YLR170C / APS1

Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR170C / APS1

Click on Significant Values for Screen Details ID:SGTC_31|Compound:0508-1974|FD-Score:-3.36|P-value:5.49E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:4.97|P-value:9.70E-7 ID:SGTC_57|Compound:miconazole|FD-Score:6.28|P-value:8.38E-10 ID:SGTC_68|Compound:0986-0284|FD-Score:4.01|P-value:6.14E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:5.30|P-value:1.83E-7 ID:SGTC_178|Compound:4092-0806|FD-Score:5.95|P-value:5.77E-9 ID:SGTC_181|Compound:1447-1644|FD-Score:4.20|P-value:2.86E-5 ID:SGTC_188|Compound:3229-0966|FD-Score:-4.20|P-value:2.30E-5 ID:SGTC_201|Compound:4262-0159|FD-Score:4.78|P-value:2.29E-6 ID:SGTC_207|Compound:4185-0010|FD-Score:24.40|P-value:5.31E-122 ID:SGTC_221|Compound:trifluoperazine|FD-Score:7.91|P-value:1.47E-14 ID:SGTC_252|Compound:miconazole|FD-Score:5.36|P-value:1.40E-7 ID:SGTC_254|Compound:nsc-64875|FD-Score:5.22|P-value:2.76E-7 ID:SGTC_308|Compound:4092-1169|FD-Score:4.32|P-value:1.76E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.66|P-value:1.92E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:12.70|P-value:1.66E-34 ID:SGTC_315|Compound:k915-0449|FD-Score:3.53|P-value:3.72E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:6.23|P-value:1.16E-9 ID:SGTC_327|Compound:1273-0057|FD-Score:5.07|P-value:6.01E-7 ID:SGTC_363|Compound:0455-0021|FD-Score:5.46|P-value:8.24E-8 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.15|P-value:3.60E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.42|P-value:7.53E-8 ID:SGTC_514|Compound:4466-0038|FD-Score:9.41|P-value:7.52E-20 ID:SGTC_515|Compound:4092-1064|FD-Score:4.13|P-value:3.92E-5 ID:SGTC_649|Compound:1123-0311|FD-Score:6.35|P-value:5.61E-10 ID:SGTC_679|Compound:0422-0091|FD-Score:-3.65|P-value:1.98E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:10.80|P-value:1.36E-25 ID:SGTC_700|Compound:3453-2283|FD-Score:3.36|P-value:6.54E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:3.31|P-value:7.94E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:5.30|P-value:1.84E-7 ID:SGTC_788|Compound:1182-0090|FD-Score:6.53|P-value:1.86E-10 ID:SGTC_966|Compound:1300-0360|FD-Score:3.32|P-value:7.51E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:-4.01|P-value:5.03E-5 ID:SGTC_1066|Compound:ketoconazole|FD-Score:-6.58|P-value:9.39E-11 ID:SGTC_1072|Compound:oxiconazole|FD-Score:11.60|P-value:4.64E-29 ID:SGTC_1078|Compound:idebenone|FD-Score:4.61|P-value:5.11E-6 ID:SGTC_1088|Compound:bifonazole|FD-Score:4.29|P-value:2.03E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:8.21|P-value:1.57E-15 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.53|P-value:3.71E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.69|P-value:2.06E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:5.37|P-value:1.29E-7 ID:SGTC_1318|Compound:1280-3875|FD-Score:4.74|P-value:2.85E-6 ID:SGTC_1432|Compound:4049-0298|FD-Score:4.07|P-value:4.89E-5 ID:SGTC_1455|Compound:4262-0120|FD-Score:-3.63|P-value:2.12E-4 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:-3.56|P-value:2.68E-4 ID:SGTC_1571|Compound:st070080|FD-Score:4.00|P-value:6.41E-5 ID:SGTC_1635|Compound:st007035|FD-Score:6.91|P-value:1.62E-11 ID:SGTC_1647|Compound:st011722|FD-Score:-3.94|P-value:6.63E-5 ID:SGTC_1740|Compound:st038286|FD-Score:3.36|P-value:6.71E-4 ID:SGTC_1750|Compound:st081859|FD-Score:20.20|P-value:1.30E-84 ID:SGTC_1754|Compound:st042065|FD-Score:4.48|P-value:8.78E-6 ID:SGTC_1755|Compound:st041960|FD-Score:-5.13|P-value:3.28E-7 ID:SGTC_1760|Compound:st045453|FD-Score:5.62|P-value:3.47E-8 ID:SGTC_1786|Compound:berberine|FD-Score:3.68|P-value:2.15E-4 ID:SGTC_1855|Compound:st056195|FD-Score:4.19|P-value:2.99E-5 ID:SGTC_1859|Compound:st055998|FD-Score:6.07|P-value:2.89E-9 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.98|P-value:6.87E-5 ID:SGTC_2006|Compound:4011487|FD-Score:10.60|P-value:8.01E-25 ID:SGTC_2021|Compound:4019055|FD-Score:6.82|P-value:2.93E-11 ID:SGTC_2063|Compound:5246145|FD-Score:-3.35|P-value:5.72E-4 ID:SGTC_2117|Compound:5521686|FD-Score:3.49|P-value:4.30E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:8.19|P-value:1.84E-15 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.27|P-value:9.01E-4 ID:SGTC_2337|Compound:9009472|FD-Score:3.69|P-value:2.07E-4 ID:SGTC_2358|Compound:9037157|FD-Score:-3.34|P-value:5.78E-4 ID:SGTC_2387|Compound:9077560|FD-Score:3.94|P-value:8.32E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.86|P-value:8.93E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.70|P-value:2.02E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:3.61|P-value:2.83E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.68|P-value:1.77E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.36|P-value:1.39E-7 ID:SGTC_2777|Compound:climbazole|FD-Score:3.98|P-value:6.93E-5 ID:SGTC_2778|Compound:tioconazole|FD-Score:5.86|P-value:9.62E-9 ID:SGTC_2926|Compound:9010726|FD-Score:3.32|P-value:7.57E-4 ID:SGTC_3020|Compound:9089140|FD-Score:4.45|P-value:1.01E-5 ID:SGTC_3037|Compound:9091026|FD-Score:3.91|P-value:9.34E-5 ID:SGTC_3092|Compound:9117248|FD-Score:3.83|P-value:1.26E-4 ID:SGTC_3136|Compound:9095672|FD-Score:-3.44|P-value:4.20E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.73|P-value:1.78E-4 ID:SGTC_3155|Compound:9099265|FD-Score:-3.38|P-value:5.02E-4 ID:SGTC_3308|Compound:9128332|FD-Score:8.46|P-value:2.28E-16 ID:SGTC_31|Compound:0508-1974|FD-Score:-3.36|P-value:5.49E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:4.97|P-value:9.70E-7 ID:SGTC_57|Compound:miconazole|FD-Score:6.28|P-value:8.38E-10 ID:SGTC_68|Compound:0986-0284|FD-Score:4.01|P-value:6.14E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:5.30|P-value:1.83E-7 ID:SGTC_178|Compound:4092-0806|FD-Score:5.95|P-value:5.77E-9 ID:SGTC_181|Compound:1447-1644|FD-Score:4.20|P-value:2.86E-5 ID:SGTC_188|Compound:3229-0966|FD-Score:-4.20|P-value:2.30E-5 ID:SGTC_201|Compound:4262-0159|FD-Score:4.78|P-value:2.29E-6 ID:SGTC_207|Compound:4185-0010|FD-Score:24.40|P-value:5.31E-122 ID:SGTC_221|Compound:trifluoperazine|FD-Score:7.91|P-value:1.47E-14 ID:SGTC_252|Compound:miconazole|FD-Score:5.36|P-value:1.40E-7 ID:SGTC_254|Compound:nsc-64875|FD-Score:5.22|P-value:2.76E-7 ID:SGTC_308|Compound:4092-1169|FD-Score:4.32|P-value:1.76E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.66|P-value:1.92E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:12.70|P-value:1.66E-34 ID:SGTC_315|Compound:k915-0449|FD-Score:3.53|P-value:3.72E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:6.23|P-value:1.16E-9 ID:SGTC_327|Compound:1273-0057|FD-Score:5.07|P-value:6.01E-7 ID:SGTC_363|Compound:0455-0021|FD-Score:5.46|P-value:8.24E-8 ID:SGTC_445|Compound:e6 berbamine|FD-Score:4.15|P-value:3.60E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.42|P-value:7.53E-8 ID:SGTC_514|Compound:4466-0038|FD-Score:9.41|P-value:7.52E-20 ID:SGTC_515|Compound:4092-1064|FD-Score:4.13|P-value:3.92E-5 ID:SGTC_649|Compound:1123-0311|FD-Score:6.35|P-value:5.61E-10 ID:SGTC_679|Compound:0422-0091|FD-Score:-3.65|P-value:1.98E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:10.80|P-value:1.36E-25 ID:SGTC_700|Compound:3453-2283|FD-Score:3.36|P-value:6.54E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:3.31|P-value:7.94E-4 ID:SGTC_705|Compound:1124-0212|FD-Score:5.30|P-value:1.84E-7 ID:SGTC_788|Compound:1182-0090|FD-Score:6.53|P-value:1.86E-10 ID:SGTC_966|Compound:1300-0360|FD-Score:3.32|P-value:7.51E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:-4.01|P-value:5.03E-5 ID:SGTC_1066|Compound:ketoconazole|FD-Score:-6.58|P-value:9.39E-11 ID:SGTC_1072|Compound:oxiconazole|FD-Score:11.60|P-value:4.64E-29 ID:SGTC_1078|Compound:idebenone|FD-Score:4.61|P-value:5.11E-6 ID:SGTC_1088|Compound:bifonazole|FD-Score:4.29|P-value:2.03E-5 ID:SGTC_1130|Compound:3454-2858|FD-Score:8.21|P-value:1.57E-15 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.53|P-value:3.71E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.69|P-value:2.06E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:5.37|P-value:1.29E-7 ID:SGTC_1318|Compound:1280-3875|FD-Score:4.74|P-value:2.85E-6 ID:SGTC_1432|Compound:4049-0298|FD-Score:4.07|P-value:4.89E-5 ID:SGTC_1455|Compound:4262-0120|FD-Score:-3.63|P-value:2.12E-4 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:-3.56|P-value:2.68E-4 ID:SGTC_1571|Compound:st070080|FD-Score:4.00|P-value:6.41E-5 ID:SGTC_1635|Compound:st007035|FD-Score:6.91|P-value:1.62E-11 ID:SGTC_1647|Compound:st011722|FD-Score:-3.94|P-value:6.63E-5 ID:SGTC_1740|Compound:st038286|FD-Score:3.36|P-value:6.71E-4 ID:SGTC_1750|Compound:st081859|FD-Score:20.20|P-value:1.30E-84 ID:SGTC_1754|Compound:st042065|FD-Score:4.48|P-value:8.78E-6 ID:SGTC_1755|Compound:st041960|FD-Score:-5.13|P-value:3.28E-7 ID:SGTC_1760|Compound:st045453|FD-Score:5.62|P-value:3.47E-8 ID:SGTC_1786|Compound:berberine|FD-Score:3.68|P-value:2.15E-4 ID:SGTC_1855|Compound:st056195|FD-Score:4.19|P-value:2.99E-5 ID:SGTC_1859|Compound:st055998|FD-Score:6.07|P-value:2.89E-9 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.98|P-value:6.87E-5 ID:SGTC_2006|Compound:4011487|FD-Score:10.60|P-value:8.01E-25 ID:SGTC_2021|Compound:4019055|FD-Score:6.82|P-value:2.93E-11 ID:SGTC_2063|Compound:5246145|FD-Score:-3.35|P-value:5.72E-4 ID:SGTC_2117|Compound:5521686|FD-Score:3.49|P-value:4.30E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:8.19|P-value:1.84E-15 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.27|P-value:9.01E-4 ID:SGTC_2337|Compound:9009472|FD-Score:3.69|P-value:2.07E-4 ID:SGTC_2358|Compound:9037157|FD-Score:-3.34|P-value:5.78E-4 ID:SGTC_2387|Compound:9077560|FD-Score:3.94|P-value:8.32E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.86|P-value:8.93E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.70|P-value:2.02E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:3.61|P-value:2.83E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.68|P-value:1.77E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:5.36|P-value:1.39E-7 ID:SGTC_2777|Compound:climbazole|FD-Score:3.98|P-value:6.93E-5 ID:SGTC_2778|Compound:tioconazole|FD-Score:5.86|P-value:9.62E-9 ID:SGTC_2926|Compound:9010726|FD-Score:3.32|P-value:7.57E-4 ID:SGTC_3020|Compound:9089140|FD-Score:4.45|P-value:1.01E-5 ID:SGTC_3037|Compound:9091026|FD-Score:3.91|P-value:9.34E-5 ID:SGTC_3092|Compound:9117248|FD-Score:3.83|P-value:1.26E-4 ID:SGTC_3136|Compound:9095672|FD-Score:-3.44|P-value:4.20E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.73|P-value:1.78E-4 ID:SGTC_3155|Compound:9099265|FD-Score:-3.38|P-value:5.02E-4 ID:SGTC_3308|Compound:9128332|FD-Score:8.46|P-value:2.28E-16

Top fitness defect scores for YLR170C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_207 4185-0010 24.40 4.5 µM 5.31E-122 endomembrane recycling 3 1.86E-131
2 SGTC_1750 st081859 20.20 2.4 µM 1.30E-84 endomembrane recycling 15 3.64E-91
3 SGTC_312 4092-0653 12.70 6.8 µM 1.66E-34 ergosterol depletion effects on membrane 6 3.78E-37
4 SGTC_1072 oxiconazole 11.60 14.9 nM 4.64E-29 ergosterol depletion effects on membrane 1 2.83E-31
5 SGTC_689 0833-0039 10.80 98.0 µM 1.36E-25 ergosterol depletion effects on membrane 2 1.55E-27
6 SGTC_2006 4011487 10.60 200.0 µM 8.01E-25 endomembrane recycling 14 1.05E-26
7 SGTC_514 4466-0038 9.41 2.6 nM 7.52E-20 cell wall 26 2.42E-21
8 SGTC_3308 9128332 8.46 17.6 µM 2.28E-16 plasma membrane duress 27 1.38E-17
9 SGTC_1130 3454-2858 8.21 15.9 µM 1.57E-15 NEO1 22 1.11E-16
10 SGTC_2249 haloperidol 8.19 116.4 µM 1.84E-15 ergosterol depletion effects on membrane 21 1.32E-16
11 SGTC_221 trifluoperazine 7.91 10.3 µM 1.47E-14 NEO1-PIK1 87 1.24E-15
12 SGTC_1635 st007035 6.91 42.4 µM 1.62E-11 118 2.37E-12
13 SGTC_2021 4019055 6.82 173.0 µM 2.93E-11 endomembrane recycling 30 4.50E-12
14 SGTC_788 1182-0090 6.53 188.0 µM 1.86E-10 endomembrane recycling 29 3.32E-11
15 SGTC_649 1123-0311 6.35 367.0 µM 5.61E-10 endomembrane recycling 23 1.09E-10
16 SGTC_57 miconazole 6.28 162.5 nM 8.38E-10 ergosterol depletion effects on membrane 8 1.68E-10
17 SGTC_320 4092-0846 6.23 5.3 µM 1.16E-9 ergosterol depletion effects on membrane 14 2.38E-10
18 SGTC_1859 st055998 6.07 20.0 µM 2.89E-9 7 6.39E-10
19 SGTC_178 4092-0806 5.95 87.5 µM 5.77E-9 ergosterol depletion effects on membrane 40 1.35E-9
20 SGTC_2778 tioconazole 5.86 65.1 nM 9.62E-9 ergosterol depletion effects on membrane 31 2.34E-9

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.669 0 YFL034W_p YFL034W_p hom Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk
0.630 0 YHL019C APM2 hom Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport
0.622 0 YLR169W_d YLR169W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.585 4.22E-307 YBL010C_p YBL010C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles
0.563 6.41E-280 YKL135C APL2 hom Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress
0.559 4.42E-275 YLR171W_d YLR171W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.554 2.02E-269 YPR029C APL4 hom Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
0.443 7.11E-161 YMR071C TVP18 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments
0.423 7.27E-146 YKL136W_d YKL136W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF APL2/YKL135C
0.380 1.02E-115 YJL207C LAA1 hom AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene
0.347 9.40E-96 YOR115C TRS33 hom One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.331 7.74E-87 YGL233W SEC15 het Essential 113 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis prior to SNARE-mediated fusion; interacts with and functions as a downstream effector of active, GTP-bound Sec4p, a Rab family GTPase
0.322 4.93E-82 YER180C-A SLO1 hom Protein interacting with Arl3p, which is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO
0.319 4.19E-80 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.319 4.25E-80 YER031C YPT31 hom Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication