YLR182W / SWI6

Transcription cofactor; forms complexes with Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; also binds Stb1p to regulate transcription at START; cell wall stress induces phosphorylation by Mpk1p, which regulates Swi6p localization; required for the unfolded protein response, independently of its known transcriptional coactivators

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR182W / SWI6

Click on Significant Values for Screen Details ID:SGTC_34|Compound:0469-0683|FD-Score:3.59|P-value:5.37E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:6.37|P-value:2.23E-9 ID:SGTC_87|Compound:0100-0052|FD-Score:3.49|P-value:7.44E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:6.91|P-value:9.49E-11 ID:SGTC_163|Compound:1327-0036|FD-Score:6.20|P-value:5.83E-9 ID:SGTC_268|Compound:camptothecin|FD-Score:3.54|P-value:6.33E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:4.87|P-value:3.91E-6 ID:SGTC_393|Compound:acivicin|FD-Score:-3.44|P-value:5.41E-4 ID:SGTC_411|Compound:enrofloxacin|FD-Score:-3.62|P-value:2.95E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.78|P-value:8.88E-11 ID:SGTC_530|Compound:4358-1714|FD-Score:3.62|P-value:4.74E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:3.79|P-value:2.65E-4 ID:SGTC_703|Compound:3875-0075|FD-Score:3.42|P-value:9.22E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:3.54|P-value:6.31E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:3.93|P-value:1.66E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:4.27|P-value:4.71E-5 ID:SGTC_1070|Compound:indatraline|FD-Score:5.03|P-value:2.00E-6 ID:SGTC_1076|Compound:itraconazole|FD-Score:3.97|P-value:1.41E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.53|P-value:6.46E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:4.36|P-value:3.34E-5 ID:SGTC_1244|Compound:0416-0015|FD-Score:-3.80|P-value:1.55E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.64|P-value:4.51E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:5.41|P-value:3.34E-7 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.92|P-value:1.71E-4 ID:SGTC_1384|Compound:3089-0840|FD-Score:3.58|P-value:5.39E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-3.90|P-value:1.07E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.87|P-value:2.06E-4 ID:SGTC_1868|Compound:st057644|FD-Score:3.42|P-value:9.05E-4 ID:SGTC_1917|Compound:st066507|FD-Score:5.20|P-value:8.95E-7 ID:SGTC_1927|Compound:st060202|FD-Score:3.45|P-value:8.21E-4 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:-3.52|P-value:4.11E-4 ID:SGTC_1934|Compound:st074720|FD-Score:-4.56|P-value:8.12E-6 ID:SGTC_1936|Compound:st074407|FD-Score:-3.99|P-value:7.66E-5 ID:SGTC_1944|Compound:st076371|FD-Score:3.52|P-value:6.69E-4 ID:SGTC_2040|Compound:5100729|FD-Score:4.77|P-value:5.99E-6 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.08|P-value:9.62E-5 ID:SGTC_2265|Compound:7929201|FD-Score:3.99|P-value:1.33E-4 ID:SGTC_2309|Compound:7664088|FD-Score:4.51|P-value:1.77E-5 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.65|P-value:4.39E-4 ID:SGTC_2429|Compound:5902844|FD-Score:4.00|P-value:1.30E-4 ID:SGTC_2444|Compound:5485484|FD-Score:4.20|P-value:6.20E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:6.84|P-value:1.45E-10 ID:SGTC_2814|Compound:7977482|FD-Score:4.41|P-value:2.74E-5 ID:SGTC_2827|Compound:7993847|FD-Score:4.46|P-value:2.22E-5 ID:SGTC_2870|Compound:9038528|FD-Score:3.55|P-value:6.09E-4 ID:SGTC_2871|Compound:9038510|FD-Score:-4.39|P-value:1.59E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-8.01|P-value:2.54E-14 ID:SGTC_2963|Compound:9082507|FD-Score:3.62|P-value:4.72E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.48|P-value:7.68E-4 ID:SGTC_3135|Compound:9127742|FD-Score:3.96|P-value:1.49E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.87|P-value:1.21E-4 ID:SGTC_34|Compound:0469-0683|FD-Score:3.59|P-value:5.37E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:6.37|P-value:2.23E-9 ID:SGTC_87|Compound:0100-0052|FD-Score:3.49|P-value:7.44E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:6.91|P-value:9.49E-11 ID:SGTC_163|Compound:1327-0036|FD-Score:6.20|P-value:5.83E-9 ID:SGTC_268|Compound:camptothecin|FD-Score:3.54|P-value:6.33E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:4.87|P-value:3.91E-6 ID:SGTC_393|Compound:acivicin|FD-Score:-3.44|P-value:5.41E-4 ID:SGTC_411|Compound:enrofloxacin|FD-Score:-3.62|P-value:2.95E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.78|P-value:8.88E-11 ID:SGTC_530|Compound:4358-1714|FD-Score:3.62|P-value:4.74E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:3.79|P-value:2.65E-4 ID:SGTC_703|Compound:3875-0075|FD-Score:3.42|P-value:9.22E-4 ID:SGTC_708|Compound:3448-5400|FD-Score:3.54|P-value:6.31E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:3.93|P-value:1.66E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:4.27|P-value:4.71E-5 ID:SGTC_1070|Compound:indatraline|FD-Score:5.03|P-value:2.00E-6 ID:SGTC_1076|Compound:itraconazole|FD-Score:3.97|P-value:1.41E-4 ID:SGTC_1199|Compound:1638-0010|FD-Score:3.53|P-value:6.46E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:4.36|P-value:3.34E-5 ID:SGTC_1244|Compound:0416-0015|FD-Score:-3.80|P-value:1.55E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.64|P-value:4.51E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:5.41|P-value:3.34E-7 ID:SGTC_1374|Compound:2889-5571|FD-Score:3.92|P-value:1.71E-4 ID:SGTC_1384|Compound:3089-0840|FD-Score:3.58|P-value:5.39E-4 ID:SGTC_1547|Compound:harmine|FD-Score:-3.90|P-value:1.07E-4 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.87|P-value:2.06E-4 ID:SGTC_1868|Compound:st057644|FD-Score:3.42|P-value:9.05E-4 ID:SGTC_1917|Compound:st066507|FD-Score:5.20|P-value:8.95E-7 ID:SGTC_1927|Compound:st060202|FD-Score:3.45|P-value:8.21E-4 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:-3.52|P-value:4.11E-4 ID:SGTC_1934|Compound:st074720|FD-Score:-4.56|P-value:8.12E-6 ID:SGTC_1936|Compound:st074407|FD-Score:-3.99|P-value:7.66E-5 ID:SGTC_1944|Compound:st076371|FD-Score:3.52|P-value:6.69E-4 ID:SGTC_2040|Compound:5100729|FD-Score:4.77|P-value:5.99E-6 ID:SGTC_2233|Compound:sulbentine|FD-Score:4.08|P-value:9.62E-5 ID:SGTC_2265|Compound:7929201|FD-Score:3.99|P-value:1.33E-4 ID:SGTC_2309|Compound:7664088|FD-Score:4.51|P-value:1.77E-5 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.65|P-value:4.39E-4 ID:SGTC_2429|Compound:5902844|FD-Score:4.00|P-value:1.30E-4 ID:SGTC_2444|Compound:5485484|FD-Score:4.20|P-value:6.20E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:6.84|P-value:1.45E-10 ID:SGTC_2814|Compound:7977482|FD-Score:4.41|P-value:2.74E-5 ID:SGTC_2827|Compound:7993847|FD-Score:4.46|P-value:2.22E-5 ID:SGTC_2870|Compound:9038528|FD-Score:3.55|P-value:6.09E-4 ID:SGTC_2871|Compound:9038510|FD-Score:-4.39|P-value:1.59E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-8.01|P-value:2.54E-14 ID:SGTC_2963|Compound:9082507|FD-Score:3.62|P-value:4.72E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.48|P-value:7.68E-4 ID:SGTC_3135|Compound:9127742|FD-Score:3.96|P-value:1.49E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.87|P-value:1.21E-4

Top fitness defect scores for YLR182W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_150 3970-0969 6.91 77.2 µM 9.49E-11 14 2.37E-12
2 SGTC_2620 irigenin 6.84 100.0 µM 1.45E-10 8 3.88E-12
3 SGTC_59 0330-0160 6.37 1.3 µM 2.23E-9 32 9.30E-11
4 SGTC_163 1327-0036 6.20 7.5 µM 5.83E-9 42 2.83E-10
5 SGTC_1333 1482-0047 5.41 286.0 µM 3.34E-7 5 3.13E-8
6 SGTC_1917 st066507 5.20 28.5 µM 8.95E-7 Golgi 17 9.86E-8
7 SGTC_1070 indatraline 5.03 8.8 µM 2.00E-6 60S ribosome export 12 2.51E-7
8 SGTC_386 1509-0011 4.87 3.1 µM 3.91E-6 113 5.47E-7
9 SGTC_2040 5100729 4.77 123.0 µM 5.99E-6 26 9.00E-7
10 SGTC_2309 7664088 4.51 163.9 µM 1.77E-5 16 3.18E-6
11 SGTC_2827 7993847 4.46 71.4 µM 2.22E-5 15 4.12E-6
12 SGTC_2814 7977482 4.41 43.0 µM 2.74E-5 36 5.28E-6
13 SGTC_1212 0520-0165 4.36 585.0 µM 3.34E-5 17 6.64E-6
14 SGTC_831 k061-1017 4.27 217.0 µM 4.71E-5 translation 42 9.91E-6
15 SGTC_2444 5485484 4.20 36.4 µM 6.20E-5 31 1.36E-5
16 SGTC_2233 sulbentine 4.08 40.4 µM 9.62E-5 59 2.27E-5
17 SGTC_2429 5902844 4.00 64.4 µM 1.30E-4 24 3.23E-5
18 SGTC_2265 7929201 3.99 200.0 µM 1.33E-4 21 3.32E-5
19 SGTC_1076 itraconazole 3.97 331.0 nM 1.41E-4 32 3.55E-5
20 SGTC_3135 9127742 3.96 49.5 µM 1.49E-4 22 3.77E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.167 1.68E-22 YBR068C BAP2 hom High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication
0.163 2.04E-21 YHR025W THR1 hom Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway
0.156 1.45E-19 YCR053W THR4 hom Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway
0.149 4.70E-18 YHR067W HTD2 hom Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology
0.144 4.64E-17 YDR381W YRA1 het RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member
0.143 8.60E-17 YIL052C RPL34B hom Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication
0.142 1.65E-16 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.142 1.70E-16 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.137 1.85E-15 YLR382C NAM2 hom Mitochondrial leucyl-tRNA synthetase, also has a direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance
0.129 6.43E-14 YBL071W-A KTI11 hom Zn-ribbon protein that co-purifies with Dph1 and Dph2 in a complex required for synthesis of diphthamide on translation factor eEF2 and with Elongator subunits Iki3p, Elp2p, and Elp3p involved in modification of wobble nucleosides in tRNAs
0.127 1.41E-13 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.126 2.47E-13 YDR231C COX20 hom Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.124 5.61E-13 YPL005W AEP3 hom Protein that may facilitate use of unformylated tRNA-Met in mitochondrial translation initiation; localized to the matrix face of the mitochondrial inner membrane; stabilizes the bicistronic AAP1-ATP6 mRNA
0.118 7.54E-12 YMR282C AEP2 hom Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader
0.118 8.61E-12 YCR028C-A RIM1 hom Single-stranded DNA-binding protein essential for mitochondrial genome maintenance; involved in mitochondrial DNA replication