Compound:7812892|FD-Score:-3.52|P-value:5.29E-5 ID:SGTC_2906|Compound:7926292|FD-Score:3.21|P-value:1.88E-4 ID:SGTC_2920|Compound:7982904|FD-Score:3.09|P-value:3.05E-4 ID:SGTC_3049|Compound:9092223|FD-Score:3.07|P-value:3.36E-4 ID:SGTC_3083|Compound:9117465|FD-Score:2.84|P-value:8.26E-4 ID:SGTC_3216|Compound:9129716|FD-Score:-3.96|P-value:6.52E-6 ID:SGTC_3245|Compound:9134821|FD-Score:-2.93|P-value:6.41E-4 ID:SGTC_3296|Compound:9122258|FD-Score:-3.73|P-value:2.01E-5 ID:SGTC_3346|Compound:9158254|FD-Score:3.59|P-value:3.39E-5

Top fitness defect scores for YLR129W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_617 3770-0098 6.62 35.0 µM 1.20E-13 exosome 14 1.80E-11 0.41
2 SGTC_1503 4585-0012 5.05 61.3 µM 1.12E-8 3 2.20E-7 0.17
3 SGTC_1380 2291-0730 4.96 164.0 µM 2.01E-8 3 3.55E-7 0.65
4 SGTC_2374 9071832 4.88 200.0 µM 3.20E-8 endomembrane recycling 1 5.21E-7 0.43
5 SGTC_282 k297-0036 4.68 65.7 µM 1.07E-7 1 1.41E-6 0.93
6 SGTC_1375 2910-0797 4.59 186.0 µM 1.90E-7 4 2.26E-6 0.31
7 SGTC_163 1327-0036 4.11 7.5 µM 2.68E-6 46 2.00E-5 0.21
8 SGTC_1946 st076057 3.94 65.1 µM 6.25E-6 1 4.02E-5 0.40
9 SGTC_1948 st076329 3.63 66.6 µM 2.85E-5 6 1.41E-4 0.27
10 SGTC_766 1391-0721 3.63 126.0 µM 2.94E-5 4 1.44E-4 0.05
11 SGTC_3346 9158254 3.59 43.6 µM 3.39E-5 18 1.62E-4 0.08
12 SGTC_1940 st075990 3.55 51.1 µM 4.22E-5 60S ribosome export 7 1.94E-4 0.25
13 SGTC_1221 2958-7315 3.52 257.0 µM 4.70E-5 4 2.13E-4 0.09
14 SGTC_1374 2889-5571 3.38 141.0 µM 9.09E-5 RSC complex & mRNA processing 50 3.67E-4 0.07
15 SGTC_2906 7926292 3.21 26.4 µM 1.88E-4 8 6.69E-4 0.10
16 SGTC_306 1672-3436 3.10 11.6 µM 2.92E-4 Golgi 11 9.65E-4 0.01
17 SGTC_2495 cafestol 3.10 54.5 µM 2.94E-4 Golgi 20 9.68E-4 0.02
18 SGTC_2920 7982904 3.09 15.8 µM 3.05E-4 23 9.99E-4 0.03
19 SGTC_3049 9092223 3.07 49.5 µM 3.36E-4 14 0.00108 0.20
20 SGTC_2412 st077135 3.01 33.4 µM 4.23E-4 17 0.00131 0.14

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.171 1.58E-23 YBL004W UTP20 het Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
0.164 9.67E-22 YPR136C_d YPR136C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF RRP9
0.155 1.99E-19 YLR198C_d YLR198C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIK1/YLR197W
0.151 1.69E-18 YGR158C MTR3 het Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6)
0.150 2.25E-18 YLR222C UTP13 het Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
0.132 1.58E-14 YDR478W SNM1 het Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP
0.132 1.95E-14 YHR164C DNA2 het Tripartite DNA replication factor; has single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair; cell-cycle dependent localization; forms nuclear foci upon DNA replication stress
0.126 2.12E-13 YIL046W MET30 het F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus
0.126 2.96E-13 YER171W RAD3 het 5' to 3' DNA helicase; involved in nucleotide excision repair and transcription; subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress
0.124 6.06E-13 YER127W LCP5 het Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus
0.122 1.35E-12 YJL107C_p YJL107C_p hom Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi
0.121 2.26E-12 YEL019C MMS21 het SUMO ligase and component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; mutants are sensitive to methyl methanesulfonate and show increased spontaneous mutation and mitotic recombination
0.119 5.11E-12 YDL060W TSR1 het Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.118 6.72E-12 YIL003W CFD1 het Highly conserved, iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol
0.116 1.70E-11 YLL011W SOF1 het Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p