YLR191W / PEX13

Integral peroxisomal membrane protein required for translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR191W / PEX13

Click on Significant Values for Screen Details ID:SGTC_5|Compound:0352-0601|FD-Score:3.80|P-value:1.46E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:-3.55|P-value:3.60E-4 ID:SGTC_27|Compound:0485-0001|FD-Score:-3.29|P-value:8.66E-4 ID:SGTC_271|Compound:rotenone|FD-Score:4.59|P-value:6.30E-6 ID:SGTC_336|Compound:4111-0029|FD-Score:3.55|P-value:3.63E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-3.80|P-value:1.49E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:3.86|P-value:1.18E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:3.96|P-value:8.06E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:5.08|P-value:6.67E-7 ID:SGTC_706|Compound:4262-0057|FD-Score:3.98|P-value:7.43E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:4.98|P-value:1.08E-6 ID:SGTC_779|Compound:1360-0071|FD-Score:3.63|P-value:2.77E-4 ID:SGTC_853|Compound:0419-0306|FD-Score:3.26|P-value:9.48E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:4.66|P-value:4.60E-6 ID:SGTC_942|Compound:3253-1115|FD-Score:-4.22|P-value:2.98E-5 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.83|P-value:1.32E-4 ID:SGTC_1139|Compound:k015-0024|FD-Score:3.46|P-value:4.91E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.34|P-value:7.45E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:3.77|P-value:1.68E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:4.91|P-value:1.49E-6 ID:SGTC_1392|Compound:3455-1037|FD-Score:3.43|P-value:5.36E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:-3.48|P-value:4.59E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:-3.36|P-value:6.88E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.86|P-value:1.18E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:3.31|P-value:8.11E-4 ID:SGTC_1606|Compound:st000094|FD-Score:3.60|P-value:3.00E-4 ID:SGTC_1649|Compound:st011737|FD-Score:3.62|P-value:2.82E-4 ID:SGTC_2284|Compound:7945075|FD-Score:-3.28|P-value:9.01E-4 ID:SGTC_2336|Compound:9001819|FD-Score:3.61|P-value:2.90E-4 ID:SGTC_2477|Compound:5967686|FD-Score:3.46|P-value:4.88E-4 ID:SGTC_2481|Compound:5478948|FD-Score:4.37|P-value:1.60E-5 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:4.00|P-value:7.01E-5 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.90|P-value:1.03E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:4.02|P-value:6.40E-5 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:4.90|P-value:1.51E-6 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.59|P-value:3.16E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:-3.30|P-value:8.38E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.90|P-value:1.04E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.46|P-value:4.91E-4 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:3.86|P-value:1.17E-4 ID:SGTC_2793|Compound:7325131|FD-Score:-3.42|P-value:5.67E-4 ID:SGTC_2806|Compound:7952793|FD-Score:12.70|P-value:1.04E-33 ID:SGTC_2809|Compound:7964133|FD-Score:-4.47|P-value:1.04E-5 ID:SGTC_2850|Compound:9015429|FD-Score:3.63|P-value:2.75E-4 ID:SGTC_2855|Compound:9016525|FD-Score:3.75|P-value:1.77E-4 ID:SGTC_2906|Compound:7926292|FD-Score:-3.28|P-value:8.93E-4 ID:SGTC_2924|Compound:9010168|FD-Score:3.35|P-value:7.09E-4 ID:SGTC_2992|Compound:9074591|FD-Score:5.24|P-value:3.05E-7 ID:SGTC_2995|Compound:9067767|FD-Score:3.64|P-value:2.63E-4 ID:SGTC_3298|Compound:9116858|FD-Score:3.31|P-value:8.15E-4 ID:SGTC_3303|Compound:9125618|FD-Score:6.82|P-value:4.16E-11 ID:SGTC_3305|Compound:9127027|FD-Score:5.49|P-value:8.77E-8 ID:SGTC_5|Compound:0352-0601|FD-Score:3.80|P-value:1.46E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:-3.55|P-value:3.60E-4 ID:SGTC_27|Compound:0485-0001|FD-Score:-3.29|P-value:8.66E-4 ID:SGTC_271|Compound:rotenone|FD-Score:4.59|P-value:6.30E-6 ID:SGTC_336|Compound:4111-0029|FD-Score:3.55|P-value:3.63E-4 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:-3.80|P-value:1.49E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:3.86|P-value:1.18E-4 ID:SGTC_653|Compound:0203-0016|FD-Score:3.96|P-value:8.06E-5 ID:SGTC_690|Compound:glyoxal|FD-Score:5.08|P-value:6.67E-7 ID:SGTC_706|Compound:4262-0057|FD-Score:3.98|P-value:7.43E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:4.98|P-value:1.08E-6 ID:SGTC_779|Compound:1360-0071|FD-Score:3.63|P-value:2.77E-4 ID:SGTC_853|Compound:0419-0306|FD-Score:3.26|P-value:9.48E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:4.66|P-value:4.60E-6 ID:SGTC_942|Compound:3253-1115|FD-Score:-4.22|P-value:2.98E-5 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.83|P-value:1.32E-4 ID:SGTC_1139|Compound:k015-0024|FD-Score:3.46|P-value:4.91E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.34|P-value:7.45E-4 ID:SGTC_1313|Compound:1220-0047|FD-Score:3.77|P-value:1.68E-4 ID:SGTC_1380|Compound:2291-0730|FD-Score:4.91|P-value:1.49E-6 ID:SGTC_1392|Compound:3455-1037|FD-Score:3.43|P-value:5.36E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:-3.48|P-value:4.59E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:-3.36|P-value:6.88E-4 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.86|P-value:1.18E-4 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:3.31|P-value:8.11E-4 ID:SGTC_1606|Compound:st000094|FD-Score:3.60|P-value:3.00E-4 ID:SGTC_1649|Compound:st011737|FD-Score:3.62|P-value:2.82E-4 ID:SGTC_2284|Compound:7945075|FD-Score:-3.28|P-value:9.01E-4 ID:SGTC_2336|Compound:9001819|FD-Score:3.61|P-value:2.90E-4 ID:SGTC_2477|Compound:5967686|FD-Score:3.46|P-value:4.88E-4 ID:SGTC_2481|Compound:5478948|FD-Score:4.37|P-value:1.60E-5 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:4.00|P-value:7.01E-5 ID:SGTC_2581|Compound:avocatin a|FD-Score:3.90|P-value:1.03E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:4.02|P-value:6.40E-5 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:4.90|P-value:1.51E-6 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.59|P-value:3.16E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:-3.30|P-value:8.38E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.90|P-value:1.04E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:3.46|P-value:4.91E-4 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:3.86|P-value:1.17E-4 ID:SGTC_2793|Compound:7325131|FD-Score:-3.42|P-value:5.67E-4 ID:SGTC_2806|Compound:7952793|FD-Score:12.70|P-value:1.04E-33 ID:SGTC_2809|Compound:7964133|FD-Score:-4.47|P-value:1.04E-5 ID:SGTC_2850|Compound:9015429|FD-Score:3.63|P-value:2.75E-4 ID:SGTC_2855|Compound:9016525|FD-Score:3.75|P-value:1.77E-4 ID:SGTC_2906|Compound:7926292|FD-Score:-3.28|P-value:8.93E-4 ID:SGTC_2924|Compound:9010168|FD-Score:3.35|P-value:7.09E-4 ID:SGTC_2992|Compound:9074591|FD-Score:5.24|P-value:3.05E-7 ID:SGTC_2995|Compound:9067767|FD-Score:3.64|P-value:2.63E-4 ID:SGTC_3298|Compound:9116858|FD-Score:3.31|P-value:8.15E-4 ID:SGTC_3303|Compound:9125618|FD-Score:6.82|P-value:4.16E-11 ID:SGTC_3305|Compound:9127027|FD-Score:5.49|P-value:8.77E-8

Top fitness defect scores for YLR191W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2806 7952793 12.70 58.4 µM 1.04E-33 1 5.57E-37
2 SGTC_3303 9125618 6.82 40.6 µM 4.16E-11 8 4.52E-12
3 SGTC_3305 9127027 5.49 53.8 µM 8.77E-8 4 2.06E-8
4 SGTC_2992 9074591 5.24 71.4 µM 3.05E-7 6 8.10E-8
5 SGTC_690 glyoxal 5.08 20.3 µM 6.67E-7 59 1.92E-7
6 SGTC_769 0302-0231 4.98 76.0 µM 1.08E-6 17 3.26E-7
7 SGTC_1380 2291-0730 4.91 164.0 µM 1.49E-6 9 4.64E-7
8 SGTC_2614 arthonioic acid 4.90 13.4 µM 1.51E-6 9 4.70E-7
9 SGTC_939 1165-0479 4.66 45.3 µM 4.60E-6 13 1.60E-6
10 SGTC_271 rotenone 4.59 740.0 µM 6.30E-6 14 2.26E-6
11 SGTC_2481 5478948 4.37 45.2 µM 1.60E-5 PDR1 25 6.30E-6
12 SGTC_2607 solasodine 4.02 47.4 µM 6.40E-5 57 2.88E-5
13 SGTC_2512 diallyl trisulfide 4.00 49.2 µM 7.01E-5 7 3.19E-5
14 SGTC_706 4262-0057 3.98 46.9 µM 7.43E-5 fatty acid desaturase (OLE1) 33 3.40E-5
15 SGTC_653 0203-0016 3.96 55.2 µM 8.06E-5 13 3.71E-5
16 SGTC_2581 avocatin a 3.90 64.0 µM 1.03E-4 sphingolipid biosynthesis & PDR1 53 4.84E-5
17 SGTC_2762 leflunomide 3.90 42.1 µM 1.04E-4 30 4.90E-5
18 SGTC_2775 cyproheptadine 3.86 69.6 µM 1.17E-4 20 5.60E-5
19 SGTC_1545 lovastatin 3.86 49.4 µM 1.18E-4 26 5.65E-5
20 SGTC_598 3937-0236 3.86 20.2 µM 1.18E-4 ERG2 26 5.66E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.131 2.55E-14 YOR005C DNL4 hom DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth
0.117 1.01E-11 YDR333C RQC1 hom Component of the ribosome quality control complex (RQC); RQC (Rqc1p-Ltn1p-Tae2p-Cdc48p-Npl4p-Ufd1p), is a ribosome-bound complex required for the degradation of polypeptides arising from stalled translation; required along with Ltn1p for recruitment of the Cdc48p-Npl4p-Ufd1p AAA ATPase complex to the RQC
0.115 2.29E-11 YBR262C AIM5 hom Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture
0.107 4.42E-10 YJL016W_p YJL016W_p hom Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; conserved in closely related Saccharomyces species
0.104 1.37E-9 YMR115W MGR3 hom Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA
0.103 1.93E-9 YMR135W-A_d YMR135W-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.100 5.89E-9 YER154W OXA1 hom Mitochondrial inner membrane insertase, mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane, interacts with mitochondrial ribosomes; conserved from bacteria to animals
0.098 1.09E-8 YDR146C SWI5 hom Transcription factor that recruits Mediator and Swi/Snf complexes; activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; required for expression of the HO gene controlling mating type switching; localization to nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase; SWI5 has a paralog, ACE2, that arose from the whole genome duplication
0.098 1.25E-8 YPL182C_d YPL182C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CTI6/YPL181W
0.094 4.19E-8 YHL037C_d YHL037C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.093 5.87E-8 YGL164C YRB30 hom RanGTP-binding protein, inhibits RanGAP1 (Rna1p)-mediated GTP hydrolysis of RanGTP (Gsp1p); shares similarity to proteins in other fungi but not in higher eukaryotes
0.092 9.66E-8 YPL134C ODC1 hom Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation
0.091 1.27E-7 YOL052C SPE2 hom S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically
0.090 1.79E-7 YKL210W UBA1 het Ubiquitin activating enzyme (E1); involved in ubiquitin-mediated protein degradation and essential for viability; protein abundance increases in response to DNA replication stress
0.089 2.20E-7 YOR173W DCS2 hom Non-essential, stress induced regulatory protein; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway; mutant has increased aneuploidy tolerance