YLR150W / STM1

Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR150W / STM1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:16.00|P-value:6.05E-50 ID:SGTC_109|Compound:0132-0036|FD-Score:-3.92|P-value:1.88E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:-3.47|P-value:8.40E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:17.90|P-value:6.01E-62 ID:SGTC_160|Compound:3453-0671|FD-Score:4.08|P-value:6.40E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:4.55|P-value:1.01E-5 ID:SGTC_361|Compound:000s-0510|FD-Score:5.02|P-value:1.32E-6 ID:SGTC_363|Compound:0455-0021|FD-Score:-4.43|P-value:2.82E-5 ID:SGTC_386|Compound:1509-0011|FD-Score:4.16|P-value:4.75E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.69|P-value:4.13E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:-3.52|P-value:7.16E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:3.55|P-value:4.20E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:3.85|P-value:1.49E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.30|P-value:9.41E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.61|P-value:3.41E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-3.62|P-value:5.28E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.35|P-value:7.98E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.42|P-value:6.33E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:-6.26|P-value:5.64E-9 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.43|P-value:6.13E-4 ID:SGTC_1559|Compound:coumarin 343|FD-Score:3.32|P-value:8.86E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.46|P-value:5.61E-4 ID:SGTC_1635|Compound:st007035|FD-Score:5.36|P-value:2.66E-7 ID:SGTC_1745|Compound:st081495|FD-Score:-4.14|P-value:8.57E-5 ID:SGTC_1818|Compound:st052136|FD-Score:-3.42|P-value:9.96E-4 ID:SGTC_1885|Compound:st057546|FD-Score:4.75|P-value:4.32E-6 ID:SGTC_2057|Compound:5236571|FD-Score:4.10|P-value:6.03E-5 ID:SGTC_2139|Compound:5578692|FD-Score:3.41|P-value:6.56E-4 ID:SGTC_2460|Compound:5552655|FD-Score:-4.28|P-value:5.18E-5 ID:SGTC_2469|Compound:5655019|FD-Score:3.79|P-value:1.81E-4 ID:SGTC_2474|Compound:5321570|FD-Score:4.80|P-value:3.55E-6 ID:SGTC_2479|Compound:5617353|FD-Score:4.13|P-value:5.43E-5 ID:SGTC_2557|Compound:derrustone|FD-Score:3.84|P-value:1.52E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-4.02|P-value:1.35E-4 ID:SGTC_2966|Compound:9084041|FD-Score:3.92|P-value:1.14E-4 ID:SGTC_3097|Compound:9117246|FD-Score:3.78|P-value:1.91E-4 ID:SGTC_3300|Compound:9124615|FD-Score:4.79|P-value:3.62E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:16.00|P-value:6.05E-50 ID:SGTC_109|Compound:0132-0036|FD-Score:-3.92|P-value:1.88E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:-3.47|P-value:8.40E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:17.90|P-value:6.01E-62 ID:SGTC_160|Compound:3453-0671|FD-Score:4.08|P-value:6.40E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:4.55|P-value:1.01E-5 ID:SGTC_361|Compound:000s-0510|FD-Score:5.02|P-value:1.32E-6 ID:SGTC_363|Compound:0455-0021|FD-Score:-4.43|P-value:2.82E-5 ID:SGTC_386|Compound:1509-0011|FD-Score:4.16|P-value:4.75E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.69|P-value:4.13E-4 ID:SGTC_550|Compound:4123-0385|FD-Score:-3.52|P-value:7.16E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:3.55|P-value:4.20E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:3.85|P-value:1.49E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.30|P-value:9.41E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.61|P-value:3.41E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-3.62|P-value:5.28E-4 ID:SGTC_1176|Compound:0848-0131|FD-Score:3.35|P-value:7.98E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.42|P-value:6.33E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:-6.26|P-value:5.64E-9 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.43|P-value:6.13E-4 ID:SGTC_1559|Compound:coumarin 343|FD-Score:3.32|P-value:8.86E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.46|P-value:5.61E-4 ID:SGTC_1635|Compound:st007035|FD-Score:5.36|P-value:2.66E-7 ID:SGTC_1745|Compound:st081495|FD-Score:-4.14|P-value:8.57E-5 ID:SGTC_1818|Compound:st052136|FD-Score:-3.42|P-value:9.96E-4 ID:SGTC_1885|Compound:st057546|FD-Score:4.75|P-value:4.32E-6 ID:SGTC_2057|Compound:5236571|FD-Score:4.10|P-value:6.03E-5 ID:SGTC_2139|Compound:5578692|FD-Score:3.41|P-value:6.56E-4 ID:SGTC_2460|Compound:5552655|FD-Score:-4.28|P-value:5.18E-5 ID:SGTC_2469|Compound:5655019|FD-Score:3.79|P-value:1.81E-4 ID:SGTC_2474|Compound:5321570|FD-Score:4.80|P-value:3.55E-6 ID:SGTC_2479|Compound:5617353|FD-Score:4.13|P-value:5.43E-5 ID:SGTC_2557|Compound:derrustone|FD-Score:3.84|P-value:1.52E-4 ID:SGTC_2694|Compound:st077685|FD-Score:-4.02|P-value:1.35E-4 ID:SGTC_2966|Compound:9084041|FD-Score:3.92|P-value:1.14E-4 ID:SGTC_3097|Compound:9117246|FD-Score:3.78|P-value:1.91E-4 ID:SGTC_3300|Compound:9124615|FD-Score:4.79|P-value:3.62E-6

Top fitness defect scores for YLR150W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
1 SGTC_138 0850-0259 17.90 40.9 µM 6.01E-62 cell wall 10 7.95E-72
2 SGTC_58 0957-0393 16.00 9.0 µM 6.05E-50 cell wall 25 8.49E-58
3 SGTC_1635 st007035 5.36 42.4 µM 2.66E-7 154 4.07E-8
4 SGTC_361 000s-0510 5.02 1.4 µM 1.32E-6 15 2.58E-7
5 SGTC_2474 5321570 4.80 43.3 µM 3.55E-6 3 8.05E-7
6 SGTC_3300 9124615 4.79 50.5 µM 3.62E-6 6 8.23E-7
7 SGTC_1885 st057546 4.75 99.9 µM 4.32E-6 7 1.01E-6
8 SGTC_236 1509-0011 4.55 5.3 µM 1.01E-5 358 2.69E-6
9 SGTC_386 1509-0011 4.16 3.1 µM 4.75E-5 137 1.59E-5
10 SGTC_2479 5617353 4.13 43.9 µM 5.43E-5 34 1.85E-5
11 SGTC_2057 5236571 4.10 38.3 µM 6.03E-5 RPP1 & pyrimidine depletion 27 2.09E-5
12 SGTC_160 3453-0671 4.08 289.7 µM 6.40E-5 38 2.24E-5
13 SGTC_2966 9084041 3.92 48.0 µM 1.14E-4 33 4.35E-5
14 SGTC_806 3966-4455 3.85 5.9 µM 1.49E-4 22 5.92E-5
15 SGTC_2557 derrustone 3.84 83.8 µM 1.52E-4 38 6.04E-5
16 SGTC_2469 5655019 3.79 90.8 µM 1.81E-4 24 7.38E-5
17 SGTC_3097 9117246 3.78 49.5 µM 1.91E-4 14 7.84E-5
18 SGTC_1049 3226-0134 3.61 66.0 µM 3.41E-4 39 1.52E-4
19 SGTC_784 4579-0127 3.55 173.0 µM 4.20E-4 37 1.93E-4
20 SGTC_1565 sinapyl alcohol 3.46 95.1 µM 5.61E-4 47 2.69E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.370 3.80E-109 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.359 8.95E-103 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.359 1.66E-102 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.317 2.09E-79 YML057C-A_d YML057C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene CMP2/YML057W
0.312 7.03E-77 YPL269W KAR9 hom Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase
0.308 1.50E-74 YKL033W-A_p YKL033W-A_p hom Putative protein of unknown function; similar to uncharacterized proteins from other fungi
0.307 3.04E-74 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.306 1.90E-73 YJL080C SCP160 hom Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins
0.305 3.90E-73 YDR351W SBE2 hom Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth
0.304 8.74E-73 YDR335W MSN5 hom Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm
0.302 8.88E-72 YOR127W RGA1 hom GTPase-activating protein for polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.300 1.45E-70 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.297 4.21E-69 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.290 3.38E-66 YKR042W UTH1 hom Protein involved in cell wall biogenesis; required for mitochondrial autophagy; mitochondrial outer membrane and cell wall localized SUN family member; involved in the oxidative stress response, life span during starvation, and cell death; UTH1 has a paralog, NCA3, that arose from the whole genome duplication
0.289 2.07E-65 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain