YLR142W / PUT1

Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR142W / PUT1

Click on Significant Values for Screen Details ID:SGTC_308|Compound:4092-1169|FD-Score:3.33|P-value:1.58E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:3.36|P-value:1.39E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:4.16|P-value:3.21E-6 ID:SGTC_368|Compound:fentichlor|FD-Score:3.13|P-value:3.53E-4 ID:SGTC_394|Compound:menadione|FD-Score:3.24|P-value:2.24E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:3.72|P-value:2.84E-5 ID:SGTC_535|Compound:2293-4129|FD-Score:4.22|P-value:2.47E-6 ID:SGTC_690|Compound:glyoxal|FD-Score:3.09|P-value:4.08E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:-3.03|P-value:4.61E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:5.68|P-value:3.75E-10 ID:SGTC_1129|Compound:3453-1384|FD-Score:5.52|P-value:1.09E-9 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.68|P-value:2.83E-5 ID:SGTC_1172|Compound:0370-0043|FD-Score:4.37|P-value:1.08E-6 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.12|P-value:3.76E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:2.97|P-value:6.48E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:2.87|P-value:9.66E-4 ID:SGTC_1610|Compound:st001799|FD-Score:-3.01|P-value:4.93E-4 ID:SGTC_1613|Compound:st002381|FD-Score:-3.04|P-value:4.40E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-4.10|P-value:3.77E-6 ID:SGTC_1727|Compound:st034309|FD-Score:3.21|P-value:2.56E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.95|P-value:9.55E-6 ID:SGTC_1760|Compound:st045453|FD-Score:2.89|P-value:8.93E-4 ID:SGTC_1914|Compound:st062367|FD-Score:-3.94|P-value:8.56E-6 ID:SGTC_2085|Compound:5307070|FD-Score:4.52|P-value:4.75E-7 ID:SGTC_2098|Compound:5376439|FD-Score:4.92|P-value:4.68E-8 ID:SGTC_2103|Compound:5378138|FD-Score:3.16|P-value:3.14E-4 ID:SGTC_2262|Compound:9014885|FD-Score:-4.18|P-value:2.47E-6 ID:SGTC_2568|Compound:diosmetin|FD-Score:2.92|P-value:7.90E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.15|P-value:3.22E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:4.01|P-value:7.08E-6 ID:SGTC_2695|Compound:st077686|FD-Score:2.92|P-value:7.97E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-3.16|P-value:2.71E-4 ID:SGTC_2950|Compound:9072895|FD-Score:3.79|P-value:2.01E-5 ID:SGTC_2951|Compound:9072950|FD-Score:-2.94|P-value:6.45E-4 ID:SGTC_2987|Compound:9018338|FD-Score:2.97|P-value:6.62E-4 ID:SGTC_2989|Compound:9073649|FD-Score:2.92|P-value:8.09E-4 ID:SGTC_3001|Compound:9076041|FD-Score:-4.10|P-value:3.72E-6 ID:SGTC_3002|Compound:9075603|FD-Score:-2.85|P-value:9.23E-4 ID:SGTC_3016|Compound:9080866|FD-Score:-3.50|P-value:6.55E-5 ID:SGTC_3208|Compound:9114115|FD-Score:-4.52|P-value:4.05E-7 ID:SGTC_3296|Compound:9122258|FD-Score:3.39|P-value:1.22E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:3.33|P-value:1.58E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:3.36|P-value:1.39E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:4.16|P-value:3.21E-6 ID:SGTC_368|Compound:fentichlor|FD-Score:3.13|P-value:3.53E-4 ID:SGTC_394|Compound:menadione|FD-Score:3.24|P-value:2.24E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:3.72|P-value:2.84E-5 ID:SGTC_535|Compound:2293-4129|FD-Score:4.22|P-value:2.47E-6 ID:SGTC_690|Compound:glyoxal|FD-Score:3.09|P-value:4.08E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:-3.03|P-value:4.61E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:5.68|P-value:3.75E-10 ID:SGTC_1129|Compound:3453-1384|FD-Score:5.52|P-value:1.09E-9 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.68|P-value:2.83E-5 ID:SGTC_1172|Compound:0370-0043|FD-Score:4.37|P-value:1.08E-6 ID:SGTC_1175|Compound:0741-0056|FD-Score:3.12|P-value:3.76E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:2.97|P-value:6.48E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:2.87|P-value:9.66E-4 ID:SGTC_1610|Compound:st001799|FD-Score:-3.01|P-value:4.93E-4 ID:SGTC_1613|Compound:st002381|FD-Score:-3.04|P-value:4.40E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-4.10|P-value:3.77E-6 ID:SGTC_1727|Compound:st034309|FD-Score:3.21|P-value:2.56E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.95|P-value:9.55E-6 ID:SGTC_1760|Compound:st045453|FD-Score:2.89|P-value:8.93E-4 ID:SGTC_1914|Compound:st062367|FD-Score:-3.94|P-value:8.56E-6 ID:SGTC_2085|Compound:5307070|FD-Score:4.52|P-value:4.75E-7 ID:SGTC_2098|Compound:5376439|FD-Score:4.92|P-value:4.68E-8 ID:SGTC_2103|Compound:5378138|FD-Score:3.16|P-value:3.14E-4 ID:SGTC_2262|Compound:9014885|FD-Score:-4.18|P-value:2.47E-6 ID:SGTC_2568|Compound:diosmetin|FD-Score:2.92|P-value:7.90E-4 ID:SGTC_2596|Compound:sinensetin|FD-Score:3.15|P-value:3.22E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:4.01|P-value:7.08E-6 ID:SGTC_2695|Compound:st077686|FD-Score:2.92|P-value:7.97E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-3.16|P-value:2.71E-4 ID:SGTC_2950|Compound:9072895|FD-Score:3.79|P-value:2.01E-5 ID:SGTC_2951|Compound:9072950|FD-Score:-2.94|P-value:6.45E-4 ID:SGTC_2987|Compound:9018338|FD-Score:2.97|P-value:6.62E-4 ID:SGTC_2989|Compound:9073649|FD-Score:2.92|P-value:8.09E-4 ID:SGTC_3001|Compound:9076041|FD-Score:-4.10|P-value:3.72E-6 ID:SGTC_3002|Compound:9075603|FD-Score:-2.85|P-value:9.23E-4 ID:SGTC_3016|Compound:9080866|FD-Score:-3.50|P-value:6.55E-5 ID:SGTC_3208|Compound:9114115|FD-Score:-4.52|P-value:4.05E-7 ID:SGTC_3296|Compound:9122258|FD-Score:3.39|P-value:1.22E-4

Top fitness defect scores for YLR142W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1082 camptothecin 5.68 424.9 nM 3.75E-10 DNA damage response 22 6.92E-9
2 SGTC_1129 3453-1384 5.52 223.0 µM 1.09E-9 14 1.72E-8
3 SGTC_2098 5376439 4.92 882.5 nM 4.68E-8 3 4.22E-7
4 SGTC_2085 5307070 4.52 144.1 µM 4.75E-7 superoxide 18 3.05E-6
5 SGTC_1172 0370-0043 4.37 85.0 µM 1.08E-6 14 6.17E-6
6 SGTC_535 2293-4129 4.22 48.2 µM 2.47E-6 NEO1 54 1.24E-5
7 SGTC_367 0335-0881 4.16 7.1 µM 3.21E-6 ubiquinone biosynthesis & proteasome 70 1.56E-5
8 SGTC_2603 homopterocarpin 4.01 100.0 µM 7.08E-6 36 3.06E-5
9 SGTC_1728 st035614 3.95 33.8 µM 9.55E-6 49 3.95E-5
10 SGTC_2950 9072895 3.79 21.5 µM 2.01E-5 45 7.47E-5
11 SGTC_531 3788-1495 3.72 174.0 µM 2.84E-5 unfolded protein response 25 1.01E-4
12 SGTC_3296 9122258 3.39 64.0 µM 1.22E-4 redox potentiating 36 3.51E-4
13 SGTC_320 4092-0846 3.36 5.3 µM 1.39E-4 ergosterol depletion effects on membrane 75 3.90E-4
14 SGTC_308 4092-1169 3.33 104.0 µM 1.58E-4 plasma membrane duress 78 4.36E-4
15 SGTC_394 menadione 3.24 8.3 µM 2.24E-4 superoxide 56 5.90E-4
16 SGTC_1727 st034309 3.21 9.9 µM 2.56E-4 86 6.62E-4
17 SGTC_2103 5378138 3.16 10.0 µM 3.14E-4 50 7.87E-4
18 SGTC_2596 sinensetin 3.15 100.0 µM 3.22E-4 65 8.05E-4
19 SGTC_368 fentichlor 3.13 4.6 µM 3.53E-4 54 8.71E-4
20 SGTC_1175 0741-0056 3.12 27.6 µM 3.76E-4 61 9.19E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.143 7.54E-17 YBL088C TEL1 hom Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; regulates P-body formation induced by replication stress; homolog of human ataxia-telangiectasia mutated (ATM) gene, the gene responsible for ataxia telangiectasia (AT) (OMIM 607585)
0.129 6.01E-14 YMR020W FMS1 hom Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis
0.126 2.13E-13 YBR099C_d YBR099C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4
0.117 1.14E-11 YAL056W GPB2 hom Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; GPB2 has a paralog, GPB1, that arose from the whole genome duplication
0.111 9.76E-11 YDR386W MUS81 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
0.108 3.95E-10 YOL152W FRE7 hom Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels
0.108 4.19E-10 YHR110W ERP5 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.104 1.70E-9 YPR144C NOC4 het Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits
0.103 2.00E-9 YDL113C ATG20 hom Sorting nexin family member required for the cytoplasm-to-vacuole targeting (Cvt) pathway and for endosomal sorting; has a Phox homology domain that binds phosphatidylinositol-3-phosphate; interacts with Snx4p; potential Cdc28p substrate
0.100 7.16E-9 YBR293W VBA2 hom Permease of basic amino acids in the vacuolar membrane
0.100 7.68E-9 YPL090C RPS6A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S6, no bacterial homolog; RPS6A has a paralog, RPS6B, that arose from the whole genome duplication
0.097 1.71E-8 YPR037C ERV2 hom Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER
0.095 3.21E-8 YOL086W-A MHF1 hom Component of the heterotetrameric MHF histone-fold complex; in humans the MMF complex interacts with both DNA and Mph1p ortholog FANCM, a Fanconi anemia complementation group protein, to stabilize and remodel blocked replication forks and repair damaged DNA; mhf1 srs2 double mutants are MMS hypersensitive; ortholog of human centromere constitutive-associated network (CCAN) subunit CENP-S, also known as MHF1
0.093 7.49E-8 YDR464W SPP41 het Protein involved in negative regulation of expression of spliceosome components PRP4 and PRP3
0.092 1.09E-7 YAL062W GDH3 hom NADP(+)-dependent glutamate dehydrogenase; synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources; GDH3 has a paralog, GDH1, that arose from the whole genome duplication