HIPHOP chemogenomics database

YLR179C

Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus

Zygosity: Homozygous strain

fixedexpanded
Profile for YLR179C / YLR179C

Click on Significant Values for Screen Details

Top fitness defect scores for YLR179C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2823	7987624	4.18	58.4 µM	6.21E-7		24	1.47E-5
2	SGTC_2631	bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone	4.11	100.0 µM	8.95E-7		33	1.94E-5
3	SGTC_1747	st037496	3.71	66.6 µM	8.20E-6		21	1.03E-4
4	SGTC_374	0880-0231	3.64	82.3 µM	1.16E-5	iron homeostasis	29	1.34E-4
5	SGTC_1347	1493-0251	3.63	600.0 nM	1.24E-5	mitochondrial response to ROS	21	1.42E-4
6	SGTC_65	0798-0905	3.53	35.0 µM	2.06E-5	calcium & mitochondrial duress	113	2.07E-4
7	SGTC_1262	0737-0114	3.46	49.6 µM	2.97E-5		39	2.74E-4
8	SGTC_2035	5154463	3.33	94.6 µM	5.36E-5		33	4.28E-4
9	SGTC_987	1497-1013	3.30	404.0 µM	6.15E-5		29	4.76E-4
10	SGTC_1451	4152-0210	3.30	104.0 µM	6.23E-5		51	4.80E-4
11	SGTC_350	k064-0020	3.29	19.8 µM	6.57E-5	heme requiring	47	5.00E-4
12	SGTC_2794	7785382	3.10	27.3 µM	1.59E-4		81	9.79E-4
13	SGTC_779	1360-0071	3.04	233.0 µM	2.03E-4	fatty acid desaturase (OLE1)	79	0.00118
14	SGTC_324	1315-0088	3.00	19.6 µM	2.41E-4	RSC & ERG11	35	0.00134
15	SGTC_2426	5582046	2.97	32.2 µM	2.72E-4		68	0.00147
16	SGTC_1706	st031321	2.91	10.0 µM	3.56E-4	TSC3-RPN4	45	0.00180
17	SGTC_1009	4106-0057	2.91	9.9 µM	3.60E-4		53	0.00182
18	SGTC_2058	5236698	2.89	133.0 µM	3.95E-4		81	0.00195
19	SGTC_2006	4011487	2.83	200.0 µM	5.01E-4	endomembrane recycling	160	0.00234
20	SGTC_2002	4023503	2.81	131.0 µM	5.48E-4	mitochondrial processes	107	0.00250

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.404	1.21E-131	YGR022C_d	YGR022C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
0.328	5.02E-85	YJL171C	YJL171C	hom	GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.321	3.37E-81	YDR312W	SSF2	hom	Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.317	5.04E-79	YNL166C	BNI5	hom	Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.305	1.06E-72	YPR180W	AOS1	het	Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
0.301	3.14E-71	YLR213C	CRR1	hom	Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation
0.296	6.72E-69	YDR521W_d	YDR521W_d	hom	Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.295	3.34E-68	YDL222C	FMP45	hom	Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.284	3.07E-63	YGR292W	MAL12	hom	Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose
0.281	1.00E-61	YGR136W	LSB1	hom	Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein increases in abundance and forms nuclear foci in response to DNA replication stress
0.280	2.97E-61	YKL166C	TPK3	hom	cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication
0.280	2.50E-61	YGR077C	PEX8	hom	Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p
0.278	1.15E-60	YIL010W	DOT5	hom	Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.275	4.22E-59	YDL157C_p	YDL157C_p	hom	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.264	1.14E-54	YBR274W	CHK1	hom	Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase