HIPHOP chemogenomics database

YLR182W / SWI6

Transcription cofactor; forms complexes with Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; also binds Stb1p to regulate transcription at START; cell wall stress induces phosphorylation by Mpk1p, which regulates Swi6p localization; required for the unfolded protein response, independently of its known transcriptional coactivators

Zygosity: Homozygous strain

fixedexpanded
Profile for YLR182W / SWI6

Click on Significant Values for Screen Details

Top fitness defect scores for YLR182W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_150	3970-0969	6.91	77.2 µM	9.49E-11		14	2.37E-12
2	SGTC_2620	irigenin	6.84	100.0 µM	1.45E-10		8	3.88E-12
3	SGTC_59	0330-0160	6.37	1.3 µM	2.23E-9		32	9.30E-11
4	SGTC_163	1327-0036	6.20	7.5 µM	5.83E-9		42	2.83E-10
5	SGTC_1333	1482-0047	5.41	286.0 µM	3.34E-7		5	3.13E-8
6	SGTC_1917	st066507	5.20	28.5 µM	8.95E-7	Golgi	17	9.86E-8
7	SGTC_1070	indatraline	5.03	8.8 µM	2.00E-6	60S ribosome export	12	2.51E-7
8	SGTC_386	1509-0011	4.87	3.1 µM	3.91E-6		113	5.47E-7
9	SGTC_2040	5100729	4.77	123.0 µM	5.99E-6		26	9.00E-7
10	SGTC_2309	7664088	4.51	163.9 µM	1.77E-5		16	3.18E-6
11	SGTC_2827	7993847	4.46	71.4 µM	2.22E-5		15	4.12E-6
12	SGTC_2814	7977482	4.41	43.0 µM	2.74E-5		36	5.28E-6
13	SGTC_1212	0520-0165	4.36	585.0 µM	3.34E-5		17	6.64E-6
14	SGTC_831	k061-1017	4.27	217.0 µM	4.71E-5	translation	42	9.91E-6
15	SGTC_2444	5485484	4.20	36.4 µM	6.20E-5		31	1.36E-5
16	SGTC_2233	sulbentine	4.08	40.4 µM	9.62E-5		59	2.27E-5
17	SGTC_2429	5902844	4.00	64.4 µM	1.30E-4		24	3.23E-5
18	SGTC_2265	7929201	3.99	200.0 µM	1.33E-4		21	3.32E-5
19	SGTC_1076	itraconazole	3.97	331.0 nM	1.41E-4		32	3.55E-5
20	SGTC_3135	9127742	3.96	49.5 µM	1.49E-4		22	3.77E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.167	1.68E-22	YBR068C	BAP2	hom	High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication
0.163	2.04E-21	YHR025W	THR1	hom	Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway
0.156	1.45E-19	YCR053W	THR4	hom	Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway
0.149	4.70E-18	YHR067W	HTD2	hom	Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology
0.144	4.64E-17	YDR381W	YRA1	het	RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member
0.143	8.60E-17	YIL052C	RPL34B	hom	Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication
0.142	1.65E-16	YER052C	HOM3	hom	Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.142	1.70E-16	YJR013W	GPI14	het	Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.137	1.85E-15	YLR382C	NAM2	hom	Mitochondrial leucyl-tRNA synthetase, also has a direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance
0.129	6.43E-14	YBL071W-A	KTI11	hom	Zn-ribbon protein that co-purifies with Dph1 and Dph2 in a complex required for synthesis of diphthamide on translation factor eEF2 and with Elongator subunits Iki3p, Elp2p, and Elp3p involved in modification of wobble nucleosides in tRNAs
0.127	1.41E-13	YDR375C	BCS1	hom	Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.126	2.47E-13	YDR231C	COX20	hom	Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.124	5.61E-13	YPL005W	AEP3	hom	Protein that may facilitate use of unformylated tRNA-Met in mitochondrial translation initiation; localized to the matrix face of the mitochondrial inner membrane; stabilizes the bicistronic AAP1-ATP6 mRNA
0.118	7.54E-12	YMR282C	AEP2	hom	Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader
0.118	8.61E-12	YCR028C-A	RIM1	hom	Single-stranded DNA-binding protein essential for mitochondrial genome maintenance; involved in mitochondrial DNA replication