YLR179C

Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR179C / YLR179C

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:3.53|P-value:2.06E-5 ID:SGTC_284|Compound:0988-0104|FD-Score:2.79|P-value:5.87E-4 ID:SGTC_324|Compound:1315-0088|FD-Score:3.00|P-value:2.41E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:3.29|P-value:6.57E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:3.64|P-value:1.16E-5 ID:SGTC_708|Compound:3448-5400|FD-Score:-3.39|P-value:5.00E-5 ID:SGTC_779|Compound:1360-0071|FD-Score:3.04|P-value:2.03E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:-2.74|P-value:8.30E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:2.77|P-value:6.41E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-3.79|P-value:6.40E-6 ID:SGTC_987|Compound:1497-1013|FD-Score:3.30|P-value:6.15E-5 ID:SGTC_1009|Compound:4106-0057|FD-Score:2.91|P-value:3.60E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-4.51|P-value:1.03E-7 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.46|P-value:2.97E-5 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.63|P-value:1.24E-5 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.30|P-value:6.23E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.36|P-value:1.19E-13 ID:SGTC_1463|Compound:k081-0032|FD-Score:-6.06|P-value:1.50E-12 ID:SGTC_1583|Compound:clindamycin|FD-Score:-2.96|P-value:3.40E-4 ID:SGTC_1703|Compound:st026983|FD-Score:2.74|P-value:7.13E-4 ID:SGTC_1706|Compound:st031321|FD-Score:2.91|P-value:3.56E-4 ID:SGTC_1745|Compound:st081495|FD-Score:-3.50|P-value:2.92E-5 ID:SGTC_1747|Compound:st037496|FD-Score:3.71|P-value:8.20E-6 ID:SGTC_2002|Compound:4023503|FD-Score:2.81|P-value:5.48E-4 ID:SGTC_2006|Compound:4011487|FD-Score:2.83|P-value:5.01E-4 ID:SGTC_2035|Compound:5154463|FD-Score:3.33|P-value:5.36E-5 ID:SGTC_2053|Compound:5265679|FD-Score:-3.26|P-value:8.98E-5 ID:SGTC_2058|Compound:5236698|FD-Score:2.89|P-value:3.95E-4 ID:SGTC_2240|Compound:6690706|FD-Score:-2.78|P-value:7.05E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.70|P-value:1.06E-5 ID:SGTC_2321|Compound:7390090|FD-Score:-3.57|P-value:2.06E-5 ID:SGTC_2351|Compound:9026858|FD-Score:-2.70|P-value:9.70E-4 ID:SGTC_2374|Compound:9071832|FD-Score:2.69|P-value:8.79E-4 ID:SGTC_2379|Compound:9035213|FD-Score:2.73|P-value:7.57E-4 ID:SGTC_2426|Compound:5582046|FD-Score:2.97|P-value:2.72E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.51|P-value:2.73E-5 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:4.11|P-value:8.95E-7 ID:SGTC_2794|Compound:7785382|FD-Score:3.10|P-value:1.59E-4 ID:SGTC_2823|Compound:7987624|FD-Score:4.18|P-value:6.21E-7 ID:SGTC_2824|Compound:7998404|FD-Score:-2.92|P-value:4.01E-4 ID:SGTC_2826|Compound:7992541|FD-Score:-2.88|P-value:4.63E-4 ID:SGTC_3089|Compound:9117425|FD-Score:-2.81|P-value:6.28E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:3.53|P-value:2.06E-5 ID:SGTC_284|Compound:0988-0104|FD-Score:2.79|P-value:5.87E-4 ID:SGTC_324|Compound:1315-0088|FD-Score:3.00|P-value:2.41E-4 ID:SGTC_350|Compound:k064-0020|FD-Score:3.29|P-value:6.57E-5 ID:SGTC_374|Compound:0880-0231|FD-Score:3.64|P-value:1.16E-5 ID:SGTC_708|Compound:3448-5400|FD-Score:-3.39|P-value:5.00E-5 ID:SGTC_779|Compound:1360-0071|FD-Score:3.04|P-value:2.03E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:-2.74|P-value:8.30E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:2.77|P-value:6.41E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:-3.79|P-value:6.40E-6 ID:SGTC_987|Compound:1497-1013|FD-Score:3.30|P-value:6.15E-5 ID:SGTC_1009|Compound:4106-0057|FD-Score:2.91|P-value:3.60E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:-4.51|P-value:1.03E-7 ID:SGTC_1262|Compound:0737-0114|FD-Score:3.46|P-value:2.97E-5 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.63|P-value:1.24E-5 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.30|P-value:6.23E-5 ID:SGTC_1462|Compound:k081-0014|FD-Score:-6.36|P-value:1.19E-13 ID:SGTC_1463|Compound:k081-0032|FD-Score:-6.06|P-value:1.50E-12 ID:SGTC_1583|Compound:clindamycin|FD-Score:-2.96|P-value:3.40E-4 ID:SGTC_1703|Compound:st026983|FD-Score:2.74|P-value:7.13E-4 ID:SGTC_1706|Compound:st031321|FD-Score:2.91|P-value:3.56E-4 ID:SGTC_1745|Compound:st081495|FD-Score:-3.50|P-value:2.92E-5 ID:SGTC_1747|Compound:st037496|FD-Score:3.71|P-value:8.20E-6 ID:SGTC_2002|Compound:4023503|FD-Score:2.81|P-value:5.48E-4 ID:SGTC_2006|Compound:4011487|FD-Score:2.83|P-value:5.01E-4 ID:SGTC_2035|Compound:5154463|FD-Score:3.33|P-value:5.36E-5 ID:SGTC_2053|Compound:5265679|FD-Score:-3.26|P-value:8.98E-5 ID:SGTC_2058|Compound:5236698|FD-Score:2.89|P-value:3.95E-4 ID:SGTC_2240|Compound:6690706|FD-Score:-2.78|P-value:7.05E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.70|P-value:1.06E-5 ID:SGTC_2321|Compound:7390090|FD-Score:-3.57|P-value:2.06E-5 ID:SGTC_2351|Compound:9026858|FD-Score:-2.70|P-value:9.70E-4 ID:SGTC_2374|Compound:9071832|FD-Score:2.69|P-value:8.79E-4 ID:SGTC_2379|Compound:9035213|FD-Score:2.73|P-value:7.57E-4 ID:SGTC_2426|Compound:5582046|FD-Score:2.97|P-value:2.72E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.51|P-value:2.73E-5 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:4.11|P-value:8.95E-7 ID:SGTC_2794|Compound:7785382|FD-Score:3.10|P-value:1.59E-4 ID:SGTC_2823|Compound:7987624|FD-Score:4.18|P-value:6.21E-7 ID:SGTC_2824|Compound:7998404|FD-Score:-2.92|P-value:4.01E-4 ID:SGTC_2826|Compound:7992541|FD-Score:-2.88|P-value:4.63E-4 ID:SGTC_3089|Compound:9117425|FD-Score:-2.81|P-value:6.28E-4

Top fitness defect scores for YLR179C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2823 7987624 4.18 58.4 µM 6.21E-7 24 1.47E-5
2 SGTC_2631 bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone 4.11 100.0 µM 8.95E-7 33 1.94E-5
3 SGTC_1747 st037496 3.71 66.6 µM 8.20E-6 21 1.03E-4
4 SGTC_374 0880-0231 3.64 82.3 µM 1.16E-5 iron homeostasis 29 1.34E-4
5 SGTC_1347 1493-0251 3.63 600.0 nM 1.24E-5 mitochondrial response to ROS 21 1.42E-4
6 SGTC_65 0798-0905 3.53 35.0 µM 2.06E-5 calcium & mitochondrial duress 113 2.07E-4
7 SGTC_1262 0737-0114 3.46 49.6 µM 2.97E-5 39 2.74E-4
8 SGTC_2035 5154463 3.33 94.6 µM 5.36E-5 33 4.28E-4
9 SGTC_987 1497-1013 3.30 404.0 µM 6.15E-5 29 4.76E-4
10 SGTC_1451 4152-0210 3.30 104.0 µM 6.23E-5 51 4.80E-4
11 SGTC_350 k064-0020 3.29 19.8 µM 6.57E-5 heme requiring 47 5.00E-4
12 SGTC_2794 7785382 3.10 27.3 µM 1.59E-4 81 9.79E-4
13 SGTC_779 1360-0071 3.04 233.0 µM 2.03E-4 fatty acid desaturase (OLE1) 79 0.00118
14 SGTC_324 1315-0088 3.00 19.6 µM 2.41E-4 RSC & ERG11 35 0.00134
15 SGTC_2426 5582046 2.97 32.2 µM 2.72E-4 68 0.00147
16 SGTC_1706 st031321 2.91 10.0 µM 3.56E-4 TSC3-RPN4 45 0.00180
17 SGTC_1009 4106-0057 2.91 9.9 µM 3.60E-4 53 0.00182
18 SGTC_2058 5236698 2.89 133.0 µM 3.95E-4 81 0.00195
19 SGTC_2006 4011487 2.83 200.0 µM 5.01E-4 endomembrane recycling 160 0.00234
20 SGTC_2002 4023503 2.81 131.0 µM 5.48E-4 mitochondrial processes 107 0.00250

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.404 1.21E-131 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.328 5.02E-85 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.321 3.37E-81 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.317 5.04E-79 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.305 1.06E-72 YPR180W AOS1 het Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.301 3.14E-71 YLR213C CRR1 hom Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation
0.296 6.72E-69 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.295 3.34E-68 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.284 3.07E-63 YGR292W MAL12 hom Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
0.281 1.00E-61 YGR136W LSB1 hom Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.280 2.97E-61 YKL166C TPK3 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication
0.280 2.50E-61 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.278 1.15E-60 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.275 4.22E-59 YDL157C_p YDL157C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.264 1.14E-54 YBR274W CHK1 hom Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase