YLR138W / NHA1

Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR138W / NHA1

Click on Significant Values for Screen Details ID:SGTC_25|Compound:0118-0223|FD-Score:3.47|P-value:1.07E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:-4.17|P-value:4.14E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:6.62|P-value:8.21E-13 ID:SGTC_70|Compound:0141-0289|FD-Score:-3.64|P-value:4.98E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:3.26|P-value:2.59E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:6.24|P-value:1.44E-11 ID:SGTC_159|Compound:3970-0959|FD-Score:3.42|P-value:1.34E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:5.20|P-value:1.44E-8 ID:SGTC_341|Compound:1486-1430|FD-Score:-3.33|P-value:1.90E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.80|P-value:2.52E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.25|P-value:2.70E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:3.01|P-value:6.70E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:3.55|P-value:7.66E-5 ID:SGTC_709|Compound:3807-1509|FD-Score:2.92|P-value:9.16E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.61|P-value:5.94E-5 ID:SGTC_856|Compound:0433-0016|FD-Score:3.13|P-value:4.22E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:3.25|P-value:2.64E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:2.91|P-value:9.54E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:-3.32|P-value:1.99E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:-3.16|P-value:3.61E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:3.66|P-value:4.70E-5 ID:SGTC_1534|Compound:6-azauridine|FD-Score:-2.93|P-value:8.74E-4 ID:SGTC_1548|Compound:st061468|FD-Score:3.18|P-value:3.44E-4 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:4.82|P-value:1.41E-7 ID:SGTC_1684|Compound:st024538|FD-Score:2.90|P-value:9.95E-4 ID:SGTC_1745|Compound:st081495|FD-Score:3.73|P-value:3.49E-5 ID:SGTC_1775|Compound:st081588|FD-Score:3.24|P-value:2.73E-4 ID:SGTC_1779|Compound:st039427|FD-Score:4.85|P-value:1.14E-7 ID:SGTC_1884|Compound:5633444|FD-Score:3.18|P-value:3.44E-4 ID:SGTC_1945|Compound:st075991|FD-Score:-3.03|P-value:6.10E-4 ID:SGTC_2069|Compound:5228469|FD-Score:2.98|P-value:7.42E-4 ID:SGTC_2176|Compound:5809774|FD-Score:3.19|P-value:3.32E-4 ID:SGTC_2184|Compound:6075246|FD-Score:-2.97|P-value:7.63E-4 ID:SGTC_2269|Compound:7935389|FD-Score:-2.98|P-value:7.19E-4 ID:SGTC_2316|Compound:5844804|FD-Score:2.93|P-value:8.88E-4 ID:SGTC_2364|Compound:9055074|FD-Score:2.98|P-value:7.54E-4 ID:SGTC_2399|Compound:5884133|FD-Score:-5.22|P-value:1.26E-8 ID:SGTC_2421|Compound:5690543|FD-Score:3.66|P-value:4.71E-5 ID:SGTC_2423|Compound:st077119|FD-Score:-4.81|P-value:1.36E-7 ID:SGTC_2441|Compound:5730946|FD-Score:2.90|P-value:9.81E-4 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:3.51|P-value:9.04E-5 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.97|P-value:1.18E-5 ID:SGTC_2837|Compound:9008476|FD-Score:5.01|P-value:4.46E-8 ID:SGTC_2841|Compound:9004761|FD-Score:2.98|P-value:7.33E-4 ID:SGTC_2907|Compound:7721985|FD-Score:-2.90|P-value:9.69E-4 ID:SGTC_3116|Compound:9124943|FD-Score:3.58|P-value:6.78E-5 ID:SGTC_3224|Compound:9130643|FD-Score:2.97|P-value:7.60E-4 ID:SGTC_3306|Compound:9127676|FD-Score:3.49|P-value:1.01E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:3.47|P-value:1.07E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:-4.17|P-value:4.14E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:6.62|P-value:8.21E-13 ID:SGTC_70|Compound:0141-0289|FD-Score:-3.64|P-value:4.98E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:3.26|P-value:2.59E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:6.24|P-value:1.44E-11 ID:SGTC_159|Compound:3970-0959|FD-Score:3.42|P-value:1.34E-4 ID:SGTC_335|Compound:4077-0256|FD-Score:5.20|P-value:1.44E-8 ID:SGTC_341|Compound:1486-1430|FD-Score:-3.33|P-value:1.90E-4 ID:SGTC_421|Compound:streptovitacin|FD-Score:3.80|P-value:2.52E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.25|P-value:2.70E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:3.01|P-value:6.70E-4 ID:SGTC_665|Compound:3914-0008|FD-Score:3.55|P-value:7.66E-5 ID:SGTC_709|Compound:3807-1509|FD-Score:2.92|P-value:9.16E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:3.61|P-value:5.94E-5 ID:SGTC_856|Compound:0433-0016|FD-Score:3.13|P-value:4.22E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:3.25|P-value:2.64E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:2.91|P-value:9.54E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:-3.32|P-value:1.99E-4 ID:SGTC_1160|Compound:4092-0570|FD-Score:-3.16|P-value:3.61E-4 ID:SGTC_1454|Compound:4239-0054|FD-Score:3.66|P-value:4.70E-5 ID:SGTC_1534|Compound:6-azauridine|FD-Score:-2.93|P-value:8.74E-4 ID:SGTC_1548|Compound:st061468|FD-Score:3.18|P-value:3.44E-4 ID:SGTC_1560|Compound:lithocholic acid|FD-Score:4.82|P-value:1.41E-7 ID:SGTC_1684|Compound:st024538|FD-Score:2.90|P-value:9.95E-4 ID:SGTC_1745|Compound:st081495|FD-Score:3.73|P-value:3.49E-5 ID:SGTC_1775|Compound:st081588|FD-Score:3.24|P-value:2.73E-4 ID:SGTC_1779|Compound:st039427|FD-Score:4.85|P-value:1.14E-7 ID:SGTC_1884|Compound:5633444|FD-Score:3.18|P-value:3.44E-4 ID:SGTC_1945|Compound:st075991|FD-Score:-3.03|P-value:6.10E-4 ID:SGTC_2069|Compound:5228469|FD-Score:2.98|P-value:7.42E-4 ID:SGTC_2176|Compound:5809774|FD-Score:3.19|P-value:3.32E-4 ID:SGTC_2184|Compound:6075246|FD-Score:-2.97|P-value:7.63E-4 ID:SGTC_2269|Compound:7935389|FD-Score:-2.98|P-value:7.19E-4 ID:SGTC_2316|Compound:5844804|FD-Score:2.93|P-value:8.88E-4 ID:SGTC_2364|Compound:9055074|FD-Score:2.98|P-value:7.54E-4 ID:SGTC_2399|Compound:5884133|FD-Score:-5.22|P-value:1.26E-8 ID:SGTC_2421|Compound:5690543|FD-Score:3.66|P-value:4.71E-5 ID:SGTC_2423|Compound:st077119|FD-Score:-4.81|P-value:1.36E-7 ID:SGTC_2441|Compound:5730946|FD-Score:2.90|P-value:9.81E-4 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:3.51|P-value:9.04E-5 ID:SGTC_2729|Compound:fluphenazine|FD-Score:3.97|P-value:1.18E-5 ID:SGTC_2837|Compound:9008476|FD-Score:5.01|P-value:4.46E-8 ID:SGTC_2841|Compound:9004761|FD-Score:2.98|P-value:7.33E-4 ID:SGTC_2907|Compound:7721985|FD-Score:-2.90|P-value:9.69E-4 ID:SGTC_3116|Compound:9124943|FD-Score:3.58|P-value:6.78E-5 ID:SGTC_3224|Compound:9130643|FD-Score:2.97|P-value:7.60E-4 ID:SGTC_3306|Compound:9127676|FD-Score:3.49|P-value:1.01E-4

Top fitness defect scores for YLR138W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 6.62 9.0 µM 8.21E-13 cell wall 180 1.79E-11
2 SGTC_138 0850-0259 6.24 40.9 µM 1.44E-11 cell wall 101 2.23E-10
3 SGTC_335 4077-0256 5.20 27.6 µM 1.44E-8 5 9.85E-8
4 SGTC_2837 9008476 5.01 45.5 µM 4.46E-8 13 2.66E-7
5 SGTC_1779 st039427 4.85 55.0 µM 1.14E-7 10 6.09E-7
6 SGTC_1560 lithocholic acid 4.82 53.1 µM 1.41E-7 2 7.34E-7
7 SGTC_2729 fluphenazine 3.97 10.7 µM 1.18E-5 11 3.66E-5
8 SGTC_421 streptovitacin 3.80 30.0 mM 2.52E-5 24 7.19E-5
9 SGTC_1745 st081495 3.73 74.0 µM 3.49E-5 RNA processing & uracil transport 80 9.57E-5
10 SGTC_1454 4239-0054 3.66 42.6 µM 4.70E-5 43 1.24E-4
11 SGTC_2421 5690543 3.66 90.7 µM 4.71E-5 24 1.25E-4
12 SGTC_769 0302-0231 3.61 76.0 µM 5.94E-5 57 1.53E-4
13 SGTC_3116 9124943 3.58 49.5 µM 6.78E-5 28 1.72E-4
14 SGTC_665 3914-0008 3.55 307.0 µM 7.66E-5 28 1.92E-4
15 SGTC_2653 dihydrofissinolide 3.51 100.0 µM 9.04E-5 7 2.22E-4
16 SGTC_3306 9127676 3.49 59.8 µM 1.01E-4 38 2.46E-4
17 SGTC_25 0118-0223 3.47 35.7 µM 1.07E-4 29 2.58E-4
18 SGTC_159 3970-0959 3.42 50.0 µM 1.34E-4 112 3.15E-4
19 SGTC_137 0438-0332 3.26 85.4 µM 2.59E-4 ubiquinone biosynthesis & proteasome 165 5.64E-4
20 SGTC_980 1473-0395 3.25 201.0 µM 2.64E-4 28 5.74E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.243 2.16E-46 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.237 5.80E-44 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.235 2.14E-43 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.226 5.70E-40 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.217 3.43E-37 YLR150W STM1 hom Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery
0.205 3.46E-33 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.200 1.00E-31 YDR351W SBE2 hom Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth
0.200 1.80E-31 YPL269W KAR9 hom Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase
0.199 2.44E-31 YDR149C_d YDR149C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene NUM1; null mutation blocks anaerobic growth
0.198 5.74E-31 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.196 2.22E-30 YML057C-A_d YML057C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene CMP2/YML057W
0.186 1.44E-27 YMR152W YIM1 hom Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress
0.186 1.57E-27 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.184 5.09E-27 YJL080C SCP160 hom Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins
0.183 1.26E-26 YDR335W MSN5 hom Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm