YLR178C / TFS1

Protein that interacts with and inhibits carboxypeptidase Y and Ira2p; phosphatidylethanolamine-binding protein (PEBP) family member; targets to vacuolar membranes during stationary phase; acetylated by NatB N-terminal acetyltransferase; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR178C / TFS1

Click on Significant Values for Screen Details ID:SGTC_286|Compound:k060-0067|FD-Score:2.66|P-value:9.78E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:-2.88|P-value:3.96E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:3.20|P-value:9.49E-5 ID:SGTC_357|Compound:1325-0123|FD-Score:-6.62|P-value:6.56E-15 ID:SGTC_472|Compound:calcifediol|FD-Score:3.42|P-value:3.30E-5 ID:SGTC_480|Compound:am 92016|FD-Score:-2.88|P-value:4.09E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-2.94|P-value:3.06E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:3.33|P-value:5.25E-5 ID:SGTC_796|Compound:1234-0020|FD-Score:3.26|P-value:7.28E-5 ID:SGTC_849|Compound:0386-0493|FD-Score:-2.70|P-value:8.52E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:3.21|P-value:9.10E-5 ID:SGTC_882|Compound:0843-0131|FD-Score:2.77|P-value:6.27E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:2.78|P-value:5.99E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:2.84|P-value:4.70E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-2.79|P-value:5.87E-4 ID:SGTC_1109|Compound:tnp00067|FD-Score:-3.27|P-value:7.02E-5 ID:SGTC_1111|Compound:tnp00062|FD-Score:-2.66|P-value:9.67E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:-4.14|P-value:7.09E-7 ID:SGTC_1189|Compound:1431-2119|FD-Score:2.75|P-value:6.74E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.42|P-value:3.36E-5 ID:SGTC_1272|Compound:0839-0021|FD-Score:2.68|P-value:8.93E-4 ID:SGTC_1485|Compound:3909-9022|FD-Score:-3.16|P-value:1.17E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:-2.86|P-value:4.43E-4 ID:SGTC_1554|Compound:st069299|FD-Score:-3.10|P-value:1.56E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:-3.26|P-value:7.44E-5 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:-2.72|P-value:7.80E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:-2.70|P-value:8.27E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:-3.62|P-value:1.27E-5 ID:SGTC_1916|Compound:st067606|FD-Score:4.09|P-value:9.60E-7 ID:SGTC_1920|Compound:st075728|FD-Score:2.78|P-value:5.87E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.28|P-value:3.15E-7 ID:SGTC_2108|Compound:5365811|FD-Score:-2.71|P-value:7.95E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.17|P-value:1.10E-4 ID:SGTC_2128|Compound:5255449|FD-Score:-2.77|P-value:6.27E-4 ID:SGTC_2188|Compound:6126565|FD-Score:-3.05|P-value:1.95E-4 ID:SGTC_2202|Compound:7226349|FD-Score:2.97|P-value:2.70E-4 ID:SGTC_2205|Compound:7238770|FD-Score:2.73|P-value:7.22E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.61|P-value:1.30E-5 ID:SGTC_2467|Compound:5474540|FD-Score:-2.84|P-value:4.82E-4 ID:SGTC_2602|Compound:kawain|FD-Score:2.85|P-value:4.41E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:-4.27|P-value:3.32E-7 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:7.35|P-value:5.79E-18 ID:SGTC_2993|Compound:9054257|FD-Score:-2.72|P-value:7.64E-4 ID:SGTC_2996|Compound:9066192|FD-Score:-2.66|P-value:9.96E-4 ID:SGTC_3084|Compound:9116877|FD-Score:2.77|P-value:6.30E-4 ID:SGTC_3088|Compound:9117578|FD-Score:-2.72|P-value:7.84E-4 ID:SGTC_3316|Compound:9136639|FD-Score:2.81|P-value:5.30E-4 ID:SGTC_3354|Compound:9151612|FD-Score:2.91|P-value:3.46E-4 ID:SGTC_286|Compound:k060-0067|FD-Score:2.66|P-value:9.78E-4 ID:SGTC_341|Compound:1486-1430|FD-Score:-2.88|P-value:3.96E-4 ID:SGTC_343|Compound:4130-2827|FD-Score:3.20|P-value:9.49E-5 ID:SGTC_357|Compound:1325-0123|FD-Score:-6.62|P-value:6.56E-15 ID:SGTC_472|Compound:calcifediol|FD-Score:3.42|P-value:3.30E-5 ID:SGTC_480|Compound:am 92016|FD-Score:-2.88|P-value:4.09E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-2.94|P-value:3.06E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:3.33|P-value:5.25E-5 ID:SGTC_796|Compound:1234-0020|FD-Score:3.26|P-value:7.28E-5 ID:SGTC_849|Compound:0386-0493|FD-Score:-2.70|P-value:8.52E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:3.21|P-value:9.10E-5 ID:SGTC_882|Compound:0843-0131|FD-Score:2.77|P-value:6.27E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:2.78|P-value:5.99E-4 ID:SGTC_1100|Compound:amiodarone|FD-Score:2.84|P-value:4.70E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-2.79|P-value:5.87E-4 ID:SGTC_1109|Compound:tnp00067|FD-Score:-3.27|P-value:7.02E-5 ID:SGTC_1111|Compound:tnp00062|FD-Score:-2.66|P-value:9.67E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:-4.14|P-value:7.09E-7 ID:SGTC_1189|Compound:1431-2119|FD-Score:2.75|P-value:6.74E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.42|P-value:3.36E-5 ID:SGTC_1272|Compound:0839-0021|FD-Score:2.68|P-value:8.93E-4 ID:SGTC_1485|Compound:3909-9022|FD-Score:-3.16|P-value:1.17E-4 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:-2.86|P-value:4.43E-4 ID:SGTC_1554|Compound:st069299|FD-Score:-3.10|P-value:1.56E-4 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:-3.26|P-value:7.44E-5 ID:SGTC_1577|Compound:3(2'-chlorophenyl)-7-ethoxycoumarin|FD-Score:-2.72|P-value:7.80E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:-2.70|P-value:8.27E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:-3.62|P-value:1.27E-5 ID:SGTC_1916|Compound:st067606|FD-Score:4.09|P-value:9.60E-7 ID:SGTC_1920|Compound:st075728|FD-Score:2.78|P-value:5.87E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.28|P-value:3.15E-7 ID:SGTC_2108|Compound:5365811|FD-Score:-2.71|P-value:7.95E-4 ID:SGTC_2125|Compound:5246583|FD-Score:3.17|P-value:1.10E-4 ID:SGTC_2128|Compound:5255449|FD-Score:-2.77|P-value:6.27E-4 ID:SGTC_2188|Compound:6126565|FD-Score:-3.05|P-value:1.95E-4 ID:SGTC_2202|Compound:7226349|FD-Score:2.97|P-value:2.70E-4 ID:SGTC_2205|Compound:7238770|FD-Score:2.73|P-value:7.22E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.61|P-value:1.30E-5 ID:SGTC_2467|Compound:5474540|FD-Score:-2.84|P-value:4.82E-4 ID:SGTC_2602|Compound:kawain|FD-Score:2.85|P-value:4.41E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:-4.27|P-value:3.32E-7 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:7.35|P-value:5.79E-18 ID:SGTC_2993|Compound:9054257|FD-Score:-2.72|P-value:7.64E-4 ID:SGTC_2996|Compound:9066192|FD-Score:-2.66|P-value:9.96E-4 ID:SGTC_3084|Compound:9116877|FD-Score:2.77|P-value:6.30E-4 ID:SGTC_3088|Compound:9117578|FD-Score:-2.72|P-value:7.84E-4 ID:SGTC_3316|Compound:9136639|FD-Score:2.81|P-value:5.30E-4 ID:SGTC_3354|Compound:9151612|FD-Score:2.91|P-value:3.46E-4

Top fitness defect scores for YLR178C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2622 2-methoxyxanthone 7.35 59.9 µM 5.79E-18 3 1.02E-13
2 SGTC_1916 st067606 4.09 49.2 µM 9.60E-7 35 2.19E-5
3 SGTC_2402 5553605 3.61 200.0 µM 1.30E-5 44 1.53E-4
4 SGTC_472 calcifediol 3.42 10.0 µM 3.30E-5 15 3.08E-4
5 SGTC_1204 4049-0315 3.42 18.3 µM 3.36E-5 53 3.12E-4
6 SGTC_734 2023-0417 3.33 80.0 µM 5.25E-5 ergosterol biosynthesis 39 4.36E-4
7 SGTC_796 1234-0020 3.26 70.7 µM 7.28E-5 SWF1 & branched chain AA biosynthesis 47 5.58E-4
8 SGTC_871 0574-0004 3.21 149.0 µM 9.10E-5 79 6.59E-4
9 SGTC_343 4130-2827 3.20 29.8 µM 9.49E-5 64 6.80E-4
10 SGTC_2125 5246583 3.17 200.0 µM 1.10E-4 tubulin folding & SWR complex 87 7.59E-4
11 SGTC_2202 7226349 2.97 200.0 µM 2.70E-4 35 0.00149
12 SGTC_3354 9151612 2.91 71.4 µM 3.46E-4 57 0.00180
13 SGTC_2602 kawain 2.85 100.0 µM 4.41E-4 89 0.00216
14 SGTC_1100 amiodarone 2.84 5.1 µM 4.70E-4 58 0.00227
15 SGTC_3316 9136639 2.81 10.6 µM 5.30E-4 63 0.00248
16 SGTC_1920 st075728 2.78 45.7 µM 5.87E-4 90 0.00268
17 SGTC_1055 3448-0672 2.78 86.0 µM 5.99E-4 100 0.00272
18 SGTC_882 0843-0131 2.77 351.0 µM 6.27E-4 81 0.00281
19 SGTC_3084 9116877 2.77 49.5 µM 6.30E-4 35 0.00282
20 SGTC_1189 1431-2119 2.75 7.3 µM 6.74E-4 112 0.00297

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.131 2.98E-14 YNL332W THI12 hom Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
0.118 5.91E-12 YKL151C YKL151C hom NADHX dehydratase; converts (S)-NADHX to NADH in an ATP-dependent manner; homologous to Carkd in mammals, and the C-terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; YKL151C promoter contains STREs (stress response elements) and expression is induced by heat shock or methyl methanesulfonate; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; protein abundance increases in response to DNA replication stress
0.114 3.50E-11 YMR075W RCO1 hom Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p
0.112 7.85E-11 YMR095C SNO1 hom Protein of unconfirmed function, involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase
0.109 2.15E-10 YKL168C KKQ8 hom Putative serine/threonine protein kinase with unknown cellular role; KKQ8 has a paralog, HAL5, that arose from the whole genome duplication
0.105 1.25E-9 YDR061W_p YDR061W_p hom Protein with similarity to ATP-binding cassette (ABC) transporter family members; lacks predicted membrane-spanning regions; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance
0.102 2.74E-9 YOL024W_p YOL024W_p hom Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site; YOL024W has a paralog, IGD1, that arose from the whole genome duplication
0.093 6.25E-8 YJL068C YJL068C hom Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D
0.091 1.33E-7 YGL003C CDH1 hom Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including Cdc20p, Ase1p, Cin8p and Fin1p
0.090 1.63E-7 YJR019C TES1 hom Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids
0.090 1.73E-7 YOR163W DDP1 hom Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; high specificity for diadenosine hexa- and pentaphosphates; contains endopolyphosphatase activity with a high affinity for polyphosphates, an activity also observed for its human DIPP homologs; possesses mRNA decapping activity; nudix hydrolase family member; protein abundance increases in response to DNA replication stress
0.089 2.50E-7 YPR152C URN1 hom Putative protein of unknown function containing WW and FF domains; overexpression causes accumulation of cells in G1 phase
0.089 2.57E-7 YDL039C PRM7 hom Pheromone-regulated protein, predicted to have one transmembrane segment; promoter contains Gcn4p binding elements
0.084 1.21E-6 YNL097C-B_p YNL097C-B_p hom Putative protein of unknown function
0.082 1.73E-6 YOR037W CYC2 hom Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)