YLR167W / RPS31

Fusion protein cleaved to yield ribosomal protein S31 and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B; homologous to mammalian ribosomal protein S27A, no bacterial homolog

Zygosity: Heterozygous strain
fixedexpanded
Profile for YLR167W / RPS31

Click on Significant Values for Screen Details ID:SGTC_37|Compound:0566-0070|FD-Score:4.30|P-value:3.68E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.83|P-value:1.75E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:3.90|P-value:1.61E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:5.45|P-value:2.46E-7 ID:SGTC_110|Compound:0850-0284|FD-Score:3.95|P-value:1.35E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:3.81|P-value:2.22E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:-3.42|P-value:6.96E-4 ID:SGTC_317|Compound:4495-0002|FD-Score:3.72|P-value:3.03E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:3.80|P-value:2.31E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:3.46|P-value:7.29E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:4.44|P-value:2.12E-5 ID:SGTC_372|Compound:0155-0182|FD-Score:-11.30|P-value:3.59E-26 ID:SGTC_722|Compound:3534-0461|FD-Score:-3.34|P-value:8.90E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:-3.54|P-value:4.76E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:6.50|P-value:9.49E-10 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.51|P-value:6.13E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:-4.00|P-value:9.57E-5 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:4.29|P-value:3.74E-5 ID:SGTC_1206|Compound:3978-0017|FD-Score:-3.59|P-value:3.94E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.57|P-value:4.99E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:3.88|P-value:1.72E-4 ID:SGTC_1438|Compound:4092-1045|FD-Score:4.65|P-value:9.03E-6 ID:SGTC_1681|Compound:tripelennamine|FD-Score:3.65|P-value:3.91E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.41|P-value:7.13E-4 ID:SGTC_1865|Compound:st057639|FD-Score:-3.80|P-value:1.93E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:-4.00|P-value:9.27E-5 ID:SGTC_1871|Compound:st057448|FD-Score:3.64|P-value:3.96E-4 ID:SGTC_2040|Compound:5100729|FD-Score:3.57|P-value:4.97E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.79|P-value:2.36E-4 ID:SGTC_2145|Compound:5634607|FD-Score:4.88|P-value:3.30E-6 ID:SGTC_2158|Compound:5657123|FD-Score:3.82|P-value:2.18E-4 ID:SGTC_2159|Compound:5658611|FD-Score:4.17|P-value:6.05E-5 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:4.58|P-value:1.20E-5 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:-4.52|P-value:1.22E-5 ID:SGTC_2787|Compound:5284540|FD-Score:-3.37|P-value:8.08E-4 ID:SGTC_3068|Compound:9116768|FD-Score:4.07|P-value:8.63E-5 ID:SGTC_3069|Compound:9117009|FD-Score:-3.67|P-value:3.00E-4 ID:SGTC_3113|Compound:9123498|FD-Score:4.36|P-value:2.87E-5 ID:SGTC_3150|Compound:9097574|FD-Score:4.31|P-value:3.54E-5 ID:SGTC_3157|Compound:9099274|FD-Score:3.46|P-value:7.20E-4 ID:SGTC_3158|Compound:9100007|FD-Score:3.54|P-value:5.48E-4 ID:SGTC_3215|Compound:9129942|FD-Score:4.28|P-value:4.00E-5 ID:SGTC_3224|Compound:9130643|FD-Score:5.70|P-value:7.12E-8 ID:SGTC_3264|Compound:9137442|FD-Score:3.43|P-value:7.95E-4 ID:SGTC_3349|Compound:9149703|FD-Score:-5.21|P-value:5.84E-7 ID:SGTC_37|Compound:0566-0070|FD-Score:4.30|P-value:3.68E-5 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.83|P-value:1.75E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:3.90|P-value:1.61E-4 ID:SGTC_78|Compound:0336-0123|FD-Score:5.45|P-value:2.46E-7 ID:SGTC_110|Compound:0850-0284|FD-Score:3.95|P-value:1.35E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:3.81|P-value:2.22E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:-3.42|P-value:6.96E-4 ID:SGTC_317|Compound:4495-0002|FD-Score:3.72|P-value:3.03E-4 ID:SGTC_319|Compound:1348-1596|FD-Score:3.80|P-value:2.31E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:3.46|P-value:7.29E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:4.44|P-value:2.12E-5 ID:SGTC_372|Compound:0155-0182|FD-Score:-11.30|P-value:3.59E-26 ID:SGTC_722|Compound:3534-0461|FD-Score:-3.34|P-value:8.90E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:-3.54|P-value:4.76E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:6.50|P-value:9.49E-10 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.51|P-value:6.13E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:-4.00|P-value:9.57E-5 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:4.29|P-value:3.74E-5 ID:SGTC_1206|Compound:3978-0017|FD-Score:-3.59|P-value:3.94E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.57|P-value:4.99E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:3.88|P-value:1.72E-4 ID:SGTC_1438|Compound:4092-1045|FD-Score:4.65|P-value:9.03E-6 ID:SGTC_1681|Compound:tripelennamine|FD-Score:3.65|P-value:3.91E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.41|P-value:7.13E-4 ID:SGTC_1865|Compound:st057639|FD-Score:-3.80|P-value:1.93E-4 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:-4.00|P-value:9.27E-5 ID:SGTC_1871|Compound:st057448|FD-Score:3.64|P-value:3.96E-4 ID:SGTC_2040|Compound:5100729|FD-Score:3.57|P-value:4.97E-4 ID:SGTC_2042|Compound:p-Dimethylaminoacetophenone|FD-Score:3.79|P-value:2.36E-4 ID:SGTC_2145|Compound:5634607|FD-Score:4.88|P-value:3.30E-6 ID:SGTC_2158|Compound:5657123|FD-Score:3.82|P-value:2.18E-4 ID:SGTC_2159|Compound:5658611|FD-Score:4.17|P-value:6.05E-5 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:4.58|P-value:1.20E-5 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:-4.52|P-value:1.22E-5 ID:SGTC_2787|Compound:5284540|FD-Score:-3.37|P-value:8.08E-4 ID:SGTC_3068|Compound:9116768|FD-Score:4.07|P-value:8.63E-5 ID:SGTC_3069|Compound:9117009|FD-Score:-3.67|P-value:3.00E-4 ID:SGTC_3113|Compound:9123498|FD-Score:4.36|P-value:2.87E-5 ID:SGTC_3150|Compound:9097574|FD-Score:4.31|P-value:3.54E-5 ID:SGTC_3157|Compound:9099274|FD-Score:3.46|P-value:7.20E-4 ID:SGTC_3158|Compound:9100007|FD-Score:3.54|P-value:5.48E-4 ID:SGTC_3215|Compound:9129942|FD-Score:4.28|P-value:4.00E-5 ID:SGTC_3224|Compound:9130643|FD-Score:5.70|P-value:7.12E-8 ID:SGTC_3264|Compound:9137442|FD-Score:3.43|P-value:7.95E-4 ID:SGTC_3349|Compound:9149703|FD-Score:-5.21|P-value:5.84E-7

Top fitness defect scores for YLR167W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_942 3253-1115 6.50 227.0 µM 9.49E-10 3 4.02E-11 2.31
2 SGTC_3224 9130643 5.70 49.5 µM 7.12E-8 RPP1 & pyrimidine depletion 2 6.08E-9 0.23
3 SGTC_78 0336-0123 5.45 156.8 µM 2.46E-7 3 2.57E-8 0.82
4 SGTC_2145 5634607 4.88 200.0 µM 3.30E-6 2 5.23E-7 1.09
5 SGTC_1438 4092-1045 4.65 4.0 µM 9.03E-6 2 1.68E-6 0.66
6 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 4.58 100.0 µM 1.20E-5 4 2.35E-6 0.49
7 SGTC_364 0083-0097 4.44 67.7 µM 2.12E-5 5 4.53E-6 0.33
8 SGTC_3113 9123498 4.36 49.5 µM 2.87E-5 3 6.43E-6 0.07
9 SGTC_3150 9097574 4.31 49.5 µM 3.54E-5 2 8.22E-6 0.50
10 SGTC_37 0566-0070 4.30 1.6 µM 3.68E-5 2 8.59E-6 0.11
11 SGTC_1135 dihydrocapsaicin 4.29 536.7 nM 3.74E-5 5 8.76E-6 0.49
12 SGTC_3215 9129942 4.28 49.5 µM 4.00E-5 3 9.46E-6 0.02
13 SGTC_2159 5658611 4.17 73.8 µM 6.05E-5 5 1.53E-5 0.28
14 SGTC_3068 9116768 4.07 49.5 µM 8.63E-5 5 2.31E-5 0.00
15 SGTC_110 0850-0284 3.95 111.6 µM 1.35E-4 3 3.89E-5 0.25
16 SGTC_75 0159-0059 3.90 199.0 µM 1.61E-4 fatty acid desaturase (OLE1) 11 4.77E-5 0.04
17 SGTC_1332 1480-0653 3.88 17.5 µM 1.72E-4 TSC3-RPN4 4 5.14E-5 0.22
18 SGTC_2158 5657123 3.82 3.6 µM 2.18E-4 13 6.74E-5 0.06
19 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 3.81 44.4 nM 2.22E-4 DNA damage response 7 6.90E-5 0.10
20 SGTC_319 1348-1596 3.80 45.5 µM 2.31E-4 RSC & ERG11 9 7.23E-5 0.33

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.154 3.09E-19 YGR245C SDA1 het Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis
0.146 2.30E-17 YLL011W SOF1 het Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p
0.134 5.39E-15 YGL074C_d YGL074C_d het Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential HSF1 gene encoding heat shock transcription factor
0.128 8.98E-14 YIL083C CAB2 het Probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity)
0.121 1.80E-12 YIL145C PAN6 hom Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC
0.119 4.49E-12 YHR164C DNA2 het Tripartite DNA replication factor; has single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair; cell-cycle dependent localization; forms nuclear foci upon DNA replication stress
0.116 1.42E-11 YPL231W FAS2 het Alpha subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains the acyl-carrier protein domain and beta-ketoacyl reductase, beta-ketoacyl synthase and self-pantetheinylation activities
0.111 9.89E-11 YDR064W RPS13 het Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S13 and bacterial S15
0.111 1.14E-10 YOL026C MIM1 het Mitochondrial protein required for outer membrane protein import; cooperates with Tom70p to import the subset of proteins with multiple alpha-helical transmembrane segments, including Ugo1p, Tom20p, and others; present in a complex with Mim2p in the outer membrane that may create a local environment to facilitate membrane insertion of substrate proteins; also has a role in assembly of Tom20p into the TOM complex
0.106 7.02E-10 YML065W ORC1 het Largest subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; exhibits ATPase activity
0.106 7.12E-10 YEL019C MMS21 het SUMO ligase and component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; mutants are sensitive to methyl methanesulfonate and show increased spontaneous mutation and mitotic recombination
0.104 1.31E-9 YML093W UTP14 het Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
0.103 2.27E-9 YGR258C RAD2 hom Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
0.099 8.72E-9 YIL078W THS1 het Threonyl-tRNA synthetase, essential cytoplasmic protein
0.098 1.10E-8 YML095C RAD10 hom Single-stranded DNA endonuclease (with Rad1p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein