YLR164W / SHH4

Mitochondrial inner membrane protein of unknown function; similar to Tim18p and Sdh4p; a fraction copurifies with Sdh3p, but Shh4p is neither a stoichiometric subunit of succinate dehydrogenase nor of the TIM22 translocase; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR164W / SHH4

Click on Significant Values for Screen Details ID:SGTC_31|Compound:0508-1974|FD-Score:-3.15|P-value:2.97E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:-3.38|P-value:1.12E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:2.93|P-value:5.54E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:3.14|P-value:2.37E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:3.37|P-value:9.25E-5 ID:SGTC_565|Compound:1418-0001|FD-Score:3.13|P-value:2.48E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:-3.24|P-value:2.03E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:-2.88|P-value:8.53E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:3.47|P-value:5.75E-5 ID:SGTC_799|Compound:1310-0557|FD-Score:-3.28|P-value:1.75E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:3.22|P-value:1.77E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:5.21|P-value:3.95E-9 ID:SGTC_898|Compound:1000-0849|FD-Score:-3.44|P-value:8.70E-5 ID:SGTC_901|Compound:1112-0062|FD-Score:-6.11|P-value:1.08E-11 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.45|P-value:6.45E-5 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:2.85|P-value:7.53E-4 ID:SGTC_1602|Compound:st001878|FD-Score:3.06|P-value:3.39E-4 ID:SGTC_1613|Compound:st002381|FD-Score:-4.42|P-value:6.68E-7 ID:SGTC_1637|Compound:st007924|FD-Score:-4.02|P-value:5.51E-6 ID:SGTC_1779|Compound:st039427|FD-Score:3.41|P-value:7.54E-5 ID:SGTC_2017|Compound:5132927|FD-Score:2.92|P-value:5.83E-4 ID:SGTC_2068|Compound:5226020|FD-Score:3.41|P-value:7.56E-5 ID:SGTC_2352|Compound:9027995|FD-Score:3.00|P-value:4.19E-4 ID:SGTC_2354|Compound:9060492|FD-Score:4.43|P-value:4.65E-7 ID:SGTC_2607|Compound:solasodine|FD-Score:3.25|P-value:1.53E-4 ID:SGTC_3081|Compound:9117243|FD-Score:2.87|P-value:7.03E-4 ID:SGTC_3091|Compound:9116372|FD-Score:3.11|P-value:2.69E-4 ID:SGTC_31|Compound:0508-1974|FD-Score:-3.15|P-value:2.97E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:-3.38|P-value:1.12E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:2.93|P-value:5.54E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:3.14|P-value:2.37E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:3.37|P-value:9.25E-5 ID:SGTC_565|Compound:1418-0001|FD-Score:3.13|P-value:2.48E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:-3.24|P-value:2.03E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:-2.88|P-value:8.53E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:3.47|P-value:5.75E-5 ID:SGTC_799|Compound:1310-0557|FD-Score:-3.28|P-value:1.75E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:3.22|P-value:1.77E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:5.21|P-value:3.95E-9 ID:SGTC_898|Compound:1000-0849|FD-Score:-3.44|P-value:8.70E-5 ID:SGTC_901|Compound:1112-0062|FD-Score:-6.11|P-value:1.08E-11 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.45|P-value:6.45E-5 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:2.85|P-value:7.53E-4 ID:SGTC_1602|Compound:st001878|FD-Score:3.06|P-value:3.39E-4 ID:SGTC_1613|Compound:st002381|FD-Score:-4.42|P-value:6.68E-7 ID:SGTC_1637|Compound:st007924|FD-Score:-4.02|P-value:5.51E-6 ID:SGTC_1779|Compound:st039427|FD-Score:3.41|P-value:7.54E-5 ID:SGTC_2017|Compound:5132927|FD-Score:2.92|P-value:5.83E-4 ID:SGTC_2068|Compound:5226020|FD-Score:3.41|P-value:7.56E-5 ID:SGTC_2352|Compound:9027995|FD-Score:3.00|P-value:4.19E-4 ID:SGTC_2354|Compound:9060492|FD-Score:4.43|P-value:4.65E-7 ID:SGTC_2607|Compound:solasodine|FD-Score:3.25|P-value:1.53E-4 ID:SGTC_3081|Compound:9117243|FD-Score:2.87|P-value:7.03E-4 ID:SGTC_3091|Compound:9116372|FD-Score:3.11|P-value:2.69E-4

Top fitness defect scores for YLR164W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_884 0851-0618 5.21 334.0 µM 3.95E-9 3 9.32E-8
2 SGTC_2354 9060492 4.43 162.0 µM 4.65E-7 9 4.78E-6
3 SGTC_628 1636-0253 3.47 16.0 µM 5.75E-5 sphingolipid biosynthesis & PDR1 50 2.57E-4
4 SGTC_1374 2889-5571 3.45 141.0 µM 6.45E-5 RSC complex & mRNA processing 64 2.82E-4
5 SGTC_1779 st039427 3.41 55.0 µM 7.54E-5 50 3.21E-4
6 SGTC_2068 5226020 3.41 147.0 µM 7.56E-5 43 3.22E-4
7 SGTC_552 k242-0005 3.37 476.0 µM 9.25E-5 37 3.81E-4
8 SGTC_2607 solasodine 3.25 47.4 µM 1.53E-4 91 5.77E-4
9 SGTC_816 0325-0417 3.22 81.3 µM 1.77E-4 34 6.52E-4
10 SGTC_360 0957-0399 3.14 1.0 µM 2.37E-4 cell wall 88 8.31E-4
11 SGTC_565 1418-0001 3.13 44.5 µM 2.48E-4 59 8.63E-4
12 SGTC_3091 9116372 3.11 49.5 µM 2.69E-4 47 9.20E-4
13 SGTC_1602 st001878 3.06 87.6 µM 3.39E-4 53 0.00112
14 SGTC_2352 9027995 3.00 87.8 µM 4.19E-4 tubulin folding & SWR complex 64 0.00133
15 SGTC_344 k064-0035 2.93 6.4 µM 5.54E-4 60S ribosome export 67 0.00168
16 SGTC_2017 5132927 2.92 60.6 µM 5.83E-4 89 0.00175
17 SGTC_3081 9117243 2.87 49.5 µM 7.03E-4 fatty acid desaturase (OLE1) 61 0.00205
18 SGTC_1587 estradiol valerate 2.85 56.1 µM 7.53E-4 53 0.00216
19 SGTC_2312 7706453 2.74 155.7 µM 0.00116 89 0.00309
20 SGTC_1427 4048-4900 2.68 550.0 nM 0.00142 89 0.00366

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.121 1.90E-12 YNL181W_p YNL181W_p het Putative oxidoreductase; required for cell viability
0.107 5.81E-10 YEL047C FRD1 hom Soluble fumarate reductase; required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to Arxula adeninovorans fumarate reductase; protein abundance increases in response to DNA replication stress; FRD1 has a paralog, OSM1, that arose from the whole genome duplication
0.098 1.09E-8 YDR416W SYF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; null mutant has splicing defect and arrests in G2/M; homologs in human and C. elegans
0.093 7.03E-8 YGL132W_d YGL132W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SNT2/YGL131C
0.086 5.99E-7 YDR043C NRG1 hom Transcriptional repressor; recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response; NRG1 has a paralog, NRG2, that arose from the whole genome duplication
0.085 7.85E-7 YDR236C FMN1 het Riboflavin kinase, produces riboflavin monophosphate (FMN); FMN is a necessary cofactor for many enzymes; predominantly localizes to the microsomal fraction and also found in the mitochondrial inner membrane
0.085 7.78E-7 YDL098C SNU23 het Component of U4/U6.U5 snRNP involved in mRNA splicing via spliceosome
0.085 8.17E-7 YJR016C ILV3 het Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids
0.081 2.32E-6 YJL163C_p YJL163C_p hom Putative protein of unknown function
0.080 3.62E-6 YBL017C PEP1 hom Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
0.077 8.06E-6 YDR539W FDC1 hom Putative phenylacrylic acid decarboxylase; essential for the decarboxylation of aromatic carboxylic acids to the corresponding vinyl derivatives; homolog of E. coli UbiD; GFP-fusion protein localizes to the cytoplasm
0.074 1.85E-5 YOR299W BUD7 hom Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; BUD7 has a paralog, BCH1, that arose from the whole genome duplication
0.073 2.05E-5 YPL152W RRD2 hom Peptidyl-prolyl cis/trans-isomerase; also activates the phosphotyrosyl phosphatase activity of protein phosphatase 2A (PP2A); regulates G1 phase progression, the osmoresponse, microtubule dynamics; subunit of the Tap42p-Pph21p-Rrd2p complex; protein abundance increases in response to DNA replication stress
0.073 2.07E-5 YLR446W_p YLR446W_p hom Putative hexokinase; transcript is upregulated during sporulation and the unfolded protein response; YLR446W is not an essential gene
0.073 2.41E-5 YDR127W ARO1 hom Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids