HIPHOP chemogenomics database

YLR153C / ACS2

Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions

Zygosity: Heterozygous strain

fixedexpanded
Profile for YLR153C / ACS2

Click on Significant Values for Screen Details

Top fitness defect scores for YLR153C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_3304	9125678	27.50	46.1 µM	9.82E-125		4	4.44E-167	3.48
2	SGTC_451	chloral hydrate	14.30	100.0 µM	2.30E-35		2	6.81E-47	7.67
3	SGTC_528	3492-0019	10.70	172.0 µM	1.45E-20	calcium & mitochondrial duress	3	5.15E-27	2.01
4	SGTC_794	k038-0031	9.34	316.0 µM	4.00E-16	ubiquinone biosynthesis & proteasome	3	4.65E-21	0.79
5	SGTC_1317	1273-0028	8.86	910.0 nM	1.12E-14	azole & statin	3	4.07E-19	1.06
6	SGTC_851	0394-0702	8.07	453.0 µM	1.70E-12	mitochondrial processes	5	3.39E-16	1.62
7	SGTC_3120	9124077	7.49	49.5 µM	5.42E-11		9	3.49E-14	1.34
8	SGTC_63	0099-0242	7.43	26.7 µM	7.65E-11	mitochondrial stress	9	5.54E-14	1.47
9	SGTC_3288	9119690	6.91	36.2 µM	1.31E-9		9	2.47E-12	0.62
10	SGTC_69	0096-0274	6.63	206.7 µM	5.50E-9	mitochondrial processes	16	1.69E-11	0.16
11	SGTC_676	falcarinol	6.39	140.0 µM	1.78E-8		3	8.07E-11	1.04
12	SGTC_158	k038-0087	6.37	26.4 µM	1.99E-8	ubiquinone biosynthesis & proteasome	13	9.40E-11	0.30
13	SGTC_273	hydroxyurea	6.23	18.1 mM	3.93E-8	heme biosynthesis & mitochondrial translocase	4	2.33E-10	0.37
14	SGTC_1255	0566-0045	6.18	221.0 µM	4.98E-8	excess fatty acid	5	3.20E-10	0.10
15	SGTC_795	0685-0265	6.08	78.0 µM	8.11E-8	excess fatty acid	3	6.13E-10	0.10
16	SGTC_1590	st077108	5.58	57.8 µM	7.44E-7		2	1.18E-8	0.54
17	SGTC_902	1120-0002	5.43	2.1 µM	1.41E-6	azole & statin	10	2.77E-8	0.01
18	SGTC_115	0527-0192	5.15	112.0 µM	4.54E-6		8	1.31E-7	0.10
19	SGTC_924	2046-0044	5.03	21.3 µM	7.15E-6		2	2.40E-7	0.35
20	SGTC_1168	k815-0004	4.90	80.5 µM	1.19E-5	DNA damage response	9	4.76E-7	0.00

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.483	1.63E-195	YKL019W	RAM2	het	Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor
0.475	2.81E-188	YGL155W	CDC43	het	Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis
0.365	2.68E-106	YKL058W	TOA2	het	TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA; protein abundance increases in response to DNA replication stress
0.333	1.49E-87	YLR229C	CDC42	het	Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins
0.315	3.00E-78	YLR230W_d	YLR230W_d	het	Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential CDC42 gene which encodes a small Rho-like GTPase essential for establishment and maintenance of cell polarity
0.239	7.76E-45	YPL028W	ERG10	het	Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis
0.232	2.62E-42	YDR309C	GIC2	hom	Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region
0.205	4.94E-33	YPR034W	ARP7	het	Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.193	1.29E-29	YOR045W	TOM6	hom	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex
0.191	5.39E-29	YDR475C	JIP4	hom	Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.182	2.52E-26	YGL049C	TIF4632	hom	Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); TIF4632 has a paralog, TIF4631, that arose from the whole genome duplication
0.167	1.86E-22	YMR033W	ARP9	het	Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.160	1.00E-20	YMR127C	SAS2	hom	Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family
0.159	2.05E-20	YOR254C	SEC63	het	Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.155	2.14E-19	YCR033W	SNT1	hom	Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolerance