YLR193C / UPS1

Phosphatidic acid transfer protein; plays a role in phospholipid metabolism by transporting phosphatidic acid from the outer to the inner mitochondrial membrane; localizes to the mitochondrial intermembrane space; null mutant has altered cardiolipin and phosphatidic acid levels; ortholog of human PRELI

Zygosity: Homozygous strain
fixedexpanded
Profile for YLR193C / UPS1

Click on Significant Values for Screen Details ID:SGTC_149|Compound:3970-0822|FD-Score:3.38|P-value:1.91E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:-7.59|P-value:5.56E-15 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.70|P-value:3.50E-9 ID:SGTC_513|Compound:4245-1575|FD-Score:4.54|P-value:1.06E-6 ID:SGTC_540|Compound:1187-0821|FD-Score:3.06|P-value:6.31E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.27|P-value:2.89E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:3.13|P-value:4.88E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:5.24|P-value:2.37E-8 ID:SGTC_1119|Compound:parthenolide|FD-Score:4.48|P-value:1.43E-6 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.45|P-value:1.48E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:-3.50|P-value:2.16E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:3.15|P-value:4.52E-4 ID:SGTC_1609|Compound:st001574|FD-Score:-3.14|P-value:8.20E-4 ID:SGTC_1834|Compound:st055981|FD-Score:3.08|P-value:5.83E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.06|P-value:6.45E-4 ID:SGTC_2332|Compound:7982454|FD-Score:-4.73|P-value:8.22E-7 ID:SGTC_2375|Compound:9072683|FD-Score:3.49|P-value:1.22E-4 ID:SGTC_2391|Compound:6285546|FD-Score:3.47|P-value:1.35E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-3.66|P-value:1.15E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.15|P-value:4.59E-4 ID:SGTC_2943|Compound:9068529|FD-Score:-3.11|P-value:8.95E-4 ID:SGTC_3220|Compound:9131269|FD-Score:-3.34|P-value:3.93E-4 ID:SGTC_3231|Compound:9132313|FD-Score:3.29|P-value:2.72E-4 ID:SGTC_3297|Compound:9117502|FD-Score:3.21|P-value:3.66E-4 ID:SGTC_149|Compound:3970-0822|FD-Score:3.38|P-value:1.91E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:-7.59|P-value:5.56E-15 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.70|P-value:3.50E-9 ID:SGTC_513|Compound:4245-1575|FD-Score:4.54|P-value:1.06E-6 ID:SGTC_540|Compound:1187-0821|FD-Score:3.06|P-value:6.31E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.27|P-value:2.89E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:3.13|P-value:4.88E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:5.24|P-value:2.37E-8 ID:SGTC_1119|Compound:parthenolide|FD-Score:4.48|P-value:1.43E-6 ID:SGTC_1247|Compound:0448-0043|FD-Score:3.45|P-value:1.48E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:-3.50|P-value:2.16E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:3.15|P-value:4.52E-4 ID:SGTC_1609|Compound:st001574|FD-Score:-3.14|P-value:8.20E-4 ID:SGTC_1834|Compound:st055981|FD-Score:3.08|P-value:5.83E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.06|P-value:6.45E-4 ID:SGTC_2332|Compound:7982454|FD-Score:-4.73|P-value:8.22E-7 ID:SGTC_2375|Compound:9072683|FD-Score:3.49|P-value:1.22E-4 ID:SGTC_2391|Compound:6285546|FD-Score:3.47|P-value:1.35E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-3.66|P-value:1.15E-4 ID:SGTC_2858|Compound:9025781|FD-Score:3.15|P-value:4.59E-4 ID:SGTC_2943|Compound:9068529|FD-Score:-3.11|P-value:8.95E-4 ID:SGTC_3220|Compound:9131269|FD-Score:-3.34|P-value:3.93E-4 ID:SGTC_3231|Compound:9132313|FD-Score:3.29|P-value:2.72E-4 ID:SGTC_3297|Compound:9117502|FD-Score:3.21|P-value:3.66E-4

Top fitness defect scores for YLR193C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_871 0574-0004 5.24 149.0 µM 2.37E-8 18 8.14E-8
2 SGTC_513 4245-1575 4.54 41.7 µM 1.06E-6 unfolded protein response 88 2.83E-6
3 SGTC_1119 parthenolide 4.48 318.5 nM 1.43E-6 TSC3-RPN4 27 3.76E-6
4 SGTC_2375 9072683 3.49 200.0 µM 1.22E-4 mitochondrial processes 28 2.38E-4
5 SGTC_2391 6285546 3.47 200.0 µM 1.35E-4 29 2.62E-4
6 SGTC_1247 0448-0043 3.45 5.8 µM 1.48E-4 ERG2 72 2.84E-4
7 SGTC_149 3970-0822 3.38 46.1 µM 1.91E-4 tubulin folding & SWR complex 136 3.60E-4
8 SGTC_3231 9132313 3.29 49.5 µM 2.72E-4 17 5.01E-4
9 SGTC_690 glyoxal 3.27 20.3 µM 2.89E-4 125 5.31E-4
10 SGTC_3297 9117502 3.21 71.4 µM 3.66E-4 28 6.60E-4
11 SGTC_1332 1480-0653 3.15 17.5 µM 4.52E-4 TSC3-RPN4 38 8.04E-4
12 SGTC_2858 9025781 3.15 9.0 µM 4.59E-4 sphingolipid biosynthesis & PDR1 155 8.15E-4
13 SGTC_704 1310-0270 3.13 142.0 µM 4.88E-4 66 8.63E-4
14 SGTC_1834 st055981 3.08 52.8 µM 5.83E-4 RPP1 & pyrimidine depletion 69 0.00102
15 SGTC_540 1187-0821 3.06 17.3 µM 6.31E-4 41 0.00110
16 SGTC_2309 7664088 3.06 163.9 µM 6.45E-4 99 0.00112
17 SGTC_2027 5150920 2.93 200.0 µM 0.00102 47 0.00172
18 SGTC_2035 5154463 2.92 94.6 µM 0.00106 69 0.00177
19 SGTC_212 3807-4682 2.91 38.8 µM 0.00106 tubulin folding & SWR complex 151 0.00178
20 SGTC_423 5-fluorouracil 2.87 457.0 µM 0.00123 exosome 79 0.00205

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.151 1.15E-18 YOR364W_d YOR364W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C
0.144 5.15E-17 YKL213C DOA1 hom WD repeat protein required for ubiquitin-mediated protein degradation; forms a complex with Cdc48p; plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase; protein increases in abundance and relocalizes from nucleus to nuclear periphery upon DNA replication stress
0.134 6.98E-15 YDR041W RSM10 het Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins
0.124 4.76E-13 YJR117W STE24 hom Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans
0.118 7.63E-12 YML007W YAP1 hom Basic leucine zipper (bZIP) transcription factor; required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; Yap1p is degraded in the nucleus after the oxidative stress has passed; mediates resistance to cadmium; YAP1 has a paralog, CAD1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.112 7.48E-11 YGR208W SER2 hom Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source
0.109 2.24E-10 YOR346W REV1 hom Deoxycytidyl transferase; involved in repair of abasic sites and adducted guanines in damaged DNA by translesion synthesis (TLS); forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.109 2.34E-10 YOR124C UBP2 hom Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; interacts with Rsp5p and is required for MVB sorting of membrane proteins; can cleave polyubiquitin and has isopeptidase activity
0.105 9.51E-10 YDR385W EFT2 hom Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT2 has a paralog, EFT1, that arose from the whole genome duplication
0.103 2.47E-9 YMR257C PET111 hom Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane
0.101 4.02E-9 YLR106C MDN1 het Huge dynein-related AAA-type ATPase (midasin), forms extended pre-60S particle with the Rix1 complex (Rix1p-Ipi1p-Ipi3p); acts in removal of ribosomal biogenesis factors at successive steps of pre-60S assembly and export from nucleus
0.101 4.80E-9 YGR190C_d YGR190C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W
0.100 7.91E-9 YLR285W NNT1 hom S-adenosylmethionine-dependent methyltransferase; has a role in rDNA silencing and in lifespan determination
0.098 1.16E-8 YKL074C MUD2 hom Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65
0.098 1.16E-8 YBR082C UBC4 hom Ubiquitin-conjugating enzyme (E2); mediates degradation of abnormal or excess proteins, including calmodulin and histone H3; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response; UBC4 has a paralog, UBC5, that arose from the whole genome duplication