YLR139C / SLS1

Mitochondrial membrane protein that coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR139C / SLS1

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:3.72|P-value:5.57E-4 ID:SGTC_33|Compound:0986-0033|FD-Score:4.23|P-value:1.05E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.58|P-value:5.09E-7 ID:SGTC_100|Compound:0086-0128|FD-Score:3.65|P-value:6.93E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.38|P-value:6.09E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.91|P-value:3.16E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:-3.59|P-value:8.55E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:5.50|P-value:7.20E-7 ID:SGTC_236|Compound:1509-0011|FD-Score:6.00|P-value:7.17E-8 ID:SGTC_310|Compound:1273-0058|FD-Score:12.00|P-value:4.50E-26 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.73|P-value:5.54E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:-5.09|P-value:4.18E-6 ID:SGTC_355|Compound:1311-2252|FD-Score:3.89|P-value:3.24E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:4.10|P-value:1.63E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:3.52|P-value:0.00100 ID:SGTC_660|Compound:4031-1742|FD-Score:-5.19|P-value:2.83E-6 ID:SGTC_691|Compound:1548-0686|FD-Score:3.69|P-value:6.04E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:5.42|P-value:1.00E-6 ID:SGTC_761|Compound:k216-0224|FD-Score:3.70|P-value:5.84E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:5.00|P-value:5.92E-6 ID:SGTC_892|Compound:0929-0076|FD-Score:3.70|P-value:5.92E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.68|P-value:6.33E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:-3.94|P-value:2.86E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:-4.18|P-value:1.26E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:5.07|P-value:4.42E-6 ID:SGTC_1147|Compound:3809-1045|FD-Score:3.91|P-value:3.08E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.81|P-value:4.15E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:4.12|P-value:1.50E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:5.42|P-value:9.97E-7 ID:SGTC_1623|Compound:st003709|FD-Score:5.51|P-value:6.86E-7 ID:SGTC_1624|Compound:st003710|FD-Score:4.61|P-value:2.70E-5 ID:SGTC_1626|Compound:st003712|FD-Score:5.60|P-value:4.56E-7 ID:SGTC_1627|Compound:st003713|FD-Score:9.24|P-value:2.86E-16 ID:SGTC_1742|Compound:st038235|FD-Score:5.68|P-value:3.19E-7 ID:SGTC_1800|Compound:st050079|FD-Score:-4.16|P-value:1.35E-4 ID:SGTC_1809|Compound:st050081|FD-Score:-4.03|P-value:2.08E-4 ID:SGTC_1843|Compound:st055809|FD-Score:3.87|P-value:3.48E-4 ID:SGTC_2006|Compound:4011487|FD-Score:-3.68|P-value:6.51E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-3.67|P-value:6.57E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:-4.47|P-value:4.54E-5 ID:SGTC_2138|Compound:5575593|FD-Score:3.96|P-value:2.55E-4 ID:SGTC_2157|Compound:5649910|FD-Score:-3.92|P-value:3.01E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.16|P-value:1.35E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.73|P-value:1.67E-5 ID:SGTC_2264|Compound:7948757|FD-Score:3.76|P-value:4.84E-4 ID:SGTC_2271|Compound:7849410|FD-Score:-7.15|P-value:1.98E-10 ID:SGTC_2273|Compound:7815444|FD-Score:-5.84|P-value:1.59E-7 ID:SGTC_2274|Compound:7947094|FD-Score:4.41|P-value:5.58E-5 ID:SGTC_2321|Compound:7390090|FD-Score:4.60|P-value:2.74E-5 ID:SGTC_2345|Compound:9052315|FD-Score:3.55|P-value:9.30E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.71|P-value:5.73E-4 ID:SGTC_2401|Compound:5128683|FD-Score:3.89|P-value:3.27E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:4.26|P-value:9.32E-5 ID:SGTC_2449|Compound:5812982|FD-Score:-4.85|P-value:1.10E-5 ID:SGTC_2450|Compound:5739737|FD-Score:3.53|P-value:9.71E-4 ID:SGTC_2488|Compound:5268135|FD-Score:4.14|P-value:1.43E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:3.84|P-value:3.82E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:4.18|P-value:1.23E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:4.39|P-value:5.94E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:4.04|P-value:1.97E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.54|P-value:9.79E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:5.19|P-value:2.71E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.07|P-value:1.82E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:-3.84|P-value:3.92E-4 ID:SGTC_2700|Compound:st077718|FD-Score:-3.54|P-value:9.87E-4 ID:SGTC_2714|Compound:st079313|FD-Score:4.34|P-value:7.17E-5 ID:SGTC_2749|Compound:bexarotene|FD-Score:4.00|P-value:2.24E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:-5.60|P-value:4.86E-7 ID:SGTC_2804|Compound:7954240|FD-Score:3.73|P-value:5.40E-4 ID:SGTC_2857|Compound:9024691|FD-Score:-4.27|P-value:9.45E-5 ID:SGTC_2858|Compound:9025781|FD-Score:-5.00|P-value:5.97E-6 ID:SGTC_2892|Compound:9047358|FD-Score:-4.24|P-value:1.02E-4 ID:SGTC_2893|Compound:9048488|FD-Score:-3.70|P-value:6.07E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-11.30|P-value:2.33E-23 ID:SGTC_2940|Compound:9060638|FD-Score:3.86|P-value:3.61E-4 ID:SGTC_3081|Compound:9117243|FD-Score:-3.82|P-value:4.09E-4 ID:SGTC_3126|Compound:9127922|FD-Score:-5.99|P-value:8.07E-8 ID:SGTC_3129|Compound:9127257|FD-Score:-4.91|P-value:8.84E-6 ID:SGTC_3142|Compound:9086498|FD-Score:-3.97|P-value:2.59E-4 ID:SGTC_3154|Compound:9100113|FD-Score:3.56|P-value:9.11E-4 ID:SGTC_3182|Compound:9108849|FD-Score:3.69|P-value:6.01E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-4.41|P-value:5.62E-5 ID:SGTC_10|Compound:0279-0212|FD-Score:3.72|P-value:5.57E-4 ID:SGTC_33|Compound:0986-0033|FD-Score:4.23|P-value:1.05E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:5.58|P-value:5.09E-7 ID:SGTC_100|Compound:0086-0128|FD-Score:3.65|P-value:6.93E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.38|P-value:6.09E-5 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.91|P-value:3.16E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:-3.59|P-value:8.55E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:5.50|P-value:7.20E-7 ID:SGTC_236|Compound:1509-0011|FD-Score:6.00|P-value:7.17E-8 ID:SGTC_310|Compound:1273-0058|FD-Score:12.00|P-value:4.50E-26 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.73|P-value:5.54E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:-5.09|P-value:4.18E-6 ID:SGTC_355|Compound:1311-2252|FD-Score:3.89|P-value:3.24E-4 ID:SGTC_539|Compound:4859-0462|FD-Score:4.10|P-value:1.63E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:3.52|P-value:0.00100 ID:SGTC_660|Compound:4031-1742|FD-Score:-5.19|P-value:2.83E-6 ID:SGTC_691|Compound:1548-0686|FD-Score:3.69|P-value:6.04E-4 ID:SGTC_748|Compound:0136-0228|FD-Score:5.42|P-value:1.00E-6 ID:SGTC_761|Compound:k216-0224|FD-Score:3.70|P-value:5.84E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:5.00|P-value:5.92E-6 ID:SGTC_892|Compound:0929-0076|FD-Score:3.70|P-value:5.92E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.68|P-value:6.33E-4 ID:SGTC_1054|Compound:3429-0080|FD-Score:-3.94|P-value:2.86E-4 ID:SGTC_1061|Compound:3448-9325|FD-Score:-4.18|P-value:1.26E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:5.07|P-value:4.42E-6 ID:SGTC_1147|Compound:3809-1045|FD-Score:3.91|P-value:3.08E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.81|P-value:4.15E-4 ID:SGTC_1274|Compound:0865-0114|FD-Score:4.12|P-value:1.50E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:5.42|P-value:9.97E-7 ID:SGTC_1623|Compound:st003709|FD-Score:5.51|P-value:6.86E-7 ID:SGTC_1624|Compound:st003710|FD-Score:4.61|P-value:2.70E-5 ID:SGTC_1626|Compound:st003712|FD-Score:5.60|P-value:4.56E-7 ID:SGTC_1627|Compound:st003713|FD-Score:9.24|P-value:2.86E-16 ID:SGTC_1742|Compound:st038235|FD-Score:5.68|P-value:3.19E-7 ID:SGTC_1800|Compound:st050079|FD-Score:-4.16|P-value:1.35E-4 ID:SGTC_1809|Compound:st050081|FD-Score:-4.03|P-value:2.08E-4 ID:SGTC_1843|Compound:st055809|FD-Score:3.87|P-value:3.48E-4 ID:SGTC_2006|Compound:4011487|FD-Score:-3.68|P-value:6.51E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-3.67|P-value:6.57E-4 ID:SGTC_2115|Compound:tiliquinol|FD-Score:-4.47|P-value:4.54E-5 ID:SGTC_2138|Compound:5575593|FD-Score:3.96|P-value:2.55E-4 ID:SGTC_2157|Compound:5649910|FD-Score:-3.92|P-value:3.01E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.16|P-value:1.35E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.73|P-value:1.67E-5 ID:SGTC_2264|Compound:7948757|FD-Score:3.76|P-value:4.84E-4 ID:SGTC_2271|Compound:7849410|FD-Score:-7.15|P-value:1.98E-10 ID:SGTC_2273|Compound:7815444|FD-Score:-5.84|P-value:1.59E-7 ID:SGTC_2274|Compound:7947094|FD-Score:4.41|P-value:5.58E-5 ID:SGTC_2321|Compound:7390090|FD-Score:4.60|P-value:2.74E-5 ID:SGTC_2345|Compound:9052315|FD-Score:3.55|P-value:9.30E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.71|P-value:5.73E-4 ID:SGTC_2401|Compound:5128683|FD-Score:3.89|P-value:3.27E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:4.26|P-value:9.32E-5 ID:SGTC_2449|Compound:5812982|FD-Score:-4.85|P-value:1.10E-5 ID:SGTC_2450|Compound:5739737|FD-Score:3.53|P-value:9.71E-4 ID:SGTC_2488|Compound:5268135|FD-Score:4.14|P-value:1.43E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:3.84|P-value:3.82E-4 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:4.18|P-value:1.23E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:4.39|P-value:5.94E-5 ID:SGTC_2637|Compound:3-alpha-acetoxydihydrodeoxygedunin|FD-Score:4.04|P-value:1.97E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.54|P-value:9.79E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:5.19|P-value:2.71E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.07|P-value:1.82E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:-3.84|P-value:3.92E-4 ID:SGTC_2700|Compound:st077718|FD-Score:-3.54|P-value:9.87E-4 ID:SGTC_2714|Compound:st079313|FD-Score:4.34|P-value:7.17E-5 ID:SGTC_2749|Compound:bexarotene|FD-Score:4.00|P-value:2.24E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:-5.60|P-value:4.86E-7 ID:SGTC_2804|Compound:7954240|FD-Score:3.73|P-value:5.40E-4 ID:SGTC_2857|Compound:9024691|FD-Score:-4.27|P-value:9.45E-5 ID:SGTC_2858|Compound:9025781|FD-Score:-5.00|P-value:5.97E-6 ID:SGTC_2892|Compound:9047358|FD-Score:-4.24|P-value:1.02E-4 ID:SGTC_2893|Compound:9048488|FD-Score:-3.70|P-value:6.07E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-11.30|P-value:2.33E-23 ID:SGTC_2940|Compound:9060638|FD-Score:3.86|P-value:3.61E-4 ID:SGTC_3081|Compound:9117243|FD-Score:-3.82|P-value:4.09E-4 ID:SGTC_3126|Compound:9127922|FD-Score:-5.99|P-value:8.07E-8 ID:SGTC_3129|Compound:9127257|FD-Score:-4.91|P-value:8.84E-6 ID:SGTC_3142|Compound:9086498|FD-Score:-3.97|P-value:2.59E-4 ID:SGTC_3154|Compound:9100113|FD-Score:3.56|P-value:9.11E-4 ID:SGTC_3182|Compound:9108849|FD-Score:3.69|P-value:6.01E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-4.41|P-value:5.62E-5

Top fitness defect scores for YLR139C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_310 1273-0058 12.00 1.1 µM 4.50E-26 mitochondrial stress 23 2.23E-33
2 SGTC_1627 st003713 9.24 25.6 µM 2.86E-16 calcium & mitochondrial duress 7 1.24E-20
3 SGTC_236 1509-0011 6.00 5.3 µM 7.17E-8 293 9.67E-10
4 SGTC_1742 st038235 5.68 28.9 µM 3.19E-7 mitochondrial stress 55 6.65E-9
5 SGTC_1626 st003712 5.60 1.8 µM 4.56E-7 8 1.06E-8
6 SGTC_58 0957-0393 5.58 9.0 µM 5.09E-7 cell wall 238 1.22E-8
7 SGTC_1623 st003709 5.51 20.3 µM 6.86E-7 calcium & mitochondrial duress 16 1.79E-8
8 SGTC_173 1273-0061 5.50 2.7 µM 7.20E-7 mitochondrial stress 123 1.91E-8
9 SGTC_1597 7-benzyloxygramine 5.42 47.5 µM 9.97E-7 calcium & mitochondrial duress 58 2.91E-8
10 SGTC_748 0136-0228 5.42 77.9 µM 1.00E-6 redox potentiating 44 2.93E-8
11 SGTC_2682 pyrogallin 5.19 40.0 µM 2.71E-6 copper-dependent oxidative stress 9 1.05E-7
12 SGTC_1133 3473-0247 5.07 50.0 µM 4.42E-6 RSC complex & mRNA processing 20 1.99E-7
13 SGTC_767 0929-0023 5.00 86.0 µM 5.92E-6 TRP & mitochondrial translation 37 2.90E-7
14 SGTC_2250 alverine citrate 4.73 130.0 µM 1.67E-5 108 1.11E-6
15 SGTC_1624 st003710 4.61 6.2 µM 2.70E-5 calcium & mitochondrial duress 28 2.05E-6
16 SGTC_2321 7390090 4.60 138.8 µM 2.74E-5 14 2.09E-6
17 SGTC_2274 7947094 4.41 46.1 µM 5.58E-5 17 5.21E-6
18 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 4.39 13.2 µM 5.94E-5 17 5.65E-6
19 SGTC_118 0083-0097 4.38 135.3 µM 6.09E-5 translation 93 5.84E-6
20 SGTC_2714 st079313 4.34 56.9 µM 7.17E-5 6 7.20E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.368 7.14E-108 YER077C_p YER077C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport
0.364 1.78E-105 YNL177C MRPL22 hom Mitochondrial ribosomal protein of the large subunit
0.361 4.03E-104 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.360 3.99E-103 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.359 1.93E-102 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.349 6.49E-97 YLR069C MEF1 hom Mitochondrial elongation factor involved in translational elongation
0.348 3.85E-96 YML061C PIF1 hom DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells
0.347 1.99E-95 YMR282C AEP2 hom Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader
0.332 6.79E-87 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.329 1.26E-85 YPL029W SUV3 hom ATP-dependent RNA helicase, component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates RNA turnover; also required during splicing of the COX1 AI5_beta intron
0.326 6.21E-84 YOL095C HMI1 hom Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD
0.320 9.33E-81 YNL081C SWS2 hom Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency
0.320 1.42E-80 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.316 8.70E-79 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.316 1.54E-78 YDR268W MSW1 hom Mitochondrial tryptophanyl-tRNA synthetase