YLR152C_p

Putative protein of unknown function; YLR152C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR152C / YLR152C

Click on Significant Values for Screen Details ID:SGTC_12|Compound:0849-0099|FD-Score:3.06|P-value:8.64E-4 ID:SGTC_82|Compound:0054-0107|FD-Score:3.62|P-value:1.07E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:3.54|P-value:1.48E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:4.45|P-value:2.70E-6 ID:SGTC_910|Compound:3454-3003|FD-Score:3.35|P-value:3.04E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:-4.29|P-value:5.87E-6 ID:SGTC_1067|Compound:clotrimazole|FD-Score:4.08|P-value:1.52E-5 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.47|P-value:1.96E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-3.41|P-value:2.51E-4 ID:SGTC_1945|Compound:st075991|FD-Score:-4.81|P-value:4.39E-7 ID:SGTC_2056|Compound:5235370|FD-Score:-3.79|P-value:5.30E-5 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.10|P-value:7.61E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:3.58|P-value:1.28E-4 ID:SGTC_2813|Compound:7971799|FD-Score:3.58|P-value:1.25E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.72|P-value:7.19E-5 ID:SGTC_2850|Compound:9015429|FD-Score:3.04|P-value:9.56E-4 ID:SGTC_2857|Compound:9024691|FD-Score:4.28|P-value:6.03E-6 ID:SGTC_2859|Compound:9028643|FD-Score:-3.92|P-value:3.06E-5 ID:SGTC_2893|Compound:9048488|FD-Score:3.10|P-value:7.75E-4 ID:SGTC_2906|Compound:7926292|FD-Score:4.16|P-value:1.07E-5 ID:SGTC_2946|Compound:9065502|FD-Score:-3.38|P-value:2.79E-4 ID:SGTC_2949|Compound:9072542|FD-Score:-4.18|P-value:9.94E-6 ID:SGTC_2952|Compound:9073731|FD-Score:-3.22|P-value:5.11E-4 ID:SGTC_3015|Compound:9080845|FD-Score:4.03|P-value:1.90E-5 ID:SGTC_3117|Compound:9124945|FD-Score:-3.78|P-value:5.59E-5 ID:SGTC_3215|Compound:9129942|FD-Score:4.55|P-value:1.62E-6 ID:SGTC_3264|Compound:9137442|FD-Score:3.45|P-value:2.14E-4 ID:SGTC_12|Compound:0849-0099|FD-Score:3.06|P-value:8.64E-4 ID:SGTC_82|Compound:0054-0107|FD-Score:3.62|P-value:1.07E-4 ID:SGTC_259|Compound:usnic acid|FD-Score:3.54|P-value:1.48E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:4.45|P-value:2.70E-6 ID:SGTC_910|Compound:3454-3003|FD-Score:3.35|P-value:3.04E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:-4.29|P-value:5.87E-6 ID:SGTC_1067|Compound:clotrimazole|FD-Score:4.08|P-value:1.52E-5 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.47|P-value:1.96E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-3.41|P-value:2.51E-4 ID:SGTC_1945|Compound:st075991|FD-Score:-4.81|P-value:4.39E-7 ID:SGTC_2056|Compound:5235370|FD-Score:-3.79|P-value:5.30E-5 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.10|P-value:7.61E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:3.58|P-value:1.28E-4 ID:SGTC_2813|Compound:7971799|FD-Score:3.58|P-value:1.25E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.72|P-value:7.19E-5 ID:SGTC_2850|Compound:9015429|FD-Score:3.04|P-value:9.56E-4 ID:SGTC_2857|Compound:9024691|FD-Score:4.28|P-value:6.03E-6 ID:SGTC_2859|Compound:9028643|FD-Score:-3.92|P-value:3.06E-5 ID:SGTC_2893|Compound:9048488|FD-Score:3.10|P-value:7.75E-4 ID:SGTC_2906|Compound:7926292|FD-Score:4.16|P-value:1.07E-5 ID:SGTC_2946|Compound:9065502|FD-Score:-3.38|P-value:2.79E-4 ID:SGTC_2949|Compound:9072542|FD-Score:-4.18|P-value:9.94E-6 ID:SGTC_2952|Compound:9073731|FD-Score:-3.22|P-value:5.11E-4 ID:SGTC_3015|Compound:9080845|FD-Score:4.03|P-value:1.90E-5 ID:SGTC_3117|Compound:9124945|FD-Score:-3.78|P-value:5.59E-5 ID:SGTC_3215|Compound:9129942|FD-Score:4.55|P-value:1.62E-6 ID:SGTC_3264|Compound:9137442|FD-Score:3.45|P-value:2.14E-4

Top fitness defect scores for YLR152C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3215 9129942 4.55 49.5 µM 1.62E-6 5 2.64E-6
2 SGTC_363 0455-0021 4.45 3.1 µM 2.70E-6 azole & statin 48 4.29E-6
3 SGTC_2857 9024691 4.28 58.4 µM 6.03E-6 15 9.28E-6
4 SGTC_2906 7926292 4.16 26.4 µM 1.07E-5 21 1.61E-5
5 SGTC_1067 clotrimazole 4.08 1.4 µM 1.52E-5 azole & statin 41 2.25E-5
6 SGTC_3015 9080845 4.03 49.5 µM 1.90E-5 7 2.80E-5
7 SGTC_2821 7996764 3.72 71.4 µM 7.19E-5 51 1.00E-4
8 SGTC_82 0054-0107 3.62 293.8 µM 1.07E-4 14 1.46E-4
9 SGTC_2813 7971799 3.58 71.4 µM 1.25E-4 28 1.71E-4
10 SGTC_2607 solasodine 3.58 47.4 µM 1.28E-4 71 1.73E-4
11 SGTC_259 usnic acid 3.54 108.9 µM 1.48E-4 29 2.00E-4
12 SGTC_1197 1601-0112 3.47 267.0 µM 1.96E-4 32 2.61E-4
13 SGTC_3264 9137442 3.45 49.5 µM 2.14E-4 23 2.85E-4
14 SGTC_910 3454-3003 3.35 490.0 µM 3.04E-4 35 4.00E-4
15 SGTC_2514 salinomycin 3.10 42.7 µM 7.61E-4 97 9.63E-4
16 SGTC_2893 9048488 3.10 26.0 µM 7.75E-4 fatty acid desaturase (OLE1) 55 9.81E-4
17 SGTC_12 0849-0099 3.06 9.3 µM 8.64E-4 46 0.00109
18 SGTC_2850 9015429 3.04 58.4 µM 9.56E-4 52 0.00120
19 SGTC_2941 9056145 3.00 11.2 µM 0.00109 42 0.00136
20 SGTC_322 k048-0136 2.98 19.3 µM 0.00115 RSC & ERG11 48 0.00144

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.163 2.47E-21 YGL156W AMS1 hom Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway
0.125 3.61E-13 YJR046W TAH11 het DNA replication licensing factor, required for pre-replication complex assembly
0.122 1.48E-12 YGR170W PSD2 hom Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine
0.122 1.63E-12 YPR013C_p CMR3_p hom Putative zinc finger protein; YPR013C is not an essential gene
0.100 6.33E-9 YKL104C GFA1 het Glutamine-fructose-6-phosphate amidotransferase; catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; GFA1 has a paralogous region, comprising ORFs YMR084W-YMR085W, that arose from the whole genome duplication
0.099 1.08E-8 YHR035W_p YHR035W_p hom Putative protein of unknown function; not an essential gene
0.098 1.44E-8 YOL062C APM4 hom Mu2-like subunit of the clathrin associated protein complex (AP-2); involved in vesicle transport
0.095 4.02E-8 YMR247W-A_p YMR247W-A_p hom Putative protein of unknown function
0.094 4.51E-8 YLR281C_p YLR281C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR281C is not an essential gene
0.093 7.22E-8 YGR010W NMA2 hom Nicotinic acid mononucleotide adenylyltransferase; catalyzes the transfer of the adenylyl moiety of ATP to nicotinamide mononucleotide to form NAD; involved in de novo and salvage synthesis of NAD(+); NMA2 has a paralog, NMA1, that arose from the whole genome duplication
0.091 1.46E-7 YBL028C YBL028C hom Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis
0.089 2.29E-7 YKR034W DAL80 hom Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Gzf3p; DAL80 has a paralog, GZF3, that arose from the whole genome duplication
0.087 5.24E-7 YPR199C ARR1 hom Transcriptional activator of the basic leucine zipper (bZIP) family, required for transcription of genes involved in resistance to arsenic compounds
0.086 7.01E-7 YLR394W CST9 hom SUMO E3 ligase; required for synaptonemal complex formation; localizes to synapsis initiation sites on meiotic chromosomes; potential Cdc28p substrate
0.086 7.11E-7 YGR099W TEL2 het Subunit of the ASTRA complex, involved in chromatin remodeling; subunit of the telomere cap complex DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect; involved in the stability or biogenesis of PIKKs such as TORC1